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    FLOT1 flotillin 1 [ Homo sapiens (human) ]

    Gene ID: 10211, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Circ_0003855 involvement of esophageal cancer progression through miR-622/FLOT1.

    Circ_0003855 involvement of esophageal cancer progression through miR-622/FLOT1.
    Tian J, Hu X, Zhang X., Free PMC Article

    05/2/2024
    Flotillin-1 palmitoylation is essential for its stability and subsequent tumor promoting capabilities.

    Flotillin-1 palmitoylation is essential for its stability and subsequent tumor promoting capabilities.
    McClellan B, Wilson CN, Brenner AJ, Jolly CA, deGraffenried L.

    04/2/2024
    FLOT1 promotes gastric cancer progression and metastasis through BCAR1/ERK signaling.

    FLOT1 promotes gastric cancer progression and metastasis through BCAR1/ERK signaling.
    Wang R, Huang W, Cai K, Xiao S, Zhang W, Hu X, Guo J, Mao L, Yuan W, Xu Y, Chen Z, Chen Z, Lai C., Free PMC Article

    11/21/2023
    The roles of FLOT1 in human diseases (Review).

    The roles of FLOT1 in human diseases (Review).
    Zhan Z, Ye M, Jin X., Free PMC Article

    10/2/2023
    EIF4A3 Acts on the PI3K-AKT-ERK1/2-P70S6K Pathway through FLOT1 to Influence the Development of Lung Adenocarcinoma.

    EIF4A3 Acts on the PI3K-AKT-ERK1/2-P70S6K Pathway through FLOT1 to Influence the Development of Lung Adenocarcinoma.
    Yu W, Liang J, Fang T, Jiang J, Zhao R, Li R, Han J, Tian H., Free PMC Article

    07/7/2023
    FLOT1 knockdown inhibits growth of AML cells through triggering apoptosis and pyroptosis.

    FLOT1 knockdown inhibits growth of AML cells through triggering apoptosis and pyroptosis.
    Mao S, Qian Y, Wei W, Lin X, Ling Q, Ye W, Li F, Pan J, Zhou Y, Zhao Y, Huang X, Huang J, Hu C, Li M, Sun J, Jin J.

    03/9/2023
    Lipid raft protein flotillin-1 is important for the interaction between SOS1 and H-Ras/K-Ras, leading to Ras activation.

    Lipid raft protein flotillin-1 is important for the interaction between SOS1 and H-Ras/K-Ras, leading to Ras activation.
    Jin H, Koh M, Lim H, Yong HY, Kim ES, Kim SY, Kim K, Jung J, Ryu WJ, Choi KY, Moon A.

    03/8/2023
    Flotillin-1 is a prognostic biomarker for glioblastoma and promotes cancer development through enhancing invasion and altering tumour microenvironment.

    Flotillin-1 is a prognostic biomarker for glioblastoma and promotes cancer development through enhancing invasion and altering tumour microenvironment.
    Wang R, Chen Z, Zhang Y, Xiao S, Zhang W, Hu X, Xiao Q, Liu Q, Wang X., Free PMC Article

    02/11/2023
    Flotillin-1 promotes EMT of gastric cancer via stabilizing Snail.

    Flotillin-1 promotes EMT of gastric cancer via stabilizing Snail.
    Huang Y, Guo Y, Xu Y, Liu F, Dai S., Free PMC Article

    01/21/2023
    Flotillin-1 promotes progression and dampens chemosensitivity to cisplatin in gastric cancer via ERK and AKT signaling pathways.

    Flotillin-1 promotes progression and dampens chemosensitivity to cisplatin in gastric cancer via ERK and AKT signaling pathways.
    Wei J, Wang R, Lu Y, He S, Ding Y.

    02/12/2022
    Long non-coding RNA A1BG-AS1 promotes tumorigenesis in breast cancer by sponging microRNA-485-5p and consequently increasing expression of FLOT1 expression.

    Long non-coding RNA A1BG-AS1 promotes tumorigenesis in breast cancer by sponging microRNA-485-5p and consequently increasing expression of FLOT1 expression.
    Cai S, Zhou Y, Pan Y, Liu P, Yu K, Chen S.

    01/1/2022
    Circulating small extracellular vesicles increase after an acute bout of moderate-intensity exercise in pregnant compared to non-pregnant women.

    Circulating small extracellular vesicles increase after an acute bout of moderate-intensity exercise in pregnant compared to non-pregnant women.
    Mohammad S, Hutchinson KA, da Silva DF, Bhattacharjee J, McInnis K, Burger D, Adamo KB., Free PMC Article

    11/6/2021
    MicroRNA4855p suppresses the progression of esophageal squamous cell carcinoma by targeting flotillin1 and inhibits the epithelialmesenchymal transition.

    MicroRNA‑485‑5p suppresses the progression of esophageal squamous cell carcinoma by targeting flotillin‑1 and inhibits the epithelial‑mesenchymal transition.
    Zhao R, Shan Y, Zhou X, Zhang C, Zhao R, Zhao L, Shan B., Free PMC Article

    11/6/2021
    Caveolin-1, tetraspanin CD81 and flotillins in lymphocyte cell membrane organization, signaling and immunopathology.

    Caveolin-1, tetraspanin CD81 and flotillins in lymphocyte cell membrane organization, signaling and immunopathology.
    Schaffer AM, Minguet S.

    08/14/2021
    Flotillin and AP2A1/2 Promote IGF-1 Receptor Association with Clathrin and Internalization in Primary Human Keratinocytes.

    Flotillin and AP2A1/2 Promote IGF-1 Receptor Association with Clathrin and Internalization in Primary Human Keratinocytes.
    Dam DHM, Jelsma SA, Yu JM, Liu H, Kong B, Paller AS., Free PMC Article

    04/3/2021
    Flotillin is a Novel Diagnostic Blood Marker of Alzheimer's Disease.

    Flotillin is a Novel Diagnostic Blood Marker of Alzheimer's Disease.
    Abdullah M, Kimura N, Akatsu H, Hashizume Y, Ferdous T, Tachita T, Iida S, Zou K, Matsubara E, Michikawa M.

    12/5/2020
    analysis of how flotillin-mediated endocytosis and ALIX-syntenin-1-mediated exocytosis protect the cell membrane from damage caused by necroptosis

    Flotillin-mediated endocytosis and ALIX-syntenin-1-mediated exocytosis protect the cell membrane from damage caused by necroptosis.
    Fan W, Guo J, Gao B, Zhang W, Ling L, Xu T, Pan C, Li L, Chen S, Wang H, Zhang J, Wang X.

    07/11/2020
    study identified FLOT1 as a novel MDD risk gene whose expression level may play a role in MDD. In addition, our findings also suggest that risk variants may confer risk of MDD through affecting expression of FLOT1.

    Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder.
    Zhong J, Li S, Zeng W, Li X, Gu C, Liu J, Luo XJ., Free PMC Article

    03/21/2020
    Results show that FLOT1 promotes tumor development, induces epithelial-mesenchymal transition, and modulates the cell cycle in lung adenocarcinoma by simultaneously affecting the Erk and Akt signaling pathways.

    FLOT1 promotes tumor development, induces epithelial-mesenchymal transition, and modulates the cell cycle by regulating the Erk/Akt signaling pathway in lung adenocarcinoma.
    Zhang L, Mao Y, Mao Q, Fan W, Xu L, Chen Y, Xu L, Wang J., Free PMC Article

    03/14/2020
    the presence of Flotillin-1, in addition to Flotillin-2 in the cardiac intercalated disc, is reported.

    Flotillins in the intercalated disc are potential modulators of cardiac excitability.
    Kessler EL, van Stuijvenberg L, van Bavel JJA, van Bennekom J, Zwartsen A, Rivaud MR, Vink A, Efimov IR, Postma AV, van Tintelen JP, Remme CA, Vos MA, Banning A, de Boer TP, Tikkanen R, van Veen TAB.

    01/11/2020
    FLOT1 protein expression was significantly associated with serous epithelial ovarian tumor

    Flotillin 1 is differentially expressed in human epithelial ovarian tumors.
    Li J, Zuo X, Shi J, Zhang J, Duan X, Xu G.

    07/6/2019
    A new mechanism of sumoylated Flot-1-mediating Snail stabilization is presented.

    Sumoylation of Flotillin-1 promotes EMT in metastatic prostate cancer by suppressing Snail degradation.
    Jang D, Kwon H, Choi M, Lee J, Pak Y., Free PMC Article

    05/25/2019
    Together, the data revealed that FLOT1 and FLOT2 are crucial for Anaplasma replication in host cells, likely by aiding vesicular traffic of low-density lipoprotein-derived free cholesterol to Anaplasma inclusions.

    Infection by Anaplasma phagocytophilum Requires Recruitment of Low-Density Lipoprotein Cholesterol by Flotillins.
    Xiong Q, Lin M, Huang W, Rikihisa Y., Free PMC Article

    05/18/2019
    Results showed that flotillin-1 and flotillin-2 expression were upregulated in HCCLM3 cells following 45 degrees C heat treatment and in residual HCCLM3 xenografts cells after insufficient RFA.

    Insufficient radiofrequency ablation promotes the metastasis of residual hepatocellular carcinoma cells via upregulating flotillin proteins.
    Zhang N, Li H, Qin C, Ma D, Zhao Y, Zhu W, Wang L., Free PMC Article

    04/20/2019
    flotillin-1 is a tumorigenic protein that plays an important role in promoting the proliferation and tumorigenicity of LUAD.

    Flotilin-1 promotes the tumorigenicity and progression of malignant phenotype in human lung adenocarcinoma.
    Guo AY, Liang XJ, Liu RJ, Li XX, Bi W, Zhou LY, Tang CE, Yan A, Chen ZC, Zhang PF., Free PMC Article

    08/4/2018
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