| Association of Polymorphism CHRNA5 and CHRNA3 Gene in People Addicted to Nicotine. | Association of Polymorphism CHRNA5 and CHRNA3 Gene in People Addicted to Nicotine.
Chmielowiec K, Chmielowiec J, Strońska-Pluta A, Trybek G, Śmiarowska M, Suchanecka A, Woźniak G, Jaroń A, Grzywacz A., Free PMC Article | 10/8/2022 |
| Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM)-like Symptoms Associated with Anti-ganglionic Acetylcholine Receptor Antibodies. | Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM)-like Symptoms Associated with Anti-ganglionic Acetylcholine Receptor Antibodies.
Kitazaki Y, Ikawa M, Kishitani T, Kamisawa T, Nakane S, Nakamoto Y, Hamano T., Free PMC Article | 09/4/2021 |
| Familial Autonomic Ganglionopathy Caused by Rare CHRNA3 Genetic Variants. | Familial Autonomic Ganglionopathy Caused by Rare CHRNA3 Genetic Variants.
Shibao CA, Joos K, Phillips JA 3rd, Cogan J, Newman JH, Hamid R, Meiler J, Capra J, Sheehan J, Vetrini F, Yang Y, Black B, Diedrich A, Roberston D, Biaggioni I., Free PMC Article | 07/24/2021 |
| Association Between Nicotine-dependent Gene Polymorphism and Smoking Cessation in Patients With Lung Cancer. | Association Between Nicotine-dependent Gene Polymorphism and Smoking Cessation in Patients With Lung Cancer.
Gu F, Zhao C, Jiang T, Li X, Mao Y, Zhou C. | 04/3/2021 |
| The relationship between CHRNA5/A3/B4 gene cluster polymorphisms and lung cancer risk: An updated meta-analysis and systematic review. | The relationship between CHRNA5/A3/B4 gene cluster polymorphisms and lung cancer risk: An updated meta-analysis and systematic review.
Yi X, Li W, Wang Y, Chen X, Ye F, Sun G, Chen J., Free PMC Article | 02/27/2021 |
| Antibodies to the alpha3 subunit of the ganglionic-type nicotinic acetylcholine receptors in patients with autoimmune encephalitis. | Antibodies to the α3 subunit of the ganglionic-type nicotinic acetylcholine receptors in patients with autoimmune encephalitis.
Yamakawa M, Mukaino A, Kimura A, Nagasako Y, Kitazaki Y, Maeda Y, Higuchi O, Takamatsu K, Watari M, Yoshikura N, Ikawa M, Sugimoto I, Sakurai Y, Matsuo H, Ando Y, Shimohata T, Nakane S. | 12/19/2020 |
| [Analysis of polymorphism rs1051730 of CHRNA3 in patients with dual pathology in a Mexican population].", trans "Analisis del polimorfismo rs1051730 de CHRNA3 en pacientes con patologia dual en poblacion mexicana. | [Analysis of polymorphism rs1051730 of CHRNA3 in patients with dual pathology in a Mexican population].
Genis-Mendoza A, Rodriguez-Sibrian L, Martinez-Magana J, Tovilla-Zarate C, Juarez-Rojo I, Gonzalez-Castro T, Lopez-Narvaez M, Lanzagorta N, Escamilla M, Nicolini H. | 10/24/2020 |
| Results find rs578776 polymorphism in CHRNA3 not associated with head and neck cancer (HNC) risk. | Polymorphisms of CHRNA3 and CHRNA5: Head and neck cancer and cigarette consumption intensity in a Brazilian population.
Silva MR, Gattás GJF, De Antonio J, Firigato I, Curioni OA, Gonçalves FT., Free PMC Article | 06/20/2020 |
| Truncating mutations in CHRNA3 gene causes Congenital anomalies of the kidney and urinary tract and Autonomic Dysfunction. | CAKUT and Autonomic Dysfunction Caused by Acetylcholine Receptor Mutations.
Mann N, Kause F, Henze EK, Gharpure A, Shril S, Connaughton DM, Nakayama M, Klämbt V, Majmundar AJ, Wu CW, Kolvenbach CM, Dai R, Chen J, van der Ven AT, Ityel H, Tooley MJ, Kari JA, Bownass L, El Desoky S, De Franco E, Shalaby M, Tasic V, Bauer SB, Lee RS, Beckel JM, Yu W, Mane SM, Lifton RP, Reutter H, Ellard S, Hibbs RE, Kawate T, Hildebrandt F., Free PMC Article | 04/4/2020 |
| Gene variance in the CHRNA5/CHRNA3 is associated with risk of lumbar disc herniation. | CHRNA5/CHRNA3 gene cluster is a risk factor for lumbar disc herniation: a case-control study.
Yang X, Guo X, Huang Z, Da Y, Xing W, Li F, Li M, Sun K, Jia H, Zhu Y., Free PMC Article | 01/18/2020 |
| CHRNA3/5 polymorphisms are associated with nicotine dependence, lung cancer, and chronic obstructive pulmonary disease in Mexicans. | CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms are associated with heavy smoking, lung cancer, and chronic obstructive pulmonary disease in a mexican population.
Pérez-Morales R, González-Zamora A, González-Delgado MF, Calleros Rincón EY, Olivas Calderón EH, Martínez-Ramírez OC, Rubio J. | 07/20/2019 |
| Results indicate rs4887074 is associated with nicotinic receptor CHRNB4 expression, and along with two regulatory variants of nicotinic receptors CHRNA3 and CHRNA5, modulates the effect of rs16969968 on nicotine dependence risk. | Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence.
Lee SH, Ahn WY, Seweryn M, Sadee W., Free PMC Article | 03/16/2019 |
| All four variants were significantly associated (P < 1.4 x 10(-6)) with blood DNA methylation of IREB2, CHRNA3 and PSMA4, of which two, including IREB2 and PSMA4, were also differentially methylated in Chronic obstructive pulmonary disease cases and controls | Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics.
Nedeljkovic I, Carnero-Montoro E, Lahousse L, van der Plaat DA, de Jong K, Vonk JM, van Diemen CC, Faiz A, van den Berge M, Obeidat M, Bossé Y, Nickle DC, Consortium B, Uitterlinden AG, van Meurs JJB, Stricker BCH, Brusselle GG, Postma DS, Boezen HM, van Duijn CM, Amin N., Free PMC Article | 02/16/2019 |
| In our analysis, we found one pair of SNPs in CHRNA1 and CHRNA7, plus one pair of SNPs in CHRNA2 and CHRNA3 reached corrected significance in tests for GxG interaction. Our study suggested evidence of interactions between CHRNs in controlling the risk of NSCL/P. | Evaluating the effect of nicotinic cholinergic receptor genes on the risk of nonsyndromic cleft lip with or without cleft palate.
Wang M, Liu D, Schwender H, Wang H, Wang P, Zhou Z, Li J, Wu T, Zhu H, Beaty TH. | 12/22/2018 |
| Frequency of the cholinergic receptor nicotinic alpha 5 (CHRNA5) rs16969968-A allele and cholinergic receptor nicotinic alpha 3 (CHRNA3) rs1051730-T allele were significantly higher in lung cancer than in normal controls. | CHRNA5 and CHRNA3 polymorphism and lung cancer susceptibility in Palestinian population.
Ayesh BM, Al-Masri R, Abed AA., Free PMC Article | 09/29/2018 |
| Data indicate potential associations between CHRNA3polymorphisms and schizophrenia susceptibility, and the significant variants identified in our study may be used as genetic biomarkers for schizophrenia susceptibility in Chinese Han population | Association analysis of CHRNA3 polymorphisms with schizophrenia in a Chinese Han population: A case-control study.
Li G, Bai M, Guo C, Zhu L, Wang L, Yuan D, Jin T, He Y., Free PMC Article | 06/23/2018 |
| The rs13180 (IREB2), rs16969968 (CHRNA5) and rs1051730 (CHRNA3) were significantly associated with Chronic obstructive pulmonary disease (COPD) in additive model [Padj =0.00001, odds ratio (OR)=0.64; Padj =0.0001, OR=1.41 and Padj =0.0001, OR=1.47]. The C-G haplotype by rs13180 and rs1051730 was a protective factor for COPD in our population (Padj =0.0005, OR=0.61). | IREB2, CHRNA5, CHRNA3, FAM13A & hedgehog interacting protein genes polymorphisms & risk of chronic obstructive pulmonary disease in Tatar population from Russia.
Korytina GF, Akhmadishina LZ, Viktorova EV, Kochetova OV, Viktorova TV., Free PMC Article | 01/20/2018 |
| our results show that a genomic region with functionally related genes, such as the CHRNA5/CHRNA3/CHRNB4 cluster, is under coordinated regulatory control. | The CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations.
Barrie ES, Hartmann K, Lee SH, Frater JT, Seweryn M, Wang D, Sadee W., Free PMC Article | 01/13/2018 |
| CHRNA3 genetic risk score was associated with successful smoking cessation in a Chinese rural population. | Relative contribution of genetic, individual, and self-efficacy factors to smoking cessation in a Chinese rural population.
Wang Q, Li S, Li H, Yang X, Jiang F, Zhang N, Han M, Jia C. | 12/9/2017 |
| The minor allele increased the risk of COPD when compared to the population at large. Homozygosity for the risk allele was associated in both cohorts with all-cause mortality, with any type of cancer among the COPD patients and with the number of pack-years among the male smokers. | CHRNA5/CHRNA3 Locus Associates with Increased Mortality among Smokers.
Kupiainen H, Kuokkanen M, Kontto J, Virtamo J, Salomaa V, Lindqvist A, Kilpeläinen M, Laitinen T. | 11/26/2017 |
| The results of this study suggests a pleiotropic role of Chr15q25 CHRNA5-CHRNA3-CHRNB4 gene cluster with complex influences in ADHD, tobacco smoking and cognitive performance. | Pleiotropic effects of Chr15q25 nicotinic gene cluster and the relationship between smoking, cognition and ADHD.
Schuch JB, Polina ER, Rovaris DL, Kappel DB, Mota NR, Cupertino RB, Silva KL, Guimarães-da-Silva PO, Karam RG, Salgado CAI, White MJ, Rohde LA, Grevet EH, Bau CHD. | 09/9/2017 |
| both rs578776 and rs938682 of CHRNA3 were significantly associated with the susceptibility of lung cancer. | Association between two CHRNA3 variants and susceptibility of lung cancer: a meta-analysis.
Qu X, Wang K, Dong W, Shen H, Wang Y, Liu Q, Du J., Free PMC Article | 01/14/2017 |
| the association of 3 selected single-nucleotide polymorphisms (CHRNA3 rs1051730, rs6495308, and CHRNA5 rs55853898) with nicotine dependence in an isolated population of Kashubians from Poland, is reported. | Association Between CHRNA3 and CHRNA5 Nicotine Receptor Subunit Gene Variants and Nicotine Dependence in an Isolated Populationof Kashubians in Poland.
Kita-Milczarska K, Sieminska A, Jassem E., Free PMC Article | 12/31/2016 |
| CHRNA3 rs1051730 (G > A) and AGPHD1 rs8034191 (A > G) were more susceptible to lung cancers than noncarriers. | Different effects of the three polymorphisms on 15q25.1 onlung cancer risk: Evidence from published literatures.
Sun H, Pan Y, He B, Deng Q, Ying H, Chen J, Liu X, Wang S. | 12/31/2016 |
| focus on the CHRNA5/A3/B4 gene cluster and its role in nicotine dependence (review) | Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism.
Wen L, Jiang K, Yuan W, Cui W, Li MD. | 12/17/2016 |