| ATF5-Mediated Mitochondrial Unfolded Protein Response (UPR[mt]) Protects Neurons Against Oxygen-Glucose Deprivation and Cerebral Ischemia. | ATF5-Mediated Mitochondrial Unfolded Protein Response (UPR(mt)) Protects Neurons Against Oxygen-Glucose Deprivation and Cerebral Ischemia.
An H, Zhou B, Hayakawa K, Durán Laforet V, Park JH, Nakamura Y, Mandeville ET, Liu N, Guo S, Yu Z, Shi J, Wu D, Li W, Lo EH, Ji X. | 07/11/2024 |
| Nescient helix-loop-helix 1 (Nhlh1) is a novel activating transcription factor 5 (ATF5) target gene in olfactory and vomeronasal sensory neurons in mice. | Nescient helix-loop-helix 1 (Nhlh1) is a novel activating transcription factor 5 (ATF5) target gene in olfactory and vomeronasal sensory neurons in mice.
Ishii C, Nakano H, Higashiseto R, Ooki Y, Umemura M, Takahashi S, Takahashi Y. | 04/11/2024 |
| The mitochondrial UPR induced by ATF5 attenuates intervertebral disc degeneration via cooperating with mitophagy. | The mitochondrial UPR induced by ATF5 attenuates intervertebral disc degeneration via cooperating with mitophagy.
Xu WN, Zheng HL, Yang RZ, Sun YF, Peng BR, Liu C, Song J, Jiang SD, Zhu LX., Free PMC Article | 03/15/2024 |
| Activating transcription factor 5 (ATF5) controls intestinal tuft and goblet cell expansion upon succinate-induced type 2 immune responses in mice. | Activating transcription factor 5 (ATF5) controls intestinal tuft and goblet cell expansion upon succinate-induced type 2 immune responses in mice.
Nakano H, Hata A, Ishimura U, Kosugi R, Miyamoto E, Nakamura K, Muramatsu T, Ogasawara M, Yamada M, Umemura M, Takahashi S, Takahashi Y. | 08/9/2023 |
| TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m[7]G methylation of ATF5 mRNA. | TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m(7)G methylation of ATF5 mRNA.
Chen XZ, Li XM, Xu SJ, Hu S, Wang T, Li RF, Liu CY, Xue JQ, Zhou LY, Wang YH, Li PF, Wang K., Free PMC Article | 07/3/2023 |
| ATF5 regulates tubulointerstitial injury in diabetic kidney disease via mitochondrial unfolded protein response. | ATF5 regulates tubulointerstitial injury in diabetic kidney disease via mitochondrial unfolded protein response.
Liu Y, Zhang L, Zhang S, Liu J, Li X, Yang K, Yang D, Liu Y, Sun L, Liu F, Xiao L., Free PMC Article | 04/28/2023 |
| ATF5 is a regulator of ER stress and beta-cell apoptosis in different mouse models of genetic- and diet-induced obesity and diabetes mellitus. | ATF5 is a regulator of ER stress and β-cell apoptosis in different mouse models of genetic- and diet-induced obesity and diabetes mellitus.
Ma J, Liu Y, Valladolid-Acebes I, Recio-López P, Peng G, Li J, Berggren PO, Juntti-Berggren L, Tong N. | 01/7/2023 |
| ATF5 is a regulator of exercise-induced mitochondrial quality control in skeletal muscle. | ATF5 is a regulator of exercise-induced mitochondrial quality control in skeletal muscle.
Slavin MB, Kumari R, Hood DA., Free PMC Article | 12/24/2022 |
| ER, Mitochondria, and ISR Regulation by mt-HSP70 and ATF5 upon Procollagen Misfolding in Osteoblasts. | ER, Mitochondria, and ISR Regulation by mt-HSP70 and ATF5 upon Procollagen Misfolding in Osteoblasts.
Gorrell L, Makareeva E, Omari S, Otsuru S, Leikin S., Free PMC Article | 10/22/2022 |
| ATF5 deficiency causes abnormal cortical development. | ATF5 deficiency causes abnormal cortical development.
Umemura M, Kaneko Y, Tanabe R, Takahashi Y., Free PMC Article | 10/23/2021 |
| Requirement of activating transcription factor 5 for murine fetal liver erythropoiesis. | Requirement of activating transcription factor 5 for murine fetal liver erythropoiesis.
Zhang S, Chen JJ., Free PMC Article | 08/1/2020 |
| Study reports that reduced levels of ATF5 in brain of Huntington's disease patients, probably due to its sequestration into the characteristic PolyQ containing neuronal inclusion bodies, correlates with decreased levels of the antiapoptotic protein MCL1, a transcriptional target of ATF5. Also provides evidence of decreased ATF5 being deleterious by rendering neurons more vulnerable to polyQ-induced apoptosis. | The neuroprotective transcription factor ATF5 is decreased and sequestered into polyglutamine inclusions in Huntington's disease.
Hernández IH, Torres-Peraza J, Santos-Galindo M, Ramos-Morón E, Fernández-Fernández MR, Pérez-Álvarez MJ, Miranda-Vizuete A, Lucas JJ. | 06/16/2018 |
| Data indicate activating transcription factor 5 (ATF5) as a member of the transcriptional network governing pancreatic beta-cell survival during stress. | ATF5 regulates β-cell survival during stress.
Juliana CA, Yang J, Rozo AV, Good A, Groff DN, Wang SZ, Green MR, Stoffers DA., Free PMC Article | 04/21/2018 |
| ATF5 is one of the transcription factors crucial for the vomeronasal sensory formation. | Activating transcription factor 5 (ATF5) is essential for the maturation and survival of mouse basal vomeronasal sensory neurons.
Nakano H, Iida Y, Suzuki M, Aoki M, Umemura M, Takahashi S, Takahashi Y. | 11/19/2016 |
| Atf5 is required for mouse olfactory bulb development via interneuron. | Activating transcription factor 5 is required for mouse olfactory bulb development via interneuron.
Umemura M, Tsunematsu K, Shimizu YI, Nakano H, Takahashi S, Higashiura Y, Okabe M, Takahashi Y. | 05/14/2016 |
| Data indicate that downregulation of ATF5 inhibits adipogenesis through C/EBPalpha by impairing the interaction with p300-C/EBPbeta. | p300-dependent acetylation of activating transcription factor 5 enhances C/EBPβ transactivation of C/EBPα during 3T3-L1 differentiation.
Zhao Y, Zhang YD, Zhang YY, Qian SW, Zhang ZC, Li SF, Guo L, Liu Y, Wen B, Lei QY, Tang QQ, Li X., Free PMC Article | 03/22/2014 |
| Both ATF5 and CHOP have proapoptotic functions in mouse embryonic fibroblasts. | CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis.
Teske BF, Fusakio ME, Zhou D, Shan J, McClintick JN, Kilberg MS, Wek RC., Free PMC Article | 03/1/2014 |
| Adult neurons express ATF5; its levels increase upon endoplasmic reticulum stress as a neuroprotective mechanism. | Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus.
Torres-Peraza JF, Engel T, Martín-Ibáñez R, Sanz-Rodríguez A, Fernández-Fernández MR, Esgleas M, Canals JM, Henshall DC, Lucas JJ. | 06/1/2013 |
| ATF5 is required for terminal differentiation and survival of olfactory sensory neurons. | Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons.
Wang SZ, Ou J, Zhu LJ, Green MR., Free PMC Article | 01/26/2013 |
| BBF2H7-ATF5-MCL1 pathway specifically suppressed ER stress-induced apoptosis in chondrocytes. | The endoplasmic reticulum stress transducer BBF2H7 suppresses apoptosis by activating the ATF5-MCL1 pathway in growth plate cartilage.
Izumi S, Saito A, Kanemoto S, Kawasaki N, Asada R, Iwamoto H, Oki M, Miyagi H, Ochi M, Imaizumi K., Free PMC Article | 12/29/2012 |
| These findings indicate a reciprocal interaction between ATF5 and Shh in which Shh stimulates ATF5 expression and in which ATF5 contributes to Shh-stimulated cerebellar granule neuron progenitor cell expansion. | Reciprocal actions of ATF5 and Shh in proliferation of cerebellar granule neuron progenitor cells.
Lee HY, Angelastro JM, Kenney AM, Mason CA, Greene LA., Free PMC Article | 09/29/2012 |
| Data show that transcription factor ATF5 is expressed in the postnatal brain. | Regulated ATF5 loss-of-function in adult mice blocks formation and causes regression/eradication of gliomas.
Arias A, Lamé MW, Santarelli L, Hen R, Greene LA, Angelastro JM., Free PMC Article | 05/12/2012 |
| essential in malignant glioma genesis and ATF5-mediated survival pathway identified | A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications.
Sheng Z, Li L, Zhu LJ, Smith TW, Demers A, Ross AH, Moser RP, Green MR., Free PMC Article | 06/28/2010 |
| At the postnatal stage, Atf5 was expressed in epiphyseal chondrocytes and osteoblasts lining the bone trabeculae. | Spatio-temporal expression of activating transcription factor 5 in the skeletal development of mouse limb.
Satake H, Ito K, Takahara M, Furukawa T, Takagi M, Ogino T, Shinomura T. | 01/21/2010 |
| Fasting resulted in elevation of the expression of both Atf5 mRNA subtypes, Atf5-R1 and R2, in the liver. | Fasting induced up-regulation of activating transcription factor 5 in mouse liver.
Shimizu YI, Morita M, Ohmi A, Aoyagi S, Ebihara H, Tonaki D, Horino Y, Iijima M, Hirose H, Takahashi S, Takahashi Y. | 01/21/2010 |