| Novel role for Ddx39 in differentiation and telomere length regulation of embryonic stem cells. | Novel role for Ddx39 in differentiation and telomere length regulation of embryonic stem cells.
Nai S, Wang M, Yang J, Ling B, Dong Q, Yang X, Du X, Lu M, Liu L, Yu Z, Chen L., | 11/7/2024 |
| Intron Retention of DDX39A Driven by SNRPD2 is a Crucial Splicing Axis for Oncogenic MYC/Spliceosome Program in Hepatocellular Carcinoma. | Intron Retention of DDX39A Driven by SNRPD2 is a Crucial Splicing Axis for Oncogenic MYC/Spliceosome Program in Hepatocellular Carcinoma.
Chang C, Li L, Su L, Yang F, Zha Q, Sun M, Tao L, Wang M, Song K, Jiang L, Gao H, Liang Y, Xu C, Yong C, Wang M, Huang J, Liu J, Jin W, Lv W, Dong H, Li Q, Bu F, Yan S, Qi H, Zhao S, Zhu Y, Wang Y, Shi J, Qiao Y, Xu J, Chabot B, Chen J., Free PMC Article | 10/3/2024 |
| Parsing the roles of DExD-box proteins DDX39A and DDX39B in alternative RNA splicing. | Parsing the roles of DExD-box proteins DDX39A and DDX39B in alternative RNA splicing.
Banerjee S, Nagasawa CK, Widen SG, Garcia-Blanco MA., Free PMC Article | 08/22/2024 |
| Terminal regions of UAP56 and URH49 are required for their distinct complex formation functioning to an essential role in mRNA processing and export. | Terminal regions of UAP56 and URH49 are required for their distinct complex formation functioning to an essential role in mRNA processing and export.
Fujita KI, Yamazaki T, Mayeda A, Masuda S. | 03/15/2024 |
| Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes. | Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes.
Fujita KI, Ito M, Irie M, Harada K, Fujiwara N, Ikeda Y, Yoshioka H, Yamazaki T, Kojima M, Mikami B, Mayeda A, Masuda S., Free PMC Article | 02/16/2024 |
| DDX39 as a predictor of clinical prognosis and immune checkpoint therapy efficacy in patients with clear cell renal cell carcinoma. | DDX39 as a predictor of clinical prognosis and immune checkpoint therapy efficacy in patients with clear cell renal cell carcinoma.
Bao Y, Jiang A, Dong K, Gan X, Gong W, Wu Z, Liu B, Bao Y, Wang J, Wang L., Free PMC Article | 03/19/2022 |
| The Mammalian Ecdysoneless Protein Interacts with RNA Helicase DDX39A To Regulate Nuclear mRNA Export. | The Mammalian Ecdysoneless Protein Interacts with RNA Helicase DDX39A To Regulate Nuclear mRNA Export.
Saleem I, Mirza S, Sarkar A, Raza M, Mohapatra B, Mushtaq I, Kim JH, Mishra NK, Alsaleem MA, Rakha EA, Qiu F, Guda C, Band H, Band V., Free PMC Article | 07/24/2021 |
| SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. | SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.
Shi P, Guo Y, Su Y, Zhu M, Fu Y, Chi H, Wu J, Huang J. | 03/13/2021 |
| UAP56- and URH49-dependent mRNA export pathways are integrated into NXF1 through the remodeling of each complex formation by ATP loading. | URH49 exports mRNA by remodeling complex formation and mediating the NXF1-dependent pathway.
Fujita KI, Yamazaki T, Harada K, Seno S, Matsuda H, Masuda S. | 04/11/2020 |
| DDX39 regulates hepatocellular carcinoma progression by activating Wnt/beta-catenin pathway. | DDX39 promotes hepatocellular carcinoma growth and metastasis through activating Wnt/β-catenin pathway.
Zhang T, Ma Z, Liu L, Sun J, Tang H, Zhang B, Zou Y, Li H., Free PMC Article | 12/7/2019 |
| DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation | The RNA helicase DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation.
Nakata D, Nakao S, Nakayama K, Araki S, Nakayama Y, Aparicio S, Hara T, Nakanishi A. | 06/10/2017 |
| DDX39A is a potential biomarker for unfavorable neuroblastoma | Identification of DDX39A as a Potential Biomarker for Unfavorable Neuroblastoma Using a Proteomic Approach.
Otake K, Uchida K, Ide S, Kobayashi Y, Kobayashi I, Kusunoki M. | 06/4/2016 |
| The protein levels of DDX39 were found to be higher in malignant pleural mesothelioma cell lines compared to normal pleural mesothelial cells. | Up-regulation of DDX39 in human malignant pleural mesothelioma cell lines compared to normal pleural mesothelial cells.
Kuramitsu Y, Tominaga W, Baron B, Tokuda K, Wang Y, Kitagawa T, Nakamura K. | 08/31/2013 |
| Results suggest that DDX39 is a suppressor of invasion and loss of its function predicts disease progression in bladder cancers. | DDX39 acts as a suppressor of invasion for bladder cancer.
Kato M, Wei M, Yamano S, Kakehashi A, Tamada S, Nakatani T, Wanibuchi H., Free PMC Article | 04/13/2013 |
| -dependent RNA helicase DDX39 has a role in poor prognosis of patients with gastrointestinal stromal tumor | Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor.
Kikuta K, Kubota D, Saito T, Orita H, Yoshida A, Tsuda H, Suehara Y, Katai H, Shimada Y, Toyama Y, Sato K, Yao T, Kaneko K, Beppu Y, Murakami Y, Kawai A, Kondo T. | 06/23/2012 |
| Requirement of DDX39 DEAD box RNA helicase for genome integrity and telomere protection | Requirement of DDX39 DEAD box RNA helicase for genome integrity and telomere protection.
Yoo HH, Chung IK. | 12/17/2011 |
| UAP56 and URH49 exhibit an intrinsic CRM1-independent nucleocytoplasmic shuttling | The cellular DExD/H-box RNA-helicases UAP56 and URH49 exhibit a CRM1-independent nucleocytoplasmic shuttling activity.
Thomas M, Lischka P, Müller R, Stamminger T., Free PMC Article | 12/10/2011 |
| Mx proteins exert their antiviral activity against IAV by interfering with the function of the RNA helicases UAP56 and URH49 | Interferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49.
Wisskirchen C, Ludersdorfer TH, Müller DA, Moritz E, Pavlovic J., Free PMC Article | 12/10/2011 |
| Data show that the two closely related RNA helicases UAP56 and URH49 have evolved to form distinct mRNA export machineries, which regulate mitosis at different steps. | The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression.
Yamazaki T, Fujiwara N, Yukinaga H, Ebisuya M, Shiki T, Kurihara T, Kioka N, Kambe T, Nagao M, Nishida E, Masuda S., Free PMC Article | 02/26/2011 |
| Using a UL69 viral mutant that is unable to bind UAP56 and URH49, the authors demonstrated that UL69's interaction with UAP56 or URH49 does not contribute to the growth phenotype associated with the UL69 deletion mutant. | Binding of the human cytomegalovirus (HCMV) tegument protein UL69 to UAP56/URH49 is not required for efficient replication of HCMV.
Kronemann D, Hagemeier SR, Cygnar D, Phillips S, Bresnahan WA., Free PMC Article | 09/27/2010 |
| DDX39 is a novel RNA helicase capable of promoting cancer cell growth | DDX39, upregulated in lung squamous cell cancer, displays RNA helicase activities and promotes cancer cell growth.
Sugiura T, Nagano Y, Noguchi Y. | 01/21/2010 |
| CIP29 physically and functionally associates with DDX39, suggesting their cooperation in the RNA metabolism. | Intracellular characterization of DDX39, a novel growth-associated RNA helicase.
Sugiura T, Sakurai K, Nagano Y. | 01/21/2010 |
| Reducing the expression of UAP56 and URH49 resulted in a reduction in reporter gene expression as well as cell death within 72 h suggest that both helicases have essential but largely overlapping functions in the processing and export of mammalian mRNAs. | Nuclear localization of poly(A)+ mRNA following siRNA reduction of expression of the mammalian RNA helicases UAP56 and URH49.
Kapadia F, Pryor A, Chang TH, Johnson LF. | 01/21/2010 |
| Regulation of URH49 mRNA expression and comparison with the related UAP56 RNA helicase. | Growth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56.
Pryor A, Tung L, Yang Z, Kapadia F, Chang TH, Johnson LF., Free PMC Article | 01/21/2010 |