| Revealing Prdx4 as a potential diagnostic and therapeutic target for acute pancreatitis based on machine learning analysis. | Revealing Prdx4 as a potential diagnostic and therapeutic target for acute pancreatitis based on machine learning analysis.
Lu Z, Tang Y, Qin R, Han Z, Chen H, Cao L, Zhang P, Yang X, Yu W, Cheng N, Sun Y., Free PMC Article | 05/1/2024 |
| The combination of the low immunohistochemical expression of peroxiredoxin 4 and perilipin 2 predicts longer survival in pancreatic ductal adenocarcinoma with peroxiredoxin 4 possibly playing a main role. | The combination of the low immunohistochemical expression of peroxiredoxin 4 and perilipin 2 predicts longer survival in pancreatic ductal adenocarcinoma with peroxiredoxin 4 possibly playing a main role.
Han J, Itoh T, Shioya A, Sakurai M, Oyama T, Kumagai M, Takamura H, Okuro M, Mukai T, Kitakata H, Inagaki M, Higashi M, Guo X, Yamada S. | 12/20/2023 |
| Peroxiredoxin 4 regulates tumor-cell-like characteristics of fibroblast-like synoviocytes in rheumatoid arthritis through PI3k/Akt signaling pathway. | Peroxiredoxin 4 regulates tumor-cell-like characteristics of fibroblast-like synoviocytes in rheumatoid arthritis through PI3k/Akt signaling pathway.
Aihaiti Y, Tuerhong X, Zheng H, Cai Y, Yang M, Xu P. | 05/7/2022 |
| Association of glutamate cystein ligase (GCL) activity Peroxiredoxin 4 (prxR4) and apelin levels in women with preeclampsia. | Association of glutamate cystein ligase (GCL) activity Peroxiredoxin 4 (prxR4) and apelin levels in women with preeclampsia.
Mazloomi S, Khodadadi I, Alizadeh N, Shafiee G. | 09/25/2021 |
| Overexpression of PRDX4 Modulates Tumor Microenvironment and Promotes Urethane-Induced Lung Tumorigenesis. | Overexpression of PRDX4 Modulates Tumor Microenvironment and Promotes Urethane-Induced Lung Tumorigenesis.
Zheng J, Guo X, Nakamura Y, Zhou X, Yamaguchi R, Zhang J, Ishigaki Y, Uramoto H, Yamada S., Free PMC Article | 09/11/2021 |
| [Differential expression of PRDX4 in alveolar macrophages of patients with silicosis]. | [Differential expression of PRDX4 in alveolar macrophages of patients with silicosis].
Han K, Du SS, Wang H, Qiao JJ, Zhang X, Wang P, Shen FH. | 02/13/2021 |
| Hepatocellular carcinoma (HCC) tumors with low expression of PRDX4 had higher ROS levels, malignancy, and associated with reduced overall survival. In HCC cell lines, its knockdown led to increased intracellular ROS level and suppressed cell proliferation, inducing cell death. These results indicate that PRDX4 has an inhibitory effect in the initiation of HCC, but a dual (inhibitory or promoting) role in the progression. | The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma.
Guo X, Noguchi H, Ishii N, Homma T, Hamada T, Hiraki T, Zhang J, Matsuo K, Yokoyama S, Ishibashi H, Fukushige T, Kanekura T, Fujii J, Uramoto H, Tanimoto A, Yamada S. | 06/27/2020 |
| The PRDX4 expression and EGFR mutation status were significantly associated with the prognosis of patients with stage I lung adenocarcinoma, and EGFR mutations affected the role of PRDX4 in the proliferation of lung adenocarcinoma cells. | The impact of PRDX4 and the EGFR mutation status on cellular proliferation in lung adenocarcinoma.
Mizutani K, Guo X, Shioya A, Zhang J, Zheng J, Kurose N, Ishibashi H, Motono N, Uramoto H, Yamada S., Free PMC Article | 05/2/2020 |
| PRDX4 reduces anoikis and promotes tumorigenesis and metastasis of hepatocellular carcinoma cells through stabilization of the beta-catenin protein and upregulation of ID2. | Peroxiredoxin 4 suppresses anoikis and augments growth and metastasis of hepatocellular carcinoma cells through the β-catenin/ID2 pathway.
Wang W, Shen XB, Huang DB, Jia W, Liu WB, He YF. | 04/11/2020 |
| n this article, the characteristics of peroxiredoxin 4 in physiological functions and the cancer-related research progress of mammalian peroxiredoxin 4 is reviewed. We believe that peroxiredoxin 4 has the potential of serving as a novel target for multiple cancers. | PRDX4 and Its Roles in Various Cancers.
Jia W, Chen P, Cheng Y., Free PMC Article | 01/11/2020 |
| These features indicate that PRDX4 plays an important role in protecting against liver injury following BDL and might be a promising therapeutic modality for cholestatic diseases. | Protective Effects of Peroxiredoxin 4 (PRDX4) on Cholestatic Liver Injury.
Zhang J, Guo X, Hamada T, Yokoyama S, Nakamura Y, Zheng J, Kurose N, Ishigaki Y, Uramoto H, Tanimoto A, Yamada S., Free PMC Article | 12/22/2018 |
| Significant reduction in mRNA and protein levels of PrdxIV was observed in HEK293 cells overexpressing pathologically relevant recombinant mutant GNE protein (D207V and V603L) compared with vector control. Downregulation of PrdxIV keep the ER in a reduced (redox) state that may contribute to misfolding and aggregation of proteins in GNE myopathy. | Mutation in GNE Downregulates Peroxiredoxin IV Altering ER Redox Homeostasis.
Chanana P, Padhy G, Bhargava K, Arya R. | 07/21/2018 |
| levels of peroxiredoxin 4 are higher in patients with prediabetes, but are similar in subjects with and without insulin resistance, which suggests that the main factor for its increased levels is hyperglycaemia and not insulin sensitivity state. | Increased peroxiredoxin 4 levels in patients with prediabetes compared to normal glucose tolerance subjects.
Gateva A, Assyov Y, Velikova T, Kamenov Z. | 10/14/2017 |
| Results show that ERp44 binds the oxidized but not the reduced form of Prx4; the ERp44-Prx4 complex is formed via thiol-disulfide interchange reactions, and its crystal structure reveals a redox-dependent recognition. | Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention.
Yang K, Li DF, Wang X, Liang J, Sitia R, Wang CC, Wang X. | 05/6/2017 |
| Prdx4 expression was closely related to follicular development and has aprominent role in protecting human and mouse granulosa cells from reactive oxygen species damage. | Implication of Differential Peroxiredoxin 4 Expression with Age in Ovaries of Mouse and Human for Ovarian Aging.
Qian Y, Shao L, Yuan C, Jiang CY, Liu J, Gao C, Gao L, Cui YG, Jiang SW, Liu JY, Meng Y. | 12/17/2016 |
| Positive Prx 4 expression is significantly correlated with recurrence and shorter disease-free survival in patients with early-stage lung squamous cell carcinoma. | Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma.
Hwang JA, Song JS, Yu DY, Kim HR, Park HJ, Park YS, Kim WS, Choi CM., Free PMC Article | 06/11/2016 |
| An off-pathway reaction in the Prx4-mediated oxidative protein folding. | A novel reaction of peroxiredoxin 4 towards substrates in oxidative protein folding.
Zhu L, Yang K, Wang X, Wang X, Wang CC., Free PMC Article | 12/19/2015 |
| Findings suggest that elevated serum Prx4 levels are associated with a higher risk of incident type 2 diabetes | Circulating peroxiredoxin 4 and type 2 diabetes risk: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study.
Abbasi A, Corpeleijn E, Gansevoort RT, Gans RO, Struck J, Schulte J, Hillege HL, van der Harst P, Stolk RP, Navis G, Bakker SJ., Free PMC Article | 04/4/2015 |
| Prx4 is a circulating antioxidant and is independently associated with increased risk of cardiovascular and all-cause mortality in T2DM. | Serum peroxiredoxin 4: a marker of oxidative stress associated with mortality in type 2 diabetes (ZODIAC-28).
Gerrits EG, Alkhalaf A, Landman GW, van Hateren KJ, Groenier KH, Struck J, Schulte J, Gans RO, Bakker SJ, Kleefstra N, Bilo HJ., Free PMC Article | 01/24/2015 |
| these data suggest an important role of Prdx4 in maintaining insulin levels and improving the ER folding capacity also under conditions of a high insulin requirement. | Peroxiredoxin 4 improves insulin biosynthesis and glucose-induced insulin secretion in insulin-secreting INS-1E cells.
Mehmeti I, Lortz S, Elsner M, Lenzen S., Free PMC Article | 12/20/2014 |
| there is a significant difference in concentration of Prx4 between cardiac arrest patients with good and poor outcome | CT-proAVP (copeptin), MR-proANP and Peroxiredoxin 4 after cardiac arrest: release profiles and correlation to outcome.
Annborn M, Dankiewicz J, Nielsen N, Rundgren M, Smith JG, Hertel S, Struck J, Friberg H. | 11/8/2014 |
| The structure and function of PRDX4 as well as its sensitivity to hyperoxidation. [Review] | Regulating the level of intracellular hydrogen peroxide: the role of peroxiredoxin IV.
Martin RE, Cao Z, Bulleid NJ. | 09/6/2014 |
| expression of PRDX4 in PCOS ovaries appeared to be mediated through oxidative stress in GCs. We reported that the deficiency of antioxidant PRDX4 was associated with pathophysiological mechanism of PCOS. | Downregulated expression of peroxiredoxin 4 in granulosa cells from polycystic ovary syndrome.
Meng Y, Qian Y, Gao L, Cai LB, Cui YG, Liu JY., Free PMC Article | 08/9/2014 |
| peroxiredoxin IV recycling in the endoplasmic reticulum is much less efficient than in the cytosol or mitochondria, leading to the protection of peroxiredoxin IV from hyperoxidation. | Lack of an efficient endoplasmic reticulum-localized recycling system protects peroxiredoxin IV from hyperoxidation.
Cao Z, Subramaniam S, Bulleid NJ., Free PMC Article | 04/26/2014 |
| Remarkably, the Prx4-dependent formation of native disulfide bonds was accelerated when PDI was combined with ERp46 or P5, suggesting that PDIs work synergistically to increase the rate and fidelity of oxidative protein folding. | Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding.
Sato Y, Kojima R, Okumura M, Hagiwara M, Masui S, Maegawa K, Saiki M, Horibe T, Suzuki M, Inaba K., Free PMC Article | 02/15/2014 |