| Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation. | Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation.
Parunov LA, Liang Y, Lu Q, Shibeko AM, Tucker EI, Lee TK, Ataullakhanov FI, Scott DE, Ovanesov MV., Free PMC Article | 06/16/2023 |
| A non-circulating pool of factor XI associated with glycosaminoglycans in mice. | A non-circulating pool of factor XI associated with glycosaminoglycans in mice.
Mohammed BM, Cheng Q, Matafonov A, Verhamme IM, Emsley J, McCrae KR, McCarty OJT, Gruber A, Gailani D., Free PMC Article | 08/22/2020 |
| interfering with the FXIIa-FXI interaction could inhibit thromboinflammatory processes without compromising hemostasis. Inhibiting FXI activation with anti-FXI antibody 14E11 reduces myocardial ischemia-reperfusion injury. | Factor XI contributes to myocardial ischemia-reperfusion injury in mice.
Lorentz CU, Verbout NG, Cao Z, Liu L, Hinds MT, McCarty OJT, Ivanov I, Tucker EI, Gailani D, Gruber A., Free PMC Article | 02/2/2019 |
| FXI(-/-) mice have a mild hemostatic defect after injury to the saphenous vein but not after transection of the tail or vessels in the abdominal wall. | Factor XI-deficient mice exhibit increased bleeding after injury to the saphenous vein.
Ay C, Hisada Y, Cooley BC, Mackman N. | 07/21/2018 |
| FXI protects against sepsis derived from Streptococcus pneumoniae or Klebsiella pneumoniae pneumonia at least in part by enhancing the phagocytic capacity of neutrophils by a mechanism that is independent of activation via FXIIa. | Coagulation factor XI improves host defence during murine pneumonia-derived sepsis independent of factor XII activation.
Stroo I, Zeerleder S, Ding C, Luken BM, Roelofs JJTH, de Boer OJ, Meijers JCM, Castellino FJ, van 't Veer C, van der Poll T. | 05/5/2018 |
| FXI attenuates part of the allergic response to repeated administration of house dust mite in the airways by a mechanism that is independent of activation via FXII. | Factor XI deficiency enhances the pulmonary allergic response to house dust mite in mice independent of factor XII.
Stroo I, Yang J, de Boer JD, Roelofs JJ, van 't Veer C, Castellino FJ, Zeerleder S, van der Poll T. | 06/24/2017 |
| Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease. | Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.
Sparkenbaugh EM, Chantrathammachart P, Chandarajoti K, Mackman N, Key NS, Pawlinski R., Free PMC Article | 08/6/2016 |
| FXI deprivation was shown to slow down atherogenesis in Apoe knockout mice. | Factor XI Deficiency Protects Against Atherogenesis in Apolipoprotein E/Factor XI Double Knockout Mice.
Shnerb Ganor R, Harats D, Schiby G, Gailani D, Levkovitz H, Avivi C, Tamarin I, Shaish A, Salomon O., Free PMC Article | 07/16/2016 |
| anion-binding sites on FXIa that are required for expression of heparin's cofactor activity during protease inhibition by antithrombin are also required for expression of polyP cofactor activity during FXI activation | Factor XI anion-binding sites are required for productive interactions with polyphosphate.
Geng Y, Verhamme IM, Smith SA, Cheng Q, Sun M, Sheehan JP, Morrissey JH, Gailani D., Free PMC Article | 02/28/2015 |
| Factor XI antisense oligonucleotides safely prevent thrombus formation on acutely ruptured atherosclerotic plaques in mice. | Factor XI regulates pathological thrombus formation on acutely ruptured atherosclerotic plaques.
van Montfoort ML, Kuijpers MJ, Knaup VL, Bhanot S, Monia BP, Roelofs JJ, Heemskerk JW, Meijers JC. | 09/13/2014 |
| Data conclude that within the mouse F11, Klkb1, Cyp4v3 gene cluster, F11 and Cyp4v3 frequently display striking parallel transcriptional responses suggesting the presence of shared regulatory elements. | Regulation of the F11, Klkb1, Cyp4v3 gene cluster in livers of metabolically challenged mice.
Safdar H, Cleuren AC, Cheung KL, Gonzalez FJ, Vos HL, Inoue Y, Reitsma PH, van Vlijmen BJ., Free PMC Article | 05/31/2014 |
| Studies indicate that targeting factor XI (FXI) by knocking out the gene prevents arterial and vein thrombosis. | Congenital factor XI deficiency: an update.
Duga S, Salomon O. | 03/22/2014 |
| Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica. | Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica.
Luo D, Szaba FM, Kummer LW, Plow EF, Mackman N, Gailani D, Smiley ST., Free PMC Article | 10/1/2011 |
| fXI and fXII contribute to thrombus formation even when factor VIIa/tissue factor initiates thrombosis. | A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo.
Cheng Q, Tucker EI, Pine MS, Sisler I, Matafonov A, Sun MF, White-Adams TC, Smith SA, Hanson SR, McCarty OJ, Renné T, Gruber A, Gailani D., Free PMC Article | 01/1/2011 |
| apolipoprotein E receptor 2 (ApoER2, LRP8), a member of the LDL receptor family, is a platelet receptor for FXI. | Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2).
White-Adams TC, Berny MA, Tucker EI, Gertz JM, Gailani D, Urbanus RT, de Groot PG, Gruber A, McCarty OJ., Free PMC Article | 01/21/2010 |
| fXI may have functions in regulation of inflammation or tissue repair distinct from its role in coagulation | The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice.
Cheng Q, Zhao Y, Lawson WE, Polosukhin VV, Johnson JE, Blackwell TS, Gailani D., Free PMC Article | 01/21/2010 |
| FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse. | FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse.
Rosen ED, Gailani D, Castellino FJ. | 01/21/2010 |
| FIX and FXI deficiency cause similar effects in the carotid artery injury model | Effects of factor IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice.
Wang X, Cheng Q, Xu L, Feuerstein GZ, Hsu MY, Smith PL, Seiffert DA, Schumacher WA, Ogletree ML, Gailani D. | 01/21/2010 |
| Gene targeting of tissue factor, factor X, and factor VII in mice: their involvement in embryonic development | Gene targeting of tissue factor, factor X, and factor VII in mice: their involvement in embryonic development.
Aasrum M, Prydz H. | 01/21/2010 |