| The Elusive Structure of Centro-Chromatin: Molecular Order or Dynamic Heterogenetity? | The Elusive Structure of Centro-Chromatin: Molecular Order or Dynamic Heterogenetity?
Nagpal H, Fierz B. | 05/8/2021 |
| A genetic memory initiates the epigenetic loop necessary to preserve centromere position. | A genetic memory initiates the epigenetic loop necessary to preserve centromere position.
Hoffmann S, Izquierdo HM, Gamba R, Chardon F, Dumont M, Keizer V, Hervé S, McNulty SM, Sullivan BA, Manel N, Fachinetti D., Free PMC Article | 04/17/2021 |
| CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and mitotic kinetochore localization | CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and mitotic kinetochore localization.
Watanabe R, Hara M, Okumura EI, Hervé S, Fachinetti D, Ariyoshi M, Fukagawa T., Free PMC Article | 06/6/2020 |
| two key conformational changes within the CENP-A nucleosome upon CENP-C binding, are reported. | CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail.
Ali-Ahmad A, Bilokapić S, Schäfer IB, Halić M, Sekulić N., Free PMC Article | 05/16/2020 |
| CENP-N stabilizes CENP-A nucleosomes alone and additively with CENP-C in vitro. However, removal of CENP-C and CENP-N from cells, or mutating CENP-A so that it no longer interacts with CENP-C or CENP-N, had no effect on centromeric CENP-A stability in vivo. Thus, the stability of CENP-A nucleosomes in chromatin does not arise solely from its interactions with CENP-C or CENP-N. | Constitutive centromere-associated network contacts confer differential stability on CENP-A nucleosomes in vitro and in the cell.
Cao S, Zhou K, Zhang Z, Luger K, Straight AF., Free PMC Article | 02/9/2019 |
| Collectively, these studies clarify how CENP-N and CENP-C decode and stabilize the non-canonical CENP-A nucleosome to enforce epigenetic centromere specification and kinetochore assembly. | Decoding the centromeric nucleosome through CENP-N.
Pentakota S, Zhou K, Smith C, Maffini S, Petrovic A, Morgan GP, Weir JR, Vetter IR, Musacchio A, Luger K., Free PMC Article | 08/25/2018 |
| Levels of centromere aberrations increase upon depletion of CENP-A, CENP-C, and CENP-T/W, during replicative senescence, and in cancer cells. | Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T.
Giunta S, Funabiki H., Free PMC Article | 04/14/2018 |
| Upon cross-linking, the entire CENPA/CENPB/CENPC/CENPT complex is nuclease-protected over an alpha-satellite dimer that comprises the fundamental unit of centromeric chromatin. We conclude that CENPA/CENPC and CENPT pathways for kinetochore assembly are physically integrated over young alpha-satellite dimers. | CENPT bridges adjacent CENPA nucleosomes on young human α-satellite dimers.
Thakur J, Henikoff S., Free PMC Article | 01/6/2018 |
| Whereas CENP-C recruits a single MIS12:NDC80 complex, the authors show here that CENP-T binds one MIS12:NDC80 and two NDC80 complexes upon phosphorylation by the mitotic CDK1:Cyclin B complex at three distinct CENP-T sites. | Molecular basis of outer kinetochore assembly on CENP-T.
Huis In 't Veld PJ, Jeganathan S, Petrovic A, Singh P, John J, Krenn V, Weissmann F, Bange T, Musacchio A., Free PMC Article | 10/28/2017 |
| CENP-C specifically binds alpha satellite non-coding RNAs. | Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C.
McNulty SM, Sullivan LL, Sullivan BA., Free PMC Article | 09/23/2017 |
| CENP-C and CENP-I are key factors connecting kinetochore to CENP-A assembly. | CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.
Shono N, Ohzeki J, Otake K, Martins NM, Nagase T, Kimura H, Larionov V, Earnshaw WC, Masumoto H., Free PMC Article | 09/24/2016 |
| A nonhistone centromere protein, CENP-C, binds and reshapes the nucleosome, sliding the DNA gyres back to positions similar to those in canonical nucleosomes containing conventional histone H3. | CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres.
Falk SJ, Lee J, Sekulic N, Sennett MA, Lee TH, Black BE., Free PMC Article | 07/30/2016 |
| HPV18 E7 inhibited the binding of CENP-C to alpha-satellite DNAs. | The human papillomavirus18 E7 protein inhibits CENP-C binding to α-satellite DNA.
Yaginuma Y, Yoshimoto M, Eguchi A, Tokuda A, Takahashi S. | 03/12/2016 |
| We used a synthetic system to dissect how CenH3(CENP-A) contributes to the accumulation of CENP-C and CENP-T, two key components that are necessary for the formation of functional kinetochores | HJURP involvement in de novo CenH3(CENP-A) and CENP-C recruitment.
Tachiwana H, Müller S, Blümer J, Klare K, Musacchio A, Almouzni G. | 01/16/2016 |
| CENP-C recruits the Ndc80 complex through its interactions with KNL1 and the Mis12 complex at kinetochores during chromosome segregation. | Distinct organization and regulation of the outer kinetochore KMN network downstream of CENP-C and CENP-T.
Rago F, Gascoigne KE, Cheeseman IM., Free PMC Article | 01/16/2016 |
| The CENP-A/histone H3.3 nucleosome forms an unexpectedly stable structure and allows the binding of the essential centromeric protein, CENP-C, which is ectopically mislocalized in the chromosomes of CENP-A overexpressing tumor cells. | Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3.
Arimura Y, Shirayama K, Horikoshi N, Fujita R, Taguchi H, Kagawa W, Fukagawa T, Almouzni G, Kurumizaka H., Free PMC Article | 10/24/2015 |
| CENP-C, a CCAN subunit, is crucial for kinetochore assembly because it links centromeres with the microtubule-binding interface of kinetochores. | CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochores.
Klare K, Weir JR, Basilico F, Zimniak T, Massimiliano L, Ludwigs N, Herzog F, Musacchio A., Free PMC Article | 10/10/2015 |
| CENP-B directly binds both CENP-A's amino-terminal tail and CENP-C, a key nucleator of kinetochore assembly | DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function.
Fachinetti D, Han JS, McMahon MA, Ly P, Abdullah A, Wong AJ, Cleveland DW., Free PMC Article | 09/26/2015 |
| CENP-C affects nucleosome shape and dynamics in a manner analogous to allosteric regulation of enzymes. CENP-C depletion leads to rapid removal of CENP-A from centromeres, indicating their collaboration in maintaining centromere identity. | Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere.
Falk SJ, Guo LY, Sekulic N, Smoak EM, Mani T, Logsdon GA, Gupta K, Jansen LE, Van Duyne GD, Vinogradov SA, Lampson MA, Black BE., Free PMC Article | 06/27/2015 |
| CENP-C works as an important factor for centromeric M18BP1 recruitment | CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin.
Dambacher S, Deng W, Hahn M, Sadic D, Fröhlich J, Nuber A, Hoischen C, Diekmann S, Leonhardt H, Schotta G., Free PMC Article | 12/22/2012 |
| Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore. | Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore.
Screpanti E, De Antoni A, Alushin GM, Petrovic A, Melis T, Nogales E, Musacchio A., Free PMC Article | 07/16/2011 |
| DNMT3B interacts with CENP-C to modulate DNA methylation and the histone code at centromere. | DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions.
Gopalakrishnan S, Sullivan BA, Trazzi S, Della Valle G, Robertson KD., Free PMC Article | 01/21/2010 |
| C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation | The C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation.
Trazzi S, Perini G, Bernardoni R, Zoli M, Reese JC, Musacchio A, Della Valle G., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.
Yosifova A, Mushiroda T, Stoianov D, Vazharova R, Dimova I, Karachanak S, Zaharieva I, Milanova V, Madjirova N, Gerdjikov I, Tolev T, Velkova S, Kirov G, Owen MJ, O'Donovan MC, Toncheva D, Nakamura Y. | 04/8/2009 |
| CENP-C and CENP-H co-localize to the CENP-A chromatin domain. | Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres.
Alonso A, Fritz B, Hasson D, Abrusan G, Cheung F, Yoda K, Radlwimmer B, Ladurner AG, Warburton PE., Free PMC Article | 01/21/2010 |