| Thioredoxin domain containing 5 is involved in the hepatic storage of squalene into lipid droplets in a sex-specific way. | Thioredoxin domain containing 5 is involved in the hepatic storage of squalene into lipid droplets in a sex-specific way.
Sánchez-Marco J, Bidooki SH, Abuobeid R, Barranquero C, Herrero-Continente T, Arnal C, Martínez-Beamonte R, Lasheras R, Surra JC, Navarro MA, Rodríguez-Yoldi MJ, Arruebo M, Sebastian V, Osada J. | 02/1/2024 |
| A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice. | A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice.
Zhou J, Wu Y, Rauova L, Koma G, Wang L, Poncz M, Li H, Liu T, Fong KP, Bennett JS, Kunapuli SP, Essex DW., Free PMC Article | 04/9/2022 |
| Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-beta signaling in kidney fibroblasts. | Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-β signaling in kidney fibroblasts.
Chen YT, Jhao PY, Hung CT, Wu YF, Lin SJ, Chiang WC, Lin SL, Yang KC., Free PMC Article | 09/25/2021 |
| Inhibition of ER stress by targeting the IRE1alpha-TXNDC5 pathway alleviates crystalline silica-induced pulmonary fibrosis. | Inhibition of ER stress by targeting the IRE1α-TXNDC5 pathway alleviates crystalline silica-induced pulmonary fibrosis.
Chen X, Li C, Liu J, He Y, Wei Y, Chen J. | 06/19/2021 |
| Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFbeta signaling through TGFBR1 stabilization. | Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization.
Lee TH, Yeh CF, Lee YT, Shih YC, Chen YT, Hung CT, You MY, Wu PC, Shentu TP, Huang RT, Lin YS, Wu YF, Lin SJ, Lu FL, Tsao PN, Lin TH, Lo SC, Tseng YS, Wu WL, Chen CN, Wu CC, Lin SL, Sperling AI, Guzy RD, Fang Y, Yang KC., Free PMC Article | 09/19/2020 |
| TXNDC5 mRNA and protein were highly upregulated in hypertrophied/failing mouse left ventricle. Targeted disruption of Txndc5 in mice revealed protective effects against isoproterenol-induced cardiac hypertrophy, reduced fibrosis by approximately 70%, and markedly improved left ventricle function. | Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation.
Shih YC, Chen CL, Zhang Y, Mellor RL, Kanter EM, Fang Y, Wang HC, Hung CT, Nong JY, Chen HJ, Lee TH, Tseng YS, Chen CN, Wu CC, Lin SL, Yamada KA, Nerbonne JM, Yang KC., Free PMC Article | 09/14/2019 |
| Hypoxia induced TXCNDC5 expression, which contributed to adiponectin expression, cytokine production and the cellular proliferation and migration of fibroblasts in rheumatoid arthritis. | Investigate pathogenic mechanism of TXNDC5 in rheumatoid arthritis.
Wang L, Zheng Y, Xu H, Yan X, Chang X., Free PMC Article | 07/6/2013 |
| Txndc5 reflects the anti-steatotic properties of squalene and the sensitivity to lipid accumulation. | Proteomics and gene expression analyses of squalene-supplemented mice identify microsomal thioredoxin domain-containing protein 5 changes associated with hepatic steatosis.
Ramírez-Torres A, Barceló-Batllori S, Martínez-Beamonte R, Navarro MA, Surra JC, Arnal C, Guillén N, Acín S, Osada J. | 05/25/2013 |
| ERp46 plays a protective role in palmitic acid -induced cell apoptosis by decreasing the endoplasmic reticulum stress response and might be a novel target for anti-diabetic drugs. | Role of ERp46 in β-cell lipoapoptosis through endoplasmic reticulum stress pathway as well as the protective effect of exendin-4.
Chen DL, Xiang JN, Yang LY. | 02/9/2013 |
| Potential role for TXNDC5 in resistance to nitrosative stress. | Involvement of thioredoxin domain-containing 5 in resistance to nitrosative stress.
Lee HW, Hitchcock TM, Park SH, Mi R, Kraft JD, Luo J, Cao W. | 01/1/2011 |
| ERp46 may be an important component in the phenomenon of "glucose toxicity" involved in insulin production at the posttranslational level. | ERp46 is reduced by high glucose and regulates insulin content in pancreatic beta-cells.
Alberti A, Karamessinis P, Peroulis M, Kypreou K, Kavvadas P, Pagakis S, Politis PK, Charonis A. | 01/21/2010 |
| both ERp19 and ERp46 and their respective mRNAs are highly expressed in the liver as compared with other tissues | ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins.
Knoblach B, Keller BO, Groenendyk J, Aldred S, Zheng J, Lemire BD, Li L, Michalak M. | 01/21/2010 |
| PC-TRP was expressed at high levels in all plasma cells isolated from bone marrow or lamina propria. | Identification of a novel thioredoxin-related protein, PC-TRP, which is preferentially expressed in plasma cells.
Wrammert J, Källberg E, Leanderson T. | 01/21/2010 |