| Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation. | Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation.
Shipman GA, Padilla R, Horth C, Hu B, Bareke E, Vitorino FN, Gongora JM, Garcia BA, Lu C, Majewski J., Free PMC Article | 10/18/2024 |
| Multilevel Regulation of NF-kappaB Signaling by NSD2 Suppresses Kras-Driven Pancreatic Tumorigenesis. | Multilevel Regulation of NF-κB Signaling by NSD2 Suppresses Kras-Driven Pancreatic Tumorigenesis.
Feng W, Niu N, Lu P, Chen Z, Rao H, Zhang W, Ma C, Liu C, Xu Y, Gao WQ, Xue J, Li L., Free PMC Article | 09/24/2024 |
| ISWI chromatin remodeling complexes recruit NSD2 and H3K36me2 in pericentromeric heterochromatin. | ISWI chromatin remodeling complexes recruit NSD2 and H3K36me2 in pericentromeric heterochromatin.
Goto N, Suke K, Yonezawa N, Nishihara H, Handa T, Sato Y, Kujirai T, Kurumizaka H, Yamagata K, Kimura H., Free PMC Article | 05/9/2024 |
| Wolf-Hirschhorn syndrome candidate 1 (Whsc1) methyltransferase signals via a Pitx2-miR-23/24 axis to effect tooth development. | Wolf-Hirschhorn syndrome candidate 1 (Whsc1) methyltransferase signals via a Pitx2-miR-23/24 axis to effect tooth development.
Su D, Eliason S, Sun Z, Shao F, Amendt BA., Free PMC Article | 11/30/2023 |
| Extracellular vesicle-derived CircWhsc1 promotes cardiomyocyte proliferation and heart repair by activating TRIM59/STAT3/Cyclin B2 pathway. | Extracellular vesicle-derived CircWhsc1 promotes cardiomyocyte proliferation and heart repair by activating TRIM59/STAT3/Cyclin B2 pathway.
Wei G, Li C, Jia X, Xie J, Tang Z, Jin M, Chen Q, Sun Y, He S, Li X, Chen Y, Zheng H, Liao W, Liao Y, Bin J, Huang S., Free PMC Article | 11/7/2023 |
| NSD2 promotes pressure overload-induced cardiac hypertrophy via activating circCmiss1/TfR1/ferroptosis signaling. | NSD2 promotes pressure overload-induced cardiac hypertrophy via activating circCmiss1/TfR1/ferroptosis signaling.
Xu QR, Liu JL, Zhu RR, Huang WX, Huang H, Liu JC, Xu XP, Zhou XL. | 07/25/2023 |
| Histone methyltransferase Nsd2 ensures maternal-fetal immune tolerance by promoting regulatory T-cell recruitment. | Histone methyltransferase Nsd2 ensures maternal-fetal immune tolerance by promoting regulatory T-cell recruitment.
Zhang L, Long X, Yin Y, Wang J, Zhu H, Chen J, Wang Y, Chen Y, Wang X., Free PMC Article | 05/7/2022 |
| METTL3 enhances NSD2 mRNA stability to reduce renal impairment and interstitial fibrosis in mice with diabetic nephropathy. | METTL3 enhances NSD2 mRNA stability to reduce renal impairment and interstitial fibrosis in mice with diabetic nephropathy.
Tang W, Zhao Y, Zhang H, Peng Y, Rui Z., Free PMC Article | 04/9/2022 |
| Wolf-Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation. | Wolf-Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation.
Liu C, Cai B, Li D, Yao Y., Free PMC Article | 03/12/2022 |
| PP2Cdelta Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway. | PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway.
Lv N, Jin S, Liang Z, Wu X, Kang Y, Su L, Dong Y, Wang B, Ma T, Shi L., Free PMC Article | 03/5/2022 |
| Inhibition of WHSC1 Allows for Reprogramming of the Immune Compartment in Prostate Cancer. | Inhibition of WHSC1 Allows for Reprogramming of the Immune Compartment in Prostate Cancer.
Want MY, Karasik E, Gillard B, McGray AJR, Battaglia S., Free PMC Article | 10/9/2021 |
| The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice. | The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice.
Dobenecker MW, Marcello J, Becker A, Rudensky E, Bhanu NV, Carrol T, Garcia BA, Prinjha R, Yurchenko V, Tarakhovsky A., Free PMC Article | 05/15/2021 |
| H3K36 dimethylation by MMSET promotes classical non-homologous end-joining at unprotected telomeres. | H3K36 dimethylation by MMSET promotes classical non-homologous end-joining at unprotected telomeres.
de Krijger I, van der Torre J, Peuscher MH, Eder M, Jacobs JJL., Free PMC Article | 12/12/2020 |
| Nsd2 as a critical epigenetic regulator for Tfh differentiation. | Histone methyltransferase Nsd2 is required for follicular helper T cell differentiation.
Long X, Zhang L, Zhang Y, Min M, Lin B, Chen J, Ma X, Zhai S, Cai Z, Liu Y, Lu Y, Che N, Tan W, Qin J, Wang X., Free PMC Article | 07/18/2020 |
| NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2. | NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2.
Zhou XL, Zhu RR, Wu X, Xu H, Li YY, Xu QR, Liu S, Huang H, Xu X, Wan L, Wu QC, Liu JC., Free PMC Article | 04/18/2020 |
| NSD2 circular RNA promotes metastasis of colorectal cancer by targeting miR-199b-5p-mediated DDR1 and JAG1 signalling. | NSD2 circular RNA promotes metastasis of colorectal cancer by targeting miR-199b-5p-mediated DDR1 and JAG1 signalling.
Chen LY, Zhi Z, Wang L, Zhao YY, Deng M, Liu YH, Qin Y, Tian MM, Liu Y, Shen T, Sun LN, Li JM. | 04/11/2020 |
| Nsd2 coordinates germinal center B cell positive selection by enhancing both BCR signaling and T cell help. | Methyltransferase Nsd2 Ensures Germinal Center Selection by Promoting Adhesive Interactions between B Cells and Follicular Dendritic Cells.
Chen J, Li N, Yin Y, Zheng N, Min M, Lin B, Zhang L, Long X, Zhang Y, Cai Z, Zhai S, Qin J, Wang X. | 12/7/2019 |
| that Whsc1 links silencing of the pluripotency regulatory network with activation of mesendoderm lineages | Whsc1 links pluripotency exit with mesendoderm specification.
Tian TV, Di Stefano B, Stik G, Vila-Casadesús M, Sardina JL, Vidal E, Dasti A, Segura-Morales C, De Andrés-Aguayo L, Gómez A, Goldmann J, Jaenisch R, Graf T., Free PMC Article | 11/30/2019 |
| SPT6 recruitment is abrogated in cells lacking the histone methyltransferase NSD2. SPT6 interacts with NSD2. | SPT6 interacts with NSD2 and facilitates interferon-induced transcription.
Ouda R, Sarai N, Nehru V, Patel MC, Debrosse M, Bachu M, Chereji RV, Eriksson PR, Clark DJ, Ozato K. | 04/6/2019 |
| NSD2 is a driver of metastatic prostate cancer progression. | NSD2 is a conserved driver of metastatic prostate cancer progression.
Aytes A, Giacobbe A, Mitrofanova A, Ruggero K, Cyrta J, Arriaga J, Palomero L, Farran-Matas S, Rubin MA, Shen MM, Califano A, Abate-Shen C., Free PMC Article | 02/9/2019 |
| Results suggest a critical role of histone-lysine N-methyltransferase Nsd2-mediated histone H3K36 methylation in adipose tissue development and function. | Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function.
Zhuang L, Jang Y, Park YK, Lee JE, Jain S, Froimchuk E, Broun A, Liu C, Gavrilova O, Ge K., Free PMC Article | 12/22/2018 |
| MMSET promotes AICDA-mediated DNA breaks at the donor switch region during immunoglobulin class switch recombination. | Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination.
Nguyen HV, Dong J, Panchakshari RA, Kumar V, Alt FW, Bories JC., Free PMC Article | 06/30/2018 |
| Whsc1 plays an important role at several points of hematopoietic development. | Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development.
Campos-Sanchez E, Deleyto-Seldas N, Dominguez V, Carrillo-de-Santa-Pau E, Ura K, Rocha PP, Kim J, Aljoufi A, Esteve-Codina A, Dabad M, Gut M, Heyn H, Kaneda Y, Nimura K, Skok JA, Martinez-Frias ML, Cobaleda C., Free PMC Article | 03/3/2018 |
| findings highlight a pivotal link between an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1, to drive prostate cancer metastasis. | AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis.
Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, Jiang M, Kan S, Sun T, Ren J, Pan Q, Li X, Zhang P, Hu G, Wang Y, Wang X, Li Q, Qin J., Free PMC Article | 09/9/2017 |
| WHSC1-deficient mice display craniofacial defects that overlap with Wolf-Hirschhorn syndrome, including cochlea anomalies | Auditory hair cell defects as potential cause for sensorineural deafness in Wolf-Hirschhorn syndrome.
Ahmed M, Ura K, Streit A., Free PMC Article | 07/30/2016 |