| beta-endorphin and opioid growth factor as biomarkers of physical ability in multiple sclerosis. | β-endorphin and opioid growth factor as biomarkers of physical ability in multiple sclerosis.
Patel C, Thomas G, Zomorodi N, Zagon IS, McLaughlin PJ. | 06/26/2021 |
| Morphine interacts with OGFR and may suppress lung cancer proliferation and progression. | Morphine Suppresses Lung Cancer Cell Proliferation Through the Interaction with Opioid Growth Factor Receptor: An In Vitro and Human Lung Tissue Study.
Kim JY, Ahn HJ, Kim JK, Kim J, Lee SH, Chae HB. | 07/15/2017 |
| The blockade of OGF signaling by MNTX releases cells from their arrest and boosts the effect of Doc | Peripheral opioid antagonist enhances the effect of anti-tumor drug by blocking a cell growth-suppressive pathway in vivo.
Suzuki M, Chiwaki F, Sawada Y, Ashikawa M, Aoyagi K, Fujita T, Yanagihara K, Komatsu M, Narita M, Suzuki T, Nagase H, Kushima R, Sakamoto H, Fukagawa T, Katai H, Nakagama H, Yoshida T, Uezono Y, Sasaki H., Free PMC Article | 03/26/2016 |
| The OGF-OGFr axis may be a feasible target for treatment of cancer of the ovary (i) in a prophylactic fashion, (ii) following cytoreduction or (iii) in conjunction with standard chemotherapy for additive effectiveness | Targeting the opioid growth factor: opioid growth factor receptor axis for treatment of human ovarian cancer.
Zagon IS, Donahue R, McLaughlin PJ. | 09/28/2013 |
| OGF-OGFr axis is a determinant of the progression of human ovarian cancer | Under-expression of the opioid growth factor receptor promotes progression of human ovarian cancer.
Donahue RN, McLaughlin PJ, Zagon IS. | 04/14/2012 |
| These data are the first to report that theOGFr system is a native biological regulator of cell proliferation in Hepatocellular carcinoma | The opioid growth factor-opioid growth factor receptor axis regulates cell proliferation of human hepatocellular cancer.
Avella DM, Kimchi ET, Donahue RN, Tagaram HR, McLaughlin PJ, Zagon IS, Staveley-O'Carroll KF., Free PMC Article | 02/22/2010 |
| OGF and OGFR are present in follicular-derived thyroid cancers, and that OGF serves in a inhibitory manner to maintain homeostasis of cell proliferation. | Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis.
McLaughlin PJ, Zagon IS, Park SS, Conway A, Donahue RN, Goldenberg D., Free PMC Article | 01/21/2010 |
| Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers. | Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers.
Zagon IS, Donahue RN, McLaughlin PJ. | 01/21/2010 |
| Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis. | Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis.
Donahue RN, McLaughlin PJ, Zagon IS. | 01/21/2010 |
| the regulation of cell proliferation by the OGF-OGFr axis is dependent on nucleocytoplasmic translocation and reliant on the integrity of two NLSs in OGFr to interact with transport receptors. | Dependence on nuclear localization signals of the opioid growth factor receptor in the regulation of cell proliferation.
Cheng F, McLaughlin PJ, Verderame MF, Zagon IS. | 01/21/2010 |
| Results indicate that both p16(INK4a) and p21(WAF1/CIP1) are required for the opioid growth factor (OGF)-OGF receptor axis to inhibit cell proliferation in normal cells. | The OGF-OGFr axis utilizes the p16INK4a and p21WAF1/CIP1 pathways to restrict normal cell proliferation.
Cheng F, McLaughlin PJ, Verderame MF, Zagon IS., Free PMC Article | 01/21/2010 |
| supports opioid growth factor receptor (OGFr) gene function as a regulator of cell proliferation that impacts on tumorigenic expression, and suggest that molecular and pharmacological manipulation of OGFr may prevent or delay human pancreatic cancer. | Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor.
Zagon IS, Kreiner S, Heslop JJ, Conway AB, Morgan CR, McLaughlin PJ. | 01/21/2010 |
| Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers | Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers.
Zagon IS, McLaughlin PJ. | 01/21/2010 |
| Gene therapy to reinstate more OGFr and enhance OGFr function, could serve as a useful treatment for inhibiting tumor progression in head and neck cancers. | Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor.
McLaughlin PJ, Zagon IS. | 01/21/2010 |
| These data indicate that the OGF receptor is integral to cell replication of SCCHN, and support treatment modalities that amplify OGFr in order to decrease the growth of these neoplasias. | Overexpression of the opioid growth factor receptor downregulates cell proliferation of human squamous carcinoma cells of the head and neck.
McLaughlin PJ, Verderame MF, Hankins JL, Zagon IS. | 01/21/2010 |