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    CGB3 chorionic gonadotropin subunit beta 3 [ Homo sapiens (human) ]

    Gene ID: 1082, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    A prospective cohort study on association of first-trimester serum biomarkers and risk of isolated foetal congenital heart defects.

    A prospective cohort study on association of first-trimester serum biomarkers and risk of isolated foetal congenital heart defects.
    Hematian MN, Hessami K, Torabi S, Saleh M, Nouri B, Saleh M.

    03/12/2022
    In this study, we observed that abnormal levels of serum hCG titers and the local presentation of lesions with varying intervals after antecedent term pregnancy were the most common presenting features of extrauterine ETT [Epithelioid trophoblastic tumor].

    Clinical characteristics and outcomes of extrauterine epithelioid trophoblastic tumors.
    Zhang T, Zeng X, Xu H, Gao L, Xiong L, An R, Xue Y.

    04/25/2020
    risk for giving birth to a child with cerebral palsy was higher in women who did not have high hCG concentrations in the 1st trimester and low hCG concentrations in the 2nd trimester

    Maternal concentrations of human chorionic gonadotropin (hCG) and risk for cerebral palsy (CP) in the child. A case control study.
    Eskild A, Monkerud L, Jukic AM, Åsvold BO, Lie KK., Free PMC Article

    12/22/2018
    The presence of hCGbeta positive tumor cells appears to potentially reflect the aggressive behavior of mucoepidermoid carcinoma and adenoid cystic carcinoma

    Immunohistochemical study of the expression of human chorionic gonadotropin-β in salivary gland tumors.
    Meda S, Reginald BA, Reddy BS.

    11/3/2018
    Chorionic Gonadotropin, beta Subunit promoted the migration and invasion of CRC in vitro and in vivo but had no effect on the proliferation of tumor cells.

    B Subunit of Human Chorionic Gonadotropin Promotes Tumor Invasion and Predicts Poor Prognosis of Early-Stage Colorectal Cancer.
    Li J, Yin M, Song W, Cui F, Wang W, Wang S, Zhu H.

    03/17/2018
    the results of this study provide novel evidence supporting a role of hCG in regulating the differentiation of peripheral FOXP3(+) Tregs, which affect the pregnancy outcomes of patients with a history of recurrent implantation failure

    Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells.
    Diao LH, Li GG, Zhu YC, Tu WW, Huang CY, Lian RC, Chen X, Li YY, Zhang T, Huang Y, Zeng Y.

    12/30/2017
    Serum hCG-beta levels of POD 12 and 14 and the fold increase of hCG-beta levels from POD 12 to 14 significantly predict pregnancy outcomes after fresh and frozen cycles.

    Serum hCG-β levels of postovulatory day 12 and 14 with the sequential application of hCG-β fold change significantly increased predictability of pregnancy outcome after IVF-ET cycle.
    Sung N, Kwak-Kim J, Koo HS, Yang KM., Free PMC Article

    03/11/2017
    Data indicate the diagnostic criteria of chorionic gonadotropin beta subunit (beta-hCG) and alpha-Fetoprotein (alphaFP) in CSF and serum, which may advance the early and formal diagnosis of intracranial germ cell tumors (ICGCTs).

    An update on the clinical diagnostic value of β-hCG and αFP for intracranial germ cell tumors.
    Hu M, Guan H, Lau CC, Terashima K, Jin Z, Cui L, Wang Y, Li G, Yao Y, Guo Y, Li YM, Zhong D, Xiao J, Wan X, Lian X, Feng F, Ren H, Zhao Y, Cheng X, Gu F., Free PMC Article

    10/22/2016
    All pregnancies with serious complications had serum beta-human chorionic gonadotropin levels of 1.0-5.0 mIU/ml.

    Occult abnormal pregnancies after first post-embryo transfer serum beta-human chorionic gonadotropin levels of 1.0-5.0 mIU/mL.
    Maslow BS, Bartolucci A, Sueldo C, Engmann L, Benadiva C, Nulsen JC 3rd.

    08/20/2016
    hCGB serum concentrations differed significantly between Asian and European women during the first trimester of pregnancy.

    Effect of ethnicity on first trimester biomarkers for combined trisomy 21 screening: results from a multicenter study in six Asian countries.
    Manotaya S, Zitzler J, Li X, Wibowo N, Pham TM, Kang MS, Lee CN.

    05/14/2016
    reveals a positive feedback loop between glial cells missing 1 and Human chorionic gonadotropin regulating placental hCGbeta expression and cell differentiation

    A Positive Feedback Loop between Glial Cells Missing 1 and Human Chorionic Gonadotropin (hCG) Regulates Placental hCGβ Expression and Cell Differentiation.
    Cheong ML, Wang LJ, Chuang PY, Chang CW, Lee YS, Lo HF, Tsai MS, Chen H., Free PMC Article

    04/30/2016
    For Down syndrome affected pregnancies, the median MoM of first trimester PAPP-A, PlGF, and AFP were significantly reduced, and free-beta-hCG were significantly elevated.

    First trimester screening for Down syndrome using nuchal translucency, maternal serum pregnancy-associated plasma protein A, free-β human chorionic gonadotrophin, placental growth factor, and α-fetoprotein.
    Huang T, Dennis A, Meschino WS, Rashid S, Mak-Tam E, Cuckle H.

    04/9/2016
    Maternal serum hCGB was not associated with fetal open spina bifida.

    First trimester maternal serum alpha-fetoprotein is not raised in pregnancies with open spina bifida.
    Spencer K, Khalil A, Brown L, Mills I, Horne H.

    03/19/2016
    First trimester hCGbeta was not associated with placenta accreta.

    Elevated first trimester PAPP--a is associated with increased risk of placenta accreta.
    Desai N, Krantz D, Roman A, Fleischer A, Boulis S, Rochelson B.

    03/19/2016
    Data suggest that low serum levels of hCGB/ADAM12 are biomarkers in diagnosis of continued incomplete spontaneous abortion; here, hCGB/ADAM12 indicate success/failure of single dose of misoprostol/oxytocic in treatment of early pregnancy failure.

    Serum biomarkers may help predict successful misoprostol management of early pregnancy failure.
    Schreiber CA, Ratcliffe SJ, Quinley KE, Miller C, Sammel MD., Free PMC Article

    03/19/2016
    The results indicate that gal-3 might be regulated by Human chorionic gonadotropin (hCG)in preparing the endometrium for embryonic implantation.

    Human chorionic gonadotropin (hCG) regulation of galectin-3 expression in endometrial epithelial cells and endometrial stromal cells.
    Yang H, Lei CX, Zhang W.

    03/2/2016
    Depending on its source of production, glycoforms of hCG display different biological activities and functions that are essential for pregnancy outcome.[review]

    Review: hCGs: different sources of production, different glycoforms and functions.
    Fournier T, Guibourdenche J, Evain-Brion D.

    01/2/2016
    CGB was higher in pregnant women with chronic renal insufficiency compared to controls and women with renal disease and normal renal function.

    First-trimester combined screening for trisomy 21 in women with renal disease.
    Valentin M, Muller F, Beaujard MP, Dreux S, Czerkiewicz I, Meyer V, Leruez M, Ville Y, Salomon LJ.

    12/5/2015
    Data suggest that initial serum beta-HCG levels in women after transfer of vitrified--warmed cleavage-stage embryos are lower than those after transfer of slow cooled--thawed cleavage-stage embryos.

    Implantation of fresh and thawed-warmed embryos in single embryo transfer cycles: interpreting the initial beta-HCG.
    Sites CK, St Marie P, Rahil T.

    12/5/2015
    Median free betahCG MoM in the control group was 1.04, and 1.08 (P = 0.859) in the placenta praevia group compared with 0.81 in the abnormally invasive placentation group (P = 0.06).

    First trimester maternal serum biochemical markers of aneuploidy in pregnancies with abnormally invasive placentation.
    Thompson O, Otigbah C, Nnochiri A, Sumithran E, Spencer K.

    11/21/2015
    Case Report: Krukenberg tumor presenting as back pain and a positive urine pregnancy test due to elevated urinary CGB.

    Krukenberg tumor presenting as back pain and a positive urine pregnancy test: a case report and literature review.
    Moghazy D, Al-Hendy O, Al-Hendy A., Free PMC Article

    10/31/2015
    Hyperglycosylated human chorionic gonadotropin is associated with gestational trophoblastic diseases

    Proportion hyperglycosylated hCG: a new test for discriminating gestational trophoblastic diseases.
    Cole LA.

    07/25/2015
    Time-to-pregnancy >/=24 months in spontaneously conceived pregnancies is associated with decreased levels of PAPP-A and free beta-hCG.

    Longer time-to-pregnancy in spontaneously conceived pregnancies is associated with lower PAPP-A and free β-hCG in first trimester screening for Down syndrome.
    Kirkegaard I, Uldbjerg N, Tabor A, Henriksen TB.

    05/16/2015
    The concentration of cell-free beta-HCG mRNA in maternal plasma may be applicable to the prenatal diagnosis of placenta accreta.

    Maternal plasma levels of cell-free β-HCG mRNA as a prenatal diagnostic indicator of placenta accrete.
    Zhou J, Li J, Yan P, Ye YH, Peng W, Wang S, Wang XT.

    05/16/2015
    placenta-mediated adverse pregnancy outcome (PMAPO) before term but not PMAPO at term associated with elevated serum level in second trimester

    Mid-trimester maternal serum AFP and hCG as markers of preterm and term adverse pregnancy outcomes.
    Tancrède S, Bujold E, Giguère Y, Renald MH, Girouard J, Forest JC.

    05/2/2015
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