| this study shows that Myc binding protein 2 suppresses M2-like phenotypes in macrophages during zymosan-induced inflammation in mice | Myc binding protein 2 suppresses M2-like phenotypes in macrophages during zymosan-induced inflammation in mice.
Pierre S, Zhang DD, Suo J, Kern K, Tarighi N, Scholich K. | 11/10/2018 |
| nuclear localization of Ran was strongly increased in MYCBP2-deficient DRGs | MYCBP2 Is a Guanosine Exchange Factor for Ran Protein and Determines Its Localization in Neurons of Dorsal Root Ganglia.
Dörr A, Pierre S, Zhang DD, Henke M, Holland S, Scholich K., Free PMC Article | 02/20/2016 |
| Arf-bp1 and Pam are novel regulators of circadian gene expression that target Rev-erb alpha for degradation | E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha.
Yin L, Joshi S, Wu N, Tong X, Lazar MA., Free PMC Article | 01/28/2016 |
| Mycbp2 and Robo2 were found to cooperate within a genetic network that has profound effects on axon guidance | The E3 ubiquitin ligase Mycbp2 genetically interacts with Robo2 to modulate axon guidance in the mouse olfactory system.
James G, Key B, Beverdam A. | 02/7/2015 |
| Phr1 is identified as a key regulator of a core axon degeneration program that balances axon survival and loss in various neuronal cell types. | The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction.
Babetto E, Beirowski B, Russler EV, Milbrandt J, DiAntonio A., Free PMC Article | 12/21/2013 |
| The ubiquitin ligase complex containing Pam-Fbxo45 likely targets additional synaptic and axonal proteins, which may explain the overlapping neurodevelopmental defects observed in Phr1 and Fbxo45 deficiency. | The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains.
Han S, Kim S, Bahl S, Li L, Burande CF, Smith N, James M, Beauchamp RL, Bhide P, DiAntonio A, Ramesh V., Free PMC Article | 11/24/2012 |
| These results show that Phr1 is an essential regulator of retinal ganglion cell projection during both dLGN and SC topographic map development. | Phr1 is required for proper retinocollicular targeting of nasal-dorsal retinal ganglion cells.
Vo BQ, Bloom AJ, Culican SM. | 08/6/2011 |
| p38 MAPK activation can inhibit activity-induced ion channel internalization and MYCBP2 regulates internalization of TRPV1 in peripheral sensory neurons as well as duration of thermal hyperalgesia through p38 MAPK | The ubiquitin ligase MYCBP2 regulates transient receptor potential vanilloid receptor 1 (TRPV1) internalization through inhibition of p38 MAPK signaling.
Holland S, Coste O, Zhang DD, Pierre SC, Geisslinger G, Scholich K., Free PMC Article | 03/26/2011 |
| Structures of both the first and second PHR domains of Mus musculus (mouse) Phr1 (MYC binding protein 2, Mycbp2) have been determined, revealing a novel beta sandwich fold composed of 11 antiparallel beta-strands. | Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1.
Sampathkumar P, Ozyurt SA, Miller SA, Bain KT, Rutter ME, Gheyi T, Abrams B, Wang Y, Atwell S, Luz JG, Thompson DA, Wasserman SR, Emtage JS, Park EC, Rongo C, Jin Y, Klemke RL, Sauder JM, Burley SK., Free PMC Article | 04/19/2010 |
| Results show that a loss-of-function allele of Phr1 resulting in respiratory distress at birth. | An essential gene mutagenesis screen across the highly conserved piebald deletion region of mouse chromosome 14.
Hagarman JA, O'Brien TP. | 01/21/2010 |
| Protein Associated with Myc (PAM) was identified as a binding partner of KCC2. | The RCC1 domain of protein associated with Myc (PAM) interacts with and regulates KCC2.
Garbarini N, Delpire E., Free PMC Article | 01/21/2010 |
| Thus, efficacious pathfinding requires Phr1 activity for coordinating the cytoskeletal organization that distinguishes axons from growth cones. | The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics.
Lewcock JW, Genoud N, Lettieri K, Pfaff SL. | 01/21/2010 |
| Phr1 is required for formation of major CNS axon tracts via a mechanism that is both cell-nonautonomous and independent of DLK. | The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons.
Bloom AJ, Miller BR, Sanes JR, DiAntonio A., Free PMC Article | 01/21/2010 |