| N[6] -Methyladenosine-Modified CBX1 Regulates Nasopharyngeal Carcinoma Progression Through Heterochromatin Formation and STAT1 Activation. | N(6) -Methyladenosine-Modified CBX1 Regulates Nasopharyngeal Carcinoma Progression Through Heterochromatin Formation and STAT1 Activation.
Zhao Y, Huang S, Tan X, Long L, He Q, Liang X, Bai J, Li Q, Lin J, Li Y, Liu N, Ma J, Chen Y., Free PMC Article | 01/11/2023 |
| HP1 proteins compact DNA into mechanically and positionally stable phase separated domains. | HP1 proteins compact DNA into mechanically and positionally stable phase separated domains.
Keenen MM, Brown D, Brennan LD, Renger R, Khoo H, Carlson CR, Huang B, Grill SW, Narlikar GJ, Redding S., Free PMC Article | 01/29/2022 |
| Beyond the Nucleosome: Nucleosome-Protein Interactions and Higher Order Chromatin Structure. | Beyond the Nucleosome: Nucleosome-Protein Interactions and Higher Order Chromatin Structure.
Lobbia VR, Trueba Sanchez MC, van Ingen H. | 05/8/2021 |
| The gamma-irradiation-induced hyperphosphorylation of the HP1beta protein; thus, HP1beta-S88ph could be considered as an important marker of DNA damage. | DNA Damage Changes Distribution Pattern and Levels of HP1 Protein Isoforms in the Nucleolus and Increases Phosphorylation of HP1β-Ser88.
Legartová S, Lochmanová G, Zdráhal Z, Kozubek S, Šponer J, Krepl M, Pokorná P, Bártová E., Free PMC Article | 06/6/2020 |
| the prolyl residue of the PXXVXL motif appears to play a role distinct from that of Pro in the known HP1beta CSD-PXVXL complexes. | Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1.
Liu Y, Qin S, Lei M, Tempel W, Zhang Y, Loppnau P, Li Y, Min J., Free PMC Article | 06/3/2017 |
| Data show that heterochromatin protein 1-beta (HP1beta) is a prototypic HP1 protein exemplifying most basal chromatin binding and effects. | Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin.
Hiragami-Hamada K, Soeroes S, Nikolov M, Wilkins B, Kreuz S, Chen C, De La Rosa-Velázquez IA, Zenn HM, Kost N, Pohl W, Chernev A, Schwarzer D, Jenuwein T, Lorincz M, Zimmermann B, Walla PJ, Neumann H, Baubec T, Urlaub H, Fischle W., Free PMC Article | 09/10/2016 |
| increased HP1beta expression is associated with the poor prognosis in breast cancer | HP1β is a biomarker for breast cancer prognosis and PARP inhibitor therapy.
Lee YH, Liu X, Qiu F, O'Connor TR, Yen Y, Ann DK., Free PMC Article | 01/30/2016 |
| In this review, we summarize the current knowledge about targeting and functional mechanisms of PRCs, emphasizing the recent breakthroughs related to CBX proteins under a number of physiological and pathological conditions. | Epigenetic regulation by polycomb group complexes: focus on roles of CBX proteins.
Ma RG, Zhang Y, Sun TT, Cheng B., Free PMC Article | 01/17/2015 |
| Data suggest the reduction of Heterochromatin Protein 1 isoforms HP1beta followed by a decrease in HP1alpha contributes to the pathogenesis of thyroid carcinomas, and their loss is a potential marker of thyroid malignancy and metastatic potential, respectively. | Heterochromatin protein 1 expression is reduced in human thyroid malignancy.
Tretiakova MS, Bond SD, Wheeler D, Contreras A, Kocherginsky M, Kroll TG, Hale TK. | 09/6/2014 |
| Phosphorylation at Ser89 and Ser175 results in localized conformational changes in HP1beta that do not compromise the ability of the protein to bind chromatin. | Characterization of the effects of phosphorylation by CK2 on the structure and binding properties of human HP1β.
Munari F, Gajda MJ, Hiragami-Hamada K, Fischle W, Zweckstetter M. | 05/17/2014 |
| HP1 isoforms distinctly augment AR signaling and cell growth in prostate cancer. Therefore, silencing of HP1beta and HP1gamma may be a promising therapeutic strategy for treatment of prostate cancer. | Human heterochromatin protein 1 isoforms regulate androgen receptor signaling in prostate cancer.
Itsumi M, Shiota M, Yokomizo A, Kashiwagi E, Takeuchi A, Tatsugami K, Inokuchi J, Song Y, Uchiumi T, Naito S. | 11/2/2013 |
| The structural plasticity of HP1beta supports its ability to bind and connect a wide variety of binding partners in epigenetic processes. | Structural plasticity in human heterochromatin protein 1β.
Munari F, Rezaei-Ghaleh N, Xiang S, Fischle W, Zweckstetter M., Free PMC Article | 10/26/2013 |
| HP1beta which is associated with PCNA in regions of DNA repair, is bound and does not exchange with the mobile pool, suggesting that HP1beta in association with PCNA may be a component of a DNA repair complex. | Dynamics of the HP1β-PCNA-containing complexes in DNA replication and repair.
Trembecka-Lucas DO, Szczurek AT, Dobrucki JW., Free PMC Article | 08/31/2013 |
| The HP1beta interactome is enriched with Lys methylated proteins.Role of HP1beta in DNA damage response. | A method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response.
Liu H, Galka M, Mori E, Liu X, Lin YF, Wei R, Pittock P, Voss C, Dhami G, Li X, Miyaji M, Lajoie G, Chen B, Li SS., Free PMC Article | 08/31/2013 |
| study finds that while HP1apha and beta stimulate homologous recombination and single-strand annealing, HP1gamma has an inhibitory role | Differential contribution of HP1 proteins to DNA end resection and homology-directed repair.
Soria G, Almouzni G., Free PMC Article | 08/3/2013 |
| Methylation of lysine 9 in histone H3 directs alternative modes of highly dynamic interaction of heterochromatin protein hHP1beta with the nucleosome | Methylation of lysine 9 in histone H3 directs alternative modes of highly dynamic interaction of heterochromatin protein hHP1β with the nucleosome.
Munari F, Soeroes S, Zenn HM, Schomburg A, Kost N, Schröder S, Klingberg R, Rezaei-Ghaleh N, Stützer A, Gelato KA, Walla PJ, Becker S, Schwarzer D, Zimmermann B, Fischle W, Zweckstetter M., Free PMC Article | 12/22/2012 |
| a novel mechanism of KAP-1-mediated chromatin restructuring via Chk2-regulated HP1-beta exchange from heterochromatin, promoting DNA repair. | Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatin.
Bolderson E, Savage KI, Mahen R, Pisupati V, Graham ME, Richard DJ, Robinson PJ, Venkitaraman AR, Khanna KK., Free PMC Article | 11/17/2012 |
| HP1 beta and PCNA, a key player in DNA replication, are closely spaced components of a multiprotein complex involved in replication, both in S phase and during DNA repair, and that the functional complex requires formation of an HP1 dimer. | A heterochromatin protein 1 (HP1) dimer and a proliferating cell nuclear antigen (PCNA) protein interact in vivo and are parts of a multiprotein complex involved in DNA replication and DNA repair.
Trembecka-Lucas DO, Dobrucki JW. | 10/13/2012 |
| Abrogating GRP/GRPR signaling specifically down-regulates HP1(Hsbeta) expression and inhibiting GRPR signaling, or ablating HP1(Hsbeta) expression, increases colon cancer cell invasiveness in vitro. | Gastrin-releasing peptide signaling alters colon cancer invasiveness via heterochromatin protein 1Hsβ.
Tell R, Rivera CA, Eskra J, Taglia LN, Blunier A, Wang QT, Benya RV., Free PMC Article | 05/28/2011 |
| HP1beta is involved in the proliferation of AR-expressing prostate cancer cells and progression to CRPC as an AR coactivator. | Human heterochromatin protein 1 isoform HP1beta enhances androgen receptor activity and is implicated in prostate cancer growth.
Shiota M, Song Y, Yokomizo A, Tada Y, Kuroiwa K, Eto M, Oda Y, Inokuchi J, Uchiumi T, Fujimoto N, Seki N, Naito S. | 09/20/2010 |
| Mislocalized lamins can induce ubiquitin-mediated proteasomal degradation of certain HP1 isoforms by activation of FBXW10, a member of the F-box family of proteins that is involved in E3 ubiquitin ligase activity. | Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10.
Chaturvedi P, Parnaik VK., Free PMC Article | 09/13/2010 |
| a nonconventional interaction between HP1 and a tissue-specific transcription factor, MyoD. In addition, they strongly suggest that HP1 isoforms play important roles during muscle terminal differentiation in an isoform-dependent manner. | Differential cooperation between heterochromatin protein HP1 isoforms and MyoD in myoblasts.
Yahi H, Fritsch L, Philipot O, Guasconi V, Souidi M, Robin P, Polesskaya A, Losson R, Harel-Bellan A, Ait-Si-Ali S., Free PMC Article | 01/21/2010 |
| when HP1beta was co-expressed with TIF1beta/S473A, but not TIF1beta/S473E, the colocalization of TIF1beta/S473A and HP1beta to the promoters of Cdc2 and Cdc25A was enhanced. | Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1.
Chang CW, Chou HY, Lin YS, Huang KH, Chang CJ, Hsu TC, Lee SC., Free PMC Article | 01/21/2010 |
| findings reveal an unrecognized signalling cascade that helps to initiate the DNA damage response, altering chromatin by modifying a histone-code mediator protein, HP1, but not the code itself | HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response.
Ayoub N, Jeyasekharan AD, Bernal JA, Venkitaraman AR. | 01/21/2010 |
| HP1 recruitment-release is a sequential mechanism that is precisely regulated and highly dependent on transcription. | Regulation of an inducible promoter by an HP1beta-HP1gamma switch.
Mateescu B, Bourachot B, Rachez C, Ogryzko V, Muchardt C., Free PMC Article | 01/21/2010 |