| MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex. | MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex.
Djajawi TM, Liu L, Gong JN, Huang AS, Luo MJ, Xu Z, Okamoto T, Call MJ, Huang DCS, van Delft MF., Free PMC Article | 09/25/2021 |
| MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment. | MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment.
Haschka MD, Karbon G, Soratroi C, O'Neill KL, Luo X, Villunger A., Free PMC Article | 09/25/2021 |
| The Novel Histone Deacetylase Inhibitor, OBP-801, Induces Apoptosis in Rhabdoid Tumors by Releasing the Silencing of NOXA. | The Novel Histone Deacetylase Inhibitor, OBP-801, Induces Apoptosis in Rhabdoid Tumors by Releasing the Silencing of NOXA.
Sugimoto Y, Katsumi Y, Iehara T, Kaneda D, Tomoyasu C, Ouchi K, Yoshida H, Miyachi M, Yagyu S, Kikuchi K, Tsuchiya K, Kuwahara Y, Sakai T, Hosoi H. | 08/7/2021 |
| mitochondrial targeting domain peptide induces necrotic cell death by interaction with the VDAC2 protein. | Noxa mitochondrial targeting domain induces necrosis via VDAC2 and mitochondrial catastrophe.
Han JH, Park J, Myung SH, Lee SH, Kim HY, Kim KS, Seo YW, Kim TH., Free PMC Article | 07/11/2020 |
| These results identify NOXA mRNA destabilization/MCL-1 adaptation as a non-genomic mechanism that limits apoptotic responses. | Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies.
Montero J, Gstalder C, Kim DJ, Sadowicz D, Miles W, Manos M, Cidado JR, Paul Secrist J, Tron AE, Flaherty K, Stephen Hodi F, Yoon CH, Letai A, Fisher DE, Haq R., Free PMC Article | 03/7/2020 |
| both caspase-8-dependent and -independent apoptotic mechanisms are activated in triple-negative breast cancer cells undergoing sustained endoplasmic reticulum stress. | Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells.
Cano-González A, Mauro-Lizcano M, Iglesias-Serret D, Gil J, López-Rivas A., Free PMC Article | 08/3/2019 |
| Data from pull-down assay between the Noxo1 and Noxa1 showed that the SH3 domains (Noxa1) is responsible for interaction with Noxo1 C-terminal tail harboring proline rich region. | C-terminal tail of NADPH oxidase organizer 1 (Noxo1) mediates interaction with NADPH oxidase activator (Noxa1) in the NOX1 complex.
Shrestha P, Yun JH, Ko YJ, Kim M, Bae YS, Lee W. | 08/12/2017 |
| A NOXA1 peptide blocked NOXA1-Nox1 binding. The finding identifies a NOXA1-activating domain and an isoform-specific Nox1 inhibitor. | Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration.
Ranayhossaini DJ, Rodriguez AI, Sahoo S, Chen BB, Mallampalli RK, Kelley EE, Csanyi G, Gladwin MT, Romero G, Pagano PJ., Free PMC Article | 03/8/2014 |
| Phosphorylation of Thr341 allows Noxo1 to sufficiently interact with Noxa1, an interaction that participates in Nox1 activation | Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1.
Yamamoto A, Takeya R, Matsumoto M, Nakayama KI, Sumimoto H. | 11/23/2013 |
| Noxa1 has quite different kinetic properties from p67(phox) and suggest that Noxa1 may function as a moderate activator of Nox2. | Noxa1 as a moderate activator of Nox2-based NADPH oxidase.
Kawano M, Miyamoto K, Kaito Y, Sumimoto H, Tamura M. | 04/21/2012 |
| Tks4 and Tks5 directly bind to NoxA1. The integrity of the N-terminal PRR of NoxA1 is essential for this direct interaction with the Tks proteins. | Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation.
Gianni D, DerMardirossian C, Bokoch GM., Free PMC Article | 07/23/2011 |
| The Nox1-dependent generation of reactive oxygen species is dependent on Src phosphorylation of NoxA1 and Tks4. Blockage of phosphorylation of NoxA1 and Tks4 decreases Nox1-dependent ROS generation and blocks SrcYF-induced invadopodia formation. | c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells.
Gianni D, Taulet N, DerMardirossian C, Bokoch GM., Free PMC Article | 06/25/2011 |
| The first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 and NOXA1 and membrane-bound p22(phox), is presented. | Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1.
Dutta S, Rittinger K., Free PMC Article | 09/13/2010 |
| these results demonstrate that phosphorylation of NoxA1 is a part of the feedback mechanism that functions through activation of Rac with a net outcome of negative modulation of Nox1 activity. | Phosphorylation of serine282 in NADPH oxidase activator 1 by Erk desensitizes EGF-induced ROS generation.
Oh H, Jung HY, Kim J, Bae YS. | 05/10/2010 |
| NoxA1 is the functional homolog of p67phox in vascular smooth muscle cells (VSMC) that regulates redox signaling and VSMC phenotype. | Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries.
Niu XL, Madamanchi NR, Vendrov AE, Tchivilev I, Rojas M, Madamanchi C, Brandes RP, Krause KH, Humphries J, Smith A, Burnand KG, Runge MS., Free PMC Article | 03/15/2010 |
| a novel, inhibitory function for Noxa1 in Duox1 regulation. | Inhibitory action of NoxA1 on dual oxidase activity in airway cells.
Pacquelet S, Lehmann M, Luxen S, Regazzoni K, Frausto M, Noack D, Knaus UG., Free PMC Article | 01/21/2010 |
| Essential role of NOXA1 in generation of reacgtive oxygen species induced by oxidized low density lipoprotein in endothelial cells is reported. | Essential role of NOXA1 in generation of reactive oxygen species induced by oxidized low-density lipoprotein in human vascular endothelial cells.
Honjo T, Otsui K, Shiraki R, Kawashima S, Sawamura T, Yokoyama M, Inoue N. | 01/21/2010 |
| PKA-phosphorylated NoxA1 is a new binding partner of 14-3-3 protein; this forms the basis of a novel mechanism regulating the formation of ROS by Nox1 and, potentially, other NoxA1-regulated Nox family members | Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding.
Kim JS, Diebold BA, Babior BM, Knaus UG, Bokoch GM. | 01/21/2010 |
| These studies demonstrate that, in reconstituted NOX1/NOXO1/NOXA1 systems, the NOXA1 SH3 domain is not required for function but, when present, can critically modulate the activity of the enzyme system. | NOX1 NADPH oxidase regulation by the NOXA1 SH3 domain.
Valente AJ, El Jamali A, Epperson TK, Gamez MJ, Pearson DW, Clark RA. | 01/21/2010 |