| Expression of HLA-DR and KLRG1 enhances the cytotoxic potential and cytokine secretion capacity of CD3[+] T cells in tuberculosis patients. | Expression of HLA-DR and KLRG1 enhances the cytotoxic potential and cytokine secretion capacity of CD3(+) T cells in tuberculosis patients.
Yang Y, Shi H, Zhou Y, Zhou Y. | 06/17/2024 |
| KLRG1-expressing CD8+ T cells are exhausted and polyfunctional in patients with chronic hepatitis B. | KLRG1-expressing CD8+ T cells are exhausted and polyfunctional in patients with chronic hepatitis B.
Wang L, Liao F, Yang L, Jiang L, Duan L, Wang B, Mu D, Chen J, Huang Y, Hu Q, Chen W., Free PMC Article | 05/29/2024 |
| KLRG1 expression on natural killer cells is associated with HIV persistence, and its targeting promotes the reduction of the viral reservoir. | KLRG1 expression on natural killer cells is associated with HIV persistence, and its targeting promotes the reduction of the viral reservoir.
Astorga-Gamaza A, Perea D, Sanchez-Gaona N, Calvet-Mirabent M, Gallego-Cortés A, Grau-Expósito J, Sanchez-Cerrillo I, Rey J, Castellví J, Curran A, Burgos J, Navarro J, Suanzes P, Falcó V, Genescà M, Martín-Gayo E, Buzon MJ., Free PMC Article | 11/3/2023 |
| KLRG1 is reduced on NK cells in SLE patients, inversely correlates with disease activity and is modulated by hydroxychloroquine in vitro. | KLRG1 is reduced on NK cells in SLE patients, inversely correlates with disease activity and is modulated by hydroxychloroquine in vitro.
Novelli L, Barbati C, Capuano C, Recalchi S, Ceccarelli F, Vomero M, Alessandri C, Morrone S, Conti F. | 04/19/2023 |
| N-cadherin protects oral cancer cells from NK cell killing in the circulation by inducing NK cell functional exhaustion via the KLRG1 receptor. | N-cadherin protects oral cancer cells from NK cell killing in the circulation by inducing NK cell functional exhaustion via the KLRG1 receptor.
Lou C, Wu K, Shi J, Dai Z, Xu Q., Free PMC Article | 10/1/2022 |
| Increased expression of TIGIT and KLRG1 correlates with impaired CD56(bright) NK cell immunity in HPV16-related cervical intraepithelial neoplasia. | Increased expression of TIGIT and KLRG1 correlates with impaired CD56(bright) NK cell immunity in HPV16-related cervical intraepithelial neoplasia.
Nie Y, Liu D, Yang W, Li Y, Zhang L, Cheng X, Chen R, Yuan B, Zhang G, Wang H., Free PMC Article | 04/30/2022 |
| Expression and Clinical Significance of KLRG1 and 2B4 on T Cells in the Peripheral Blood and Tumour of Patients with Cervical Cancer. | Expression and Clinical Significance of KLRG1 and 2B4 on T Cells in the Peripheral Blood and Tumour of Patients with Cervical Cancer.
Guo Y, Feng Y, Fan P, Yao X, Peng Y, Wang R, Kuerban G. | 04/23/2022 |
| Expression of KLRG1 and CD127 defines distinct CD8(+) subsets that differentially impact patient outcome in follicular lymphoma. | Expression of KLRG1 and CD127 defines distinct CD8(+) subsets that differentially impact patient outcome in follicular lymphoma.
Wu H, Tang X, Kim HJ, Jalali S, Pritchett JC, Villasboas JC, Novak AJ, Yang ZZ, Ansell SM., Free PMC Article | 01/15/2022 |
| Development of Antihuman Killer Cell Lectin-Like Receptor Subfamily G Member 1 Monoclonal Antibodies for Flow Cytometry. | Development of Antihuman Killer Cell Lectin-Like Receptor Subfamily G Member 1 Monoclonal Antibodies for Flow Cytometry.
Asano T, Nanamiya R, Tanaka T, Kaneko MK, Kato Y. | 01/8/2022 |
| Functions and clinical significance of KLRG1 in the development of lung adenocarcinoma and immunotherapy. | Functions and clinical significance of KLRG1 in the development of lung adenocarcinoma and immunotherapy.
Yang X, Zheng Y, Han Z, Zhang X., Free PMC Article | 10/23/2021 |
| An atlas of immune cell exhaustion in HIV-infected individuals revealed by single-cell transcriptomics. | An atlas of immune cell exhaustion in HIV-infected individuals revealed by single-cell transcriptomics.
Wang S, Zhang Q, Hui H, Agrawal K, Karris MAY, Rana TM., Free PMC Article | 06/5/2021 |
| KLRG1 and CD103 Expressions Define Distinct Intestinal Tissue-Resident Memory CD8 T Cell Subsets Modulated in Crohn's Disease. | KLRG1 and CD103 Expressions Define Distinct Intestinal Tissue-Resident Memory CD8 T Cell Subsets Modulated in Crohn's Disease.
Bottois H, Ngollo M, Hammoudi N, Courau T, Bonnereau J, Chardiny V, Grand C, Gergaud B, Allez M, Le Bourhis L., Free PMC Article | 04/13/2021 |
| KLRG1+ natural killer cells exert a novel antifibrotic function in chronic hepatitis B. | KLRG1+ natural killer cells exert a novel antifibrotic function in chronic hepatitis B.
Wijaya RS, Read SA, Schibeci S, Eslam M, Azardaryany MK, El-Khobar K, van der Poorten D, Lin R, Yuen L, Lam V, George J, Douglas MW, Ahlenstiel G. | 11/28/2020 |
| The findings provide new insights into the roles of KLRG1 and CD57 expression in human T cells, forming the basis for a refined model of CD8(+) T cell differentiation during Cytomegalovirus infection. | Early KLRG1(+) but Not CD57(+)CD8(+) T Cells in Primary Cytomegalovirus Infection Predict Effector Function and Viral Control.
Hoji A, Popescu ID, Pipeling MR, Shah PD, Winters SA, McDyer JF., Free PMC Article | 05/23/2020 |
| The presence of KLRG1 was identified on pathogenic inclusion body myositis muscle invading T cells. | Highly differentiated cytotoxic T cells in inclusion body myositis.
Greenberg SA, Pinkus JL, Kong SW, Baecher-Allan C, Amato AA, Dorfman DM. | 05/16/2020 |
| Tuberculosis-associated immune reconstitution inflammatory syndrome is preceded by a high level of exhausted (KLRG1+PD-1+) CD8hi T cells. | Increased KLRG1 and PD-1 expression on CD8 T lymphocytes in TB-IRIS.
Goovaerts O, Massinga-Loembé M, Ondoa P, Ceulemans A, Worodria W, Mayanja-Kizza H, Colebunders R, Kestens L, TB-IRIS Study Group., Free PMC Article | 01/11/2020 |
| This study delineated the profile of KLRG1+CD4+ T cells in patients with tuberculosis and suggests that M. tuberculosis infection drives CD4+ T cells to acquire increased effector function in a terminally differentiated state. | The Role of KLRG1 in Human CD4+ T-Cell Immunity Against Tuberculosis.
Hu Z, Zhao HM, Li CL, Liu XH, Barkan D, Lowrie DB, Lu SH, Fan XY. | 06/29/2019 |
| high coexpression of PD-1, TIGIT, and KLRG-1 on MiHA-reactive CD8(+) T cells was associated with relapse after allo-SCT. Taken together, these findings indicate that MiHA-specific CD8(+) T cells of relapsed patients have a distinctive coinhibitory expression signature compared with patients who stay in remission. | Increased Coexpression of PD-1, TIGIT, and KLRG-1 on Tumor-Reactive CD8(+) T Cells During Relapse after Allogeneic Stem Cell Transplantation.
Hutten TJA, Norde WJ, Woestenenk R, Wang RC, Maas F, Kester M, Falkenburg JHF, Berglund S, Luznik L, Jansen JH, Schaap N, Dolstra H, Hobo W. | 03/9/2019 |
| KLRG1 might contribute to the impaired antitumor immunity of memory T cells in tumor microenvironment | KLRG1 restricts memory T cell antitumor immunity.
Li L, Wan S, Tao K, Wang G, Zhao E., Free PMC Article | 03/24/2018 |
| Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5'-Monophosphate-Activated Protein Kinase | Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5'-Monophosphate-Activated Protein Kinase.
Müller-Durovic B, Lanna A, Covre LP, Mills RS, Henson SM, Akbar AN., Free PMC Article | 10/7/2017 |
| The results suggest that a disease-associated SNP located within the 3'UTR of KLRG1 directly interferes with miR-584-5p binding, allowing for KLRG1 mRNA differential accumulation, which in turn may contribute to pathogenesis of pemphigus. | A 3'UTR polymorphism marks differential KLRG1 mRNA levels through disruption of a miR-584-5p binding site and associates with pemphigus foliaceus susceptibility.
Cipolla GA, Park JK, de Oliveira LA, Lobo-Alves SC, de Almeida RC, Farias TD, Lemos Dde S, Malheiros D, Lavker RM, Petzl-Erler ML., Free PMC Article | 06/3/2017 |
| Demonstrate the presence of increased KLRG1-expressing T-cells in tuberculosis-treated individuals, and present KLRG1 as a marker of decreased human T-cell proliferation following BCG-vaccination. | KLRG1 and PD-1 expression are increased on T-cells following tuberculosis-treatment and identify cells with different proliferative capacities in BCG-vaccinated adults.
Boer MC, van Meijgaarden KE, Goletti D, Vanini V, Prins C, Ottenhoff TH, Joosten SA. | 12/24/2016 |
| This finding provides a rationale for the reciprocal expression of KLRG1 and CD103 in different CD8(+) T-cell subsets. | TGF-β downregulates KLRG1 expression in mouse and human CD8(+) T cells.
Schwartzkopff S, Woyciechowski S, Aichele U, Flecken T, Zhang N, Thimme R, Pircher H. | 10/31/2015 |
| high levels of TfRs such as those found on activated lymphocytes were found to be associated with decreased KLRG1 inhibitory function, indicating that TfRs may sequester KLRG1 from interacting with cadherins. | Transferrin' activation: bonding with transferrin receptors tunes KLRG1 function.
Steinle A. | 07/26/2014 |
| More T cells were KLRG1+ in the synovial fluid of patients with spondylarthritis/rheumatoid arthritis than crystal arthritis or controls. Those T cells were more functionally active, and migrated towards the synovial fluid of SpA/RA patients. | Senescence marker killer cell lectin-like receptor G1 (KLRG1) contributes to TNF-α production by interaction with its soluble E-cadherin ligand in chronically inflamed joints.
Melis L, Van Praet L, Pircher H, Venken K, Elewaut D. | 07/19/2014 |