| HSFAS mediates fibroblast proliferation, migration, trans-differentiation and apoptosis in hypertrophic scars via interacting with ADAMTS8. | HSFAS mediates fibroblast proliferation, migration, trans-differentiation and apoptosis in hypertrophic scars via interacting with ADAMTS8.
Ma F, Liu H, Xia T, Zhang Z, Ma S, Hao Y, Shen J, Jiang Y, Li N., Free PMC Article | 04/4/2024 |
| ADAMTS8 inhibits glioma development in vitro and in vivo. | ADAMTS8 inhibits glioma development in vitro and in vivo.
Zhou B, Liu Y, Ma G, Wang X, Chang B, Lu H, Feng X. | 08/19/2023 |
| The Prognostic Value of ADAMTS8 and Its Role as a Tumor Suppressor in Breast Cancer. | The Prognostic Value of ADAMTS8 and Its Role as a Tumor Suppressor in Breast Cancer.
Zhang Q, Kanyomse Q, Luo C, Mo Q, Zhao X, Wang L, Peng W, Ren G. | 02/11/2023 |
| ADAMTS8 inhibited lung cancer progression through suppressing VEGFA. | ADAMTS8 inhibited lung cancer progression through suppressing VEGFA.
Zhang Y, Hu K, Qu Z, Xie Z, Tian F. | 03/19/2022 |
| Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8. | Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8.
Santamaria S, Martin DR, Dong X, Yamamoto K, Apte SS, Ahnström J., Free PMC Article | 12/18/2021 |
| ADAMTS8 is frequently down-regulated in colorectal cancer and functions as a tumor suppressor. | ADAMTS8 is frequently down-regulated in colorectal cancer and functions as a tumor suppressor.
Li L, Yuan S, Zhao X, Luo T. | 10/24/2020 |
| Study revealed upregulation of ADAMTS8 and downregulation of FRAS1 and SOSTDC1 in primary fibroblasts from linear morphoea (LM) lesions. SOSTDC1 knock-down recapitulated the reduced TGF -beta1 responsiveness and LM fibroblast migration, while overexpression of ADAMTS 8 induced myofibroblast markers. | Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause profibrotic changes in linear morphoea fibroblasts.
Badshah II, Brown S, Weibel L, Rose A, Way B, Sebire N, Inman G, Harper J, O'Shaughnessy RFL. | 08/1/2020 |
| The expression level of ADAMTS8 mRNA increased 3.5 fold in Hip Degenerative Arthritis group when compared with Femoral neck fractures group. | The role of ADAMTS genes in the end stage of hip osteoarthritis.
Ayanoglu T, Atalar H, Esen E, Ataoğlu MB, Turanlı S, Demircan K., Free PMC Article | 08/17/2019 |
| This study showed that ADAMTS1, 8, and 18 are highly expressed in GC and its nodal metastases, suggesting important roles of these proteases in carcinogenesis and lymphatic metastasis. The findings from the present study indicate that these proteases may be promising candidates for novel and alternative treatments in GC (gastric cancer) | Differentially regulated ADAMTS1, 8, and 18 in gastric adenocarcinoma.
Kilic MO, Aynekin B, Kara A, Icen D, Demircan K. | 12/9/2017 |
| ADAMTS8 hypermethylation is associated with decreased expression in gastric cancer. | Downregulation of ADAMTS8 by DNA Hypermethylation in Gastric Cancer and Its Clinical Significance.
Chen J, Zhang J, Li X, Zhang C, Zhang H, Jin J, Dai D., Free PMC Article | 02/18/2017 |
| Study uncovers the tumor suppressive function of ADAMTS8 and its frequent methylation in certain tumors could be developed as a potential biomarker. | The metalloprotease ADAMTS8 displays antitumor properties through antagonizing EGFR-MEK-ERK signaling and is silenced in carcinomas by CpG methylation.
Choi GC, Li J, Wang Y, Li L, Zhong L, Ma B, Su X, Ying J, Xiang T, Rha SY, Yu J, Sung JJ, Tsao SW, Chan AT, Tao Q. | 11/8/2014 |
| ADAMTS 8, CCL23, and TNFSF15 are implicated in anti-angiogenic activities | Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease.
He S, Tan W, Wang S, Wu C, Wang P, Wang B, Su X, Zhao J, Guo X, Xiang Y. | 06/28/2014 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Human variation in alcohol response is influenced by variation in neuronal signaling genes.
Joslyn G, Ravindranathan A, Brush G, Schuckit M, White RL. | 04/7/2010 |
| ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of atherosclerotic plaques | ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques.
Wågsäter D, Björk H, Zhu C, Björkegren J, Valen G, Hamsten A, Eriksson P. | 01/21/2010 |
| Downdownregulation of METH-2 expression in primary NSCLC, often associated with promoter hypermethylation, is a frequent event, which may be related to the development of the disease. | METH-2 silencing and promoter hypermethylation in NSCLC.
Dunn JR, Panutsopulos D, Shaw MW, Heighway J, Dormer R, Salmo EN, Watson SG, Field JK, Liloglou T., Free PMC Article | 01/21/2010 |
| Immunohistochemistry and Western analysis indicated downregulation of ADAMTS-8 protein in >77% brain tumours. A role for ADAMTS-8 in brain tumorigenesis, warranting further investigation into its role in regulation of tumour angiogenesis. | Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours.
Dunn JR, Reed JE, du Plessis DG, Shaw EJ, Reeves P, Gee AL, Warnke P, Walker C., Free PMC Article | 01/21/2010 |
| ADAMTS8 and ADAMTS15 have emerged as novel predictors of survival in patients with breast carcinoma | ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma.
Porter S, Span PN, Sweep FC, Tjan-Heijnen VC, Pennington CJ, Pedersen TX, Johnsen M, Lund LR, Rømer J, Edwards DR. | 01/21/2010 |
| Ability of ADAMTS-8 to cleave aggrecan at aggrecanase-susceptible Glu373-Ala374 peptide bond. Presence of ADAMTS-8 mRNA transcripts in normal and osteoarthritic human cartilage. (ADAMTS-8) | ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage.
Collins-Racie LA, Flannery CR, Zeng W, Corcoran C, Annis-Freeman B, Agostino MJ, Arai M, DiBlasio-Smith E, Dorner AJ, Georgiadis KE, Jin M, Tan XY, Morris EA, LaVallie ER. | 01/21/2010 |