| The M3 Muscarinic Acetylcholine Receptor Can Signal through Multiple G Protein Families. | The M3 Muscarinic Acetylcholine Receptor Can Signal through Multiple G Protein Families.
Smith JS, Hilibrand AS, Skiba MA, Dates AN, Calvillo-Miranda VG, Kruse AC., Free PMC Article | 08/21/2024 |
| Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults. | Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults.
Zhang X, Yao S, Bao P, Du M, Hu G, Chu C, Wang D, Chen C, Ma Q, Jia H, Sun Y, Yan Y, Liao Y, Niu Z, Man Z, Wang L, Gao W, Li H, Zhang J, Luo W, Wang X, Wang Y, Mu J., Free PMC Article | 07/1/2024 |
| Muscarinic Acetylcholine Receptor M3 Expression and Survival in Human Colorectal Carcinoma-An Unexpected Correlation to Guide Future Treatment? | Muscarinic Acetylcholine Receptor M3 Expression and Survival in Human Colorectal Carcinoma-An Unexpected Correlation to Guide Future Treatment?
Lobbes LA, Schütze MA, Droeser R, Arndt M, Pozios I, Lauscher JC, Hering NA, Weixler B., Free PMC Article | 05/22/2023 |
| CHRM3-Associated miRNAs May Play a Role in Bile Acid-Induced Proliferation of H508 Colon Cancer Cells. | CHRM3-Associated miRNAs May Play a Role in Bile Acid-Induced Proliferation of H508 Colon Cancer Cells.
Aktan Ç, Tekin F, Oruç N, Özütemiz Ö., Free PMC Article | 03/19/2023 |
| Impaired sweating in patients with cholinergic urticaria is linked to low expression of acetylcholine receptor CHRM3 and acetylcholine esterase in sweat glands. | Impaired sweating in patients with cholinergic urticaria is linked to low expression of acetylcholine receptor CHRM3 and acetylcholine esterase in sweat glands.
Wang Y, Scheffel J, Vera CA, Liu W, Günzel D, Terhorst-Molawi D, Maurer M, Altrichter S., Free PMC Article | 09/3/2022 |
| Expression of M3 muscarinic acetylcholine receptors in gastric cancer. | Expression of M3 muscarinic acetylcholine receptors in gastric cancer.
Mehedinţeanu AM, Mirea CS, Stovicek PO, Schenker M, Stancu MI, Ciurea AM, Streba L, Istrate-Ofiţeru AM, Sas TN, Vere CC., Free PMC Article | 06/18/2022 |
| Methylation-reprogrammed CHRM3 results in vascular dysfunction in the human umbilical vein following IVF-ETdagger. | Methylation-reprogrammed CHRM3 results in vascular dysfunction in the human umbilical vein following IVF-ET†.
Shi Y, Liu J, Zhu D, Lu L, Zhang M, Li W, Zeng H, Yu X, Guo J, Zhang Y, Zhou X, Gao Q, Xia F, Chen Y, Li M, Sun M. | 05/14/2022 |
| Muscarinic receptor M3 contributes to vascular and neural growth factor up-regulation in severe asthma. | Muscarinic receptor M3 contributes to vascular and neural growth factor up-regulation in severe asthma.
Folino A, Carriero V, Bullone M, Bertolini F, Di Stefano A, Profita M, Balbi B, Pieper M, Ricciardolo FLM. | 06/12/2021 |
| M3 muscarinic acetylcholine receptor-reactive Th17 cells in primary Sjogren's syndrome. | M3 muscarinic acetylcholine receptor-reactive Th17 cells in primary Sjögren's syndrome.
Abe S, Tsuboi H, Kudo H, Asashima H, Ono Y, Honda F, Takahashi H, Yagishita M, Hagiwara S, Kondo Y, Matsumoto I, Sumida T., Free PMC Article | 06/5/2021 |
| Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis. | Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis.
Goto Y, Ando T, Izumi H, Feng X, Arang N, Gilardi M, Wang Z, Ando K, Gutkind JS., Free PMC Article | 11/28/2020 |
| A regulatory variant of CHRM3 is associated with cannabis-induced hallucinations in European Americans. | A regulatory variant of CHRM3 is associated with cannabis-induced hallucinations in European Americans.
Cheng Z, Phokaew C, Chou YL, Lai D, Meyers JL, Agrawal A, Farrer LA, Kranzler HR, Gelernter J., Free PMC Article | 09/26/2020 |
| A homozygous missense variant in CHRM3 associated with familial urinary bladder disease. | A homozygous missense variant in CHRM3 associated with familial urinary bladder disease.
Beaman GM, Galatà G, Teik KW, Urquhart JE, Aishah A, O'Sullivan J, Bhaskar SS, Wood KA, Thomas HB, O'Keefe RT, Woolf AS, Stuart HM, Newman WG., Free PMC Article | 09/5/2020 |
| M3R has protective effects against hepatocyte lipid accumulation by activating AMPK pathway. | M3 muscarinic receptor activation reduces hepatocyte lipid accumulation via CaMKKβ/AMPK pathway.
Jadeja RN, Chu X, Wood C, Bartoli M, Khurana S. | 07/18/2020 |
| Genetic M3R ablation in human cells results in improved remyelination and is mediated by acceleration of oligodendrocyte commitment from oligodendrocyte progenitor cells. | Muscarinic Receptor M(3)R Signaling Prevents Efficient Remyelination by Human and Mouse Oligodendrocyte Progenitor Cells.
Welliver RR, Polanco JJ, Seidman RA, Sinha AK, O'Bara MA, Khaku ZM, Santiago González DA, Nishiyama A, Wess J, Feltri ML, Paez PM, Sim FJ., Free PMC Article | 10/26/2019 |
| the M3 receptor is the dominant muscarinic receptor in the human adrenal cortex. | M(3)-subtype muscarinic receptor activation stimulates intracellular calcium oscillations and aldosterone production in human adrenocortical HAC15 cells.
Malaiyandi LM, Sharthiya H, Surachaicharn N, Shams Y, Arshad M, Schupbach C, Kopf PG, Dineley KE., Free PMC Article | 05/11/2019 |
| The CHRM3 polymorphism and the Apfel score independently predict PONV susceptibility. Dexamethasone/acustimulation should be considered in patients with low Apfel score but at high genetic risk | CHRM3 rs2165870 polymorphism is independently associated with postoperative nausea and vomiting, but combined prophylaxis is effective.
Klenke S, de Vries GJ, Schiefer L, Seyffert N, Bachmann HS, Peters J, Frey UH. | 01/5/2019 |
| M3R activation-induced GRK2 recruitment is Ggamma subtype dependent in which Gbetagamma dimers with low cell membrane-affinity Ggamma9 exhibited a two-fold higher GRK2-recruitment compared to high affinity Ggamma3 expressing cells. | G protein γ (Gγ) subtype dependent targeting of GRK2 to M3 receptor by Gβγ.
Samaradivakara S, Kankanamge D, Senarath K, Ratnayake K, Karunarathne A. | 12/1/2018 |
| Regulation of molecular clock oscillations and phagocytic activity via muscarinic Ca(2+) signaling in human retinal pigment epithelial cells. | Regulation of molecular clock oscillations and phagocytic activity via muscarinic Ca(2+) signaling in human retinal pigment epithelial cells.
Ikarashi R, Akechi H, Kanda Y, Ahmad A, Takeuchi K, Morioka E, Sugiyama T, Ebisawa T, Ikeda M, Ikeda M., Free PMC Article | 11/10/2018 |
| These results indicate that not H1 but M3 receptor-induced activation of p38 MAPK might contribute to the maintenance of epithelial barrier function through down-regulation of TNF-alpha signalling and activation of EGFR. | Activation of muscarinic receptors prevents TNF-α-mediated intestinal epithelial barrier disruption through p38 MAPK.
Uwada J, Yazawa T, Islam MT, Khan MRI, Krug SM, Fromm M, Karaki SI, Suzuki Y, Kuwahara A, Yoshiki H, Sada K, Muramatsu I, Taniguchi T. | 02/24/2018 |
| Morphine-induced MOP receptor endocytosis is facilitated by concurrent M3 activation.M3 and MOP assemble in receptor heterocomplexes mainly located at the plasma membrane.M3-MOP receptor pharmacological interaction is independent of heterocomplex formation.M3 and MOP receptor heteromers disrupt upon both receptor endocytosis. | M3 muscarinic acetylcholine receptor facilitates the endocytosis of mu opioid receptor mediated by morphine independently of the formation of heteromeric complexes.
Lopez-Gimenez JF, Alvarez-Curto E, Milligan G. | 02/24/2018 |
| this study shows that anti-M3R is significantly elevated in Sjogren's syndrome plasma in comparison with rheumatoid arthritis, systemic lupus erythematosus, and healthy controls | Muscarinic type 3 receptor autoantibodies are associated with anti-SSA/Ro autoantibodies in Sjögren's syndrome.
Zuo J, Williams AE, Park YJ, Choi K, Chan AL, Reeves WH, Bubb MR, Lee YJ, Park K, Stewart CM, Cha S., Free PMC Article | 07/8/2017 |
| Interacting post-muscarinic receptor signaling pathways potentiate MMP1 expression and invasion of human colon cancer cells. | Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells.
Said AH, Hu S, Abutaleb A, Watkins T, Cheng K, Chahdi A, Kuppusamy P, Saxena N, Xie G, Raufman JP., Free PMC Article | 06/24/2017 |
| M3R expression plays an important role in early progression and invasion of colon neoplasia but is less important once tumors have spread. | Differential expression of M3 muscarinic receptors in progressive colon neoplasia and metastasis.
Cheng K, Shang AC, Drachenberg CB, Zhan M, Raufman JP., Free PMC Article | 05/27/2017 |
| This study presents the endocytic pathways of internalization for muscarinic type 3 receptor and flotillin-1/2 in salivary gland epithelial cells. knockdown of flot-1 or -2 by flotillin-specific siRNA prevented internalization and reduced the endocytic efficiency of muscarinic type 3 receptor. | Role of flotillins in the endocytosis of GPCR in salivary gland epithelial cells.
Park MY, Kim N, Wu LL, Yu GY, Park K. | 05/13/2017 |
| M3-mAChR activation leads to enhancement of hsp expression via PKC-dependent phosphorylation of HSF1, thereby stabilizing the mutant hERG-FLAG protein. Thus, M3-mAChR activators may have a therapeutic value for patients with LQT2. | M3 Muscarinic Receptor Signaling Stabilizes a Novel Mutant Human Ether-a-Go-Go-Related Gene Channel Protein via Phosphorylation of Heat Shock Factor 1 in Transfected Cells.
Mahati E, Li P, Kurata Y, Maharani N, Ikeda N, Sakata S, Ogura K, Miake J, Aiba T, Shimizu W, Nakasone N, Ninomiya H, Higaki K, Yamamoto K, Nakai A, Shirayoshi Y, Hisatome I. | 02/25/2017 |