| Comprehensive analysis of the role of interferon gamma-inducible protein 30 on immune infiltration and prognosis in clear cell renal cell carcinoma. | Comprehensive analysis of the role of interferon gamma-inducible protein 30 on immune infiltration and prognosis in clear cell renal cell carcinoma.
Wen X, Lei L, Wang F, Wang Y., Free PMC Article | 03/15/2024 |
| A Transcription Factor ZNF384, Regulated by LINC00265, Activates the Expression of IFI30 to Stimulate Malignant Progression in Glioma. | A Transcription Factor ZNF384, Regulated by LINC00265, Activates the Expression of IFI30 to Stimulate Malignant Progression in Glioma.
Yang J, Yang S, Cai J, Chen H, Sun L, Wang J, Hou G, Gu S, Ma J, Ge J. | 01/29/2024 |
| [Knockdown of interferon-gamma inducible protein 30 (IFI30) inhibits the proliferation, invasion and migration of human glioma U251 cells by activating STAT1 and promotes their apoptosis]. | [Knockdown of interferon-γ inducible protein 30 (IFI30) inhibits the proliferation, invasion and migration of human glioma U251 cells by activating STAT1 and promotes their apoptosis].
Ye J, Xu W, Chen T. | 01/29/2024 |
| Interferon-gamma inducible protein 30 promotes the epithelial-mesenchymal transition-like phenotype and chemoresistance by activating EGFR/AKT/GSK3beta/beta-catenin pathway in glioma. | Interferon-γ inducible protein 30 promotes the epithelial-mesenchymal transition-like phenotype and chemoresistance by activating EGFR/AKT/GSK3β/β-catenin pathway in glioma.
Chen Y, Xu H, Yu P, Wang Q, Li S, Ji F, Wu C, Lan Q., Free PMC Article | 11/28/2023 |
| IDO1, FAT10, IFI6, and GILT Are Involved in the Antiretroviral Activity of gamma-Interferon and IDO1 Restricts Retrovirus Infection by Autophagy Enhancement. | IDO1, FAT10, IFI6, and GILT Are Involved in the Antiretroviral Activity of γ-Interferon and IDO1 Restricts Retrovirus Infection by Autophagy Enhancement.
Kubo Y, Yasui K, Izumida M, Hayashi H, Matsuyama T., Free PMC Article | 08/6/2022 |
| Prognostic value of gamma-interferon-inducible lysosomal thiol reductase expression in female patients diagnosed with breast cancer. | Prognostic value of gamma-interferon-inducible lysosomal thiol reductase expression in female patients diagnosed with breast cancer.
Ye C, Zhou W, Wang F, Yin G, Zhang X, Kong L, Gao Z, Feng M, Zhou C, Sun D, Wang L, Liu L, Zheng C, Xiang Y, Guo M, Huang S, Yu Z. | 02/19/2022 |
| IFI30 expression predicts patient prognosis in breast cancer and dictates breast cancer cells proliferation via regulating autophagy. | IFI30 expression predicts patient prognosis in breast cancer and dictates breast cancer cells proliferation via regulating autophagy.
Fan Y, Wang X, Li Y., Free PMC Article | 01/15/2022 |
| IFI30 expression is an independent unfavourable prognostic factor in glioma. | IFI30 expression is an independent unfavourable prognostic factor in glioma.
Liu X, Song C, Yang S, Ji Q, Chen F, Li W., Free PMC Article | 06/12/2021 |
| GILT is a novel antiviral ISG that specifically inhibits the entry of selected enveloped RNA viruses in lysosomes via disruption of cathepsin L metabolism and function. | GILT restricts the cellular entry mediated by the envelope glycoproteins of SARS-CoV, Ebola virus and Lassa fever virus.
Chen D, Hou Z, Jiang D, Zheng M, Li G, Zhang Y, Li R, Lin H, Chang J, Zeng H, Guo JT, Zhao X., Free PMC Article | 01/18/2020 |
| GILT was highly expressed as observed in the public database on human gliomas and two human glioma cell lines, U373MG and U87MG cells. The downregulation of GILT by lentiviral-mediated silencing inhibits the cell growth, colony formation, and migration but promotes apoptosis and results in cell cycle arrest at the G0/G1 phase in the U373MG cells. | Lentivirus mediated γ-interferon-inducible lysosomal thiol reductase (GILT) knockdown suppresses human glioma U373MG cell proliferation.
Chen S, Wang Q, Shao X, Di G, Dai Y, Jiang X, Cheng L. | 10/12/2019 |
| Results shows that GILT expression is required for downregulation of PAX-3 proteins in late stage human melanoma cells. GILT co-localizes with PAX-3 proteins regulating its expression through the autophagy and lysosomal degradation pathway in human melanoma cells. | Autophagy-dependent crosstalk between GILT and PAX-3 influences radiation sensitivity of human melanoma cells.
Hathaway-Schrader JD, Doonan BP, Hossain A, Radwan FFY, Zhang L, Haque A., Free PMC Article | 10/20/2018 |
| GILT functions as a host restriction factor against the retroviruses. | Gamma-interferon-inducible, lysosome/endosome-localized thiolreductase, GILT, has anti-retroviral activity and its expression is counteracted by HIV-1.
Kubo Y, Izumida M, Yashima Y, Yoshii-Kamiyama H, Tanaka Y, Yasui K, Hayashi H, Matsuyama T., Free PMC Article | 02/17/2018 |
| GILT expression is anticipated to result in improved presentation of melanoma antigens and more effective antimelanoma T-cell responses. | Gamma-interferon-inducible lysosomal thiol reductase is upregulated in human melanoma.
Nguyen J, Bernert R, In K, Kang P, Sebastiao N, Hu C, Hastings KT., Free PMC Article | 01/14/2017 |
| The lysosomal thiol reductase GILT expressed by antigen-presenting cells has diverse cellular and organismal functions. (Review) | Diverse cellular and organismal functions of the lysosomal thiol reductase GILT.
Rausch MP, Hastings KT., Free PMC Article | 01/30/2016 |
| this review discusses recent studies that have advanced our understanding of the role of GILT in antigen processing and revealed surprising new functions for the enzyme.[review] | Expanding roles for GILT in immunity.
West LC, Cresswell P., Free PMC Article | 08/31/2013 |
| Single nucleotide polymorphism of the interferon-gamma-inducible protein 30 gene is associated with hyperglycemia in severely obese individuals. | A polymorphism of the interferon-gamma-inducible protein 30 gene is associated with hyperglycemia in severely obese individuals.
Turcot V, Bouchard L, Faucher G, Tchernof A, Deshaies Y, Pérusse L, Marceau P, Hould FS, Lebel S, Vohl MC. | 02/18/2012 |
| GILT is required for efficient histocompatiblity class II-restricted processing of melanoma antigen tyrosinase-related protein 1 epitope in vitro and accelerates the onset of vitiligo in TRP1-specific T-cell receptor transgenic mice. | GILT accelerates autoimmunity to the melanoma antigen tyrosinase-related protein 1.
Rausch MP, Irvine KR, Antony PA, Restifo NP, Cresswell P, Hastings KT., Free PMC Article | 10/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C. | 04/1/2009 |
| studied gene expression profile of brain lesions of a patient with Neuromyelitis optica by using DNA microarray; found marked up-regulation of interferon gamma-inducible protein 30 (IFI30), CD163, and secreted phosphoprotein 1 (SPP1, osteopontin) | Neuromyelitis optica/Devic's disease: gene expression profiling of brain lesions.
Satoh J, Obayashi S, Misawa T, Tabunoki H, Yamamura T, Arima K, Konno H. | 01/21/2010 |
| GILT-expressing melanoma cells could prove to be very promising for direct antigen presentation and CD4+ T cell recognition | Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma.
Goldstein OG, Hajiaghamohseni LM, Amria S, Sundaram K, Reddy SV, Haque A., Free PMC Article | 01/21/2010 |
| Role of the C-terminal propeptide in the activity and maturation of gamma -interferon-inducible lysosomal thiol reductase (GILT). | Role of the C-terminal propeptide in the activity and maturation of gamma -interferon-inducible lysosomal thiol reductase (GILT).
Phan UT, Lackman RL, Cresswell P., Free PMC Article | 01/21/2010 |
| Absence of gamma-interferon-inducible lysosomal thiol reductase in melanomas disrupts T cell recognition of select immunodominant epitopes. | Absence of gamma-interferon-inducible lysosomal thiol reductase in melanomas disrupts T cell recognition of select immunodominant epitopes.
Haque MA, Li P, Jackson SK, Zarour HM, Hawes JW, Phan UT, Maric M, Cresswell P, Blum JS., Free PMC Article | 01/21/2010 |