| A-Kinase Anchor Protein 95 Is Involved in ERK1/2-Elk-1 Signal Transduction in Colon Cancer. | A-Kinase Anchor Protein 95 Is Involved in ERK1/2-Elk-1 Signal Transduction in Colon Cancer.
Kong X, An P, Xu J, Liu W, Lin F, Yang Y., Free PMC Article | 02/4/2023 |
| A-Kinase Anchoring Proteins Diminish TGF-beta1/Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition. | A-Kinase Anchoring Proteins Diminish TGF-β(1)/Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition.
Zuo H, Trombetta-Lima M, Heijink IH, van der Veen CHTJ, Hesse L, Faber KN, Poppinga WJ, Maarsingh H, Nikolaev VO, Schmidt AM., Free PMC Article | 02/13/2021 |
| Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis. | Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis.
Li W, Hu J, Shi B, Palomba F, Digman MA, Gratton E, Jiang H., Free PMC Article | 10/31/2020 |
| It consists of AKAP95, PKA, and PDE4D5 and show that it forms a functional cyclic AMP (cAMP) signaling microdomain. | AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA.
Clister T, Greenwald EC, Baillie GS, Zhang J., Free PMC Article | 04/25/2020 |
| Identification of A-Kinase Anchor Protein (AKAP8) as a splicing regulatory factor that impedes EMT and breast cancer metastasis. AKAP8 not only is capable of inhibiting splicing activity of the EMT-promoting splicing regulator hnRNPM through protein-protein interaction, it also directly binds to RNA and alters splicing outcomes. Genome-wide analysis shows that AKAP8 promotes an epithelial cell state splicing program. | The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing.
Hu X, Harvey SE, Zheng R, Lyu J, Grzeskowiak CL, Powell E, Piwnica-Worms H, Scott KL, Cheng C., Free PMC Article | 04/18/2020 |
| The results of the present study demonstrate a crucial role for AKAP95 in CYP19A1 expression and oestrogen synthesis in humans luteinized granulosa cells, which implies that AKAP95 may be involved in the pathogenesis of polycystic ovary syndrome. | Role of A-kinase anchoring protein 95 in the regulation of cytochrome P450 family 19 subfamily A member 1 (CYP19A1) in human ovarian granulosa cells.
Gu Y, Xu W, Zhuang B, Fu W. | 09/14/2019 |
| The PKA-binding domain of AKAP8 and the C-terminal domain of DPY30, also called Dpy-30 motif, are crucial for the interaction between these proteins. AKAP8 interacts with DPY30 and the RII alpha regulatory subunit of PKA both in the interphase and in mitotic cells. A single amino acid substitution in DPY30 L69D affects its dimerization and completely abolishes its interaction with AKAP8. | PKA-binding domain of AKAP8 is essential for direct interaction with DPY30 protein.
Bieluszewska A, Weglewska M, Bieluszewski T, Lesniewicz K, Poreba E. | 01/12/2019 |
| These results establish AKAP95 as a mostly positive regulator of pre-mRNA splicing and a possible integrator of transcription and splicing regulation. | AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors.
Hu J, Khodadadi-Jamayran A, Mao M, Shah K, Yang Z, Nasim MT, Wang Z, Jiang H., Free PMC Article | 09/1/2018 |
| Results suggest that ALK generated by alternative transcription Initiation induces chromatin structural changes and heterochromatinization through phosphorylation of AKAP8 in the nucleus. | The Truncated Isoform of the Receptor Tyrosine Kinase ALK Generated by Alternative Transcription Initiation (ALK(ATI)) Induces Chromatin Structural Changes in the Nucleus in a Kinase Activity-Dependent Manner.
Takakura Y, Yamaguchi N, Honda T, Morii M, Yuki R, Nakayama Y, Yamaguchi N. | 06/16/2018 |
| Using a BioID proximity-based proteomic screen, we identify the nuclear pore complex protein TPR as a novel AKAP95 binding partner. We show interaction between AKAP95 and TPR in mitosis, and an AKAP95-dependent enrichment of TPR in the spindle microtubule area in metaphase, then later in the spindle midzone area. | AKAP95 interacts with nucleoporin TPR in mitosis and is important for the spindle assembly checkpoint.
López-Soop G, Rønningen T, Rogala A, Richartz N, Blomhoff HK, Thiede B, Collas P, Küntziger T., Free PMC Article | 03/10/2018 |
| Report expression of connexin 43 in ovarian cancer cells in G1/S phase. | Roles of Cx43 and AKAP95 in ovarian cancer tissues in G1/S phase.
Liu W, Hua S, Dai Y, Yuan Y, Yang J, Deng J, Huo Y, Chen X, Teng B, Yu X, Zhang Y., Free PMC Article | 11/5/2016 |
| The data indicate that AKAP95 is a novel nucleolus-associated protein with a regulatory role on rRNA production. | A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis.
Marstad A, Landsverk OJ, Strømme O, Otterlei M, Collas P, Sundan A, Brede G. | 08/13/2016 |
| Gene dosage at 19p13.12, and AKAP8 and/or AKAP8L in particular, play an important role in modulation of head size and may contribute to autism risk. | Reciprocal Relationship between Head Size, an Autism Endophenotype, and Gene Dosage at 19p13.12 Points to AKAP8 and AKAP8L.
Nebel RA, Kirschen J, Cai J, Woo YJ, Cherian K, Abrahams BS., Free PMC Article | 04/23/2016 |
| These results suggest that AKAP8 is involved in the regulation of chromatin structural changes through nuclear tyrosine phosphorylation. | Role for Tyrosine Phosphorylation of A-kinase Anchoring Protein 8 (AKAP8) in Its Dissociation from Chromatin and the Nuclear Matrix.
Kubota S, Morii M, Yuki R, Yamaguchi N, Yamaguchi H, Aoyama K, Kuga T, Tomonaga T, Yamaguchi N., Free PMC Article | 07/4/2015 |
| Ectopic AKAP95 stimulates expression of a chromosomal reporter gene in synergy with MLL1 or MLL2, whereas AKAP95 depletion impairs retinoic acid-mediated gene induction in embryonic stem cells | Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95.
Jiang H, Lu X, Shimada M, Dou Y, Tang Z, Roeder RG., Free PMC Article | 12/7/2013 |
| role of AKAP95 in DNA replication by providing a scaffold for MCM2 | Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication.
Eide T, Taskén KA, Carlson C, Williams G, Jahnsen T, Taskén K, Collas P. | 01/21/2010 |
| AKAP95 is a potential carrier protein for active caspase 3 from the cytoplasm into the nuclei in apoptotic cells. | A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association.
Kamada S, Kikkawa U, Tsujimoto Y, Hunter T., Free PMC Article | 01/21/2010 |
| AMY-1 interacts with S-AKAP84 and this protein in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. | AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex.
Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H. | 01/21/2010 |