| Variable phenotype of a null PPP1R13L allele in children with dilated cardiomyopathy. | Variable phenotype of a null PPP1R13L allele in children with dilated cardiomyopathy.
Tulbah S, Alruwaili N, Alhashem A, Aljohany A, Alhadeq F, Brotons DCA, Alwadai A, Al-Hassnan ZN. | 12/28/2023 |
| Common variants of pro-inflammatory gene IL1B and interactions with PPP1R13L and POLR1G in relation to lung cancer among Northeast Chinese. | Common variants of pro-inflammatory gene IL1B and interactions with PPP1R13L and POLR1G in relation to lung cancer among Northeast Chinese.
Yin J, Wang C, Vogel U, Ma Y, Zhang Y, Wang H, Sun Z, Du S., Free PMC Article | 05/8/2023 |
| Chitosan-Gelatin-EGCG Nanoparticle-Meditated LncRNA TMEM44-AS1 Silencing to Activate the P53 Signaling Pathway for the Synergistic Reversal of 5-FU Resistance in Gastric Cancer. | Chitosan-Gelatin-EGCG Nanoparticle-Meditated LncRNA TMEM44-AS1 Silencing to Activate the P53 Signaling Pathway for the Synergistic Reversal of 5-FU Resistance in Gastric Cancer.
Zhou M, Dong J, Huang J, Ye W, Zheng Z, Huang K, Pan Y, Cen J, Liang Y, Shu G, Ye S, Lu X, Zhang J., Free PMC Article | 08/20/2022 |
| TP53 common variants and interaction with PPP1R13L and CD3EAP SNPs and lung cancer risk and smoking behavior in a Chinese population. | TP53 common variants and interaction with PPP1R13L and CD3EAP SNPs and lung cancer risk and smoking behavior in a Chinese population.
Yin J, Hou W, Vogel U, Li X, Ma Y, Wang C, Wang H, Sun Z., Free PMC Article | 05/28/2022 |
| iASPP is essential for HIF-1alpha stabilization to promote angiogenesis and glycolysis via attenuating VHL-mediated protein degradation. | iASPP is essential for HIF-1α stabilization to promote angiogenesis and glycolysis via attenuating VHL-mediated protein degradation.
Zhao D, Zheng S, Wang X, Liu H, Zhao K, Li L, Hu Y. | 05/14/2022 |
| iASPP suppresses Gp78-mediated TMCO1 degradation to maintain Ca(2+) homeostasis and control tumor growth and drug resistance. | iASPP suppresses Gp78-mediated TMCO1 degradation to maintain Ca(2+) homeostasis and control tumor growth and drug resistance.
Zheng S, Zhao D, Hou G, Zhao S, Zhang W, Wang X, Li L, Lin L, Tang TS, Hu Y., Free PMC Article | 02/26/2022 |
| iASPP contributes to cell cortex rigidity, mitotic cell rounding, and spindle positioning. | iASPP contributes to cell cortex rigidity, mitotic cell rounding, and spindle positioning.
Mangon A, Salaün D, Bouali ML, Kuzmić M, Quitard S, Thuault S, Isnardon D, Audebert S, Puech PH, Verdier-Pinard P, Badache A., Free PMC Article | 12/25/2021 |
| Biallelic variants in PPP1R13L cause paediatric dilated cardiomyopathy. | Biallelic variants in PPP1R13L cause paediatric dilated cardiomyopathy.
Robinson HK, Zaklyazminskaya E, Povolotskaya I, Surikova Y, Mallin L, Armstrong C, Mabin D, Benke PJ, Chrisant MR, McDonald M, Marboe CC, Agre KE, Deyle DR, McWalter K, Douglas G, Balashova MS, Kaimonov V, Shirokova N, Pomerantseva E, Turner CL, Ellard S. | 07/3/2021 |
| A previously identified apoptosis inhibitor iASPP confers resistance to chemotherapeutic drugs by suppressing senescence in cancer cells. | A previously identified apoptosis inhibitor iASPP confers resistance to chemotherapeutic drugs by suppressing senescence in cancer cells.
Li H, Zhang W, Zhao K, Zhao D, Zheng S, Hu Y., Free PMC Article | 12/12/2020 |
| Study revealed increased iASPP and DeltaNp63 expression in cutaneous squamous cell carcinoma (cSCC) clinical samples, but also highlighted a significant alteration of iASPP cellular localization, with consequent deregulation of its function. Data suggest that while direct effects of iASPP and p63 upon each other's expression are maintained in cSCC, epigenetic dysregulation of the feedback loop occurs at the microRNA le... | Epigenetic Regulation of iASPP-p63 Feedback Loop in Cutaneous Squamous Cell Carcinoma.
Robinson DJ, Patel A, Purdie KJ, Wang J, Rizvi H, Hufbauer M, Ostano P, Akgül B, Chiorino G, Harwood CA, Bergamaschi D. | 06/6/2020 |
| iASPP inhibits p53 through a distinct surface overlapping the E6 footprint, opening prospects for p53-targeting precision medicine to improve cancer therapy. | iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.
Chen S, Wu J, Zhong S, Li Y, Zhang P, Ma J, Ren J, Tan Y, Wang Y, Au KF, Siebold C, Bond GL, Chen Z, Lu M, Jones EY, Lu X., Free PMC Article | 04/4/2020 |
| iASPP regulates growth and the cellular responses towards oxidative stress in choriocarcinoma cells. Its overexpression is advantageous to the pathogenesis of gestational trophoblastic disease. | Overexpression of iASPP is required for autophagy in response to oxidative stress in choriocarcinoma.
Chan KK, Wong ES, Wong IT, Cheung CL, Wong OG, Ngan HY, Cheung AN., Free PMC Article | 02/29/2020 |
| These results suggest iASPP may play an important role in progression and aggressive behavior of head and neck squamous cell carcinoma (HNSCC) and may be an efficient chemotherapeutic target for the treatment of HNSCC. | Downregulation of iASPP Expression Suppresses Proliferation, Invasion and Increases Chemosensitivity to Paclitaxel of Head and Neck Squamous Cell Carcinoma In Vitro.
Liu ZZ, Kuang WL, Zeng WJ, Xiao JY, Tian YQ. | 02/22/2020 |
| GEM and PPP1R13L were predicted as novel genes which may act as potential target or biomarkers of obesity as they occur with other 21 target genes with known obesity relationship. | Identification of key regulatory genes connected to NF-κB family of proteins in visceral adipose tissues using gene expression and weighted protein interaction network.
Sabir JSM, El Omri A, Shaik NA, Banaganapalli B, Al-Shaeri MA, Alkenani NA, Hajrah NH, Awan ZA, Zrelli H, Elango R, Khan M., Free PMC Article | 12/21/2019 |
| iASPP associates with centrosomal protein of 55 kDa (CEP55), an important cytokinetic abscission regulator. Mechanically, iASPP acts as a PP1-targeting subunit to facilitate the interaction between PP1 and CEP55 and to remove PLK1-mediated Ser436 phosphorylation in CEP55 during late mitosis. | iASPP-PP1 complex is required for cytokinetic abscission by controlling CEP55 dephosphorylation.
Gao K, Zhang Y, Shi Q, Zhang J, Zhang L, Sun H, Jiao D, Zhao X, Tao H, Wei Y, Wang Y, Saiyin H, Zhao SM, Li Y, Zhang P, Wang C., Free PMC Article | 11/9/2019 |
| Acute myeloid leukemia patients with high expressions of FHL2 and iASPP had shorter event-free survival (EFS) and overall survival (OS) than patients with low expressions. | Enhanced expressions of FHL2 and iASPP predict poor prognosis in acute myeloid leukemia.
Cheng Z, Dai Y, Pang Y, Jiao Y, Zhao H, Zhang Z, Qin T, Hu N, Zhang Y, Ke X, Chen Y, Wu D, Shi J, Fu L. | 09/14/2019 |
| High iASPP expression is associated with chemoresistant ovarian clear cell carcinoma. | Impact of iASPP on chemoresistance through PLK1 and autophagy in ovarian clear cell carcinoma.
Chan KK, Wong OG, Wong ES, Chan KK, Ip PP, Tse KY, Cheung AN. | 02/9/2019 |
| Haplotypes consisting of PPP1R13L rs1970764 and ATM rs11212592 may be associated with lung cancer. Haplotypes consisting of PPP1R13L, CD3EAP and GLTSCR1 SNPs on Chr19q13.3 may associate with lung cancer risk in the Chinese population. | GLTSCR1, ATM, PPP1R13L and CD3EAP Genetic Variants and Lung Cancer Risk in a Chinese Population.
Yin JY, Ma YG, Vogel U, Liu DH, Sun ZX. | 11/3/2018 |
| The expression of CD3EAP exon 1 was demonstrated to be significantly associated with PPP1R13L exon 1, while CD3EAP exon 3 was significantly associated with ERCC1 exon 11 in normal and non-small cell lung cancer (NSCLC) tissues. It was observed that short transcripts of ERCC1, CD3EAP and PPP1R13L are co-expressed in A549 NSCLC cell line. | Different splicing isoforms of ERCC1 affect the expression of its overlapping genes CD3EAP and PPP1R13L, and indicate a potential application in non-small cell lung cancer treatment.
Zhang G, Xue P, Cui S, Yu T, Xiao M, Zhang Q, Cai Y, Jin C, Yang J, Wu S, Lu X. | 10/13/2018 |
| Increased expression of miR-150 suppressed viability, proliferation, migration and invasion of SW480 cells. Furthermore, iASPP was a direct target of miR-150 and played a key role in its anti-colorectal cancer (CRC)function. miR-150 may be a promising predictor of prognosis in CRC patients. | MicroRNA-150 inhibits the proliferation and metastasis potential of colorectal cancer cells by targeting iASPP.
Li C, Du X, Xia S, Chen L., Free PMC Article | 09/29/2018 |
| IASPP knockdown suppressed cell viability and DNA synthesis capacity; the effect of miR-340 inhibition was partially attenuated by iASPP inhibition. | MiR-340/iASPP axis affects UVB-mediated retinal pigment epithelium (RPE) cell damage.
Yan J, Qin Y, Yu J, Peng Q, Chen X. | 08/25/2018 |
| The expression of iASPP was higher in highgrade astrocytic gliomas compared with lowgrade astrocytic gliomas. | iASPP, a microRNA‑124 target, is aberrantly expressed in astrocytoma and regulates malignant glioma cell migration and viability.
Liu X, Kang J, Sun S, Luo Y, Ji X, Zeng X, Zhao S. | 08/4/2018 |
| Data showed that iASPP could promote tumor growth by increasing autophagic flux, and iASPP could serve as a poor prognostic factor and a potential therapeutic target in lung cancer. | iASPP facilitates tumor growth by promoting mTOR-dependent autophagy in human non-small-cell lung cancer.
Xue Y, Han H, Wu L, Pan B, Dong B, Yin CC, Tian Z, Liu X, Yang Y, Zhang H, Chen Y, Chen J., Free PMC Article | 07/7/2018 |
| Sertad1 could antagonize iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells when iASPP was in the stage of overproduction. | Sertad1 antagonizes iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells.
Qiu S, Liu S, Yu T, Yu J, Wang M, Rao Q, Xing H, Tang K, Mi Y, Wang J., Free PMC Article | 07/7/2018 |
| The interactive modulation among miR-124 and iASPP in p53-mutant or -deleted cells may serve as a crucial pathway, which mediates therapy resistance when p53 is mutated or deleted, in the process of photodynamic therapy treatment of Colorectal cancer. | Wild-type and mutant p53 differentially modulate miR-124/iASPP feedback following pohotodynamic therapy in human colon cancer cell line.
Liu K, Chen W, Lei S, Xiong L, Zhao H, Liang D, Lei Z, Zhou N, Yao H, Liang Y., Free PMC Article | 06/9/2018 |