| Novel compound heterozygous variants of the SEC23A gene in a Chinese family with cranio-lenticulo-sutural dysplasia based on data from a large cohort of congenital cataract patients. | Novel compound heterozygous variants of the SEC23A gene in a Chinese family with cranio-lenticulo-sutural dysplasia based on data from a large cohort of congenital cataract patients.
Wang Q, Lin X, Lai K, Liu Y, Qin T, Tan H, Li J, Lin Z, Zhang X, Li X, Lin H, Chen W., Free PMC Article | 12/18/2023 |
| SEC23A confers ER stress resistance in gastric cancer by forming the ER stress-SEC23A-autophagy negative feedback loop. | SEC23A confers ER stress resistance in gastric cancer by forming the ER stress-SEC23A-autophagy negative feedback loop.
Cheng Q, Liu K, Xiao J, Shen K, Wang Y, Zhou X, Wang J, Xu Z, Yang L., Free PMC Article | 09/11/2023 |
| MiR-29b-3p Inhibits the Inflammation Injury in Human Umbilical Vein Endothelial Cells by Regulating SEC23A. | MiR-29b-3p Inhibits the Inflammation Injury in Human Umbilical Vein Endothelial Cells by Regulating SEC23A.
Tong Y, Zhou Z, Tang J, Feng Q. | 11/5/2022 |
| Transduction with BBF2H7/CREB3L2 upregulates SEC23A protein in erythroblasts and partially corrects the hypo-glycosylation phenotype associated with CDAII. | Transduction with BBF2H7/CREB3L2 upregulates SEC23A protein in erythroblasts and partially corrects the hypo-glycosylation phenotype associated with CDAII.
Pellegrin S, Haydn-Smith KL, Hampton-O'Neil LA, Hawley BR, Heesom KJ, Fermo E, Bianchi P, Toye AM., Free PMC Article | 01/4/2020 |
| identified Sec23a, a gene target of miR-200c, suppresses miR-200c augmented oligometastatic to polymetastatic progression via its secretome. Firstly, miR-200c over-expression and Sec23a interference accelerated oligometastatic to polymetatic progression. Secondly, Sec23a functions downstream of miR-200c. | Sec23a mediates miR-200c augmented oligometastatic to polymetastatic progression.
Sun Z, Zhou S, Tang J, Ye T, Li J, Liu D, Zhou J, Wang J, Rosie Xing H., Free PMC Article | 03/16/2019 |
| This larger GWAS yields two loci harboring genome-wide significant variants affecting serum 25-hydroxyvitamin D levels (P = 4.7x10(-9) at rs8018720 in SEC23A, and P = 1.9x10(-14) at rs10745742 in AMDHD1). | Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
Jiang X, O'Reilly PF, Aschard H, Hsu YH, Richards JB, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, Kestenbaum B, Zheng J, Luan J, Sofianopoulou E, Streeten EA, Albanes D, Lutsey PL, Yao L, Tang W, Econs MJ, Wallaschofski H, Völzke H, Zhou A, Power C, McCarthy MI, Michos ED, Boerwinkle E, Weinstein SJ, Freedman ND, Huang WY, Van Schoor NM, van der Velde N, Groot LCPGM, Enneman A, Cupples LA, Booth SL, Vasan RS, Liu CT, Zhou Y, Ripatti S, Ohlsson C, Vandenput L, Lorentzon M, Eriksson JG, Shea MK, Houston DK, Kritchevsky SB, Liu Y, Lohman KK, Ferrucci L, Peacock M, Gieger C, Beekman M, Slagboom E, Deelen J, Heemst DV, Kleber ME, März W, de Boer IH, Wood AC, Rotter JI, Rich SS, Robinson-Cohen C, den Heijer M, Jarvelin MR, Cavadino A, Joshi PK, Wilson JF, Hayward C, Lind L, Michaëlsson K, Trompet S, Zillikens MC, Uitterlinden AG, Rivadeneira F, Broer L, Zgaga L, Campbell H, Theodoratou E, Farrington SM, Timofeeva M, Dunlop MG, Valdes AM, Tikkanen E, Lehtimäki T, Lyytikäinen LP, Kähönen M, Raitakari OT, Mikkilä V, Ikram MA, Sattar N, Jukema JW, Wareham NJ, Langenberg C, Forouhi NG, Gundersen TE, Khaw KT, Butterworth AS, Danesh J, Spector T, Wang TJ, Hyppönen E, Kraft P, Kiel DP., Free PMC Article | 12/22/2018 |
| these data demonstrate an equivalent function for SEC23A/B, with evolutionary shifts in the transcription program likely accounting for the distinct phenotypes of SEC23A/B deficiency within and across species, a paradigm potentially applicable to other sets of paralogous genes. | Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo.
Khoriaty R, Hesketh GG, Bernard A, Weyand AC, Mellacheruvu D, Zhu G, Hoenerhoff MJ, McGee B, Everett L, Adams EJ, Zhang B, Saunders TL, Nesvizhskii AI, Klionsky DJ, Shavit JA, Gingras AC, Ginsburg D., Free PMC Article | 10/6/2018 |
| Mutation on serine207 of Sec23A protein changes Unc-51 like kinase 1(ULK 1) targeted phosphorylation. During elevated autophagy, induced by amino acid starvation, rapamycin, or overexpression of ULK1,phosphorylation of Sec23A reduced the interaction between vesicular transport proteins Sec23A and Sec31A. | ULK1 phosphorylates Sec23A and mediates autophagy-induced inhibition of ER-to-Golgi traffic.
Gan W, Zhang C, Siu KY, Satoh A, Tanner JA, Yu S., Free PMC Article | 05/12/2018 |
| Data indicate that vesicular transport protein SEC23A as a target of miR-375. | MicroRNA-375/SEC23A as biomarkers of the in vitro efficacy of vandetanib.
Lassalle S, Zangari J, Popa A, Ilie M, Hofman V, Long E, Patey M, Tissier F, Belléannée G, Trouette H, Catargi B, Peyrottes I, Sadoul JL, Bordone O, Bonnetaud C, Butori C, Bozec A, Guevara N, Santini J, Hénaoui IS, Lemaire G, Blanck O, Vielh P, Barbry P, Mari B, Brest P, Hofman P., Free PMC Article | 12/23/2017 |
| findings suggest that miR-21 promoted proliferation, migration, and invasion of colorectal cancer cells in vitro by down regulating the expression of Sec23A | MicroRNA-21 promotes proliferation, migration, and invasion of colorectal cancer, and tumor growth associated with down-regulation of sec23a expression.
Li C, Zhao L, Chen Y, He T, Chen X, Mao J, Li C, Lyu J, Meng QH., Free PMC Article | 10/28/2017 |
| miR-375 is involved in development of chemo-resistance to docetaxel through regulating SEC23A and YAP1 expression. | miR-375 induces docetaxel resistance in prostate cancer by targeting SEC23A and YAP1.
Wang Y, Lieberman R, Pan J, Zhang Q, Du M, Zhang P, Nevalainen M, Kohli M, Shenoy NK, Meng H, You M, Wang L., Free PMC Article | 06/24/2017 |
| ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex. | ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex.
la Cour JM, Schindler AJ, Berchtold MW, Schekman R., Free PMC Article | 06/21/2014 |
| Hypomorphic mutations of SEC23B gene account for mild phenotypes of congenital dyserythropoietic anemia type II. | Hypomorphic mutations of SEC23B gene account for mild phenotypes of congenital dyserythropoietic anemia type II.
Russo R, Langella C, Esposito MR, Gambale A, Vitiello F, Vallefuoco F, Ek T, Yang E, Iolascon A., Free PMC Article | 01/4/2014 |
| show that membrane association of COPII components, and in particular of Sec23a, is impaired by ER stress-inducing agents suggesting the existence of a dynamic interplay between protein folding and COPII assembly at the ER | Endoplasmic reticulum stress reduces COPII vesicle formation and modifies Sec23a cycling at ERESs.
Amodio G, Venditti R, De Matteis MA, Moltedo O, Pignataro P, Remondelli P. | 11/16/2013 |
| Data indicate that a synthetic polypeptide containing the N terminus of bovine AE1 bound the Sec23A-Sec24C complex through a selective interaction with Sec24C. | A new class of endoplasmic reticulum export signal PhiXPhiXPhi for transmembrane proteins and its selective interaction with Sec24C.
Otsu W, Kurooka T, Otsuka Y, Sato K, Inaba M., Free PMC Article | 09/7/2013 |
| the BBF2H7-mediated Sec23A pathway is required for ER-to-Golgi procollagen trafficking to promote collagen synthesis | BBF2H7-mediated Sec23A pathway is required for endoplasmic reticulum-to-Golgi trafficking in dermal fibroblasts to promote collagen synthesis.
Ishikura-Kinoshita S, Saeki H, Tsuji-Naito K. | 10/6/2012 |
| Sec23A overexpression reduced cell growth but did not induce apoptosis, whereas inhibition of Sec23A stimulated cell proliferation | Downregulation of Sec23A protein by miRNA-375 in prostate carcinoma.
Szczyrba J, Nolte E, Wach S, Kremmer E, Stöhr R, Hartmann A, Wieland W, Wullich B, Grässer FA. | 10/22/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Data show that coupling of the Sec23/24 and Sec13/31 layers of the COPII coat is required to drive export of collagen from the endoplasmic reticulum, and that efficient COPII assembly is essential for normal craniofacial development during embryogenesis. | Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development.
Townley AK, Feng Y, Schmidt K, Carter DA, Porter R, Verkade P, Stephens DJ. | 01/21/2010 |
| Sec23A mutation causes cranio-lenticulo-sutural dysplasia, and disrupts the nucleation of COPII coat proteins at endoplasmic reticulum exit sites. | Insights into COPII coat nucleation from the structure of Sec23.Sar1 complexed with the active fragment of Sec31.
Bi X, Mancias JD, Goldberg J., Free PMC Article | 01/21/2010 |
| When entering into mitosis, the COPII component Sec24Cp is simultaneously deglycosylated and phosphorylated; however, Sec23A is not. | Regulation of a COPII component by cytosolic O-glycosylation during mitosis.
Dudognon P, Maeder-Garavaglia C, Carpentier JL, Paccaud JP. | 01/21/2010 |