| WWP2 binds to NKRF, enhances the NF-kappaB signaling, and promotes malignant phenotypes of acute myeloid leukemia cells. | WWP2 binds to NKRF, enhances the NF-κB signaling, and promotes malignant phenotypes of acute myeloid leukemia cells.
Wang H, Lian X, Wang K, Wang S. | 02/7/2024 |
| Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1. | Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1.
Zhu J, Peng Z, Tian X, Wu T, Sun A, Yang W, Lin Q. | 06/28/2023 |
| Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X. | Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X.
You S, Xu J, Yin Z, Wu B, Wang P, Hao M, Cheng C, Liu M, Zhao Y, Jia P, Jiang H, Li D, Cao L, Zhang X, Zhang Y, Sun Y, Zhang N., Free PMC Article | 05/19/2023 |
| WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein. | WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein.
Zou J, Zhou L, Le Y, Fang Z, Zhong M, Nie F, Wei X, Zhang X, Chen Z, Cai L, Wang H, Xiong J, Fang Z, Xiang X., Free PMC Article | 02/23/2023 |
| lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1. | lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1.
Zhang Z, Lu YX, Liu F, Sang L, Shi C, Xie S, Bian W, Yang JC, Yang Z, Qu L, Chen SY, Li J, Yang L, Yan Q, Wang W, Fu P, Shao J, Li X, Lin A., Free PMC Article | 02/22/2023 |
| WWP2 confers risk to osteoarthritis by affecting cartilage matrix deposition via hypoxia associated genes. | WWP2 confers risk to osteoarthritis by affecting cartilage matrix deposition via hypoxia associated genes.
Tuerlings M, Janssen GMC, Boone I, van Hoolwerff M, Rodriguez Ruiz A, Houtman E, Suchiman HED, van der Wal RJP, Nelissen RGHH, Coutinho de Almeida R, van Veelen PA, Ramos YFM, Meulenbelt I. | 12/31/2022 |
| The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis. | The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis.
Chen H, Chew G, Devapragash N, Loh JZ, Huang KY, Guo J, Liu S, Tan ELS, Chen S, Tee NGZ, Mia MM, Singh MK, Zhang A, Behmoaras J, Petretto E., Free PMC Article | 12/17/2022 |
| miR-328-5p Induces Human Intervertebral Disc Degeneration by Targeting WWP2. | miR-328-5p Induces Human Intervertebral Disc Degeneration by Targeting WWP2.
Yan J, Wu LG, Zhang M, Fang T, Pan W, Zhao JL, Zhou Q., Free PMC Article | 10/15/2022 |
| WWP2 ameliorates oxidative stress and inflammation in atherosclerotic mice through regulation of PDCD4/HO-1 pathway. | WWP2 ameliorates oxidative stress and inflammation in atherosclerotic mice through regulation of PDCD4/HO-1 pathway.
Wang X, Ma L, Zhang S, Song Q, He X, Wang J., Free PMC Article | 10/8/2022 |
| WWP2 overexpression inhibits the antitumor effects of doxorubicin in hepatocellular carcinoma. | WWP2 overexpression inhibits the antitumor effects of doxorubicin in hepatocellular carcinoma.
Qin Y, Wang CJ, Ye HL, Ye GX, Wang S, Pan DB, Wang J, Shen HJ, Xu SQ. | 09/24/2022 |
| Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates. | Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates.
Jiang H, Chiang CY, Chen Z, Nathan S, D'Agostino G, Paulo JA, Song G, Zhu H, Gabelli SB, Cole PA., Free PMC Article | 06/11/2022 |
| DKK1 suppresses WWP2 to enhance bortezomib resistance in multiple myeloma via regulating GLI2 ubiquitination. | DKK1 suppresses WWP2 to enhance bortezomib resistance in multiple myeloma via regulating GLI2 ubiquitination.
Zhang Q, Gong W, Wu H, Wang J, Jin Q, Lin C, Xu S, Bao W, Wang Y, Wu J, Feng S, Zhao C, Chen B, Liu Z. | 12/25/2021 |
| Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma. | Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.
Mahlokozera T, Patel B, Chen H, Desouza P, Qu X, Mao DD, Hafez D, Yang W, Taiwo R, Paturu M, Salehi A, Gujar AD, Dunn GP, Mosammaparast N, Petti AA, Yano H, Kim AH., Free PMC Article | 12/11/2021 |
| ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2. | ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2.
Zhang W, Tao SS, Wang T, Zhang J, Liu X, Li YT, Chen H, Zhan YQ, Yu M, Ge CH, Li CY, Ren GM, Yang XM, Yin RH. | 07/17/2021 |
| Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury. | Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury.
Zhang N, Zhang Y, Wu B, You S, Sun Y., Free PMC Article | 04/17/2021 |
| The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules. | The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules.
Alix E, Godlee C, Cerny O, Blundell S, Tocci R, Matthews S, Liu M, Pruneda JN, Swatek KN, Komander D, Sleap T, Holden DW., Free PMC Article | 03/27/2021 |
| WWP2 ameliorates acute kidney injury by mediating p53 ubiquitylation and degradation. | WWP2 ameliorates acute kidney injury by mediating p53 ubiquitylation and degradation.
Che H, He W, Feng J, Dong W, Liu S, Chen T, Ge S, Zhou J, Liang C. | 02/27/2021 |
| ARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6-WWP2-p27 axis. | ARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6-WWP2-p27 axis.
Wang L, Shen S, Xiao H, Ding F, Wang M, Li G, Hu F., Free PMC Article | 10/31/2020 |
| WWP2 promotes proliferation of gastric cancer cells in a PTEN-dependent manner. | WWP2 regulates proliferation of gastric cancer cells in a PTEN-dependent manner.
Wang K, Liu J, Zhao X, Li H, Luo G, Yu Y, Guo Y, Zhang L, Zhu J, Wang S, Hua W, Yang A, Zhang R, Li J. | 08/1/2020 |
| We found that in addition to influencing catalytic activities, the WW domain linker regions in NEDD4-1 and WWP2 can impact product distribution, including the degree of polyubiquitination and Lys-48 versus Lys-63 linkages. We show that allosteric activation by NDFIP1 or engineered ubiquitin variants is largely mediated by relief of WW domain linker autoinhibition. | Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases.
Jiang H, Thomas SN, Chen Z, Chiang CY, Cole PA., Free PMC Article | 06/13/2020 |
| The data reveal a structural platform for Smad substrate selection by WWP2 isoform WW domains that may be significant in the context of WWP2 isoform switching linked to tumorigenesis. | Smad7 Binds Differently to Individual and Tandem WW3 and WW4 Domains of WWP2 Ubiquitin Ligase Isoforms.
Wahl LC, Watt JE, Yim HTT, De Bourcier D, Tolchard J, Soond SM, Blumenschein TMA, Chantry A., Free PMC Article | 02/29/2020 |
| WWP2 positively regulates the expression of pro-fibrotic markers and extracellular matrix genes. TGFbeta1 stimulation promotes nuclear translocation of the WWP2 isoforms containing the N-terminal region and their interaction with SMAD2. WWP2 mediates the TGFbeta1-induced nucleocytoplasmic shuttling and transcriptional activity of SMAD2. | WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling.
Chen H, Moreno-Moral A, Pesce F, Devapragash N, Mancini M, Heng EL, Rotival M, Srivastava PK, Harmston N, Shkura K, Rackham OJL, Yu WP, Sun XM, Tee NGZ, Tan ELS, Barton PJR, Felkin LE, Lara-Pezzi E, Angelini G, Beltrami C, Pravenec M, Schafer S, Bottolo L, Hubner N, Emanueli C, Cook SA, Petretto E., Free PMC Article | 12/14/2019 |
| findings suggest that WWP2 operates in a DNA-PK-dependent shutoff circuitry for RNAPII clearance that promotes DNA double-strand break repair by protecting the nonhomologous end joining machinery from collision with the transcription machinery | WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.
Caron P, Pankotai T, Wiegant WW, Tollenaere MAX, Furst A, Bonhomme C, Helfricht A, de Groot A, Pastink A, Vertegaal ACO, Luijsterburg MS, Soutoglou E, van Attikum H., Free PMC Article | 09/7/2019 |
| WWP2 expression level is downregulated in human osteoarthritis cartilage. | Wwp2 maintains cartilage homeostasis through regulation of Adamts5.
Mokuda S, Nakamichi R, Matsuzaki T, Ito Y, Sato T, Miyata K, Inui M, Olmer M, Sugiyama E, Lotz M, Asahara H., Free PMC Article | 06/29/2019 |
| WWP2 is dysregulated in various of tumors, and it promotes carcinogenesis mainly through PTEN/Akt signaling pathway | WWP2 Is One Promising Novel Oncogene.
Zhang R, Zhang J, Luo W, Luo Z, Shi S. | 06/15/2019 |