| UBE2T mediates SORBS3 ubiquitination to enhance IL-6/STAT3 signaling and promote lung adenocarcinoma progression. | UBE2T mediates SORBS3 ubiquitination to enhance IL-6/STAT3 signaling and promote lung adenocarcinoma progression.
Pu J, Wang B, Zhang D, Wang K, Yang Z, Zhu P, Song Q. | 09/23/2024 |
| Increased SORBS3 expression in brain ageing contributes to autophagic decline via YAP1-WWTR1/TAZ signaling. | Increased SORBS3 expression in brain ageing contributes to autophagic decline via YAP1-WWTR1/TAZ signaling.
Park SJ, Frake RA, Rubinsztein DC., Free PMC Article | 02/27/2023 |
| Vinexin contributes to autophagic decline in brain ageing across species. | Vinexin contributes to autophagic decline in brain ageing across species.
Park SJ, Frake RA, Karabiyik C, Son SM, Siddiqi FH, Bento CF, Sterk P, Vicinanza M, Pavel M, Rubinsztein DC., Free PMC Article | 05/21/2022 |
| Vinexin beta deficiency attenuates atherogenesis primarily by suppressing vascular inflammation and inactivating Akt-nuclear factor kappaB signaling. Our data suggest that vinexin beta could be a therapeutic target for the treatment of atherosclerosis. | Vinexin β Ablation Inhibits Atherosclerosis in Apolipoprotein E-Deficient Mice by Inactivating the Akt-Nuclear Factor κB Inflammatory Axis.
Guan H, Cheng WL, Guo J, Chao ML, Zhang Y, Gong J, Zhu XY, She ZG, Huang Z, Li H., Free PMC Article | 02/24/2018 |
| The chromosome 8p tumor suppressor genes SORBS3 and SH2D4A are physically and functionally linked and provide a molecular mechanism of inhibiting STAT3-mediated IL-6 signaling in hepatocellular carcinoma cells. | Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma.
Ploeger C, Waldburger N, Fraas A, Goeppert B, Pusch S, Breuhahn K, Wang XW, Schirmacher P, Roessler S., Free PMC Article | 08/5/2017 |
| Study identified possible epigenetic influence on differential gene expression in SORBS3 under obese conditions. | Next-generation sequencing methylation profiling of subjects with obesity identifies novel gene changes.
Day SE, Coletta RL, Kim JY, Campbell LE, Benjamin TR, Roust LR, De Filippis EA, Dinu V, Shaibi GQ, Mandarino LJ, Coletta DK., Free PMC Article | 12/17/2016 |
| Our findings revealed that Vinexin-beta acts as a novel modulator of ischaemic injury | Vinexin-β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis.
Li M, Guo S, Zhang P, Gong J, Zheng A, Zhang Y, Li H. | 09/26/2015 |
| Taken together, the findings suggest that vinexin beta modulates NS5A phosphorylation via its interaction with NS5A, thereby regulating hepatitis C virus replication, implicating vinexin beta in the viral life cycle. | Vinexin β Interacts with Hepatitis C Virus NS5A, Modulating Its Hyperphosphorylation To Regulate Viral Propagation.
Xiong W, Yang J, Wang M, Wang H, Rao Z, Zhong C, Xin X, Mo L, Yu S, Shen C, Zheng C., Free PMC Article | 09/5/2015 |
| Vinexin knockdown using siRNA delayed migration of both HaCaT human keratinocytes and A431 epidermoid carcinoma cells in scratch assay but did not affect cell proliferation. | Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo.
Kioka N, Ito T, Yamashita H, Uekawa N, Umemoto T, Motoyoshi S, Imai H, Takahashi K, Watanabe H, Yamada M, Ueda K. | 06/28/2010 |
| Rhotekin forms a complex with vinexin and may play a role at focal adhesions. | Interaction of a multi-domain adaptor protein, vinexin, with a Rho-effector, Rhotekin.
Nagata K, Ito H, Iwamoto I, Morishita R, Asano T. | 01/21/2010 |
| Vinexin is enriched at the leading edge of migrating cells, lamellipodia and and focal adhesions in well-spread cells. | Essential roles of ERK-mediated phosphorylation of vinexin in cell spreading, migration and anchorage-independent growth.
Mizutani K, Ito H, Iwamoto I, Morishita R, Deguchi T, Nozawa Y, Asano T, Nagata KI. | 01/21/2010 |
| These results suggest that vinexin beta plays a role in maintaining the phosphorylation of EGFR on the plasma membrane through the regulation of c-Cbl. | Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface.
Mitsushima M, Ueda K, Kioka N. | 01/21/2010 |
| regulates cytoskeletal organization and signal transduction--review | [A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2].
Kioka N. | 01/21/2010 |
| vinexin is a novel substrate of ERK2 and may play roles in ERK-dependent cell regulation | Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin.
Mitsushima M, Suwa A, Amachi T, Ueda K, Kioka N. | 01/21/2010 |
| phosphorylation of the AF-1 domain controls RARgamma-mediated transcription through triggering the dissociation of vinexin beta | Vinexin beta interacts with the non-phosphorylated AF-1 domain of retinoid receptor gamma (RARgamma) and represses RARgamma-mediated transcription.
Bour G, Plassat JL, Bauer A, Lalevée S, Rochette-Egly C. | 01/21/2010 |