| pH-sensing GPR68 inhibits vascular smooth muscle cell proliferation through Rap1A. | pH-sensing GPR68 inhibits vascular smooth muscle cell proliferation through Rap1A.
Williams MD, Morgan JS, Bullock MT, Poovey CE, Wisniewski ME, Francisco JT, Barajas-Nunez JA, Hijazi AM, Theobald D, Sriramula S, Mansfield KD, Holland NA, Tulis DA., | 11/4/2024 |
| Rap1A Modulates Store-Operated Calcium Entry in the Lung Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular Inflammation and Permeability. | Rap1A Modulates Store-Operated Calcium Entry in the Lung Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular Inflammation and Permeability.
Kosuru R, Romito O, Sharma GP, Ferraresso F, Ghadrdoost Nakhchi B, Yang K, Mammoto T, Mammoto A, Kastrup CJ, Zhang DX, Goldspink PH, Trebak M, Chrzanowska M., Free PMC Article | 10/25/2024 |
| Proteomic Analysis of Rap1A GTPase Signaling-Deficient C57BL/6 Mouse Pancreas and Functional Studies Identify an Essential Role of Rap1A in Pancreas Physiology. | Proteomic Analysis of Rap1A GTPase Signaling-Deficient C57BL/6 Mouse Pancreas and Functional Studies Identify an Essential Role of Rap1A in Pancreas Physiology.
Shahwar D, Baqai S, Khan F, Khan MI, Javaid S, Hameed A, Raza A, Saleem Uddin S, Hazrat H, Rahman MH, Musharraf SG, Chotani MA., Free PMC Article | 09/19/2024 |
| Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice. | Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice.
Yamamoto K, Watanabe-Takano H, Oguri-Nakamura E, Matsuno H, Horikami D, Ishii T, Ohashi R, Kubota Y, Nishiyama K, Murata T, Mochizuki N, Fukuhara S. | 12/1/2023 |
| Distinct bidirectional regulation of LFA1 and alpha4beta7 by Rap1 and integrin adaptors in T cells under shear flow. | Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow.
Kamioka Y, Ueda Y, Kondo N, Tokuhiro K, Ikeda Y, Bergmeier W, Kinashi T., Free PMC Article | 10/12/2023 |
| Rap1 regulates lumen continuity via Afadin in renal epithelia. | Rap1 regulates lumen continuity via Afadin in renal epithelia.
Hiremath C, Gao L, Geshow K, Patterson Q, Barlow H, Cleaver O, Marciano DK., Free PMC Article | 07/12/2023 |
| Rap1A accelerates homocysteine-induced ANA-1 cells inflammation via synergy of FoxO1 and DNMT3a. | Rap1A accelerates homocysteine-induced ANA-1 cells inflammation via synergy of FoxO1 and DNMT3a.
Wu H, Li Z, Yang Y, Zhang L, Yuan Y, Wang Y, Li G, Yang X. | 04/12/2023 |
| MiR-1224-5p modulates osteogenesis by coordinating osteoblast/osteoclast differentiation via the Rap1 signaling target ADCY2. | MiR-1224-5p modulates osteogenesis by coordinating osteoblast/osteoclast differentiation via the Rap1 signaling target ADCY2.
Hu L, Xie X, Xue H, Wang T, Panayi AC, Lin Z, Xiong Y, Cao F, Yan C, Chen L, Cheng P, Zha K, Sun Y, Liu G, Yu C, Hu Y, Tao R, Zhou W, Mi B, Liu G., Free PMC Article | 08/13/2022 |
| Rap1a Activity Elevated the Impact of Endogenous AGEs in Diabetic Collagen to Stimulate Increased Myofibroblast Transition and Oxidative Stress. | Rap1a Activity Elevated the Impact of Endogenous AGEs in Diabetic Collagen to Stimulate Increased Myofibroblast Transition and Oxidative Stress.
Burr SD, Dorroh CC, Stewart JA Jr., Free PMC Article | 05/21/2022 |
| Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling. | Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling.
Ishihara S, Sato T, Fujikado N, Miyazaki H, Yoshimoto T, Yamamoto H, Fukuda S, Katagiri K., Free PMC Article | 04/30/2022 |
| Rap1 in the VMH regulates glucose homeostasis. | Rap1 in the VMH regulates glucose homeostasis.
Kaneko K, Lin HY, Fu Y, Saha PK, De la Puente-Gomez AB, Xu Y, Ohinata K, Chen P, Morozov A, Fukuda M., Free PMC Article | 02/19/2022 |
| The Rap1 small GTPase is a critical mediator of the effects of stress on prefrontal cortical dysfunction. | The Rap1 small GTPase is a critical mediator of the effects of stress on prefrontal cortical dysfunction.
Kermath BA, Vanderplow AM, Bjornson KJ, Seablom EN, Novak AM, Bernhardt CR, Cahill ME. | 01/29/2022 |
| SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-kappaB and Notch signaling. | SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-κB and Notch signaling.
Robinson NJ, Miyagi M, Scarborough JA, Scott JG, Taylor DJ, Schiemann WP., Free PMC Article | 01/22/2022 |
| Rap1 Is Essential for B-Cell Locomotion, Germinal Center Formation and Normal B-1a Cell Population. | Rap1 Is Essential for B-Cell Locomotion, Germinal Center Formation and Normal B-1a Cell Population.
Ishihara S, Sato T, Sugioka R, Miwa R, Saito H, Sato R, Fukuyama H, Nakajima A, Sawai S, Kotani A, Katagiri K., Free PMC Article | 09/18/2021 |
| miR-590-3p Alleviates diabetic peripheral neuropathic pain by targeting RAP1A and suppressing infiltration by the T cells. | miR-590-3p Alleviates diabetic peripheral neuropathic pain by targeting RAP1A and suppressing infiltration by the T cells.
Wu Y, Gu Y, Shi B. | 08/7/2021 |
| Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis. | Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis.
Perdomo L, Vidal-Gómez X, Soleti R, Vergori L, Duluc L, Chwastyniak M, Bisserier M, Le Lay S, Villard A, Simard G, Meilhac O, Lezoualc'h F, Khantalin I, Veerapen R, Dubois S, Boursier J, Henni S, Gagnadoux F, Pinet F, Andriantsitohaina R, Martínez MC, Metabol study Group., Free PMC Article | 05/29/2021 |
| results identify GIPR/Rap1 signaling in the brain as a molecular pathway linking overnutrition to the control of neural leptin actions. | Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition.
Kaneko K, Fu Y, Lin HY, Cordonier EL, Mo Q, Gao Y, Yao T, Naylor J, Howard V, Saito K, Xu P, Chen SS, Chen MH, Xu Y, Williams KW, Ravn P, Fukuda M., Free PMC Article | 05/16/2020 |
| RAP1 levels are predictive of the success of chemotherapy in breast and colon cancer. | Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy.
Khattar E, Maung KZY, Chew CL, Ghosh A, Mok MMH, Lee P, Zhang J, Chor WHJ, Cildir G, Wang CQ, Mohd-Ismail NK, Chin DWL, Lee SC, Yang H, Shin YJ, Nam DH, Chen L, Kumar AP, Deng LW, Ikawa M, Gunaratne J, Osato M, Tergaonkar V., Free PMC Article | 02/29/2020 |
| Rap1 controls neuronal migration via regulation of N-cadherin expression. | The Mechanism of Rap1 Regulates N-cadherin to Control Neuronal Migration.
Yang C, Li X, Zhang B, Fu S, Li S, Shen J, Guan L, Qiao L, Lin J. | 12/14/2019 |
| Sema3A and Plexin-A1 suppress the formation of supernumerary axons in cultured neurons, which depends on Rap1 GTPases. | The Sema3A receptor Plexin-A1 suppresses supernumerary axons through Rap1 GTPases.
Wang N, Dhumale P, Chiang J, Püschel AW., Free PMC Article | 11/30/2019 |
| the Rap1-talin 1 F0 interaction has little effect on platelet GPIIb-IIIa activation and hemostasis and cannot account for the dramatic effects of loss of Rap1 activity on these platelet functions. | Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation.
Lagarrigue F, Gingras AR, Paul DS, Valadez AJ, Cuevas MN, Sun H, Lopez-Ramirez MA, Goult BT, Shattil SJ, Bergmeier W, Ginsberg MH., Free PMC Article | 08/31/2019 |
| Combined deficiency of RAP1A and RAP1B markedly impaired platelet aggregation, spreading, and clot retraction. | Functional redundancy between RAP1 isoforms in murine platelet production and function.
Stefanini L, Lee RH, Paul DS, O'Shaughnessy EC, Ghalloussi D, Jones CI, Boulaftali Y, Poe KO, Piatt R, Kechele DO, Caron KM, Hahn KM, Gibbins JM, Bergmeier W., Free PMC Article | 08/17/2019 |
| findings suggest that direct Rap1/Talin1 interaction is of particular importance in regulating the activity of different integrin classes expressed on platelets and neutrophils, which both depend on fast and dynamic integrin-mediated responses. | Direct Rap1/Talin1 interaction regulates platelet and neutrophil integrin activity in mice.
Bromberger T, Klapproth S, Rohwedder I, Zhu L, Mittmann L, Reichel CA, Sperandio M, Qin J, Moser M., Free PMC Article | 07/20/2019 |
| Rap1 plays an unanticipated role in regulating the fate of nitric oxide. | Deletion of Rap1 disrupts redox balance and impairs endothelium-dependent relaxations.
Wong KHK, Cai Y, Ying F, Chen X, Vanhoutte PM, Tang EHC. | 06/29/2019 |
| Endothelial Rap1A promotes vessel barrier maintenance in lungs in vivo, and is required for maintenance of adherens junction organization in vitro | Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier.
Lakshmikanthan S, Sobczak M, Li Calzi S, Shaw L, Grant MB, Chrzanowska-Wodnicka M., Free PMC Article | 04/27/2019 |