| Human Caspase 12 Enhances NF-kappaB Activity through Activation of IKK in Nasopharyngeal Carcinoma Cells. | Human Caspase 12 Enhances NF-κB Activity through Activation of IKK in Nasopharyngeal Carcinoma Cells.
Chow SE, Chien HT, Chu WK, Lin V, Shen TH, Huang SF., Free PMC Article | 05/29/2021 |
| Analysis of CASP12 diagnostic and prognostic values in cervical cancer based on TCGA database. | Analysis of CASP12 diagnostic and prognostic values in cervical cancer based on TCGA database.
Feng G, Beilei Z, Caizhi C, Wen Z., Free PMC Article | 09/26/2020 |
| The expression of three genes (STK26, KCNT2, CASP12) was correlated with the prognosis of skin cutaneous melanoma (SCM). STK26 and KCNT2 were significantly different between normal skin and SCM. These three hub genes have potential value as predictors for accurate diagnosis and prognosis of SCM in the future. | Common Nevus and Skin Cutaneous Melanoma: Prognostic Genes Identified by Gene Co-Expression Network Analysis.
Yang L, Xu Y, Yan Y, Luo P, Chen S, Zheng B, Yan W, Chen Y, Wang C., Free PMC Article | 03/21/2020 |
| study indicated the potential effect of Casp12 was on the activation of NF-kappaB by the degradation of IkappaBalpha in NPC cells. | Caspase 12 degrades IκBα protein and enhances MMP-9 expression in human nasopharyngeal carcinoma cell invasion.
Chu WK, Hsu CC, Huang SF, Hsu CC, Chow SE., Free PMC Article | 03/10/2018 |
| CASP12 genotype thus does not influence the phenotype of systemic lupus erythematosus in African-Americans | The anti-inflammatory CASPASE-12 gene does not influence SLE phenotype in African-Americans.
Fuchs T, Kelly JA, Simon E, Sivils KL, Hermel E. | 10/21/2017 |
| Endoplasmic reticulum stress may be associated with apoptosis of LECs, resulting in cataract formation in diabetic patients. | Calpain and Caspase-12 Expression in Lens Epithelial Cells of Diabetic Cataracts.
Ahn YJ, Kim MS, Chung SK. | 05/6/2017 |
| Endoplasmic reticulum stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy. | ER stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.
Liu L, Liu C, Lu Y, Liu L, Jiang Y., Free PMC Article | 06/4/2016 |
| Expression of caspase-12 was linked to decreased systemic and adipose tissue inflammation in a cohort of African American obese children. | Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance.
Skeldon AM, Morizot A, Douglas T, Santoro N, Kursawe R, Kozlitina J, Caprio S, Mehal WZ, Saleh M., Free PMC Article | 05/21/2016 |
| We found that RNA interference-induced Caspase-12 silencing increased NOD1, hBD1 and hBD2 expression | Caspase-12 silencing attenuates inhibitory effects of cigarette smoke extract on NOD1 signaling and hBDs expression in human oral mucosal epithelial cells.
Wang X, Qian YJ, Zhou Q, Ye P, Duan N, Huang XF, Zhu YN, Li JJ, Hu LP, Zhang WY, Han XD, Wang WM., Free PMC Article | 12/26/2015 |
| conclude that the functional CASP12L allele is not a marker for susceptibility and/or severity of CAP | Lack of association of the caspase-12 long allele with community-acquired pneumonia in people of African descent.
Chen J, Wilson ES, Dahmer MK, Quasney MW, Waterer GW, Feldman C, Wunderink RG., Free PMC Article | 01/10/2015 |
| EtOH-induced activation of caspase-12 could be one of the underlying mechanisms of hepatocyte apoptosis. | The resveratrol attenuates ethanol-induced hepatocyte apoptosis via inhibiting ER-related caspase-12 activation and PDE activity in vitro.
Liu LQ, Fan ZQ, Tang YF, Ke ZJ. | 11/22/2014 |
| Distribution of CASP12 alleles (#rs497116) in African-Americans (AA) with rheumatoid arthritis (RA). There was no difference in the overall distribution of genotypes within AA with RA, but homozygous patients had lower baseline joint-narrowing scores. | CASPASE-12 and rheumatoid arthritis in African-Americans.
Marshall L, Obaidullah M, Fuchs T, Fineberg NS, Brinkley G, Mikuls TR, Bridges SL Jr, Hermel E., Free PMC Article | 05/17/2014 |
| CASPASE-12 does not influence the susceptibility to Candida sepsis, nor has any effect on the serum cytokine concentrations in Candida sepsis patients during the course of infection. | The impact of caspase-12 on susceptibility to candidemia.
Rosentul DC, Plantinga TS, Scott WK, Alexander BD, van de Geer NM, Perfect JR, Kullberg BJ, Johnson MD, Netea MG., Free PMC Article | 06/30/2012 |
| examines the role that CASP12 plays in down-regulating inflammation, we hypothesize that pathogens which exploit the inflammatory response are restrained by an active CASP12 gene product | A possible mechanism for maintenance of the deleterious allele of human CASPASE-12.
Hermel E, Klapstein KD. | 02/4/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesGenetic variation of innate immune genes in HIV-infected african patients with or without oropharyngeal candidiasis.
Plantinga TS, Hamza OJ, Willment JA, Ferwerda B, van de Geer NM, Verweij PE, Matee MI, Banahan K, O'neill LA, Kullberg BJ, Brown GD, van der Ven AJ, Netea MG. Persistence of full-length caspase-12 and its relation to malaria in West and Central African populations.
McCall MB, Ferwerda B, Hopman J, Ploemen I, Maiga B, Daou M, Dolo A, Hermsen CC, Doumbo OK, Bedu-Addo G, van der Meer JW, Troye-Blomberg M, van der Ven AJ, Schumann RR, Sauerwein RW, Mockenhaupt FP, Netea MG. Examination of association with candidate genes for diabetic nephropathy in a Mexican American population.
Kim S, Abboud HE, Pahl MV, Tayek J, Snyder S, Tamkin J, Alcorn H Jr, Ipp E, Nast CC, Elston RC, Iyengar SK, Adler SG. | 02/15/2011 |
| Observational study of genotype prevalence. (HuGE Navigator) | Population distribution of the functional caspase-12 allele.
Kachapati K, O'Brien TR, Bergeron J, Zhang M, Dean M. | 02/15/2011 |
| Reactive oxygen species promote caspase-12 expression and tubular apoptosis in diabetic nephropathy. | Reactive oxygen species promote caspase-12 expression and tubular apoptosis in diabetic nephropathy.
Brezniceanu ML, Lau CJ, Godin N, Chénier I, Duclos A, Ethier J, Filep JG, Ingelfinger JR, Zhang SL, Chan JS., Free PMC Article | 02/15/2011 |
| the NOD2/RIP2 pathway has a role in recognition of Yersinia, but caspase-12 does not modulate innate host defense against Y. pestis | Caspase-12 and the inflammatory response to Yersinia pestis.
Ferwerda B, McCall MB, de Vries MC, Hopman J, Maiga B, Dolo A, Doumbo O, Daou M, de Jong D, Joosten LA, Tissingh RA, Reubsaet FA, Sauerwein R, van der Meer JW, van der Ven AJ, Netea MG., Free PMC Article | 02/15/2011 |
| hRPE cells express a high level of caspase-12S. The regulated expression of caspase-12S suggests that this caspase recruitment domain (CARD)-only protein may be an endogenous dominant negative regulator that modulates inflammatory responses in hRPE cells. | Regulated expression of caspase-12 gene in human retinal pigment epithelial cells suggests its immunomodulating role.
Bian ZM, Elner SG, Elner VM., Free PMC Article | 02/15/2011 |
| proteolytic activity of caspase-12 is confined to its own proenzyme | Confinement of caspase-12 proteolytic activity to autoprocessing.
Roy S, Sharom JR, Houde C, Loisel TP, Vaillancourt JP, Shao W, Saleh M, Nicholson DW., Free PMC Article | 02/15/2011 |
| Constitutively active forms of caspase-12 (rev-Deltapro1 and rev-Deltapro2) could induce cell death in cells transfected with the corresponding expression vectors. | Purification of catalytically active caspase-12 and its biochemical characterization.
Lee HJ, Lee SH, Park SH, Sharoar MG, Shin SY, Lee JS, Cho B, Park IS. | 02/15/2011 |
| Na/Ca exchanger overexpression activates caspase-12 | Na/Ca exchanger overexpression induces endoplasmic reticulum stress, caspase-12 release, and apoptosis.
Díaz-Horta O, Van Eylen F, Herchuelz A. | 02/15/2011 |
| The activation of caspase-9 and depolarization of mitochondrial membrane potential were induced by BIK, which were decreased concomitant with caspase-12 silenced. | Apoptosis induced by BIK was decreased with RNA interference of caspase-12.
Zhao X, Sun Y, Yu H, Ye L, Zhang L, Lu J, Yuan Y, Qian G, Ge S. | 02/15/2011 |
| caspase 12 has acquired deleterious mutations | Human caspase 12 has acquired deleterious mutations.
Fischer H, Koenig U, Eckhart L, Tschachler E. | 02/15/2011 |
| Csp12-L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis | Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.
Saleh M, Vaillancourt JP, Graham RK, Huyck M, Srinivasula SM, Alnemri ES, Steinberg MH, Nolan V, Baldwin CT, Hotchkiss RS, Buchman TG, Zehnbauer BA, Hayden MR, Farrer LA, Roy S, Nicholson DW. | 02/15/2011 |