| LncRNA NEAT1 induces autophagy through the miR-128-3p/ADAM28 axis to suppress apoptosis of nonsmall-cell lung cancer. | LncRNA NEAT1 induces autophagy through the miR-128-3p/ADAM28 axis to suppress apoptosis of nonsmall-cell lung cancer.
Xie Y, Zheng ZW, He HT, Chang ZB. | 10/15/2022 |
| ADAM28 from both endothelium and gastric cancer cleaves von Willebrand Factor to eliminate von Willebrand Factor-induced apoptosis of gastric cancer cells. | ADAM28 from both endothelium and gastric cancer cleaves von Willebrand Factor to eliminate von Willebrand Factor-induced apoptosis of gastric cancer cells.
Yin Q, Gu J, Qi Y, Lu Y, Yang L, Liu J, Liang X. | 05/22/2021 |
| ADAM28: Another ambivalent protease in cancer. | ADAM28: Another ambivalent protease in cancer.
Hubeau C, Rocks N, Cataldo D. | 03/28/2021 |
| [Construction of ADAM28 shRNA interference vector and its inhibitory effect on human periodontal ligament stem cells]. | [Construction of ADAM28 shRNA interference vector and its inhibitory effect on human periodontal ligament stem cells].
Zhao Z, Qiu HY, Fu L, Li J. | 02/13/2021 |
| Study demonstrates that ADAM28 is overexpressed in pancreatic cancer, and closely involved in the regulation of gemcitabine resistance. Overexpression of ADAM28 is a novel prognostic biomarker in pancreatic cancer. | Oncogenic ADAM28 induces gemcitabine resistance and predicts a poor prognosis in pancreatic cancer.
Wei L, Wen JY, Chen J, Ma XK, Wu DH, Chen ZH, Huang JL., Free PMC Article | 02/29/2020 |
| ADAM28 regulates the growth and dissemination of acute myeloid leukemia through IGFBP-3 degradation and IGF-I-induced cell proliferation. | ADAM28 promotes tumor growth and dissemination of acute myeloid leukemia through IGFBP-3 degradation and IGF-I-induced cell proliferation.
Zhang JM, Wang CC, Zhang GC, Jiang Q, Yang SM, Fu HX, Wang QM, Zhu XL, Zhu HH, Jiang H, Wang Y, Lv M, Lu J, Chen H, Han W, Chang YJ, Kong Y, Xu LP, Liu KY, Huang XJ, Zhang XH. | 11/9/2019 |
| Within placental villi, ADAM28 mRNA levels were highest in HLA-G(+) column trophoblasts, and consistent with this, ADAM28 was preferentially localized to HLA-G(+) trophoblasts within distal anchoring columns and decidual tissue. | ADAM28 localizes to HLA-G(+) trophoblasts and promotes column cell outgrowth.
De Luca LC, Le HT, Mara DL, Beristain AG. | 04/14/2018 |
| There is a relationship between the serum level of ADAM28 and the degree of the colonic cancer clinical stage. | Serum levels of ADAM10, ADAM12, ADAM17 AND ADAM28 in colorectal cancer patients.
Walkiewicz K, Nowakowska-Zajdel E, Strzelczyk J, Dzięgielewska-Gęsiak S, Muc-Wierzgoń M. | 02/24/2018 |
| miR-552 is an oncomir able to promote CRC metastasis in part through a mechanism of targeting ADAM28. | MicroRNA-552 enhances metastatic capacity of colorectal cancer cells by targeting a disintegrin and metalloprotease 28.
Wang J, Li H, Wang Y, Wang L, Yan X, Zhang D, Ma X, Du Y, Liu X, Yang Y., Free PMC Article | 02/24/2018 |
| The data demonstrate that ADAM28 is expressed by epithelial cells of several normal organs, and suggest that ADAM28 plays a role in cell survival by suppression of C1q-induced cytotoxicity in bronchial epithelial cells. | ADAM28 is expressed by epithelial cells in human normal tissues and protects from C1q-induced cell death.
Miyamae Y, Mochizuki S, Shimoda M, Ohara K, Abe H, Yamashita S, Kazuno S, Ohtsuka T, Ochiai H, Kitagawa Y, Okada Y. | 06/24/2017 |
| ADAM28 is overexpressed in primary human prostate tumor biopsies, and it promotes human prostate cancer cell proliferation and migration. | Overexpression and knock-down studies highlight that a disintegrin and metalloproteinase 28 controls proliferation and migration in human prostate cancer.
Rudnicka C, Mochizuki S, Okada Y, McLaughlin C, Leedman PJ, Stuart L, Epis M, Hoyne G, Boulos S, Johnson L, Schlaich M, Matthews V., Free PMC Article | 02/18/2017 |
| The results of this study suggest that these proteins play important roles in pulmonary inflammatory reactions elicited against etiological viral agents. | The roles of ADAM33, ADAM28, IL-13 and IL-4 in the development of lung injuries in children with lethal non-pandemic acute infectious pneumonia.
Baurakiades E, Costa VH Jr, Raboni SM, de Almeida VR, Larsen KS, Kohler JN, Gozzo Pdo C, Klassen G, Manica GC, de Noronha L. | 07/25/2015 |
| Src is an inducer of ADAM28 gene expression through the MEK/extracellular signal-regulated kinase and PI3K/mammalian target of rapamycin pathways. | Src plays a key role in ADAM28 expression in v-src-transformed epithelial cells and human carcinoma cells.
Abe H, Mochizuki S, Ohara K, Ueno M, Ochiai H, Kitagawa Y, Hino O, Sato H, Okada Y. | 06/14/2014 |
| Sequence analysis of ADAM28 genes did not reveal any putative mutations for hyperostosis cranialis interna to chromosome 8p21 | Localization of the gene for hyperostosis cranialis interna to chromosome 8p21 with analysis of three candidate genes.
Borra VM, Waterval JJ, Stokroos RJ, Manni JJ, Van Hul W. | 03/15/2014 |
| The change of ADAM28 and IGFBP-3 gene expression is present in the normal tissue in overweight/obese patients with colorectal cancer only, and the observed variability of ADAM28 and IGFBP-3 expression may be an initial process of cancer proliferation | Expression of ADAM28 and IGFBP-3 genes in patients with colorectal cancer - a preliminary report.
Nowakowska-Zajdel E, Mazurek U, Wierzgon J, Kokot T, Fatyga E, Ziolko E, Klakla K, Blazelonis A, Waniczek D, Glogowski L, Kozowicz A, Niedworok E, Muc-Wierzgon M. | 09/14/2013 |
| High ADAM28 expression is associated with B-Cell Chronic Lymphocytic Leukemia. | Ectodomain shedding of CD200 from the B-CLL cell surface is regulated by ADAM28 expression.
Twito T, Chen Z, Khatri I, Wong K, Spaner D, Gorczynski R. | 08/3/2013 |
| Human ADAM28 expression levels were positively correlated with parameters of the metabolic syndrome. | ADAM28 is elevated in humans with the metabolic syndrome and is a novel sheddase of human tumour necrosis factor-α.
Jowett JB, Okada Y, Leedman PJ, Curran JE, Johnson MP, Moses EK, Goring HH, Mochizuki S, Blangero J, Stone L, Allen H, Mitchell C, Matthews VB., Free PMC Article | 05/25/2013 |
| ADAM28 cleaves and inactivates proapoptotic VWF in carcinoma cells and enhances lung metastasis probably by promoting carcinoma cell survival within the blood vessels. | Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor.
Mochizuki S, Soejima K, Shimoda M, Abe H, Sasaki A, Okano HJ, Okano H, Okada Y. | 08/25/2012 |
| Study shows using proteomics that ADAM28 may be used as a possible biomarker of bladder cancer. | Urinary protein profiling by liquid chromatography/tandem mass spectrometry: ADAM28 is overexpressed in bladder transitional cell carcinoma.
Tyan YC, Yang MH, Chen SC, Jong SB, Chen WC, Yang YH, Chung TW, Liao PC. | 12/17/2011 |
| ADAM28 showed significant differences compared with normal individuals, so it may be a biomarker of bladder cancer. | Characterization of ADAM28 as a biomarker of bladder transitional cell carcinomas by urinary proteome analysis.
Yang MH, Chu PY, Chen SC, Chung TW, Chen WC, Tan LB, Kan WC, Wang HY, Su SB, Tyan YC. | 10/15/2011 |
| ADAM28 might actively participate in manipulating the proliferation, differentiation, and apoptosis of human dental pulp stem cells (HDPSCs). | ADAM28 manipulates proliferation, differentiation, and apoptosis of human dental pulp stem cells.
Zhao Z, Liu H, Wang D. | 07/2/2011 |
| It plays a role in cancer cell proliferation, invasion and metastasis. (review) | [ADAM28: involvement in cancer cell proliferation, invasion and metastasis].
Mochizuki S, Okada Y. | 01/29/2011 |
| These data provide the first evidence that CTGF is a novel substrate of ADAM28 and suggest that ADAM28 may promote VEGF(165)-induced angiogenesis in the breast carcinomas by the CTGF digestion in the CTGF/VEGF(165) complex. | Connective tissue growth factor is a substrate of ADAM28.
Mochizuki S, Tanaka R, Shimoda M, Onuma J, Fujii Y, Jinno H, Okada Y. | 01/15/2011 |
| High ADAM28 in serum is associated with non-small-cell lung cancers. | ADAM28 is a serological and histochemical marker for non-small-cell lung cancers.
Kuroda H, Mochizuki S, Shimoda M, Chijiiwa M, Kamiya K, Izumi Y, Watanabe M, Horinouchi H, Kawamura M, Kobayashi K, Okada Y. | 09/27/2010 |
| Upregulation of ADAM28 is associated with asbestos-related lung adenocarcinomas. | ADAM28: a potential oncogene involved in asbestos-related lung adenocarcinomas.
Wright CM, Larsen JE, Hayward NK, Martins MU, Tan ME, Davidson MR, Savarimuthu SM, McLachlan RE, Passmore LH, Windsor MN, Clarke BE, Duhig EE, Yang IA, Bowman RV, Fong KM. | 09/20/2010 |