| microRNA-193b protects against myocardial ischemia-reperfusion injury in mouse by targeting mastermind-like 1. | microRNA-193b protects against myocardial ischemia-reperfusion injury in mouse by targeting mastermind-like 1.
Zhang J, Niu J, Tian B, Zhao M. | 08/15/2020 |
| dnMAML1 expression leads to robust precocious oligodendrocytes differentiation and premature axonal myelination in the spinal cord, possibly by upregulating Nkx2.2 and downregulating Pdgfra expression. Unexpectedly, at late embryonic stages, dnMAML1 expression dramatically increased the number of oligodendrocyte precursor cells (OPCs), indicating a stage-dependent effect of Notch signaling on OPC proliferation. | Stage-dependent regulation of oligodendrocyte development and enhancement of myelin repair by dominant negative Master-mind 1 protein.
Ge X, Xiao G, Huang H, Du J, Tao Y, Yang A, Wu H, Zhang Z, Qiu M. | 02/22/2020 |
| Neuron production in mouse cerebral cortex is coordinated by the MAML1. | Coordination of Neuron Production in Mouse and Human Cerebral Cortex by the Homolog of Drosophila Mastermind Protein.
Ayoub AE, Dominguez MH, Benoit J, Ortega JA, Radonjic N, Zecevic N, Rakic P., Free PMC Article | 02/8/2020 |
| The present study shows a new role for Maml1 as a component of Shh signaling, which plays a crucial role in both development and tumorigenesis. | Maml1 acts cooperatively with Gli proteins to regulate sonic hedgehog signaling pathway.
Quaranta R, Pelullo M, Zema S, Nardozza F, Checquolo S, Lauer DM, Bufalieri F, Palermo R, Felli MP, Vacca A, Talora C, Di Marcotullio L, Screpanti I, Bellavia D., Free PMC Article | 04/7/2018 |
| Similar phenotypes were observed by conditionally misexpressing a dominant negative form of MAML1 in Mitral cells ( MCs)after their migration. Furthermore, the intracellular domain of Notch1 (NICD1) was localized to nuclei of MCs. These findings suggest that Notch signaling at embryonic stages is involved in the dendritic complexity of MCs | Olfactory Sensory Neurons Control Dendritic Complexity of Mitral Cells via Notch Signaling.
Muroyama Y, Baba A, Kitagawa M, Saito T., Free PMC Article | 05/13/2017 |
| These observations suggest that chondrocyte maturation was impaired in MAML1(-/-) mice. MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development. | MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development.
Watanabe T, Oyama T, Asada M, Harada D, Ito Y, Inagawa M, Suzuki Y, Sugano S, Katsube K, Karsenty G, Komori T, Kitagawa M, Asahara H., Free PMC Article | 06/1/2013 |
| This study demonstrated that targeting Maml1-induced tumor cell senescence and differentiation may alter the tumor microenvironment and cytokine and chemokine profiles and may also promote innate and adaptive immune cell infiltration and function. | A knockdown of Maml1 that results in melanoma cell senescence promotes an innate and adaptive immune response.
Kang S, Xie J, Miao J, Li R, Liao W, Luo R., Free PMC Article | 03/30/2013 |
| Maml-mediated Notch signaling plays a pivotal role in the initiation and maintenance of goblet cell differentiation for normal ocular surface morphogenesis. | Mastermind-like transcriptional co-activator-mediated Notch signaling is indispensable for maintaining conjunctival epithelial identity.
Zhang Y, Lam O, Nguyen MT, Ng G, Pear WS, Ai W, Wang IJ, Kao WW, Liu CY., Free PMC Article | 03/9/2013 |
| Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo. | Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.
Oyama T, Harigaya K, Sasaki N, Okamura Y, Kokubo H, Saga Y, Hozumi K, Suganami A, Tamura Y, Nagase T, Koga H, Nishimura M, Sakamoto R, Sato M, Yoshida N, Kitagawa M. | 01/7/2012 |
| Data demonstrate that Mesp2 potently represses Notch signaling by inducing the destabilization of mastermind-like 1, a core regulator of this pathway. | The repression of Notch signaling occurs via the destabilization of mastermind-like 1 by Mesp2 and is essential for somitogenesis.
Sasaki N, Kiso M, Kitagawa M, Saga Y. | 01/8/2011 |
| MAML1 is a novel modulator for NF-kappaB signaling and regulates cellular survival. | The mastermind-like 1 (MAML1) co-activator regulates constitutive NF-kappaB signaling and cell survival.
Jin B, Shen H, Lin S, Li JL, Chen Z, Griffin JD, Wu L., Free PMC Article | 06/14/2010 |
| Mam-1 is required to some extent for Notch-dependent stages in lymphopoiesis, thus supporting the notion that Mam is an essential component of the canonical Notch pathway in mammals. | Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo.
Oyama T, Harigaya K, Muradil A, Hozumi K, Habu S, Oguro H, Iwama A, Matsuno K, Sakamoto R, Sato M, Yoshida N, Kitagawa M., Free PMC Article | 01/21/2010 |
| Maml1 is specifically required for Notch2 signaling in marginal zone B cells. | The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development.
Wu L, Maillard I, Nakamura M, Pear WS, Griffin JD., Free PMC Article | 01/21/2010 |
| There seems to be close correlation of the spatial and temporal expression of Maml1, in the central nervous system (CNS) during early development, implicating a role for the Maml1 gene in neurogenesis. | Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene.
Wu L, Kobayashi K, Sun T, Gao P, Liu J, Nakamura M, Weisberg E, Mukhopadhyay NK, Griffin JD. | 01/21/2010 |
| a dominant negative mutant of MAML1 resulted in early inhibition of T-cell development and the appearance of intrathymic B cells, phenotypes consistent with Notch1 inhibition | Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.
Maillard I, Weng AP, Carpenter AC, Rodriguez CG, Sai H, Xu L, Allman D, Aster JC, Pear WS. | 01/21/2010 |
| MAML1 acts as a coactivator for MEF2C transcription and is essential for proper muscle development | The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
Shen H, McElhinny AS, Cao Y, Gao P, Liu J, Bronson R, Griffin JD, Wu L., Free PMC Article | 01/21/2010 |