| Dynamic stem-loop extension by Pol theta; and templated insertion during DNA repair. | Dynamic stem-loop extension by Pol θ and templated insertion during DNA repair.
Carvajal-Maldonado D, Li Y, Returan M, Averill AM, Doublié S, Wood RD., Free PMC Article | 08/28/2024 |
| Exosomal circPOLQ promotes macrophage M2 polarization via activating IL-10/STAT3 axis in a colorectal cancer model. | Exosomal circPOLQ promotes macrophage M2 polarization via activating IL-10/STAT3 axis in a colorectal cancer model.
Sun Z, Xu Y, Shao B, Dang P, Hu S, Sun H, Chen C, Wang C, Liu J, Liu Y, Hu J., Free PMC Article | 05/31/2024 |
| Melanoma-Derived DNA Polymerase Theta Variants Exhibit Altered DNA Polymerase Activity. | Melanoma-Derived DNA Polymerase Theta Variants Exhibit Altered DNA Polymerase Activity.
Thomas C, Avalos-Irving L, Victorino J, Green S, Andrews M, Rodrigues N, Ebirim S, Mudd A, Towle-Weicksel JB., Free PMC Article | 05/29/2024 |
| Human DNA polymerase theta; does not harbor intrinsic nuclease activity. | Human DNA polymerase θ does not harbor intrinsic nuclease activity.
Carvajal-Maldonado D, Zahn K, Jensen R, Wood RD, Doublié S. | 05/1/2024 |
| POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase. | POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase.
Peng Y, Zheng W, Chen Y, Lei X, Yang Z, Yang Y, Liang W, Sun K, Li G, Yu J., Free PMC Article | 04/12/2024 |
| The m[6]A demethylase FTO targets POLQ to promote ccRCC cell proliferation and genome stability maintenance. | The m(6)A demethylase FTO targets POLQ to promote ccRCC cell proliferation and genome stability maintenance.
He Y, Chen Y, Li Z, Wu C., Free PMC Article | 02/27/2024 |
| Poltheta; is phosphorylated by PLK1 to repair double-strand breaks in mitosis. | Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis.
Gelot C, Kovacs MT, Miron S, Mylne E, Haan A, Boeffard-Dosierre L, Ghouil R, Popova T, Dingli F, Loew D, Guirouilh-Barbat J, Del Nery E, Zinn-Justin S, Ceccaldi R., Free PMC Article | 09/18/2023 |
| [Study on enhanced sensitivity to DNA damage in POLQ knocking-down salivary of adenoid cystic carcinoma-83 cells]. | [Study on enhanced sensitivity to DNA damage in POLQ knocking-down salivary of adenoid cystic carcinoma-83 cells].
Bai H, Liu H, Zhu L, Liu C, Xiao J. | 05/12/2023 |
| Whole-exome sequencing of Indian prostate cancer reveals a novel therapeutic target: POLQ. | Whole-exome sequencing of Indian prostate cancer reveals a novel therapeutic target: POLQ.
Ravindran F, Jain A, Desai S, Menon N, Srivastava K, Bawa PS, Sateesh K, Srivatsa N, Raghunath SK, Srinivasan S, Choudhary B. | 04/27/2023 |
| Next-Generation Sequencing-Based Analysis of the Roles of DNA Polymerases nu and theta in the Replicative Bypass of 8-Oxo-7,8-dihydroguanine in Human Cells. | Next-Generation Sequencing-Based Analysis of the Roles of DNA Polymerases ν and θ in the Replicative Bypass of 8-Oxo-7,8-dihydroguanine in Human Cells.
Liu Y, Zhu X, Wang Z, Dai X, You C. | 08/27/2022 |
| DNA polymerase theta promotes CAG*CTG repeat expansions in Huntington's disease via insertion sequences of its catalytic domain. | DNA polymerase θ promotes CAG•CTG repeat expansions in Huntington's disease via insertion sequences of its catalytic domain.
Chan KY, Li X, Ortega J, Gu L, Li GM., Free PMC Article | 11/27/2021 |
| DNA polymerase theta (Poltheta) - an error-prone polymerase necessary for genome stability. | DNA polymerase theta (Polθ) - an error-prone polymerase necessary for genome stability.
Brambati A, Barry RM, Sfeir A., Free PMC Article | 05/15/2021 |
| Translesion Synthesis or Repair by Specialized DNA Polymerases Limits Excessive Genomic Instability upon Replication Stress. | Translesion Synthesis or Repair by Specialized DNA Polymerases Limits Excessive Genomic Instability upon Replication Stress.
Maiorano D, El Etri J, Franchet C, Hoffmann JS., Free PMC Article | 05/15/2021 |
| Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining. | Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining.
Feldman T, Bercovich A, Moskovitz Y, Chapal-Ilani N, Mitchell A, Medeiros JJF, Biezuner T, Kaushansky N, Minden MD, Gupta V, Milyavsky M, Livneh Z, Tanay A, Shlush LI., Free PMC Article | 05/15/2021 |
| The roles of polymerases nu and theta in replicative bypass of O (6)- and N (2)-alkyl-2'-deoxyguanosine lesions in human cells. | The roles of polymerases ν and θ in replicative bypass of O(6)- and N(2)-alkyl-2'-deoxyguanosine lesions in human cells.
Du H, Wang P, Wu J, He X, Wang Y., Free PMC Article | 01/2/2021 |
| Genetic evidence for reconfiguration of DNA polymerase theta active site for error-free translesion synthesis in human cells. | Genetic evidence for reconfiguration of DNA polymerase θ active site for error-free translesion synthesis in human cells.
Yoon JH, Johnson RE, Prakash L, Prakash S., Free PMC Article | 12/26/2020 |
| Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain. | Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain.
Huang F, Tanaka H, Knudsen BS, Rutgers JK., Free PMC Article | 11/21/2020 |
| POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks. | POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks.
Davis L, Khoo KJ, Zhang Y, Maizels N., Free PMC Article | 10/31/2020 |
| RAD52 and POLQ are both synthetic lethal with loss of the BRCA1 and BRCA2 tumor suppressor genes. Furthermore, RAD52 and POLQ have been implicated in chromosomal break repair events that use flanking repeats to restore the chromosome. Combined disruption of RAD52 and POLQ causes at least additive hypersensitivity to cisplatin and a synthetic reduction in replication fork restart velocity. | Distinct roles of RAD52 and POLQ in chromosomal break repair and replication stress response.
Kelso AA, Lopezcolorado FW, Bhargava R, Stark JM., Free PMC Article | 01/11/2020 |
| Poltheta; shows a strong preference for adding deoxyribonucleotides to RNA, but can also add ribonucleotides with relatively high efficiency in particular sequence contexts; this unique activity of Poltheta; will become invaluable for applications requiring 3' terminal modification of RNA and potentially enzymatic synthesis of RNA | One-step enzymatic modification of RNA 3' termini using polymerase θ.
Thomas C, Rusanov T, Hoang T, Augustin T, Kent T, Gaspar I, Pomerantz RT., Free PMC Article | 11/2/2019 |
| Importantly, p53 defects or depletion unexpectedly allow mutagenic RAD52 and POLtheta; pathways to hijack stalled replication forks, which the authors find reflected in p53 defective breast-cancer patient COSMIC mutational signatures. These data uncover p53 as a keystone regulator of replication homeostasis within a DNA restart network. | p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways.
Roy S, Tomaszowski KH, Luzwick JW, Park S, Li J, Murphy M, Schlacher K., Free PMC Article | 08/17/2019 |
| Expanded Substrate Scope of DNA Polymerase theta; and DNA Polymerase beta: Lyase Activity on 5'-Overhangs and Clustered Lesions. | Expanded Substrate Scope of DNA Polymerase θ and DNA Polymerase β: Lyase Activity on 5'-Overhangs and Clustered Lesions.
Laverty DJ, Greenberg MM., Free PMC Article | 07/20/2019 |
| Heightened Poltheta; expression levels were also associated with elevated mtDNA mutation rates in a selected panel of human tumor tissues, suggesting that this protein can influence mutational frequencies in tumors. T | DNA Polymerase θ Increases Mutational Rates in Mitochondrial DNA.
Wisnovsky S, Sack T, Pagliarini DJ, Laposa RR, Kelley SO., Free PMC Article | 04/6/2019 |
| Rev1 polymerase and Poltheta; conduct translesion synthesis opposite 1,N(6)-ethenodeoxyadenosine via alternative error-prone pathways | DNA polymerase θ accomplishes translesion synthesis opposite 1,N(6)-ethenodeoxyadenosine with a remarkably high fidelity in human cells.
Yoon JH, Johnson RE, Prakash L, Prakash S., Free PMC Article | 03/30/2019 |
| Based on previous studies and gene ontology database, we found that POLQ encoding DNA polymerase theta enzyme and FNIP1 encoding tumor suppressor folliculin-interacting protein might have contributed to the Interdigitating dendritic cell sarcoma (IDCS). Our study provides potential causative genetic factors of IDCS and plays a role in advancing the understanding of IDCS pathogenesis | A case of interdigitating dendritic cell sarcoma studied by whole-exome sequencing.
Hong KH, Song S, Shin W, Kang K, Cho CS, Hong YT, Han K, Moon JH. | 02/23/2019 |