| Serine Hydroxymethyltransferase 2 Deficiency in the Hematopoietic System Disrupts Erythropoiesis and Induces Anemia in Murine Models. | Serine Hydroxymethyltransferase 2 Deficiency in the Hematopoietic System Disrupts Erythropoiesis and Induces Anemia in Murine Models.
Li J, Zhang B, Li Y, Liu C, Tang X, Zhao J, Pei X, Li Y., Free PMC Article | 11/5/2024 |
| Mitochondrial outer membrane protein Samm50 protects against hypoxia-induced cardiac injury by interacting with Shmt2. | Mitochondrial outer membrane protein Samm50 protects against hypoxia-induced cardiac injury by interacting with Shmt2.
Zhou Y, Kang L, Xu R, Zhao D, Wang J, Wu J, Lin H, Ding Z, Zou Y. | 06/21/2024 |
| SHMT2 Mediates Small-Molecule-Induced Alleviation of Alzheimer Pathology Via the 5'UTR-dependent ADAM10 Translation Initiation. | SHMT2 Mediates Small-Molecule-Induced Alleviation of Alzheimer Pathology Via the 5'UTR-dependent ADAM10 Translation Initiation.
Song L, Pan QL, Zhou GF, Liu SW, Zhu BL, Lin PJ, Hu XT, Zha JS, Long Y, Luo B, Chen J, Tang Y, Tang J, Xiang XJ, Xie XY, Deng XJ, Chen GJ., Free PMC Article | 03/21/2024 |
| SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice. | SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice.
Chen G, Zhou G, Zhai L, Bao X, Tiwari N, Li J, Mottillo E, Wang J., Free PMC Article | 02/17/2024 |
| Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD. | Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD.
Ghrayeb A, Finney AC, Agranovich B, Peled D, Anand SK, McKinney MP, Sarji M, Yang D, Weissman N, Drucker S, Fernandes SI, Fernández-García J, Mahan K, Abassi Z, Tan L, Lorenzi PL, Traylor J, Zhang J, Abramovich I, Chen YE, Rom O, Mor I, Gottlieb E., | 01/10/2024 |
| The role of SHMT2 in modulating lipid metabolism in hepatocytes via glycine-mediated mTOR activation. | The role of SHMT2 in modulating lipid metabolism in hepatocytes via glycine-mediated mTOR activation.
Choi YJ, Lee G, Yun SH, Lee W, Yu J, Kim SK, Lee BH. | 06/25/2022 |
| Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders. | Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders.
Tani H, Mito T, Velagapudi V, Ishikawa K, Umehara M, Nakada K, Suomalainen A, Hayashi JI., Free PMC Article | 10/31/2020 |
| Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2. | Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2.
Escande-Beillard N, Loh A, Saleem SN, Kanata K, Hashimoto Y, Altunoglu U, Metoska A, Grandjean J, Ng FM, Pomp O, Baburajendran N, Wong J, Hill J, Beillard E, Cozzone P, Zaki M, Kayserili H, Hamada H, Shiratori H, Reversade B. | 10/10/2020 |
| SHMT2 can contribute to liver regeneration after partial hepatectomy, and this is likely related to the activation of Akt/mTOR signaling pathway by its metabolic product, glycine, in hepatocytes. | SHMT2 Promotes Liver Regeneration Through Glycine-activated Akt/mTOR Pathway.
Wang M, Yuan F, Bai H, Zhang J, Wu H, Zheng K, Zhang W, Miao M, Gong J. | 06/6/2020 |
| Knockdown of SHMT2 worsens IR injury through the ROS/JNK/P53 signaling pathway. | Downregulating Serine Hydroxymethyltransferase 2 Deteriorates Hepatic Ischemia-Reperfusion Injury through ROS/JNK/P53 Signaling in Mice.
Wu H, Bai H, Duan S, Yuan F., Free PMC Article | 04/25/2020 |
| SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis | SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis.
Anderson DD, Stover PJ., Free PMC Article | 01/21/2010 |