| MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart. | MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart.
Hasan P, Berezhnaya E, Rodríguez-Prados M, Weaver D, Bekeova C, Cartes-Saavedra B, Birch E, Beyer AM, Santos JH, Seifert EL, Elrod JW, Hajnóczky G., | 10/1/2024 |
| Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex. | Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex.
Tsai CW, Rodriguez MX, Van Keuren AM, Phillips CB, Shushunov HM, Lee JE, Garcia AM, Ambardekar AV, Cleveland JC Jr, Reisz JA, Proenza C, Chatfield KC, Tsai MF., Free PMC Article | 10/15/2022 |
| The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation. | The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation.
Vecellio Reane D, Cerqua C, Sacconi S, Salviati L, Trevisson E, Raffaello A., Free PMC Article | 07/16/2022 |
| Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients. | Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients.
Singh R, Bartok A, Paillard M, Tyburski A, Elliott M, Hajnóczky G., Free PMC Article | 04/16/2022 |
| Molecular pathophysiology of human MICU1 deficiency. | Molecular pathophysiology of human MICU1 deficiency.
Kohlschmidt N, Elbracht M, Czech A, Häusler M, Phan V, Töpf A, Huang KT, Bartok A, Eggermann K, Zippel S, Eggermann T, Freier E, Groß C, Lochmüller H, Horvath R, Hajnóczky G, Weis J, Roos A. | 01/29/2022 |
| Mechanisms of EMRE-Dependent MCU Opening in the Mitochondrial Calcium Uniporter Complex. | Mechanisms of EMRE-Dependent MCU Opening in the Mitochondrial Calcium Uniporter Complex.
Van Keuren AM, Tsai CW, Balderas E, Rodriguez MX, Chaudhuri D, Tsai MF., Free PMC Article | 11/13/2021 |
| Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity. | Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity.
Nemani N, Dong Z, Daw CC, Madaris TR, Ramachandran K, Enslow BT, Rubannelsonkumar CS, Shanmughapriya S, Mallireddigari V, Maity S, SinghMalla P, Natarajanseenivasan K, Hooper R, Shannon CE, Tourtellotte WG, Singh BB, Reeves WB, Sharma K, Norton L, Srikantan S, Soboloff J, Madesh M., Free PMC Article | 11/6/2021 |
| The structure of the MICU1-MICU2 complex unveils the regulation of the mitochondrial calcium uniporter. | The structure of the MICU1-MICU2 complex unveils the regulation of the mitochondrial calcium uniporter.
Wu W, Shen Q, Zhang R, Qiu Z, Wang Y, Zheng J, Jia Z., Free PMC Article | 04/13/2021 |
| Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2. | Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2.
Wang C, Jacewicz A, Delgado BD, Baradaran R, Long SB., Free PMC Article | 02/20/2021 |
| Dysregulation of Mitochondrial Ca(2+) Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1. | Dysregulation of Mitochondrial Ca(2+) Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1.
Debattisti V, Horn A, Singh R, Seifert EL, Hogarth MW, Mazala DA, Huang KT, Horvath R, Jaiswal JK, Hajnóczky G., Free PMC Article | 09/26/2020 |
| MICU1 confers Ca(2+)-dependent gating of the uniporter by blocking/unblocking MCU. | The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex.
Phillips CB, Tsai CW, Tsai MF., Free PMC Article | 04/25/2020 |
| Data show that phosphorylation at the N-terminal region of MICU1 leads to an increase in the basal mitochondrial Ca(2+) levels. A pool of active Akt in the mitochondria is responsible for MICU1 phosphorylation, and mitochondrion-targeted Akt strongly regulates the mitochondrial Ca(2+). The Akt-mediated phosphorylation impairs MICU1 processing and stability, culminating in ROS production and tumor progression. | Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca(2+) levels and tumor growth.
Marchi S, Corricelli M, Branchini A, Vitto VAM, Missiroli S, Morciano G, Perrone M, Ferrarese M, Giorgi C, Pinotti M, Galluzzi L, Kroemer G, Pinton P., Free PMC Article | 12/28/2019 |
| The findings unveil an essential function of MICU1 in cristae junction stabilization and provide mechanistic insights of how sophistically MICU1 controls the mitochondrial calcium uniporter-Complex while maintaining the structural mitochondrial membrane framework. | MICU1 controls cristae junction and spatially anchors mitochondrial Ca(2+) uniporter complex.
Gottschalk B, Klec C, Leitinger G, Bernhart E, Rost R, Bischof H, Madreiter-Sokolowski CT, Radulović S, Eroglu E, Sattler W, Waldeck-Weiermair M, Malli R, Graier WF., Free PMC Article | 12/21/2019 |
| MICU1 deletion sensitizes human cells to manganese-dependent cell death by disinhibiting MCU-mediated manganese uptake. | MICU1 Confers Protection from MCU-Dependent Manganese Toxicity.
Wettmarshausen J, Goh V, Huang KT, Arduino DM, Tripathi U, Leimpek A, Cheng Y, Pittis AA, Gabaldón T, Mokranjac D, Hajnóczky G, Perocchi F. | 12/14/2019 |
| Authors propose that MICU1 has to interact with the D-ring formed by the DIME domains in MCU to control the uniporter. | MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca(2+) Flux and Sensitivity to Ru360.
Paillard M, Csordás G, Huang KT, Várnai P, Joseph SK, Hajnóczky G., Free PMC Article | 06/1/2019 |
| FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation | FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation.
Shanmughapriya S, Tomar D, Dong Z, Slovik KJ, Nemani N, Natarajaseenivasan K, Carvalho E, Lu C, Corrigan K, Garikipati VNS, Ibetti J, Rajan S, Barrero C, Chuprun K, Kishore R, Merali S, Tian Y, Yang W, Madesh M., Free PMC Article | 12/22/2018 |
| drives aberrant metabolism that fuels aerobic glycolysis and chemoresistance in ovarian cancer | MICU1 drives glycolysis and chemoresistance in ovarian cancer.
Chakraborty PK, Mustafi SB, Xiong X, Dwivedi SKD, Nesin V, Saha S, Zhang M, Dhanasekaran D, Jayaraman M, Mannel R, Moore K, McMeekin S, Yang D, Zuna R, Ding K, Tsiokas L, Bhattacharya R, Mukherjee P., Free PMC Article | 11/10/2018 |
| the absence of MICU1, both Mn(2+) and Ca(2+) can pass through the uniporter, as evidenced by mitochondrial Mn(2+) uptake assays, mitochondrial membrane potential measurements, and mitoplast electrophysiology. | MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca(2+) and Mn(2+).
Kamer KJ, Sancak Y, Fomina Y, Meisel JD, Chaudhuri D, Grabarek Z, Mootha VK., Free PMC Article | 10/6/2018 |
| Mitochondrial Ca(2+) uptake is controlled by protein arginine methyl transferase 1 that asymmetrically methylates MICU1, resulting in decreased Ca(2+) sensitivity. UCP2/3 normalize Ca(2+) sensitivity of methylated MICU1 and, thus, re-establish mitochondrial Ca(2+) uptake activity. | PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells.
Madreiter-Sokolowski CT, Klec C, Parichatikanond W, Stryeck S, Gottschalk B, Pulido S, Rost R, Eroglu E, Hofmann NA, Bondarenko AI, Madl T, Waldeck-Weiermair M, Malli R, Graier WF., Free PMC Article | 08/25/2018 |
| MICU2 restricts spatial crosstalk between InsP3R and MCU channels by regulating threshold and gain of MICU1-mediated inhibition and activation of MCU. | MICU2 Restricts Spatial Crosstalk between InsP(3)R and MCU Channels by Regulating Threshold and Gain of MICU1-Mediated Inhibition and Activation of MCU.
Payne R, Hoff H, Roskowski A, Foskett JK., Free PMC Article | 07/28/2018 |
| study concludes that cooperative, high-affinity interaction of the MICU1-MICU2 complex with Ca(2+) serves as an on-off switch, leading to a tightly controlled channel, capable of responding directly to cytosolic Ca(2+) signals | High-affinity cooperative Ca(2+) binding by MICU1-MICU2 serves as an on-off switch for the uniporter.
Kamer KJ, Grabarek Z, Mootha VK., Free PMC Article | 03/31/2018 |
| MICU1 serves as a signal-noise discriminator in mitochondrial calcium signalling, limiting the energetic costs of mitochondrial Ca2+ signalling which may undermine oxidative phosphorylation, especially in tissues with highly dynamic energetic demands. | Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics.
Bhosale G, Sharpe JA, Koh A, Kouli A, Szabadkai G, Duchen MR., Free PMC Article | 11/25/2017 |
| Results showed that the SNP on EF-hand Ca2+ binding domains of MICU1 gene had no effect in phenotypic characters of bipolar disorder patients | Mutation/SNP analysis in EF-hand calcium binding domain of mitochondrial Ca[Formula: see text] uptake 1 gene in bipolar disorder patients.
Safari R, Salimi R, Tunca Z, Ozerdem A, Ceylan D, Sakizli M. | 02/4/2017 |
| Our experiments provide novel details about how MCU/EMRE is regulated by MICU1 and an original approach to investigate MCU/EMRE activation in intact cells. | Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca(2.).
Waldeck-Weiermair M, Malli R, Parichatikanond W, Gottschalk B, Madreiter-Sokolowski CT, Klec C, Rost R, Graier WF., Free PMC Article | 09/10/2016 |
| Data show that ribosomal protein S3 (RPS3) knockdown decreased mitochondrial calcium uptake 1 protein (MICU1) expression. | RPS3 regulates melanoma cell growth and apoptosis by targeting Cyto C/Ca2+/MICU1 dependent mitochondrial signaling.
Tian Y, Qin L, Qiu H, Shi D, Sun R, Li W, Liu T, Wang J, Xu T, Guo W, Kang T, Huang W, Wang G, Deng W., Free PMC Article | 08/6/2016 |