| Microbiota-derived butyrate dynamically regulates intestinal homeostasis through regulation of actin-associated protein synaptopodin. | Microbiota-derived butyrate dynamically regulates intestinal homeostasis through regulation of actin-associated protein synaptopodin.
Wang RX, Lee JS, Campbell EL, Colgan SP., Free PMC Article | 08/22/2020 |
| We show that recombinant human KIBRA WW2 domain is primarily disordered, binds SYNPO with relatively weak affinity and remains largely disordered in the complex. | Intrinsic disorder and amino acid specificity modulate binding of the WW2 domain in kidney and brain protein (KIBRA) to synaptopodin.
Kwok E, Rodriguez DJ, Kremerskothen J, Nyarko A., Free PMC Article | 06/13/2020 |
| The postsynaptic protein, synaptopodin (SYNPO) was significantly down-regulated in both dementia with Lewy bodies and Parkinson's disease dementia subgroups, suggesting a defective synaptic transmission in the demented patients. | An iTRAQ-based proteomic analysis reveals dysregulation of neocortical synaptopodin in Lewy body dementias.
Datta A, Chai YL, Tan JM, Lee JH, Francis PT, Chen CP, Sze SK, Lai MKP., Free PMC Article | 05/12/2018 |
| Urine synaptopodin is associated with serum creatinine elevation in the patients with glomerulonephritis including diabetic kidney disease regardless of urine albumin excretion. We suggest that the urine synaptopodin level can predict glomerular damage independently of the urine albumin excretion. | Urine synaptopodin excretion is an important marker of glomerular disease progression.
Kwon SK, Kim SJ, Kim HY., Free PMC Article | 08/12/2017 |
| SYNPO variants are involved in AMPA receptor trafficking and neuronal plasticity, which are associated with cognitive impairment and schizophrenia susceptibility. | Exome Sequence Data From Multigenerational Families Implicate AMPA Receptor Trafficking in Neurocognitive Impairment and Schizophrenia Risk.
Kos MZ, Carless MA, Peralta J, Blackburn A, Almeida M, Roalf D, Pogue-Geile MF, Prasad K, Gur RC, Nimgaonkar V, Curran JE, Duggirala R, Glahn DC, Blangero J, Gur RE, Almasy L., Free PMC Article | 01/14/2017 |
| This study identified and confirmed SYNPO protein changes within the postsynaptic density in schizophrenia | Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia.
Föcking M, Lopez LM, English JA, Dicker P, Wolff A, Brindley E, Wynne K, Cagney G, Cotter DR. | 12/12/2015 |
| Case Report: immunohistologically detected synaptopodin upregulation in foamy podocytes in Fabry disease due to novel alpha-galactosidase A mutation. | A heterozygous female with Fabry disease due to a novel α-galactosidase A mutation exhibits a unique synaptopodin distribution in vacuolated podocytes.
Takahashi N, Yokoi S, Kasuno K, Kogami A, Tsukimura T, Togawa T, Saito S, Ohno K, Hara M, Kurosawa H, Hirayama Y, Kurose T, Yokoyama Y, Mikami D, Kimura H, Naiki H, Sakuraba H, Iwano M. | 08/29/2015 |
| expression significantly down-regulated in presence of WT1 R458Q mutation | A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS.
Hall G, Gbadegesin RA, Lavin P, Wu G, Liu Y, Oh EC, Wang L, Spurney RF, Eckel J, Lindsey T, Homstad A, Malone AF, Phelan PJ, Shaw A, Howell DN, Conlon PJ, Katsanis N, Winn MP., Free PMC Article | 06/20/2015 |
| Shear stress induced actin binding proteins including SYNPO may play a critical role in endothelial wound healing. | Expression of synaptopodin in endothelial cells exposed to laminar shear stress and its role in endothelial wound healing.
Mun GI, Park S, Kremerskothen J, Boo YC. | 05/17/2014 |
| These results suggested that the SA is an important component of the molecular machinery controlling the calcium-dependent accumulation of AMPA-receptors (AMPA-R) at excitatory synapses. [review] | Synaptopodin and the spine apparatus organelle-regulators of different forms of synaptic plasticity?
Vlachos A. | 12/22/2012 |
| The urinary mRNA profiles of synaptopodin, podocalyxin, CD2-AP, alpha-actin4, and podocin were found to increase with the progression of diabetic nephropathy. | Urinary podocyte-associated mRNA profile in various stages of diabetic nephropathy.
Zheng M, Lv LL, Ni J, Ni HF, Li Q, Ma KL, Liu BC., Free PMC Article | 10/8/2011 |
| Podocyte BK(Ca) channels are regulated by synaptopodin, Rho, and actin microfilaments. | Regulation of podocyte BK(Ca) channels by synaptopodin, Rho, and actin microfilaments.
Kim EY, Suh JM, Chiu YH, Dryer SE., Free PMC Article | 09/27/2010 |
| Heterozygous mutations in the promoters of the ACTN4 and SYNPO genes are found in patients with idiopathic focal segmental glomerulosclerosis. | Functional analysis of promoter mutations in the ACTN4 and SYNPO genes in focal segmental glomerulosclerosis.
Dai S, Wang Z, Pan X, Wang W, Chen X, Ren H, Hao C, Han B, Chen N. | 06/14/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Human variation in alcohol response is influenced by variation in neuronal signaling genes.
Joslyn G, Ravindranathan A, Brush G, Schuckit M, White RL. | 04/7/2010 |
| Discusses isoforms of mouse Synpo, two of which are consistent with those found in human. | Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner.
Asanuma K, Kim K, Oh J, Giardino L, Chabanis S, Faul C, Reiser J, Mundel P., Free PMC Article | 10/9/2009 |
| Synaptopodin, an actin-associated protein, as a novel regulator of RhoA signalling and cell migration in kidney podocytes. | Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling.
Asanuma K, Yanagida-Asanuma E, Faul C, Tomino Y, Kim K, Mundel P. | 01/21/2010 |
| Our data suggest dendritic spine accumulation of SYNPO critically depends on interaction with postsynaptic alpha-actinin and that SYNPO may regulate spine morphology, motility and function via its distinct modes of association with the actin cytoskeleton. | Synaptopodin, a molecule involved in the formation of the dendritic spine apparatus, is a dual actin/alpha-actinin binding protein.
Kremerskothen J, Plaas C, Kindler S, Frotscher M, Barnekow A. | 01/21/2010 |
| We conclude that down-regulation of nephrin and synaptopodin is associated with proteinuria in women with preeclampsia. | Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia.
Garovic VD, Wagner SJ, Petrovic LM, Gray CE, Hall P, Sugimoto H, Kalluri R, Grande JP. | 01/21/2010 |
| Reduced expression of both synaptopodin and GLEPP1 is associated with poor response to steroid therapy in primary focal segmental glomerulosclerosis. | Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis.
Hirakawa M, Tsuruya K, Yotsueda H, Tokumoto M, Ikeda H, Katafuchi R, Fujimi S, Hirakata H, Iida M. | 01/21/2010 |
| interaction with tight junction protein MAGI-1 | Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B. | 01/21/2010 |