| PLA2G16 is a mutant p53/KLF5 transcriptional target and promotes glycolysis of pancreatic cancer. | PLA2G16 is a mutant p53/KLF5 transcriptional target and promotes glycolysis of pancreatic cancer.
Xia W, Bai H, Deng Y, Yang Y., Free PMC Article | 05/8/2021 |
| Skeletal muscle expression of adipose-specific phospholipase in peripheral artery disease. | Skeletal muscle expression of adipose-specific phospholipase in peripheral artery disease.
Parmer C, De Sousa-Coelho AL, Cheng HS, Daher G, Burkart A, Dreyfuss JM, Pan H, Prenner JC, Keilson JM, Pande R, Henkin S, Feinberg MW, Patti ME, Creager MA. | 03/6/2021 |
| PLA2G16 methylation defines an extensive field defect in histologically normal prostate tissue associated with PC. | Screening of urine identifies PLA2G16 as a field defect methylation biomarker for prostate cancer detection.
Jarrard WE, Schultz A, Etheridge T, Damodaran S, Allen GO, Jarrard D, Yang B., Free PMC Article | 02/15/2020 |
| PLA2G16 SNPs are associated with the colorectal cancer risk in the Chinese population. | Relationship between polymorphisms of the lipid metabolism-related gene PLA2G16 and risk of colorectal cancer in the Chinese population.
Xie XN, Yu J, Zhang LH, Luo ZY, Ouyang DS, Zheng LJ, Wang CY, Yang L, Chen L, Tan ZR. | 06/1/2019 |
| study uncovers two competing processes triggered by Picornaviridae virus entry: activation of a pore-activated clearance pathway and recruitment of a PLA2G16 phospholipase to enable genome release | PLA2G16 represents a switch between entry and clearance of Picornaviridae.
Staring J, von Castelmur E, Blomen VA, van den Hengel LG, Brockmann M, Baggen J, Thibaut HJ, Nieuwenhuis J, Janssen H, van Kuppeveld FJ, Perrakis A, Carette JE, Brummelkamp TR. | 04/15/2017 |
| Demonstrate increased PLA2G16 expression activates the MAPK pathway to enhance osteosarcoma metastasis. | PLA2G16 promotes osteosarcoma metastasis and drug resistance via the MAPK pathway.
Li L, Liang S, Wasylishen AR, Zhang Y, Yang X, Zhou B, Shan L, Han X, Mu T, Wang G, Xiong S., Free PMC Article | 02/18/2017 |
| our results revealed that H-rev107 is also involved in lipid accumulation in liver cells through the POR pathway via its PLA2 activity. | H-rev107 Regulates Cytochrome P450 Reductase Activity and Increases Lipid Accumulation.
Tsai FM, Chen ML, Wang LK, Lee MC., Free PMC Article | 05/28/2016 |
| Results show that osteosarcoma patients with metastasis showed higher expression of PLA2G16 at both the mRNA and protein levels and shorter overall survival suggesting it as significant prognostic factor for poor outcome. | PLA2G16 Expression in Human Osteosarcoma Is Associated with Pulmonary Metastasis and Poor Prognosis.
Liang S, Ren Z, Han X, Yang J, Shan L, Li L, Wang B, Zhang Q, Mu T, Chen K, Xiong S, Wang G., Free PMC Article | 04/16/2016 |
| suggest a novel regulatory mechanism for peroxisome biogenesis through the interaction between Pex19p and PLA/AT-3 | Interaction of Phospholipase A/Acyltransferase-3 with Pex19p: A POSSIBLE INVOLVEMENT IN THE DOWN-REGULATION OF PEROXISOMES.
Uyama T, Kawai K, Kono N, Watanabe M, Tsuboi K, Inoue T, Araki N, Arai H, Ueda N., Free PMC Article | 10/3/2015 |
| the flexible main loop of H-REV107, but not that of TIG3, is critical for its NTD to modulate its CTD in inducing cell death. | Structural and functional characterization of tumor suppressors TIG3 and H-REV107.
Wei H, Wang L, Ren X, Yu W, Lin J, Jin C, Xia B. | 07/25/2015 |
| crystal structure of the HRASLS3-LRAT chimeric enzyme in a thioester catalytic intermediate state revealed a major structural rearrangement accompanied by three-dimensional domain swapping dimerization not observed in native HRASLS | LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3.
Golczak M, Sears AE, Kiser PD, Palczewski K., Free PMC Article | 02/28/2015 |
| several mutant p53 proteins bind the Pla2g16 promoter at E26 transformation-specific (ETS) binding motifs and knockdown of ETS2 suppressed mutant p53 induction of Pla2g16. | Pla2g16 phospholipase mediates gain-of-function activities of mutant p53.
Xiong S, Tu H, Kollareddy M, Pant V, Li Q, Zhang Y, Jackson JG, Suh YA, Elizondo-Fraire AC, Yang P, Chau G, Tashakori M, Wasylishen AR, Ju Z, Solomon H, Rotter V, Liu B, El-Naggar AK, Donehower LA, Martinez LA, Lozano G., Free PMC Article | 11/8/2014 |
| Our study further suggests that the PLA/AT activity of H-rev107 may play an important role in H-rev107-mediated RAS suppression. | Phospholipase A/Acyltransferase enzyme activity of H-rev107 inhibits the H-RAS signaling pathway.
Wang CH, Shyu RY, Wu CC, Tsai TC, Wang LK, Chen ML, Jiang SY, Tsai FM., Free PMC Article | 09/13/2014 |
| an alternate mechanism for AdPLA in promoting adipose tissue lipolysis that is not contingent on the release of arachidonic acid and that is compatible with its combined PLA(1)/A(2) activity | Structure/function relationships of adipose phospholipase A2 containing a cys-his-his catalytic triad.
Pang XY, Cao J, Addington L, Lovell S, Battaile KP, Zhang N, Rao JLUM, Dennis EA, Moise AR., Free PMC Article | 01/5/2013 |
| Data show that acyl-modified forms of HRAS-like tumor suppressors HRASLS2 and HRASLS3 mimicking lipolytic activity of lecithin retinol acyltransferase LRAT. | Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins.
Golczak M, Kiser PD, Sears AE, Lodowski DT, Blaner WS, Palczewski K., Free PMC Article | 10/13/2012 |
| role of PKC isoenzymes in PP2A and HRSL3(H-REV107-1) tumor suppressor-dependent cell death induction in ovarian carcinoma cell line; verified contribution to PP2A- and HRLS3-dependent apoptosis for PKCzeta suggesting a proapoptotic function of this kinase | Atypical protein kinase C zeta exhibits a proapoptotic function in ovarian cancer.
Nazarenko I, Jenny M, Keil J, Gieseler C, Weisshaupt K, Sehouli J, Legewie S, Herbst L, Weichert W, Darb-Esfahani S, Dietel M, Schäfer R, Ueberall F, Sers C. | 03/19/2011 |
| AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. | AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency.
Jaworski K, Ahmadian M, Duncan RE, Sarkadi-Nagy E, Varady KA, Hellerstein MK, Lee HY, Samuel VT, Shulman GI, Kim KH, de Val S, Kang C, Sul HS., Free PMC Article | 05/10/2010 |
| Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA) | Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA).
Duncan RE, Sarkadi-Nagy E, Jaworski K, Ahmadian M, Sul HS., Free PMC Article | 05/10/2010 |
| H-REV107-1 is deficient in its function as a tumor suppressor in non-small cell lung carcinomas. | H-REV107-1 stimulates growth in non-small cell lung carcinomas via the activation of mitogenic signaling.
Nazarenko I, Kristiansen G, Fonfara S, Guenther R, Gieseler C, Kemmner W, Schafer R, Petersen I, Sers C., Free PMC Article | 01/21/2010 |
| Contact inhibition of growth and growth arrest caused by histone deacetylase inhibitors probably use the same mechanism to stimulate H-rev107 expression via histone acetylation in NIH3T3 cells | Induction of murine H-rev107 gene expression by growth arrest and histone acetylation: involvement of an Sp1/Sp3-binding GC-box.
Roder K, Kim KH, Sul HS. | 01/21/2010 |