| Data suggest that transport of bile acid taurocholate is retained when OstB (organic solute transporter beta subunit) is truncated to contain only the transmembrane domain with 15 additional residues on each side and co-expressed with intact OstA; shorter fragments of OstB are inactive. | Global functions of extracellular, transmembrane and cytoplasmic domains of organic solute transporter β-subunit.
Christian WV, Hinkle PM. | 07/15/2017 |
| These findings indicate that loss of OSTalpha protects against age-related weight gain and insulin resistance. | Ostα-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity.
Wheeler SG, Hammond CL, Jornayvaz FR, Samuel VT, Shulman GI, Soroka CJ, Boyer JL, Hinkle PM, Ballatori N., Free PMC Article | 04/26/2014 |
| Ileal FGF15 expression was directly correlated with plasma cholesterol levels and aortic cholesterol content. In contrast, plasma and hepatic cholesterol levels and atherosclerosis development were not reduced in apoE(-/-) mice deficient in Ostalpha. | Inhibition of ileal apical but not basolateral bile acid transport reduces atherosclerosis in apoE⁻/⁻ mice.
Lan T, Haywood J, Dawson PA., Free PMC Article | 11/16/2013 |
| Total ileal FGF15 expression was elevated almost 20-fold in Ostalpha(-/-) mice as a result of increased villus epithelial cell number and ileocyte FGF15 protein expression | Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism.
Lan T, Rao A, Haywood J, Kock ND, Dawson PA., Free PMC Article | 12/8/2012 |
| Inactivation of FXR largely unmasked the bile acid malabsorption phenotype and corrected the bile acid homeostasis defect in Ostalpha null mice. | Molecular mechanisms of altered bile acid homeostasis in organic solute transporter-alpha knockout mice.
Lan T, Haywood J, Rao A, Dawson PA., Free PMC Article | 10/29/2011 |
| Ostalpha-deficient mice efficiently eliminate excess bile acids via the feces. | Ostα depletion protects liver from oral bile acid load.
Soroka CJ, Velazquez H, Mennone A, Ballatori N, Boyer JL., Free PMC Article | 10/22/2011 |
| OSTalpha is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS homeostasis | Neurosteroid transport by the organic solute transporter OSTα-OSTβ.
Fang F, Christian WV, Gorman SG, Cui M, Huang J, Tieu K, Ballatori N., Free PMC Article | 10/23/2010 |
| These findings indicate that loss of Ostalpha provides protection from liver injury in obstructive cholestasis through adaptive responses in both the kidney and liver that enhance clearance of bile acids into urine. | Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis.
Soroka CJ, Mennone A, Hagey LR, Ballatori N, Boyer JL., Free PMC Article | 01/21/2010 |
| These findings provide direct support for the hypothesis that Ostalpha-Ostbeta is a major basolateral transporter of bile acids and conjugated steroids in the intestine, kidney, and liver. | Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver.
Ballatori N, Fang F, Christian WV, Li N, Hammond CL., Free PMC Article | 01/21/2010 |
| These data indicate that Ostalpha-Ostbeta is essential for intestinal bile acid transport in mice. | The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis.
Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA., Free PMC Article | 01/21/2010 |
| Present as heterodimers (with Ost beta) and/or heteromultimers; the interaction between Ostalpha and Ostbeta increases the stability of the proteins and is required for delivery of the heteromeric complex to the plasma membrane. | Heterodimerization, trafficking and membrane topology of the two proteins, Ost alpha and Ost beta, that constitute the organic solute and steroid transporter.
Li N, Cui Z, Fang F, Lee JY, Ballatori N., Free PMC Article | 01/21/2010 |
| These results indicate that expression of Ostalpha and Ostbeta are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor. | Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.
Boyer JL, Trauner M, Mennone A, Soroka CJ, Cai SY, Moustafa T, Zollner G, Lee JY, Ballatori N. | 01/21/2010 |
| the selective localization of OSTalpha and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption. | OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia.
Ballatori N, Christian WV, Lee JY, Dawson PA, Soroka CJ, Boyer JL, Madejczyk MS, Li N. | 01/21/2010 |
| The mouse Ostalpha and Ostbeta promoters are unusual in that they contain functional FXR and LRH elements, which mediate, respectively, positive and negative feedback regulation by bile acids. | Regulation of the mouse organic solute transporter alpha-beta, Ostalpha-Ostbeta, by bile acids.
Frankenberg T, Rao A, Chen F, Haywood J, Shneider BL, Dawson PA. | 01/21/2010 |
| In conclusion, we identified Ost-alpha/Ost-beta as a novel FXR target. Absent Ost-alpha/Ost-beta induction in CA-fed FXR(-/-) animals may contribute to increased liver injury in these animals. | Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids.
Zollner G, Wagner M, Moustafa T, Fickert P, Silbert D, Gumhold J, Fuchsbichler A, Halilbasic E, Denk H, Marschall HU, Trauner M. | 01/21/2010 |
| Co-expression of mouse Ostalpha-Ostbeta, but not the individual subunits, stimulated Na(+)-independent bile acid uptake and the apical-to-basolateral transport of taurocholate | The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter.
Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N., Free PMC Article | 01/21/2010 |
| OSTalpha and OSTbeta mRNA levels were induced in the adrenals and kidneys of wild-type, but not FXR-/-, mice | FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.
Lee H, Zhang Y, Lee FY, Nelson SF, Gonzalez FJ, Edwards PA. | 01/21/2010 |
| LXRalpha transcriptionally regulate mouse organic solute transporter alpha/beta via inverted repeat-1 elements shared with farnesoid X receptor | LXR alpha transactivates mouse organic solute transporter alpha and beta via IR-1 elements shared with FXR.
Okuwaki M, Takada T, Iwayanagi Y, Koh S, Kariya Y, Fujii H, Suzuki H. | 01/21/2010 |