| Inhibition of Crif1 protects fatty acid-induced POMC neuron-like cell-line damage by increasing CPT-1 function. | Inhibition of Crif1 protects fatty acid-induced POMC neuron-like cell-line damage by increasing CPT-1 function.
Regina-Ferreira L, Valdivieso-Rivera F, Angelim MKSC, Menezes Dos Reis L, Furino VO, Morari J, Maia de Sousa L, Consonni SR, Sponton CH, Moraes-Vieira PM, Velloso LA. | 06/3/2024 |
| Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism. | Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism.
Heo JY, Park AH, Lee MJ, Ryu MJ, Kim YK, Jang YS, Kim SJ, Shin SY, Son HJ, Stein TD, Huh YH, Chung SK, Choi SY, Kim JM, Hwang O, Shong M, Hyeon SJ, Lee J, Ryu H, Kim D, Kweon GR. | 02/1/2024 |
| CRIF1 promotes the progression of non-small-cell lung cancer by SIRT3- mediated deacetylation of PYCR1. | CRIF1 promotes the progression of non-small-cell lung cancer by SIRT3- mediated deacetylation of PYCR1.
Wang Q, Xie Z, Li C, Xu C, Ding C, Ju S, Chen J, Cui Z, Chen C, Gu B, Wei T, Zhao J. | 09/10/2022 |
| B Cell-Specific Deletion of CR6-Interacting Factor 1 Drives Lupus-like Autoimmunity by Activation of Interleukin-17, Interleukin-6, and Pathogenic Follicular Helper T Cells in a Mouse Model. | B Cell-Specific Deletion of CR6-Interacting Factor 1 Drives Lupus-like Autoimmunity by Activation of Interleukin-17, Interleukin-6, and Pathogenic Follicular Helper T Cells in a Mouse Model.
Park JS, Yang S, Hwang SH, Choi J, Kwok SK, Kong YY, Youn J, Cho ML, Park SH. | 07/2/2022 |
| Collecting Duct-Specific CR6-Interacting Factor-1-Deletion Aggravates Renal Inflammation and Fibrosis Induced by Unilateral Ureteral Obstruction. | Collecting Duct-Specific CR6-Interacting Factor-1-Deletion Aggravates Renal Inflammation and Fibrosis Induced by Unilateral Ureteral Obstruction.
Jeong JY, Na KR, Shin JA, Suh KS, Kim JJ, Lee KW, Choi DE., Free PMC Article | 12/25/2021 |
| Mitochondrial Dysfunction in Podocytes Caused by CRIF1 Deficiency Leads to Progressive Albuminuria and Glomerular Sclerosis in Mice. | Mitochondrial Dysfunction in Podocytes Caused by CRIF1 Deficiency Leads to Progressive Albuminuria and Glomerular Sclerosis in Mice.
Na KR, Jeong JY, Shin JA, Chang YK, Suh KS, Lee KW, Choi DE., Free PMC Article | 06/26/2021 |
| An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models. | An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models.
Choi MJ, Jung SB, Lee SE, Kang SG, Lee JH, Ryu MJ, Chung HK, Chang JY, Kim YK, Hong HJ, Kim H, Kim HJ, Lee CH, Mardinoglu A, Yi HS, Shong M. | 04/3/2021 |
| HFSC populations were maintained in Crif1 K15icKO mice. Results suggest that mitochondrial function in HFSCs is important for the progression of hair growth cycle, but not for maintenance of HFSCs. | Deficiency of Crif1 in hair follicle stem cells retards hair growth cycle in adult mice.
Shin JM, Ko JW, Choi CW, Lee Y, Seo YJ, Lee JH, Kim CD., Free PMC Article | 07/25/2020 |
| To investigate the impact of loss of CRIF1 in T cells, we generated a conditional CRIF1 gene ablation model using CD4-cre transgenic mice and examined the frequency of Th17 cells and regulatory T cells. | CR6-interacting factor 1 controls autoimmune arthritis by regulation of signal transducer and activator of transcription 3 pathway and T helper type 17 cells.
Park JS, Choi SY, Hwang SH, Kim SM, Choi J, Jung KA, Kwon JY, Kong YY, Cho ML, Park SH., Free PMC Article | 09/21/2019 |
| Crif1(beta-/-) mouse is a useful model for the study of beta cell failure caused by mitochondrial OxPhos dysfunction. | Disruption of CR6-interacting factor-1 (CRIF1) in mouse islet beta cells leads to mitochondrial diabetes with progressive beta cell failure.
Kim YK, Joung KH, Ryu MJ, Kim SJ, Kim H, Chung HK, Lee MH, Lee SE, Choi MJ, Chang JY, Hong HJ, Kim KS, Lee SH, Kweon GR, Kim H, Lee CH, Kim HJ, Shong M. | 12/5/2015 |
| The results identify the ROS-Sp1-Crif1 pathway to be a new mechanism underlying Abeta-induced mitochondrial dysfunction and suggest that ROS-mediated downregulation of Crif1 is a crucial event in AD pathology. | CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer's disease.
Byun J, Son SM, Cha MY, Shong M, Hwang YJ, Kim Y, Ryu H, Moon M, Kim KS, Mook-Jung I., Free PMC Article | 10/31/2015 |
| CRIF1 knockdown partially induces endothelial activation via increased ROS production and phosphorylation of p66shc | CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation.
Nagar H, Jung SB, Kwon SK, Park JB, Shong M, Song HJ, Jeon BH, Irani K, Kim CS., Free PMC Article | 01/31/2015 |
| Study showed that loss of Crif1 impairs mitochondrial oxidative phosphorylation and adipocyte differentiation in vitro and in vivo. | Mitochondrial oxidative phosphorylation reserve is required for hormone- and PPARγ agonist-induced adipogenesis.
Ryu MJ, Kim SJ, Choi MJ, Kim YK, Lee MH, Lee SE, Chung HK, Jung SB, Kim HJ, Kim KS, Jo YS, Kweon GR, Lee CH, Shong M., Free PMC Article | 11/22/2014 |
| Crif1 plays a critical role in the maintenance of both mitochondrial structure and respiration in cardiac muscles. | Cardiomyocyte specific deletion of Crif1 causes mitochondrial cardiomyopathy in mice.
Shin J, Lee SH, Kwon MC, Yang DK, Seo HR, Kim J, Kim YY, Im SK, Abel ED, Kim KT, Park WJ, Kong YY., Free PMC Article | 07/6/2013 |
| Although adipose-specific Crif1-haploinsufficient mice showed normal growth and development, they became insulin-resistant. | Crif1 deficiency reduces adipose OXPHOS capacity and triggers inflammation and insulin resistance in mice.
Ryu MJ, Kim SJ, Kim YK, Choi MJ, Tadi S, Lee MH, Lee SE, Chung HK, Jung SB, Kim HJ, Jo YS, Kim KS, Lee SH, Kim JM, Kweon GR, Park KC, Lee JU, Kong YY, Lee CH, Chung J, Shong M., Free PMC Article | 06/15/2013 |
| CRIF1 is essential for the synthesis and insertion of oxidative phosphorylation polypeptides in the mammalian mitochondrial membrane. | CRIF1 is essential for the synthesis and insertion of oxidative phosphorylation polypeptides in the mammalian mitochondrial membrane.
Kim SJ, Kwon MC, Ryu MJ, Chung HK, Tadi S, Kim YK, Kim JM, Lee SH, Park JH, Kweon GR, Ryu SW, Jo YS, Lee CH, Hatakeyama H, Goto Y, Yim YH, Chung J, Kong YY, Shong M. | 01/12/2013 |
| Results reveal that Crif1 is a novel and essential transcriptional coactivator of Elf3 for the terminal differentiation of absorptive enterocytes. | Essential role of CR6-interacting factor 1 (Crif1) in E74-like factor 3 (ELF3)-mediated intestinal development.
Kwon MC, Koo BK, Kim YY, Lee SH, Kim NS, Kim JH, Kong YY., Free PMC Article | 01/25/2010 |
| Crif1 is a novel and essential transcriptional coactivator of STAT3 that modulates its DNA binding ability. | Crif1 is a novel transcriptional coactivator of STAT3.
Kwon MC, Koo BK, Moon JS, Kim YY, Park KC, Kim NS, Kwon MY, Kong MP, Yoon KJ, Im SK, Ghim J, Han YM, Jang SK, Shong M, Kong YY., Free PMC Article | 01/21/2010 |