| GIV/Girdin, a non-receptor modulator for Galphai/s, regulates spatiotemporal signaling during sperm capacitation and is required for male fertility. | GIV/Girdin, a non-receptor modulator for Gαi/s, regulates spatiotemporal signaling during sperm capacitation and is required for male fertility.
Reynoso S, Castillo V, Katkar GD, Lopez-Sanchez I, Taheri S, Espinoza C, Rohena C, Sahoo D, Gagneux P, Ghosh P., Free PMC Article | 10/16/2021 |
| TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin. | TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin.
Swanson L, Katkar GD, Tam J, Pranadinata RF, Chareddy Y, Coates J, Anandachar MS, Castillo V, Olson J, Nizet V, Kufareva I, Das S, Ghosh P., Free PMC Article | 12/19/2020 |
| MiR-328-3p inhibits cell proliferation and metastasis in colorectal cancer by targeting Girdin and inhibiting the PI3K/Akt signaling pathway. | MiR-328-3p inhibits cell proliferation and metastasis in colorectal cancer by targeting Girdin and inhibiting the PI3K/Akt signaling pathway.
Pan S, Ren F, Li L, Liu D, Li Y, Wang A, Li W, Dong Y, Guo W. | 12/12/2020 |
| Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut | Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut.
Kuga D, Ushida K, Mii S, Enomoto A, Asai N, Nagino M, Takahashi M, Asai M., Free PMC Article | 06/24/2017 |
| This study aimed to prove the participation of mTORC2/Akt in F-actin assembling in early-stage cleavage of mouse fertilized eggs via the function of Girdin. | F-actin rearrangement is regulated by mTORC2/Akt/Girdin in mouse fertilized eggs.
Wu D, Yu D, Wang X, Yu B., Free PMC Article | 01/28/2017 |
| Akt-dependent Girdin phosphorylation regulates repair processes after acute myocardial infarction. | Akt-dependent Girdin phosphorylation regulates repair processes after acute myocardial infarction.
Hayano S, Takefuji M, Maeda K, Noda T, Ichimiya H, Kobayashi K, Enomoto A, Asai N, Takahashi M, Murohara T. | 08/20/2016 |
| GIV expression is up-regulated in liver after fibrotic injury and is required for hepatic stellate cells activation.Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. | GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis.
Lopez-Sanchez I, Dunkel Y, Roh YS, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F, Ho SB, Seki E, Brenner DA, Ghosh P., Free PMC Article | 04/30/2016 |
| GIV and its substrate Galphai3 are recruited to active integrin complexes | Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin.
Leyme A, Marivin A, Perez-Gutierrez L, Nguyen LT, Garcia-Marcos M., Free PMC Article | 12/26/2015 |
| findings suggest a potential role of Girdin/kinesin-1 interaction in the regulation of neuroblast migration in the postnatal brain | Potential involvement of kinesin-1 in the regulation of subcellular localization of Girdin.
Muramatsu A, Enomoto A, Kato T, Weng L, Kuroda K, Asai N, Asai M, Mii S, Takahashi M. | 11/7/2015 |
| Girdin phosphorylation at Y1798 was found at focal adhesions in NIH3T3 cells. Such phosphorylation was found where migration defects occurred in Girdin KO mice. | Girdin is phosphorylated on tyrosine 1798 when associated with structures required for migration.
Omori K, Asai M, Kuga D, Ushida K, Izuchi T, Mii S, Enomoto A, Asai N, Nagino M, Takahashi M. | 05/30/2015 |
| Girdin phosphorylation at S1416 induced by Akt is crucial for NMDA receptor activation associated with LTP. | Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor.
Nakai T, Nagai T, Tanaka M, Itoh N, Asai N, Enomoto A, Asai M, Yamada S, Saifullah AB, Sokabe M, Takahashi M, Yamada K., Free PMC Article | 01/24/2015 |
| Girdin was identified as a new and major regulator of the insulin signal in myoblasts and skeletal muscle. | The Akt substrate Girdin is a regulator of insulin signaling in myoblast cells.
Hartung A, Ordelheide AM, Staiger H, Melzer M, Häring HU, Lammers R. | 03/1/2014 |
| These results demonstrate that girdin and its phosphorylation play an important role in neonatal vascular development and in pathological neovascularization in the retina. | Girdin and its phosphorylation dynamically regulate neonatal vascular development and pathological neovascularization in the retina.
Ito T, Komeima K, Yasuma T, Enomoto A, Asai N, Asai M, Iwase S, Takahashi M, Terasaki H. | 07/13/2013 |
| these findings indicate that loss of Girdin in the nestin cell lineage underlies the phenotype of Girdin ncKO mice. | Similar phenotypes of Girdin germ-line and conditional knockout mice indicate a crucial role for Girdin in the nestin lineage.
Asai M, Asai N, Murata A, Yokota H, Ohmori K, Mii S, Enomoto A, Murakumo Y, Takahashi M. | 02/16/2013 |
| Girdin regulates cell movement in biological contexts that require directional cell movement | Involvement of Girdin in the determination of cell polarity during cell migration.
Ohara K, Enomoto A, Kato T, Hashimoto T, Isotani-Sakakibara M, Asai N, Ishida-Takagishi M, Weng L, Nakayama M, Watanabe T, Kato K, Kaibuchi K, Murakumo Y, Hirooka Y, Goto H, Takahashi M., Free PMC Article | 09/15/2012 |
| Girdin and its Akt-mediated phosphorylation have major roles in the migration and proliferation of vascular smooth muscle cells and vascular remodeling. | The actin-binding protein Girdin and its Akt-mediated phosphorylation regulate neointima formation after vascular injury.
Miyake H, Maeda K, Asai N, Shibata R, Ichimiya H, Isotani-Sakakibara M, Yamamura Y, Kato K, Enomoto A, Takahashi M, Murohara T. | 07/23/2011 |
| A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. | A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration.
Garcia-Marcos M, Ghosh P, Ear J, Farquhar MG., Free PMC Article | 05/31/2010 |
| Girdin as an intrinsic factor in postnatal development of the dentate gyrus and provide insights into the critical role of the DISC1/girdin interaction in postnatal neurogenesis in the dentate gyrus. | Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.
Enomoto A, Asai N, Namba T, Wang Y, Kato T, Tanaka M, Tatsumi H, Taya S, Tsuboi D, Kuroda K, Kaneko N, Sawamoto K, Miyamoto R, Jijiwa M, Murakumo Y, Sokabe M, Seki T, Kaibuchi K, Takahashi M. | 01/21/2010 |
| Girdin has an important role in tumor progression with aberrant activation of the Akt signaling pathway | An actin-binding protein Girdin regulates the motility of breast cancer cells.
Jiang P, Enomoto A, Jijiwa M, Kato T, Hasegawa T, Ishida M, Sato T, Asai N, Murakumo Y, Takahashi M. | 01/21/2010 |
| the Akt/Girdin signalling pathway is essential in VEGF-mediated postneonatal angiogenesis | Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin.
Kitamura T, Asai N, Enomoto A, Maeda K, Kato T, Ishida M, Jiang P, Watanabe T, Usukura J, Kondo T, Costantini F, Murohara T, Takahashi M. | 01/21/2010 |
| HkRP1 (A430106J12Rik) is involved in the process of tubulation of sorting nexin-1 positive membranes from early endosome subdomains. | A novel hook-related protein family and the characterization of hook-related protein 1.
Simpson F, Martin S, Evans TM, Kerr M, James DE, Parton RG, Teasdale RD, Wicking C. | 01/21/2010 |