| Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to thrombin and accelerates thrombus formation in vivo. | Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to thrombin and accelerates thrombus formation in vivo.
Elgheznawy A, Öftering P, Englert M, Mott K, Kaiser F, Kusch C, Gbureck U, Bösl MR, Schulze H, Nieswandt B, Vögtle T, Hermanns HM., Free PMC Article | 06/29/2023 |
| The ZIP3 Zinc Transporter Is Localized to Mossy Fiber Terminals and Is Required for Kainate-Induced Degeneration of CA3 Neurons. | The ZIP3 Zinc Transporter Is Localized to Mossy Fiber Terminals and Is Required for Kainate-Induced Degeneration of CA3 Neurons.
Bogdanovic M, Asraf H, Gottesman N, Sekler I, Aizenman E, Hershfinkel M., Free PMC Article | 04/9/2022 |
| ZnT3 KO mice showed abnormality in trace fear conditioning is involved in associative fear memory and extinction, but not in innate fear. | Zinc transporter 3 is involved in learned fear and extinction, but not in innate fear.
Martel G, Hevi C, Friebely O, Baybutt T, Shumyatsky GP., Free PMC Article | 02/26/2011 |
| Znt-3-deficient mice lacking synaptic Zn also show less hippocampal cell damage following kainic acid injection. Zip transporters may provide selective therapeutic targets to protect these neurons from early Zn-induced neurodegeneration following injury. | Knockout of Zn transporters Zip-1 and Zip-3 attenuates seizure-induced CA1 neurodegeneration.
Qian J, Xu K, Yoo J, Chen TT, Andrews G, Noebels JL., Free PMC Article | 02/5/2011 |
| Zip3 does not participate in the acquisition of Zn from maternal circulation for secretion into milk but, in contrast, primarily plays a role in the reuptake and cellular retention of Zn in the mammary gland from the previously secreted milk pool. | Zip3 (Slc39a3) functions in zinc reuptake from the alveolar lumen in lactating mammary gland.
Kelleher SL, Lopez V, Lönnerdal B, Dufner-Beattie J, Andrews GK., Free PMC Article | 01/21/2010 |
| Slc39a3 apparently plays a critical role in zinc homeostasis when zinc is replete, but they play important, noncompensatory roles when this metal is deficient | Slc39a1 to 3 (subfamily II) Zip genes in mice have unique cell-specific functions during adaptation to zinc deficiency.
Kambe T, Geiser J, Lahner B, Salt DE, Andrews GK., Free PMC Article | 01/21/2010 |
| ZIP1, ZIP2 and ZIP3 may play cell-specific roles in zinc homeostasis rather than primary roles in the acquisition of dietary zinc | Structure, function, and regulation of a subfamily of mouse zinc transporter genes.
Dufner-Beattie J, Langmade SJ, Wang F, Eide D, Andrews GK. | 01/21/2010 |
| Knockout mice lacking Zip3 were generated and characterized. | Generation and characterization of mice lacking the zinc uptake transporter ZIP3.
Dufner-Beattie J, Huang ZL, Geiser J, Xu W, Andrews GK., Free PMC Article | 01/21/2010 |
| Reduced expression of Zip3 ultimately resulted in cell death, indicating that mammary epithelial cells have a unique requirement for Zip3-mediated Zn(2+) import. | Zip3 plays a major role in zinc uptake into mammary epithelial cells and is regulated by prolactin.
Kelleher SL, Lönnerdal B. | 01/21/2010 |
| The expression of zinc transporter 3 (ZnT3) starts early in development, lasts throughout embryonic life, and is detected in proliferative and differentiating areas of the brain in distinct chelatable vesicular zinc pools. | Developmental expression of ZnT3 in mouse brain: correlation between the vesicular zinc transporter protein and chelatable vesicular zinc (CVZ) cells. Glial and neuronal CVZ cells interact.
Valente T, Auladell C. | 01/21/2010 |
| ZIP1 and ZIP3 zinc uptake transporter activity is controlled by zinc-stimulated endocytosis | Zinc-stimulated endocytosis controls activity of the mouse ZIP1 and ZIP3 zinc uptake transporters.
Wang F, Dufner-Beattie J, Kim BE, Petris MJ, Andrews G, Eide DJ. | 01/21/2010 |
| Mutations in the ZIP1 and ZIP3 zinc transporter genes are silent when dietary intake of zinc is normal, but can dramatically compromise the success of pregnancy when dietary intake of zinc is limiting. | Mouse ZIP1 and ZIP3 genes together are essential for adaptation to dietary zinc deficiency during pregnancy.
Dufner-Beattie J, Huang ZL, Geiser J, Xu W, Andrews GK. | 01/21/2010 |
| ZnT3-immunoreactive ependymal cells possess secretory activity directed towards the central canal. | Immunocytochemical localization of zinc transporter 3 in the ependyma of the mouse spinal cord.
Danscher G, Wang Z, Kim YK, Kim SJ, Sun Y, Jo SM. | 01/21/2010 |
| temporal and spatial patterns of expression of the mouse ZIP1, 3, 4, and 5 genes in the developing intestine and the effects of maternal dietary zinc deficiency on these patterns of expression were examined | Expression and regulation of SLC39A family zinc transporters in the developing mouse intestine.
Huang ZL, Dufner-Beattie J, Andrews GK. | 01/21/2010 |