| Deficiency of ADAR2 ameliorates metabolic-associated fatty liver disease via AMPK signaling pathways in obese mice. | Deficiency of ADAR2 ameliorates metabolic-associated fatty liver disease via AMPK signaling pathways in obese mice.
Kung ML, Cheng SM, Wang YH, Cheng KP, Li YL, Hsiao YT, Tan BC, Chen YW., Free PMC Article | 08/23/2024 |
| RNA editing enzyme ADAR2 regulates P-glycoprotein expression in murine breast cancer cells through the circRNA-miRNA pathway. | RNA editing enzyme ADAR2 regulates P-glycoprotein expression in murine breast cancer cells through the circRNA-miRNA pathway.
Omata Y, Haraguchi M, Yoshinaga S, Ogino T, Okawa M, Tsuruta A, Koyanagi S, Ohdo S. | 08/12/2024 |
| ADAR2 deficiency ameliorates non-alcoholic fatty liver disease and muscle atrophy through modulating serum amyloid A1. | ADAR2 deficiency ameliorates non-alcoholic fatty liver disease and muscle atrophy through modulating serum amyloid A1.
Kung ML, Yang TH, Lin CC, Ho JY, Hung TC, Chang CH, Huang KW, Chen CC, Chen YW., Free PMC Article | 06/13/2024 |
| The disruption of circadian rhythmicity of gene expression in the hippocampus and associated structures in Gria2[R/R] mice; a comparison with C57BL/6J and Adar2[-/-] mice strains. | The disruption of circadian rhythmicity of gene expression in the hippocampus and associated structures in Gria2(R/R) mice; a comparison with C57BL/6J and Adar2(-/-) mice strains.
Lebedeva M, Kubištová A, Spišská V, Filipovská E, Pačesová D, Svobodová I, Kuchtiak V, Balík A, Bendová Z. | 02/20/2024 |
| Pathological features of glial cells and motor neurons in the anterior horn of the spinal cord in sporadic ALS using ADAR2 conditional knockout mice. | Pathological features of glial cells and motor neurons in the anterior horn of the spinal cord in sporadic ALS using ADAR2 conditional knockout mice.
Naito M, Hideyama T, Teramoto S, Saito T, Kato H, Terashi H, Kwak S, Aizawa H. | 02/4/2023 |
| Exercise-Induced ADAR2 Protects against Nonalcoholic Fatty Liver Disease through miR-34a. | Exercise-Induced ADAR2 Protects against Nonalcoholic Fatty Liver Disease through miR-34a.
Wang Z, Zhu Y, Xia L, Li J, Song M, Yang C., Free PMC Article | 01/21/2023 |
| Heterogeneous RNA editing and influence of ADAR2 on mesothelioma chemoresistance and the tumor microenvironment. | Heterogeneous RNA editing and influence of ADAR2 on mesothelioma chemoresistance and the tumor microenvironment.
Hariharan A, Qi W, Rehrauer H, Wu L, Ronner M, Wipplinger M, Kresoja-Rakic J, Sun S, Oton-Gonzalez L, Sculco M, Serre-Beinier V, Meiller C, Blanquart C, Fonteneau JF, Vrugt B, Rüschoff JH, Opitz I, Jean D, de Perrot M, Felley-Bosco E., Free PMC Article | 12/17/2022 |
| that the mislocalization of ADAR2 in C9orf72 mediated amyotrophic lateral sclerosis/frontotemporal dementia is responsible for the alteration of RNA processing events that may impact vast cellular functions | ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.
Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, W Dickson D, Robertson J, Staats KA, Ichida JK, Petrucelli L, Van Keuren-Jensen K, Sattler R., Free PMC Article | 07/25/2020 |
| ADAR1 and ADAR2 are non-redundant and do not compensate for each other's essential functions in vivo. | The majority of A-to-I RNA editing is not required for mammalian homeostasis.
Chalk AM, Taylor S, Heraud-Farlow JE, Walkley CR., Free PMC Article | 03/21/2020 |
| ADAR2 plays a crucial role for light-induced phase-shift of the circadian clock. | A-to-I RNA editing enzyme ADAR2 regulates light-induced circadian phase-shift.
Terajima H, Yoshitane H, Yoshikawa T, Shigeyoshi Y, Fukada Y., Free PMC Article | 11/30/2019 |
| PKCzeta/ADAR2 axis is a critical regulator of colorectal cancer metastases through modulation of miR-200 levels. | The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer.
Shelton PM, Duran A, Nakanishi Y, Reina-Campos M, Kasashima H, Llado V, Ma L, Campos A, García-Olmo D, García-Arranz M, García-Olmo DC, Olmedillas-López S, Caceres JF, Diaz-Meco MT, Moscat J., Free PMC Article | 10/5/2019 |
| FMRP inhibits ADAR2 activity, absence of FMRP results in defects of RNA editing of neuronal mRNAs in the mouse model of Fragile X Syndrome. | Absence of the Fragile X Mental Retardation Protein results in defects of RNA editing of neuronal mRNAs in mouse.
Filippini A, Bonini D, Lacoux C, Pacini L, Zingariello M, Sancillo L, Bosisio D, Salvi V, Mingardi J, La Via L, Zalfa F, Bagni C, Barbon A., Free PMC Article | 07/21/2018 |
| ADARB1 mediates adenosine to inosine RNA editing in the testis, and these editing events are dispensable for male fertility in an inbred mouse strain in the lab. | Testicular adenosine to inosine RNA editing in the mouse is mediated by ADARB1.
Snyder EM, Licht K, Braun RE., Free PMC Article | 12/2/2017 |
| that ADAR2 is a mediator of injury-induced tactile allodynia and thus a potential therapeutic target for the treatment of neuropathic pain | RNA editing enzyme ADAR2 is a mediator of neuropathic pain after peripheral nerve injury.
Uchida H, Matsumura S, Okada S, Suzuki T, Minami T, Ito S. | 10/7/2017 |
| Results show that ADAR2 is important in site-specific changes of protein coding sequences but has relatively modest effects on gene expression and splicing in the adult mouse frontal cortex. | ADAR2 affects mRNA coding sequence edits with only modest effects on gene expression or splicing in vivo.
Dillman AA, Cookson MR, Galter D., Free PMC Article | 10/29/2016 |
| Thus, Adarb1 and Adarb2 have nearly exclusive expression within brain tissue, while Adar has more appreciable expression across multiple tissues. | Complex regulation of ADAR-mediated RNA-editing across tissues.
Huntley MA, Lou M, Goldstein LD, Lawrence M, Dijkgraaf GJ, Kaminker JS, Gentleman R., Free PMC Article | 10/1/2016 |
| After fear conditioning protocol, mRNA expression of ADAR2 increased in amygdala and hippocampus, and those mice had a learning-dependent increase in the alternatively spliced inactive form of ADAR2 in the amygdala. | Acquisition of conditioned fear is followed by region-specific changes in RNA editing of glutamate receptors.
Brande-Eilat N, Golumbic YN, Zaidan H, Gaisler-Salomon I. | 07/16/2016 |
| ADAR2 is a key factor for maintaining edited-miRNA population and balancing the expression of several essential miRNAs involved in cancer. | Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma.
Tomaselli S, Galeano F, Alon S, Raho S, Galardi S, Polito VA, Presutti C, Vincenti S, Eisenberg E, Locatelli F, Gallo A., Free PMC Article | 12/5/2015 |
| This study clearly demonstrates that ADAR2 influences miRNA abundance and targeting at several levels in the mouse brain. | ADAR2 induces reproducible changes in sequence and abundance of mature microRNAs in the mouse brain.
Vesely C, Tauber S, Sedlazeck FJ, Tajaddod M, von Haeseler A, Jantsch MF., Free PMC Article | 03/21/2015 |
| chronically elevated intraocular pressure in adult mice reduces expression of the ADAR2 enzyme. | Down-regulation of the RNA editing enzyme ADAR2 contributes to RGC death in a mouse model of glaucoma.
Wang AL, Carroll RC, Nawy S., Free PMC Article | 02/28/2015 |
| Analysis of editing in the filamin A encoding mRNA shows very high editing levels outside the nervous system; further shows FLNA editing is mainly achieved by ADAR2 but that in some cases ADAR1 can efficiently compensate for ADAR2. | Spatio-temporal profiling of Filamin A RNA-editing reveals ADAR preferences and high editing levels outside neuronal tissues.
Stulić M, Jantsch MF., Free PMC Article | 01/17/2015 |
| Results suggest that ADAR2-reduction is associated with progressive deterioration of nuclear architecture, resulting in vacuolated nuclei due to a Ca2+-permeable AMPA receptor-mediated mechanism | Unique nuclear vacuoles in the motor neurons of conditional ADAR2-knockout mice.
Sasaki S, Takenari Yamashita, Hideyama T, Kwak S. | 11/8/2014 |
| altered RNA editing efficiency of AMPA receptors due to down-regulation of ADAR2 has a possible role in the pathophysiology of mental disorders. | A role of ADAR2 and RNA editing of glutamate receptors in mood disorders and schizophrenia.
Kubota-Sakashita M, Iwamoto K, Bundo M, Kato T., Free PMC Article | 10/4/2014 |
| Goal-oriented overeating behavior of ADAR2 transgenic mice is associated with altered feeding, reward-related mRNAs and hyperactive brain mesolimbic region. | Hyperactive hypothalamus, motivated and non-distractible chronic overeating in ADAR2 transgenic mice.
Akubuiro A, Bridget Zimmerman M, Boles Ponto LL, Walsh SA, Sunderland J, McCormick L, Singh M., Free PMC Article | 09/28/2013 |
| The JNK1 pathway may be functionally linked to the nutrient-sensing actions of ADAR2-mediated RNA editing in professional secretory cells. | c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells.
Yang L, Huang P, Li F, Zhao L, Zhang Y, Li S, Gan Z, Lin A, Li W, Liu Y., Free PMC Article | 04/27/2013 |