| Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer's disease. | Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer's disease.
Agra Almeida Quadros AR, Li Z, Wang X, Ndayambaje IS, Aryal S, Ramesh N, Nolan M, Jayakumar R, Han Y, Stillman H, Aguilar C, Wheeler HJ, Connors T, Lopez-Erauskin J, Baughn MW, Melamed Z, Beccari MS, Olmedo Martínez L, Canori M, Lee CZ, Moran L, Draper I, Kopin AS, Oakley DH, Dickson DW, Cleveland DW, Hyman BT, Das S, Ertekin-Taner N, Lagier-Tourenne C., Free PMC Article | 01/8/2024 |
| TDP43 blocks misprocessing of STMN2 RNA. | TDP43 blocks misprocessing of STMN2 RNA.
Wood H. | 06/9/2023 |
| STMN2 overexpression promotes cell proliferation and EMT in pancreatic cancer mediated by WNT/beta-catenin signaling. | STMN2 overexpression promotes cell proliferation and EMT in pancreatic cancer mediated by WNT/β-catenin signaling.
Shao M, Wang L, Zhang Q, Wang T, Wang S. | 03/16/2023 |
| Analysis of STMN2 CA repeats in italian ALS patients shows no association. | Analysis of STMN2 CA repeats in italian ALS patients shows no association.
Doronzio PN, Lattante S, Marangi G, Martello F, Conte A, Bisogni G, Bernardo D, Patanella AK, Meleo E, Zollino M, Sabatelli M. | 01/28/2023 |
| NEK1 and STMN2 short tandem repeat lengths are not associated with Australian amyotrophic lateral sclerosis risk. | NEK1 and STMN2 short tandem repeat lengths are not associated with Australian amyotrophic lateral sclerosis risk.
Grima N, Henden L, Fearnley LG, Rowe DB, D'Silva S, Pamphlett R, Adams L, Kiernan MC, Mazumder S, Timmins HC, Zoing M, Bahlo M, Blair IP, Williams KL. | 06/18/2022 |
| STMN2 mediates nuclear translocation of Smad2/3 and enhances TGFbeta signaling by destabilizing microtubules to promote epithelial-mesenchymal transition in hepatocellular carcinoma. | STMN2 mediates nuclear translocation of Smad2/3 and enhances TGFβ signaling by destabilizing microtubules to promote epithelial-mesenchymal transition in hepatocellular carcinoma.
Zhong FJ, Sun B, Cao MM, Xu C, Li YM, Yang LY. | 09/25/2021 |
| Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia. | Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia.
Prudencio M, Humphrey J, Pickles S, Brown AL, Hill SE, Kachergus JM, Shi J, Heckman MG, Spiegel MR, Cook C, Song Y, Yue M, Daughrity LM, Carlomagno Y, Jansen-West K, de Castro CF, DeTure M, Koga S, Wang YC, Sivakumar P, Bodo C, Candalija A, Talbot K, Selvaraj BT, Burr K, Chandran S, Newcombe J, Lashley T, Hubbard I, Catalano D, Kim D, Propp N, Fennessey S, NYGC ALS Consortium, Fagegaltier D, Phatnani H, Secrier M, Fisher EM, Oskarsson B, van Blitterswijk M, Rademakers R, Graff-Radford NR, Boeve BF, Knopman DS, Petersen RC, Josephs KA, Thompson EA, Raj T, Ward M, Dickson DW, Gendron TF, Fratta P, Petrucelli L., Free PMC Article | 02/20/2021 |
| STMN2 is a key regulator functionally connected to known Parkinson's disease risk genes. Network analysis predicts a function of human STMN2 in synaptic trafficking. [Meta-Analysis} | The landscape of multiscale transcriptomic networks and key regulators in Parkinson's disease.
Wang Q, Zhang Y, Wang M, Song WM, Shen Q, McKenzie A, Choi I, Zhou X, Pan PY, Yue Z, Zhang B., Free PMC Article | 03/7/2020 |
| premature polyadenylation-mediated reduction in stathmin-2 is a hallmark of ALS-FTD that functionally links reduced nuclear TDP-43 function to enhanced neuronal vulnerability. | Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration.
Melamed Z, López-Erauskin J, Baughn MW, Zhang O, Drenner K, Sun Y, Freyermuth F, McMahon MA, Beccari MS, Artates JW, Ohkubo T, Rodriguez M, Lin N, Wu D, Bennett CF, Rigo F, Da Cruz S, Ravits J, Lagier-Tourenne C, Cleveland DW., Free PMC Article | 05/25/2019 |
| expression of STMN2, which encodes a microtubule regulator, declined after TDP-43 knockdown and TDP-43 mislocalization as well as in patient-specific motor neurons and postmortem patient spinal cord. STMN2 loss upon reduced TDP-43 function was due to altered splicing, which is functionally important, as we show STMN2 is necessary for normal axonal outgrowth and regeneration. | ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.
Klim JR, Williams LA, Limone F, Guerra San Juan I, Davis-Dusenbery BN, Mordes DA, Burberry A, Steinbaugh MJ, Gamage KK, Kirchner R, Moccia R, Cassel SH, Chen K, Wainger BJ, Woolf CJ, Eggan K., Free PMC Article | 05/25/2019 |
| RARB and STMN2 polymorphisms were not associated with sporadic CJD in the Korean population. | RARB and STMN2 polymorphisms are not associated with sporadic Creutzfeldt-Jakob disease (CJD) in the Korean population.
Jeong BH, Kim HJ, Lee KH, Carp RI, Kim YS. | 12/6/2014 |
| PAK4-SCG10 signaling occurs in gastric cancer cell invasion. | PAK4 kinase-mediated SCG10 phosphorylation involved in gastric cancer metastasis.
Guo Q, Su N, Zhang J, Li X, Miao Z, Wang G, Cheng M, Xu H, Cao L, Li F. | 09/6/2014 |
| STMN and SCG10 are similarly targeted by JNK but there are clear differences in JNK recognition and phosphorylation of the closely related family member, SCLIP. | Differences in c-Jun N-terminal kinase recognition and phosphorylation of closely related stathmin-family members.
Yip YY, Yeap YY, Bogoyevitch MA, Ng DC. | 06/14/2014 |
| CaMy1 via SCG10 couples Ca(2+) signals with the dynamics of microtubules during neuronal outgrowth in the developing brain. | Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth.
Sobczak A, Debowska K, Blazejczyk M, Kreutz MR, Kuznicki J, Wojda U. | 07/23/2011 |
| SCG10 is upregulated in the IKAP/Elp1-deficient familial dysautonomia cerebrum lending support to the concept that SCG10 elevation can alter the microtubule organization and dynamics | IKAP/Elp1 involvement in cytoskeleton regulation and implication for familial dysautonomia.
Cheishvili D, Maayan C, Cohen-Kupiec R, Lefler S, Weil M, Ast G, Razin A. | 07/23/2011 |
| Overexpression of SCG10 is associated with Liver Fibrosis. | SCG10 expression on activation of hepatic stellate cells promotes cell motility through interference with microtubules.
Paradis V, Dargere D, Bieche Y, Asselah T, Marcellin P, Vidaud M, Bedossa P., Free PMC Article | 03/12/2011 |
| SCG10 acts as an effector downstream of Rnd1 to regulate axon extensions by modulating microtubule organization. | Rnd1 regulates axon extension by enhancing the microtubule destabilizing activity of SCG10.
Li YH, Ghavampur S, Bondallaz P, Will L, Grenningloh G, Pu Schel AW., Free PMC Article | 01/21/2010 |
| STMN2 appears a novel marker of osteogenesis and osteoblast per se, that could play a role in the regulation of the adipocyte/osteoblast balance. | Stathmin-like 2, a developmentally-associated neuronal marker, is expressed and modulated during osteogenesis of human mesenchymal stem cells.
Chiellini C, Grenningloh G, Cochet O, Scheideler M, Trajanoski Z, Ailhaud G, Dani C, Amri EZ. | 01/21/2010 |
| SCLIP and SCG10 were colocalized to the Golgi apparatus of chromaffin cells in vivo and shared localization with CHGA as it transited the Golgi. | The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion.
Mahapatra NR, Taupenot L, Courel M, Mahata SK, O'Connor DT., Free PMC Article | 01/21/2010 |
| BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells. | BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells.
Gong Y, Wu J, Qiang H, Liu B, Chi Z, Chen T, Yin B, Peng X, Yuan J. | 01/21/2010 |
| Review proposes a model reconciling the microtubule regulatory properties of superior cervical ganglion protein 10 with its role as a c-Jun N-terminal kinase 1 (JNK1) effector of regeneration. | Superior cervical ganglion-10 protein as a molecular effector of c-Jun N-terminal kinase 1: implications for the therapeutic targeting of Jun N-terminal kinase in nerve regeneration.
Westerlund N, Zdrojewska J, Courtney MJ, Coffey ET. | 01/21/2010 |
| activity at opposite microtubule ends may play role role in regulating growth cone microtubules; ability to promote plus end growth may facilitate microtubule extension; ability to destabilize minus ends may provide tubulin for net plus end elongation | Stathmin family protein SCG10 differentially regulates the plus and minus end dynamics of microtubules at steady state in vitro: implications for its role in neurite outgrowth.
Manna T, Grenningloh G, Miller HP, Wilson L. | 01/21/2010 |
| RGS6 interacts with this protein and promotes neuronal differentiation; role of the G gamma subunit-like (GGL) domain of RGS6 | RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6.
Liu Z, Chatterjee TK, Fisher RA. | 01/21/2010 |
| STMN2 is required for maintaining the anchorage-independent growth state of beta-catenin/TCF-activated hepatoma cells | STMN2 is a novel target of beta-catenin/TCF-mediated transcription in human hepatoma cells.
Lee HS, Lee DC, Park MH, Yang SJ, Lee JJ, Kim DM, Jang Y, Lee JH, Choi JY, Kang YK, Kim DI, Park KC, Kim SY, Yoo HS, Choi EJ, Yeom YI. | 01/21/2010 |