| PIM2 Promotes the Development of Ovarian Endometriosis by Enhancing Glycolysis and Fibrosis. | PIM2 Promotes the Development of Ovarian Endometriosis by Enhancing Glycolysis and Fibrosis.
Wang M, Fan R, Jiang J, Sun F, Sun Y, Wang Q, Jiang A, Yu Z, Yang T. | 09/8/2023 |
| Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis. | Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis.
Lu C, Qiao P, Fu R, Wang Y, Lu J, Ling X, Liu L, Sun Y, Ren C, Yu Z., Free PMC Article | 10/1/2022 |
| PIM2 kinase has a pivotal role in plasmablast generation and plasma cell survival, opening up novel treatment options in myeloma. | PIM2 kinase has a pivotal role in plasmablast generation and plasma cell survival, opening up novel treatment options in myeloma.
Haas M, Caron G, Chatonnet F, Manenti S, Alaterre E, Devin J, Delaloy C, Bertolin G, Viel R, Pignarre A, Llamas-Gutierrez F, Marchalot A, Decaux O, Tarte K, Delpy L, Moreaux J, Fest T. | 04/30/2022 |
| Long non-coding RNA SOX21-AS1 modulates lung cancer progress upon microRNA miR-24-3p/PIM2 axis. | Long non-coding RNA SOX21-AS1 modulates lung cancer progress upon microRNA miR-24-3p/PIM2 axis.
Wang F, Gu T, Chen Y, Chen Y, Xiong D, Zhu Y., Free PMC Article | 01/22/2022 |
| Positive regulation of PFKFB3 by PIM2 promotes glycolysis and paclitaxel resistance in breast cancer. | Positive regulation of PFKFB3 by PIM2 promotes glycolysis and paclitaxel resistance in breast cancer.
Lu C, Qiao P, Sun Y, Ren C, Yu Z., Free PMC Article | 01/15/2022 |
| Fructose-1, 6-bisphosphatase 1 interacts with NF-kappaB p65 to regulate breast tumorigenesis via PIM2 induced phosphorylation. | Fructose-1, 6-bisphosphatase 1 interacts with NF-κB p65 to regulate breast tumorigenesis via PIM2 induced phosphorylation.
Lu C, Ren C, Yang T, Sun Y, Qiao P, Han X, Yu Z., Free PMC Article | 05/22/2021 |
| PIM2 promotes hepatocellular carcinoma tumorigenesis and progression through activating NF-kappaB signaling pathway. | PIM2 promotes hepatocellular carcinoma tumorigenesis and progression through activating NF-κB signaling pathway.
Tang X, Cao T, Zhu Y, Zhang L, Chen J, Liu T, Ming X, Fang S, Yuan YF, Jiang L, Huang JD, Guan XY., Free PMC Article | 03/27/2021 |
| TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells. | TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells.
Whillock AL, Mambetsariev N, Lin WW, Stunz LL, Bishop GA., Free PMC Article | 11/21/2020 |
| Inhibition of PIM2 in liver cancer decreases tumor cell proliferation in vitro and in vivo primarily through the modulation of cell cycle progression. | Inhibition of PIM2 in liver cancer decreases tumor cell proliferation in vitro and in vivo primarily through the modulation of cell cycle progression.
Kronschnabl P, Grünweller A, Hartmann RK, Aigner A, Weirauch U., Free PMC Article | 10/24/2020 |
| HSF1 protein stability is regulated by PIM2-mediated phosphorylation of HSF1 at Thr120. PIM2, pThr120-HSF1, and PD-L1 expression positively correlated with each other in breast cancer tissues. | Phosphorylation of HSF1 by PIM2 Induces PD-L1 Expression and Promotes Tumor Growth in Breast Cancer.
Yang T, Ren C, Lu C, Qiao P, Han X, Wang L, Wang D, Lv S, Sun Y, Yu Z. | 06/6/2020 |
| Phosphorylation of AMPKalpha1 by PIM2 led to decreasing AMPKalpha1 kinase activity, which in turn promoted aerobic glycolysis and tumor growth. In addition, PIM2 expression positively correlated with AMPKalpha1 Thr467 phosphorylation in Endometrial cancer tissues. Insights into the role of PIM2 and AMPKalpha1 in Endometrial cancer suggest that combination targeting of these proteins may represent a new strategy for tre... | Negative regulation of AMPKα1 by PIM2 promotes aerobic glycolysis and tumorigenesis in endometrial cancer.
Han X, Ren C, Yang T, Qiao P, Wang L, Jiang A, Meng Y, Liu Z, Du Y, Yu Z. | 02/1/2020 |
| PIM2 is associated with unfavourable chronic lymphocytic leukaemia prognosis.PIM-2 role in the CXCR4-induced chronic lymphocytic leukaemia cell migration. | Microenvironment-induced PIM kinases promote CXCR4-triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration.
Białopiotrowicz E, Górniak P, Noyszewska-Kania M, Puła B, Makuch-Łasica H, Nowak G, Bluszcz A, Szydłowski M, Jabłonska E, Piechna K, Sewastianik T, Polak A, Lech-Marańda E, Budziszewska BK, Wasylecka-Juszczyńska M, Borg K, Warzocha K, Czardybon W, Gałęzowski M, Windak R, Brzózka K, Juszczyński P., Free PMC Article | 12/14/2019 |
| PIM2 is upregulated by strongly activated tumor suppressor protein p53. | PIM2 survival kinase is upregulated in a p53-dependent manner in cells treated with camptothecin or co-treated with actinomycin D and nutlin-3a.
Zajkowicz A, Krześniak M, Gdowicz-Kłosok A, Łasut B, Rusin M. | 07/13/2019 |
| PIM2 might function as an important oncogene in gastric cancer | Proviral insertion in murine lymphomas 2 promotes stomach cancer progression by regulating apoptosis via reactive oxygen species-triggered endoplasmic reticulum stress.
Xin H, Deng Y, Cao J. | 05/25/2019 |
| These findings demonstrate an important role for the PIM2-TTP complex in breast cancer tumorigenesis. | PIM2 interacts with tristetraprolin and promotes breast cancer tumorigenesis.
Ren C, Yang T, Qiao P, Wang L, Han X, Lv S, Sun Y, Liu Z, Du Y, Yu Z., Free PMC Article | 03/30/2019 |
| High PIM2 expression is associated with Malignant Grade in Prostate Cancer. | Pim-2 Cooperates with Downstream Factor XIAP to Inhibit Apoptosis and Intensify Malignant Grade in Prostate Cancer.
Ren K, Gou X, Xiao M, He W, Kang J. | 03/2/2019 |
| our findings indicated that PIM2 was a novel regulator of HK2, and suggested a new strategy to treat breast cancer. | PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer.
Yang T, Ren C, Qiao P, Han X, Wang L, Lv S, Sun Y, Liu Z, Du Y, Yu Z., Free PMC Article | 03/2/2019 |
| we showed that RPS6KA3 knockdown reduced the propagation of human AML cells in vivo in mice. Our results point to RSK2 as a novel Pim2 target with translational therapeutic potential in FLT3-ITD AML. | RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia.
Hospital MA, Jacquel A, Mazed F, Saland E, Larrue C, Mondesir J, Birsen R, Green AS, Lambert M, Sujobert P, Gautier EF, Salnot V, Le Gall M, Decroocq J, Poulain L, Jacque N, Fontenay M, Kosmider O, Récher C, Auberger P, Mayeux P, Bouscary D, Sarry JE, Tamburini J. | 02/9/2019 |
| Inhibition of PIM2 attenuated asthma symptoms and increased expression levels of interleukin (IL)10 and forkhead box protein 3 (FOXP3) in bronchoalveolar lavage fluid. | Role of PIM2 in allergic asthma.
Du W, Chen T, Ni Y, Hou X, Yu Y, Zhou Q, Wu F, Tang W, Shi G., Free PMC Article | 06/9/2018 |
| data suggest that PIM1/2 kinase overexpression is a common feature of male reproductive organs tumors, which provoke tissue alterations and a large inflammatory response that may act synergistically during the process of tumorigenesis. | The role of PIM1/PIM2 kinases in tumors of the male reproductive system.
Jiménez-García MP, Lucena-Cacace A, Robles-Frías MJ, Narlik-Grassow M, Blanco-Aparicio C, Carnero A., Free PMC Article | 06/2/2018 |
| show that PIM1 contributes to melanoma cell proliferation and tumor growth in vivo; however, the presence of PIM2 and PIM3 could also influence the outcome. | PIM kinases as therapeutic targets against advanced melanoma.
Shannan B, Watters A, Chen Q, Mollin S, Dörr M, Meggers E, Xu X, Gimotty PA, Perego M, Li L, Benci J, Krepler C, Brafford P, Zhang J, Wei Z, Zhang G, Liu Q, Yin X, Nathanson KL, Herlyn M, Vultur A., Free PMC Article | 01/20/2018 |
| the elevated expression of PIM2 in blastic cells is associated with poor prognosis of AML patients and their resistance to induction therapy. | Elevated PIM2 gene expression is associated with poor survival of patients with acute myeloid leukemia.
Kapelko-Slowik K, Owczarek TB, Grzymajlo K, Urbaniak-Kujda D, Jazwiec B, Slowik M, Kuliczkowski K, Ugorski M. | 01/13/2018 |
| Our data provide evidence for a novel role for Pim2 in the regulation of the DNA damage response (DDR). Knockdown of Pim2 upregulates several downstream DDR markers, mimicking the effects of doxorubicin (Dox) treatment of MM cells, and suggesting a role for the kinase as a negative regulator of this pathway. | Pim2 is important for regulating DNA damage response in multiple myeloma cells.
Ramachandran J, Santo L, Siu KT, Panaroni C, Raje N., Free PMC Article | 11/18/2017 |
| These results demonstrate the involvement of PIM kinases in LIF-induced regulation in different trophoblastic cell lines which may indicate similar functions in primary cells. | PIM kinases 1, 2 and 3 in intracellular LIF signaling, proliferation and apoptosis in trophoblastic cells.
Mary Photini S, Chaiwangyen W, Weber M, Al-Kawlani B, Favaro RR, Jeschke U, Schleussner E, Morales-Prieto DM, Markert UR. | 10/21/2017 |
| PIM kinases in classical Hodgkin lymphoma exhibit pleiotropic effects, orchestrating tumor immune escape and supporting Reed-Sternberg cell survival. | Expression of PIM kinases in Reed-Sternberg cells fosters immune privilege and tumor cell survival in Hodgkin lymphoma.
Szydłowski M, Prochorec-Sobieszek M, Szumera-Ciećkiewicz A, Derezińska E, Hoser G, Wasilewska D, Szymańska-Giemza O, Jabłońska E, Białopiotrowicz E, Sewastianik T, Polak A, Czardybon W, Gałęzowski M, Windak R, Zaucha JM, Warzocha K, Brzózka K, Juszczyński P. | 09/30/2017 |