| CaMKIIdelta, Stabilized by RNA N6-Methyladenosine Reader IGF2BP2, Boosts Coxsackievirus B3-Induced Myocardial Inflammation via Interacting with TIRAP. | CaMKIIδ, Stabilized by RNA N6-Methyladenosine Reader IGF2BP2, Boosts Coxsackievirus B3-Induced Myocardial Inflammation via Interacting with TIRAP.
Xiao Q, Liu L, Qian W, Kang T, Ying R, Nie J. | 07/24/2024 |
| [PI3K/Akt/Erk signaling pathway mediates neuroprotection of CaMKgamma and CaMKdelta against ischemic reperfusion injury in mice]. | [PI3K/Akt/Erk signaling pathway mediates neuroprotection of CaMKⅡγ and CaMKⅡδ against ischemic reperfusion injury in mice].
Liu H, Lin Z, Ye J., Free PMC Article | 04/24/2024 |
| Using CRISPR-Cas9/phosphoproteomics to identify substrates of calcium/calmodulin-dependent kinase 2delta. | Using CRISPR-Cas9/phosphoproteomics to identify substrates of calcium/calmodulin-dependent kinase 2δ.
Park E, Yang CR, Raghuram V, Chen L, Chou CL, Knepper MA., Free PMC Article | 01/11/2024 |
| Researches of calcium-activated chloride channel ANO1 intervening amyotrophic lateral sclerosis progression by activating EGFR and CaMKII signaling. | Researches of calcium-activated chloride channel ANO1 intervening amyotrophic lateral sclerosis progression by activating EGFR and CaMKII signaling.
Wang Y, Liang W, Wang T, Zhang C, Yang Y, Cong C, Wang X, Wang S, Wang D, Huo D, Wang H, Su X, Tan X, Feng H. | 11/30/2023 |
| Oxidative stress-induced autonomous activation of the calcium/calmodulin-dependent kinase II involves disulfide formation in the regulatory domain. | Oxidative stress-induced autonomous activation of the calcium/calmodulin-dependent kinase II involves disulfide formation in the regulatory domain.
Rocco-Machado N, Lai L, Kim G, He Y, Luczak ED, Anderson ME, Levine RL., Free PMC Article | 01/28/2023 |
| Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance. | Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance.
Dai W, Choubey M, Patel S, Singer HA, Ozcan L., Free PMC Article | 03/26/2022 |
| Hyperglycemia regulates cardiac K(+) channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways. | Hyperglycemia regulates cardiac K(+) channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways.
Hegyi B, Borst JM, Bailey LRJ, Shen EY, Lucena AJ, Navedo MF, Bossuyt J, Bers DM., Free PMC Article | 10/23/2021 |
| CaMKII exacerbates heart failure progression by activating class I HDACs. | CaMKII exacerbates heart failure progression by activating class I HDACs.
Zhang M, Yang X, Zimmerman RJ, Wang Q, Ross MA, Granger JM, Luczak ED, Bedja D, Jiang H, Feng N., Free PMC Article | 10/9/2021 |
| CaMKII(delta) regulates osteoclastogenesis through ERK, JNK, and p38 MAPKs and CREB signalling pathway. | CaMKII(δ) regulates osteoclastogenesis through ERK, JNK, and p38 MAPKs and CREB signalling pathway.
Lu DZ, Dong W, Feng XJ, Chen H, Liu JJ, Wang H, Zang LY, Qi MC. | 05/29/2021 |
| CaM Kinase II-delta Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy. | CaM Kinase II-δ Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy.
Chen J, Fleming T, Katz S, Dewenter M, Hofmann K, Saadatmand A, Kronlage M, Werner MP, Pokrandt B, Schreiter F, Lin J, Katz D, Morgenstern J, Elwakiel A, Sinn P, Gröne HJ, Hammes HP, Nawroth PP, Isermann B, Sticht C, Brügger B, Katus HA, Hagenmueller M, Backs J. | 05/15/2021 |
| Phosphorylation of T107 by CamKIIdelta Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1. | Phosphorylation of T107 by CamKIIδ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1.
Morgenstern J, Katz S, Krebs-Haupenthal J, Chen J, Saadatmand A, Cortizo FG, Moraru A, Zemva J, Campos MC, Teleman A, Backs J, Nawroth P, Fleming T. | 05/8/2021 |
| Sphingosine kinase 1 regulates HMGB1 translocation by directly interacting with calcium/calmodulin protein kinase II-delta in sepsis-associated liver injury. | Sphingosine kinase 1 regulates HMGB1 translocation by directly interacting with calcium/calmodulin protein kinase II-δ in sepsis-associated liver injury.
Tian T, Yao D, Zheng L, Zhou Z, Duan Y, Liu B, Wang P, Li Y., Free PMC Article | 04/13/2021 |
| CaMKIIdelta Met281/282 oxidation is not required for recovery of calcium transients during acidosis. | CaMKIIδ Met281/282 oxidation is not required for recovery of calcium transients during acidosis.
Kreitmeier KG, Tarnowski D, Nanadikar MS, Baier MJ, Wagner S, Katschinski DM, Maier LS, Sag CM. | 03/28/2021 |
| Myocardial death and dysfunction after ischemia-reperfusion injury require CaMKIIdelta oxidation. | Myocardial death and dysfunction after ischemia-reperfusion injury require CaMKIIδ oxidation.
Wu Y, Wang Q, Feng N, Granger JM, Anderson ME., Free PMC Article | 10/31/2020 |
| Stabilizing cardiac ryanodine receptor prevents the development of cardiac dysfunction and lethal arrhythmia in Ca(2+)/calmodulin-dependent protein kinase IIdeltac transgenic mice. | Stabilizing cardiac ryanodine receptor prevents the development of cardiac dysfunction and lethal arrhythmia in Ca(2+)/calmodulin-dependent protein kinase IIδc transgenic mice.
Sufu-Shimizu Y, Okuda S, Kato T, Nishimura S, Uchinoumi H, Oda T, Kobayashi S, Yamamoto T, Yano M. | 10/24/2020 |
| Activation of CaMKIIdelta in response to pressure overload triggers inflammatory gene expression and activation of the NOD-like receptor pyrin domain-containing protein 3 inflammasome in cardiomyocytes. These responses provide signals for macrophage recruitment, fibrosis, and myocardial dysfunction in the heart. | Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca(2+)/Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling.
Suetomi T, Willeford A, Brand CS, Cho Y, Ross RS, Miyamoto S, Brown JH., Free PMC Article | 09/28/2019 |
| JNK2 activation up-regulates CaMKIIdelta expression in the aged atrium and may promote the occurrence of cardiac arrhythmias. | Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIIδ expression in the aged atrium.
Gao X, Wu X, Yan J, Zhang J, Zhao W, DeMarco D, Zhang Y, Bakhos M, Mignery G, Sun J, Li Z, Fill M, Ai X., Free PMC Article | 08/3/2019 |
| In summary, CaMKIIdelta and CaMKIIgamma are novel ischemia/reperfusion-induced genes that promote neuronal survival during ischemic injury. The upregulation of these CaMKII kinases led to activation of the NF-kappaB signaling pathway, which protects neurons from ischemic damage. | Ischemic Injury-Induced CaMKIIδ and CaMKIIγ Confer Neuroprotection Through the NF-κB Signaling Pathway.
Ye J, Das S, Roy A, Wei W, Huang H, Lorenz-Guertin JM, Xu Q, Jacob TC, Wang B, Sun D, Wang QJ., Free PMC Article | 07/20/2019 |
| surgical-induced Osteoarthritis mice treated with a miR-146a inhibitor significantly alleviated the destruction of articular cartilage via targeting Camk2d and Ppp3r2. | miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2.
Zhang X, Wang C, Zhao J, Xu J, Geng Y, Dai L, Huang Y, Fu SC, Dai K, Zhang X., Free PMC Article | 11/25/2017 |
| we demonstrate that the deltaC isoform of CaMKII contributes significantly to myocardial damage following ex vivo I/R. Signaling occurs through NF-kappaB and TNF-alpha and acute inhibition of the generation or function of thesemolecules has a very robust protective effect inWT animals and in those expressing CaMKIIdeltaC. | CaMKIIδ subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-κB and TNF-α.
Gray CB, Suetomi T, Xiang S, Mishra S, Blackwood EA, Glembotski CC, Miyamoto S, Westenbrink BD, Brown JH., Free PMC Article | 06/3/2017 |
| Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIdelta Lowers the Single Molecule and Cardiac Muscle Force | Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle Force.
Perkin J, Slater R, Del Favero G, Lanzicher T, Hidalgo C, Anderson B, Smith JE 3rd, Sbaizero O, Labeit S, Granzier H., Free PMC Article | 09/24/2016 |
| CaMK2d-dependent phosphorylation of RyR2-S2814 is significant in cardiomyopathy, independent of hypertrophy, induced by prolonged beta-adrenergic receptor stimulation. | CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic β-adrenergic stimulation.
Grimm M, Ling H, Willeford A, Pereira L, Gray CB, Erickson JR, Sarma S, Respress JL, Wehrens XH, Bers DM, Brown JH., Free PMC Article | 05/21/2016 |
| Data indicate that combined cardiomyocyte-specific deletion of CaM Kinase II CaMKIIdelta/gamma does not affect ischemia/reperfusion (I/R) injury. | CaM Kinase II mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injury.
Weinreuter M, Kreusser MM, Beckendorf J, Schreiter FC, Leuschner F, Lehmann LH, Hofmann KP, Rostosky JS, Diemert N, Xu C, Volz HC, Jungmann A, Nickel A, Sticht C, Gretz N, Maack C, Schneider MD, Gröne HJ, Müller OJ, Katus HA, Backs J., Free PMC Article | 06/27/2015 |
| CaMKIIdelta activation and phosphorylation of downstream targets was enhanced in aromatase knockout hearts subjected to ischemia-reperfusion | Myocardial and cardiomyocyte stress resilience is enhanced in aromatase-deficient female mouse hearts through CaMKIIδ activation.
Bell JR, Bernasochi GB, Wollermann AC, Raaijmakers AJ, Boon WC, Simpson ER, Curl CL, Mellor KM, Delbridge LM. | 06/20/2015 |
| Oxidative stress was elevated in mitochondria from Gq versus wild-type mice and respiratory rates were lower; these changes in mitochondrial function were restored by CaMKIIdelta deletion. | Mitochondrial reprogramming induced by CaMKIIδ mediates hypertrophy decompensation.
Westenbrink BD, Ling H, Divakaruni AS, Gray CB, Zambon AC, Dalton ND, Peterson KL, Gu Y, Matkovich SJ, Murphy AN, Miyamoto S, Dorn GW 2nd, Heller Brown J., Free PMC Article | 04/25/2015 |