| increased podocyte expression of RAP1GAP contributes directly to podocyte dysfunction by a mechanism that involves loss of RAP1-mediated activation of beta1 integrin | Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury.
Potla U, Ni J, Vadaparampil J, Yang G, Leventhal JS, Campbell KN, Chuang PY, Morozov A, He JC, D'Agati VD, Klotman PE, Kaufman L., Free PMC Article | 06/7/2014 |
| Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization | Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization.
Wang Y, He H, Srivastava N, Vikarunnessa S, Chen YB, Jiang J, Cowan CW, Zhang X., Free PMC Article | 05/19/2012 |
| Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities | Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.
Dai Y, Walker SA, de Vet E, Cook S, Welch HC, Lockyer PJ., Free PMC Article | 08/6/2011 |
| phosphorylation of Rap1GAP by protein kinase A plays an important role in striatal neurons by modulating Rap1 actions | Phosphorylation of Rap1GAP, a striatally enriched protein, by protein kinase A controls Rap1 activity and dendritic spine morphology.
McAvoy T, Zhou MM, Greengard P, Nairn AC., Free PMC Article | 01/21/2010 |
| The transport of the signaling complex containing the p75 receptor and Rap1 may play a role in the effect of MAG (myelin-associated glycoprotein). | Rap1 is involved in the signal transduction of myelin-associated glycoprotein.
Taniguchi J, Fujitani M, Endo M, Kubo T, Fujitani M, Miller FD, Kaplan DR, Yamashita T. | 01/21/2010 |
| CD44 stimulation induces inside-out activation of CR3 through the GTPase Rap1 | CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophages.
Vachon E, Martin R, Kwok V, Cherepanov V, Chow CW, Doerschuk CM, Plumb J, Grinstein S, Downey GP., Free PMC Article | 01/21/2010 |
| GTPase Rap1 exhibits an inverse pattern of expression to pERK in individual Ag-specific primed and tolerized T cells. | Inverse Rap1 and phospho-ERK expression discriminate the maintenance phase of tolerance and priming of antigen-specific CD4+ T cells in vitro and in vivo.
Morton AM, McManus B, Garside P, Mowat AM, Harnett MM. | 01/21/2010 |
| These findings proved a crucial role of the cross-talk between two Ras-family GTPases M-Ras and Rap1, mediated by RA-GEF-2, in adhesion signaling. | The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes.
Yoshikawa Y, Satoh T, Tamura T, Wei P, Bilasy SE, Edamatsu H, Aiba A, Katagiri K, Kinashi T, Nakao K, Kataoka T., Free PMC Article | 01/21/2010 |
| Rap1 stimulates signal transduction pathways that lead to cell proliferation and cell survival, and may play crucial roles in leukemogenesis by BCR/ABL. | BCR/ABL and IL-3 activate Rap1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion.
Jin A, Kurosu T, Tsuji K, Mizuchi D, Arai A, Fujita H, Hattori M, Minato N, Miura O. | 01/21/2010 |
| Ras plays a major role in ERK activation by cAMP, PACAP, and KCl, while Rap1 also mediates activation of a selective membrane-associated pool of ERKs. | The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells.
Obara Y, Horgan AM, Stork PJ. | 01/21/2010 |
| functional role of Rap1 in male germ cell differentiation | Impaired fertility and spermiogenetic disorders with loss of cell adhesion in male mice expressing an interfering Rap1 mutant.
Aivatiadou E, Mattei E, Ceriani M, Tilia L, Berruti G., Free PMC Article | 01/21/2010 |
| Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory. | Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory.
Morozov A, Muzzio IA, Bourtchouladze R, Van-Strien N, Lapidus K, Yin D, Winder DG, Adams JP, Sweatt JD, Kandel ER. | 01/21/2010 |
| forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling | Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
Misra UK, Pizzo SV. | 01/21/2010 |
| Expression studies show that mr-gef is expressed by young neurons of the developing rodent CNS but not by progenitor cells in the ventricular zone (VZ). | Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons.
Bithell A, Alberta J, Hornby F, Stiles CD, Williams BP. | 01/21/2010 |
| EGF-induced activation of GTPase Rap1 was sensitized in NIH3T3/EGFR-e3B1 cells. | E3B1, a human homologue of the mouse gene product Abi-1, sensitizes activation of Rap1 in response to epidermal growth factor.
Jenei V, Andersson T, Jakus J, Dib K. | 01/21/2010 |
| Results describe a link between ADAP/SKAP-55 and the Rap1/RIAM complex and provide a potential new mechanism for T cell receptor-mediated integrin activation. | RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation.
Ménasché G, Kliche S, Chen EJ, Stradal TE, Schraven B, Koretzky G., Free PMC Article | 01/21/2010 |
| Rap1 and MEKK2 are critical upstream signaling molecules mediating BDNF stimulation of ERK5 in central nervous system neurons | Brain-derived neurotrophic factor activates ERK5 in cortical neurons via a Rap1-MEKK2 signaling cascade.
Wang Y, Su B, Xia Z. | 01/21/2010 |
| ERK activation by cAMP does not require RAP1 | MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases.
Klinger M, Kudlacek O, Seidel MG, Freissmuth M, Sexl V. | 01/21/2010 |
| down-regulation of Rap1 expression following somatostatin treatment is closely related to the diminished LFA-1 expression | Somatostatin down-regulates LFA-1 activation by modulating Rap1 expression in CD4+ and CD8+ T cells.
Yoon WK, Kim HJ, Son HY, Jeong KS, Park SJ, Kim TH, An MY, Kim SH, Kim SR, Ryu SY. | 01/21/2010 |
| NF-kappaB activation could be regulated through Epac1-mediated Rap1 stimulation for LPS-induced inflammatory responses in murine macrophages | Lipopolysaccharide stimulates Epac1-mediated Rap1/NF-kappaB pathway in Raw 264.7 murine macrophages.
Moon EY, Pyo S. | 01/21/2010 |
| evidence of differential Krit1 and Rap1A expression during mouse ontogenesis and suggest a more widespread functional significance of Krit1, not restricted to vascular endothelial cells. | Mutation and expression analysis of the KRIT1 gene associated with cerebral cavernous malformations (CCM1).
Kehrer-Sawatzki H, Wilda M, Braun VM, Richter HP, Hameister H. | 01/21/2010 |
| CTLA-4 deficient mice show altered RAP-1-mediated adhesion | CTLA-4 regulation of T cell function via RAP-1-mediated adhesion.
Schneider H, Valk E, Dias Sda R, Wei B, Rudd CE. | 01/21/2010 |
| A signaling module comprising the cytosolic adapter proteins ADAP and SKAP55 is involved in TCR-mediated inside-out signaling and, the interaction between ADAP and SKAP55 is mandatory for integrin activation. | The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1.
Kliche S, Breitling D, Togni M, Pusch R, Heuer K, Wang X, Freund C, Kasirer-Friede A, Menasche G, Koretzky GA, Schraven B., Free PMC Article | 01/21/2010 |