| Targeting RCC1 to block the human soft-tissue sarcoma by disrupting nucleo-cytoplasmic trafficking of Skp2. | Targeting RCC1 to block the human soft-tissue sarcoma by disrupting nucleo-cytoplasmic trafficking of Skp2.
Zhuang M, Li F, Liang H, Su Y, Cheng L, Lin B, Zhou J, Deng R, Chen L, Lyu P, Lu Z., Free PMC Article | 04/4/2024 |
| A novel DNA methylation signature revealed GDF6 and RCC1 as potential prognostic biomarkers correlated with cell proliferation in clear cell renal cell carcinoma. | A novel DNA methylation signature revealed GDF6 and RCC1 as potential prognostic biomarkers correlated with cell proliferation in clear cell renal cell carcinoma.
Xu Z, Wu Y, Zhao G, Jin B, Jiang P. | 12/20/2023 |
| RCC1 functions as a tumor facilitator in clear cell renal cell carcinoma by dysregulating cell cycle, apoptosis, and EZH2 stability. | RCC1 functions as a tumor facilitator in clear cell renal cell carcinoma by dysregulating cell cycle, apoptosis, and EZH2 stability.
Wu Y, Xu Z, Chen X, Fu G, Tian J, Jin B., Free PMC Article | 11/1/2023 |
| RCC1 Expression as a Prognostic Marker in Colorectal Liver Oligometastases. | RCC1 Expression as a Prognostic Marker in Colorectal Liver Oligometastases.
Deng Y, Yu L, Zhao Y, Peng J, Xu Y, Qin J, Xiao B, Liu S, Li M, Fang Y, Pan Z., Free PMC Article | 03/12/2022 |
| Phosphorylation of RCC1 on Serine 11 Facilitates G1/S Transition in HPV E7-Expressing Cells. | Phosphorylation of RCC1 on Serine 11 Facilitates G1/S Transition in HPV E7-Expressing Cells.
Hou X, Qiao L, Liu R, Han X, Zhang W., Free PMC Article | 09/25/2021 |
| Down-regulation of RCC1 sensitizes immunotherapy by up-regulating PD-L1 via p27(kip1) /CDK4 axis in non-small cell lung cancer. | Down-regulation of RCC1 sensitizes immunotherapy by up-regulating PD-L1 via p27(kip1) /CDK4 axis in non-small cell lung cancer.
Zeng X, Zhong M, Yang Y, Wang Z, Zhu Y., Free PMC Article | 09/25/2021 |
| RanBP1 controls the Ran pathway in mammalian cells through regulation of mitotic RCC1 dynamics. | RanBP1 controls the Ran pathway in mammalian cells through regulation of mitotic RCC1 dynamics.
Yau KC, Arnaoutov A, Aksenova V, Kaufhold R, Chen S, Dasso M., Free PMC Article | 09/4/2021 |
| PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells. | PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.
Huang T, Yang Y, Song X, Wan X, Wu B, Sastry N, Horbinski CM, Zeng C, Tiek D, Goenka A, Liu F, Brennan CW, Kessler JA, Stupp R, Nakano I, Sulman EP, Nishikawa R, James CD, Zhang W, Xu W, Hu B, Cheng SY., Free PMC Article | 04/3/2021 |
| cyclin-dependent kinase 1 (Cdk1), a known target of E2F1, is involved in G1 checkpoint regulation, as Cdk1 knockdown hindered G1/S progression, while Cdk1 overexpression rescued RCC1 knockdown-mediated effect on G1 cell cycle progression. | Regulator of chromatin condensation 1 abrogates the G1 cell cycle checkpoint via Cdk1 in human papillomavirus E7-expressing epithelium and cervical cancer cells.
Qiao L, Zheng J, Tian Y, Zhang Q, Wang X, Chen JJ, Zhang W., Free PMC Article | 11/9/2019 |
| RCC1 regulates KT composition at the metaphase-anaphase transition in a Ran-GTP independent fashion through displacement of Shugoshin-1 and chromosomal passenger complex. | RCC1 regulates inner centromeric composition in a Ran-independent fashion.
Zhang MS, Furuta M, Arnaoutov A, Dasso M., Free PMC Article | 09/14/2019 |
| This study provides first evidence for a mutation in RCC1 as a breast cancer susceptibility allele | Exome sequencing and case-control analyses identify RCC1 as a candidate breast cancer susceptibility gene.
Riahi A, Radmanesh H, Schürmann P, Bogdanova N, Geffers R, Meddeb R, Kharrat M, Dörk T. | 12/22/2018 |
| Importin alpha3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1. | Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1.
Sankhala RS, Lokareddy RK, Begum S, Pumroy RA, Gillilan RE, Cingolani G., Free PMC Article | 04/21/2018 |
| this study has demonstrated that EBNA1 and RCC1 closely associate on the chromosomes during metaphase, suggesting an essential role for the interaction during this phase, perhaps in tethering EBNA1 to mitotic chromosomes. | Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle.
Deschamps T, Bazot Q, Leske DM, MacLeod R, Mompelat D, Tafforeau L, Lotteau V, Maréchal V, Baillie GS, Gruffat H, Wilson JB, Manet E. | 05/6/2017 |
| RCC1 expression enables the proliferation of cells that sustain DNA damage. RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence. | RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence.
Cekan P, Hasegawa K, Pan Y, Tubman E, Odde D, Chen JQ, Herrmann MA, Kumar S, Kalab P., Free PMC Article | 01/28/2017 |
| RCC1 expression is frequently lost in poorly differentiated gastric cell lines and gastric carcinoma tissues. Loss of RCC1 expression is correlated with tumor differentiation and depth of invasion. | Methylation-silencing RCC1 expression is associated with tumorigenesis and depth of invasion in gastric cancer.
Lin YL, Chen HL, Cheng SB, Yeh DC, Huang CC, P'eng FK, Tsai TC, Wu CC, Chen CM., Free PMC Article | 11/5/2016 |
| stress can disrupt the Ran gradients through RCC1-dependent and RCC1-independent mechanisms | Disruption of the ran system by cysteine oxidation of the nucleotide exchange factor RCC1.
Chatterjee M, Paschal BM., Free PMC Article | 04/25/2015 |
| PI3Kbeta regulates the nuclear envelope through upstream regulation of RCC1 and Ran | Phosphoinositide 3-kinase beta protects nuclear envelope integrity by controlling RCC1 localization and Ran activity.
Redondo-Muñoz J, Pérez-García V, Rodríguez MJ, Valpuesta JM, Carrera AC., Free PMC Article | 02/14/2015 |
| RCC1 facilitates a tight binding between the encephalomyocarditis virus leader and cellular Ran GTPase. | Guanine-nucleotide exchange factor RCC1 facilitates a tight binding between the encephalomyocarditis virus leader and cellular Ran GTPase.
Petty RV, Palmenberg AC., Free PMC Article | 08/3/2013 |
| RCC1 can induce bipolar spindle formation. Remarkably, RCC1 beads oscillate within spindles from pole to pole, a behavior that could be converted to a more typical, stable association by the addition of a kinesin together with RCC1. | Mitotic spindle assembly around RCC1-coated beads in Xenopus egg extracts.
Halpin D, Kalab P, Wang J, Weis K, Heald R., Free PMC Article | 05/5/2012 |
| discovery of the first alpha-N-methyltransferase, which we named N-terminal RCC1 methyltransferase (NRMT). | NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
Tooley CE, Petkowski JJ, Muratore-Schroeder TL, Balsbaugh JL, Shabanowitz J, Sabat M, Minor W, Hunt DF, Macara IG., Free PMC Article | 09/20/2010 |
| The authors find that RCC1 uses a conformationally flexible loop region we have termed the switchback loop in addition to its N-terminal tail to bind to the nucleosome. | RCC1 uses a conformationally diverse loop region to interact with the nucleosome: a model for the RCC1-nucleosome complex.
England JR, Huang J, Jennings MJ, Makde RD, Tan S., Free PMC Article | 05/10/2010 |
| RCC1 undergoes post-translational phosphorylation | Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro.
Horiike Y, Kobayashi H, Sekiguchi T. | 01/21/2010 |
| Therefore, we propose that RCC1 reads the histone code created by caspase-activated Mst1 to initiate apoptosis by reducing the level of RanGTP in the nucleus. | Apoptotic histone modification inhibits nuclear transport by regulating RCC1.
Wong CH, Chan H, Ho CY, Lai SK, Chan KS, Koh CG, Li HY. | 01/21/2010 |
| chromosome 1p36 was established to have linkage for adhd. | Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings.
Zhou K, Asherson P, Sham P, Franke B, Anney RJ, Buitelaar J, Ebstein R, Gill M, Brookes K, Buschgens C, Campbell D, Chen W, Christiansen H, Fliers E, Gabriëls I, Johansson L, Marco R, Mulas F, Müller U, Mulligan A, Neale BM, Rijsdijk F, Rommelse N, Uebel H, Psychogiou L, Xu X, Banaschewski T, Sonuga-Barke E, Eisenberg J, Manor I, Miranda A, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Taylor E, Thompson M, Faraone SV., Free PMC Article | 01/21/2010 |
| reduced binding affinity of RCC1 to the mitotic chromosome, which led to a reduction of RanGTP level. | Perturbation of the chromosomal binding of RCC1, Mad2 and survivin causes spindle assembly defects and mitotic catastrophe.
Ho CY, Wong CH, Li HY. | 01/21/2010 |