| Proximity-dependent recruitment of Polycomb repressive complexes by the lncRNA Airn. | Proximity-dependent recruitment of Polycomb repressive complexes by the lncRNA Airn.
Braceros AK, Schertzer MD, Omer A, Trotman JB, Davis ES, Dowen JM, Phanstiel DH, Aiden EL, Calabrese JM., Free PMC Article | 08/3/2023 |
| LncRNA-Airn alleviates acute liver injury by inhibiting hepatocyte apoptosis via the NF-kappaB signaling pathway. | LncRNA-Airn alleviates acute liver injury by inhibiting hepatocyte apoptosis via the NF-κB signaling pathway.
Shao S, Zhang Y, Zhou F, Meng X, Yu Z, Li G, Zheng L, Zhang K, Li Y, Guo B, Liu Q, Zhang M, Du X, Hong W, Han T., Free PMC Article | 01/14/2023 |
| LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis. | LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis.
Peng T, Liu M, Hu L, Guo D, Wang D, Qi B, Ren G, Hu C, Zhang F, Chun HJ, Song L, Hu J, Li Y., Free PMC Article | 11/26/2022 |
| LncRNA Airn maintains LSEC differentiation to alleviate liver fibrosis via the KLF2-eNOS-sGC pathway. | LncRNA Airn maintains LSEC differentiation to alleviate liver fibrosis via the KLF2-eNOS-sGC pathway.
Chen T, Shi Z, Zhao Y, Meng X, Zhao S, Zheng L, Han X, Hu Z, Yao Q, Lin H, Du X, Zhang K, Han T, Hong W., Free PMC Article | 10/8/2022 |
| Downregulation of long non-coding RNA AIRN promotes mitophagy in alcoholic fatty hepatocytes by promoting ubiquitination of mTOR. | Downregulation of long non-coding RNA AIRN promotes mitophagy in alcoholic fatty hepatocytes by promoting ubiquitination of mTOR.
Shen S, Wang J, Lin LM., Free PMC Article | 12/11/2021 |
| Long noncoding RNA Airn protects podocytes from diabetic nephropathy lesions via binding to Igf2bp2 and facilitating translation of Igf2 and Lamb2. | Long noncoding RNA Airn protects podocytes from diabetic nephropathy lesions via binding to Igf2bp2 and facilitating translation of Igf2 and Lamb2.
Jing F, Zhao J, Jing X, Lei G. | 06/26/2021 |
| Chromatin environments surrounding Xist, Airn, and Kcnq1ot1 suggest common mechanisms of PRC engagement and spreading. Our data indicate that lncRNA potency can be tightly linked to lncRNA abundance and that within lncRNA-targeted domains, PRCs are recruited to CGIs via lncRNA-independent mechanisms. | lncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA.
Schertzer MD, Braceros KCA, Starmer J, Cherney RE, Lee DM, Salazar G, Justice M, Bischoff SR, Cowley DO, Ariel P, Zylka MJ, Dowen JM, Magnuson T, Calabrese JM., Free PMC Article | 01/18/2020 |
| Study showed that chromosome interactions between the Airn gene body and the Slc22a3 promoter are enriched on the maternal allele because Airn expression represses these interactions on the paternal allele. These interactions are not required to upregulate Slc22a3 expression on the maternal allele, indicating that they are not essential promoter- enhancer interactions; they may serve to place both loci in close promixity. | The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes.
Andergassen D, Muckenhuber M, Bammer PC, Kulinski TM, Theussl HC, Shimizu T, Penninger JM, Pauler FM, Hudson QJ., Free PMC Article | 12/21/2019 |
| In cardiomyocytes, silencing of Airn via siRNAs augmented cell death, vulnerability to cellular stress, and reduced cell migration. It also caused less binding of Igf2bp2 to other mRNAs and reduced translation of Igf2bp2 protein. Airn's binding partners were Igf2bp2 and Rpa1. | Airn Regulates Igf2bp2 Translation in Cardiomyocytes.
Hosen MR, Militello G, Weirick T, Ponomareva Y, Dassanayaka S, Moore JB 4th, Döring C, Wysoczynski M, Jones SP, Dimmeler S, Uchida S., Free PMC Article | 09/21/2019 |
| Airn expression is both necessary and sufficient to silence Igf2r throughout embryonic stem cell differentiation. | Imprinted Igf2r silencing depends on continuous Airn lncRNA expression and is not restricted to a developmental window.
Santoro F, Mayer D, Klement RM, Warczok KE, Stukalov A, Barlow DP, Pauler FM. | 05/4/2013 |
| The results excluded a role for spliced and unspliced Airn lncRNA products and for Airn nuclear size and location in silencing Igf2r. Instead, silencing only required Airn transcriptional overlap of the Igf2r promoter, which interferes with RNA polymerase II recruitment in the absence of repressive chromatin. | Airn transcriptional overlap, but not its lncRNA products, induces imprinted Igf2r silencing.
Latos PA, Pauler FM, Koerner MV, Şenergin HB, Hudson QJ, Stocsits RR, Allhoff W, Stricker SH, Klement RM, Warczok KE, Aumayr K, Pasierbek P, Barlow DP. | 12/22/2012 |
| Airn encodes a non-protein coding transcript that is preferentially expressed from the paternal allele, and is required for silencing of three imprinted, maternally expressed protein-coding genes. | The non-coding Air RNA is required for silencing autosomal imprinted genes.
Sleutels F, Zwart R, Barlow DP. | 11/8/2010 |
| the Airn ncRNA induces imprinted Igf2r expression not by silencing the paternal Igf2r promoter, but by generating an expression bias between the two parental alleles. | An in vitro ES cell imprinting model shows that imprinted expression of the Igf2r gene arises from an allele-specific expression bias.
Latos PA, Stricker SH, Steenpass L, Pauler FM, Huang R, Senergin BH, Regha K, Koerner MV, Warczok KE, Unger C, Barlow DP., Free PMC Article | 01/21/2010 |
| findings show Air interacts with the Slc22a3 promoter chromatin & the H3K9 histone methyltransferase G9a in placenta; Air accumulates at the Slc22a3 promoter in correlation with localized H3K9 methylation & transcriptional repression | The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin.
Nagano T, Mitchell JA, Sanz LA, Pauler FM, Ferguson-Smith AC, Feil R, Fraser P. | 01/21/2010 |
| The Air noncoding RNA: an imprinted cis-silencing transcript. Review. | The Air noncoding RNA: an imprinted cis-silencing transcript.
Braidotti G, Baubec T, Pauler F, Seidl C, Smrzka O, Stricker S, Yotova I, Barlow DP., Free PMC Article | 01/21/2010 |
| Unregulated expression of the imprinted genes H19 and Igf2r in mouse uniparental fetuses | Unregulated expression of the imprinted genes H19 and Igf2r in mouse uniparental fetuses.
Sotomaru Y, Katsuzawa Y, Hatada I, Obata Y, Sasaki H, Kono T. | 01/21/2010 |
| Air noncoding RNA may specifically target silencing to the Igf2r promoter | Long-range DNase I hypersensitivity mapping reveals the imprinted Igf2r and Air promoters share cis-regulatory elements.
Pauler FM, Stricker SH, Warczok KE, Barlow DP., Free PMC Article | 01/21/2010 |
| Air silencing occurs without a role for the Igf2r promoter and any transcriptional overlap between Igf2r and Air. | Imprinted silencing of Slc22a2 and Slc22a3 does not need transcriptional overlap between Igf2r and Air.
Sleutels F, Tjon G, Ludwig T, Barlow DP., Free PMC Article | 01/21/2010 |