| Integrative analysis of anoikis-related genes prognostic signature with immunotherapy and identification of CDKN3 as a key oncogene in lung adenocarcinoma. | Integrative analysis of anoikis-related genes prognostic signature with immunotherapy and identification of CDKN3 as a key oncogene in lung adenocarcinoma.
Qin H, Wang Q, Xu J, Zeng H, Liu J, Yu F, Yang J. | 11/7/2024 |
| N6-Methyladenosine modified circ-NAB1 modulates cell cycle and epithelial-mesenchymal transition via CDKN3 in endometrial cancer. | N6-Methyladenosine modified circ-NAB1 modulates cell cycle and epithelial-mesenchymal transition via CDKN3 in endometrial cancer.
Zhang J, Zhang Y, Zhang J. | 06/6/2024 |
| Human pan-cancer analysis of the predictive biomarker for the CDKN3. | Human pan-cancer analysis of the predictive biomarker for the CDKN3.
Chen Y, Li D, Sha K, Zhang X, Liu T., Free PMC Article | 05/13/2024 |
| MicroRNA-127-3p Inhibits Cardiomyocyte Inflammation and Apoptosis after Acute Myocardial Infarction via Targeting CDKN3. | MicroRNA-127-3p Inhibits Cardiomyocyte Inflammation and Apoptosis after Acute Myocardial Infarction via Targeting CDKN3.
Zhu S, Fang Z. | 12/4/2023 |
| PSMD12 interacts with CDKN3 and facilitates pancreatic cancer progression. | PSMD12 interacts with CDKN3 and facilitates pancreatic cancer progression.
Ma J, Zhou W, Yuan Y, Wang B, Meng X. | 11/7/2023 |
| Cyclin dependent kinase inhibitor 3 (CDKN3) upregulation is associated with unfavorable prognosis in clear cell renal cell carcinoma and shapes tumor immune microenvironment: A bioinformatics analysis. | Cyclin dependent kinase inhibitor 3 (CDKN3) upregulation is associated with unfavorable prognosis in clear cell renal cell carcinoma and shapes tumor immune microenvironment: A bioinformatics analysis.
Al Sharie AH, Abu Zahra AM, El-Elimat T, Darweesh RF, Al-Khaldi AK, Abu Mousa BM, Amer MSB, Al Zu'bi YO, Al-Kammash K, Abu Lil A, Al Malkawi AA, Alazzeh Z, Alali FQ., Free PMC Article | 09/22/2023 |
| GID2 Interacts With CDKN3 and Regulates Pancreatic Cancer Growth and Apoptosis. | GID2 Interacts With CDKN3 and Regulates Pancreatic Cancer Growth and Apoptosis.
Deng X, Ma J, Zhou W, Yuan Y, Wang B, Meng X. | 06/29/2023 |
| Identifying key genes related to inflammasome in severe COVID-19 patients based on a joint model with random forest and artificial neural network. | Identifying key genes related to inflammasome in severe COVID-19 patients based on a joint model with random forest and artificial neural network.
Ou H, Fan Y, Guo X, Lao Z, Zhu M, Li G, Zhao L., Free PMC Article | 05/12/2023 |
| Identification of cell cycle-associated and -unassociated regulators for expression of a hepatocellular carcinoma oncogene cyclin-dependent kinase inhibitor 3. | Identification of cell cycle-associated and -unassociated regulators for expression of a hepatocellular carcinoma oncogene cyclin-dependent kinase inhibitor 3.
Mori J, Sawada T, Baba T, Hayakawa A, Kanemoto Y, Nishimura K, Amano R, Siril YJ, Okada M, Kurokawa T, Kato S. | 09/17/2022 |
| CDKN3 expression predicates poor prognosis and regulates adriamycin sensitivity in hepatocellular carcinoma in vitro. | CDKN3 expression predicates poor prognosis and regulates adriamycin sensitivity in hepatocellular carcinoma in vitro.
Dai W, Fang S, Cai G, Dai J, Lin G, Ye Q, Miao H, Chen M, Tan X, Chen N, Liu X, Li M., Free PMC Article | 07/10/2021 |
| Integrated transcriptomics explored the cancer-promoting genes CDKN3 in esophageal squamous cell cancer. | Integrated transcriptomics explored the cancer-promoting genes CDKN3 in esophageal squamous cell cancer.
Wang W, Liao K, Guo HC, Zhou S, Yu R, Liu Y, Pan Y, Pu J., Free PMC Article | 07/10/2021 |
| CDKN3 regulates cisplatin resistance to colorectal cancer through TIPE1. | CDKN3 regulates cisplatin resistance to colorectal cancer through TIPE1.
Li WH, Zhang L, Wu YH. | 04/3/2021 |
| The aberrant expression of miR-181d-5p and cyclin-dependent kinase inhibitor 3 (CDKN3) in non-small-cell lung cancer (NSCLC) was screened by microarray analysis. There was a high expression of CDKN3, whereas miR-181d-5p was downregulated in NSCLC. | Tumor-suppressive effects of microRNA-181d-5p on non-small-cell lung cancer through the CDKN3-mediated Akt signaling pathway in vivo and in vitro.
Gao LM, Zheng Y, Wang P, Zheng L, Zhang WL, Di Y, Chen LL, Yin XB, Tian Q, Shi SS, Xu SF. | 02/22/2020 |
| NEAT1 may exert a protective effect on HUVECs by regulating the miR-181d-5p/CDKN3A axis | Long non-coding RNA NEAT1 inhibits oxidative stress-induced vascular endothelial cell injury by activating the miR-181d-5p/CDKN3 axis.
Zhang M, Wang X, Yao J, Qiu Z. | 12/28/2019 |
| Results demonstrate that upregulation of p27 is involved in the knockdown of CDKN3-induced decrease in cell proliferation, increase in cell cycle arrest and apoptosis, decrease in invasion, and increase in radiosensitivity. | Cyclin-Dependent Kinase Inhibitor 3 Promotes Cancer Cell Proliferation and Tumorigenesis in Nasopharyngeal Carcinoma by Targeting p27.
Wang H, Chen H, Zhou H, Yu W, Lu Z., Free PMC Article | 03/3/2018 |
| the mechanism of CDKN3 overexpression in human cancer | Expression and alternative splicing of the cyclin-dependent kinase inhibitor-3 gene in human cancer.
Cress WD, Yu P, Wu J., Free PMC Article | 11/18/2017 |
| CDKN3 is frequently upregulated in gastric cancer tissues and cell lines and is related to advanced clinical stage, recurrence, and poor clinical outcome in gastric cancer. The functional data strongly suggest that CDKN3 behaves as an oncogene in gastric cancer, and downregulation of CDKN3 could inhibit gastric cancer cell proliferation, migration, and invasion, and induce cell cycle arrest and apoptosis. | Knockdown of Cyclin-Dependent Kinase Inhibitor 3 Inhibits Proliferation and Invasion in Human Gastric Cancer Cells.
Li Y, Ji S, Fu LY, Jiang T, Wu D, Meng FD., Free PMC Article | 11/4/2017 |
| CDKN3 may act as a tumor suppressor in liver tissues by modulation of the cell survival signal transduction, monitoring carcinogenesis and elimination of abnormal cells. | CDKN3 expression is negatively associated with pathological tumor stage and CDKN3 inhibition promotes cell survival in hepatocellular carcinoma.
Dai W, Miao H, Fang S, Fang T, Chen N, Li M., Free PMC Article | 04/8/2017 |
| Knockdown of Cdkn3 stabilizes Mps1 at centrosomes. | The Tumor Suppressor Cdkn3 Is Required for Maintaining the Proper Number of Centrosomes by Regulating the Centrosomal Stability of Mps1.
Srinivas V, Kitagawa M, Wong J, Liao PJ, Lee SH. | 09/10/2016 |
| CDKN3 mRNA may be a good survival biomarker and potential therapeutic target in cervical cancer | CDKN3 mRNA as a Biomarker for Survival and Therapeutic Target in Cervical Cancer.
Barrón EV, Roman-Bassaure E, Sánchez-Sandoval AL, Espinosa AM, Guardado-Estrada M, Medina I, Juárez E, Alfaro A, Bermúdez M, Zamora R, García-Ruiz C, Gomora JC, Kofman S, Pérez-Armendariz EM, Berumen J., Free PMC Article | 05/28/2016 |
| CDKN3 overexpression in lung adenocarcinoma is not attributed to alternative splicing or mutation but is likely due to increased mitotic activity, arguing against CDKN3 as a tumour suppressor | Overexpression of major CDKN3 transcripts is associated with poor survival in lung adenocarcinoma.
Fan C, Chen L, Huang Q, Shen T, Welsh EA, Teer JK, Cai J, Cress WD, Wu J., Free PMC Article | 05/14/2016 |
| CDKN3 knockdown reduces cell proliferation, invasion and promotes apoptosis in human ovarian cancer cells. | CDKN3 knockdown reduces cell proliferation, invasion and promotes apoptosis in human ovarian cancer.
Zhang LP, Li WJ, Zhu YF, Huang SY, Fang SY, Shen L, Gao YL., Free PMC Article | 04/23/2016 |
| These results highlight the importance of CDKN3 in Bcr-Abl-mediated leukemogenesis. | A critical role of CDKN3 in Bcr-Abl-mediated tumorigenesis.
Chen Q, Chen K, Guo G, Li F, Chen C, Wang S, Nalepa G, Huang S, Chen JL., Free PMC Article | 12/26/2015 |
| High CDKN3 expression is associated with colorectal cancer. | Mechanistic studies of cyclin-dependent kinase inhibitor 3 (CDKN3) in colorectal cancer.
Yang C, Sun JJ. | 12/12/2015 |
| these data identify KAP as a major regulator of cell division via interactions with numerous target proteins. aberrant splicing or miR-26a decreases KAP expression to promote glioblastoma growth and invasion. | KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway.
Li H, Jiang X, Yu Y, Huang W, Xing H, Agar NY, Yang HW, Yang B, Carroll RS, Johnson MD. | 06/20/2015 |