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    OCLN occludin [ Homo sapiens (human) ]

    Gene ID: 100506658, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Association of serum occludin levels and perihematomal edema volumes in intracranial hemorrhage patients.

    Association of serum occludin levels and perihematomal edema volumes in intracranial hemorrhage patients.
    Yuan S, Ma Q, Hou C, Zhao Y, Liu KJ, Ji X, Qi Z., Free PMC Article

    03/12/2024
    Occludin is overexpressed in tubo-ovarian high-grade serous carcinoma compared to mesothelioma and is a marker of tumor progression and chemoresistance.

    Occludin is overexpressed in tubo-ovarian high-grade serous carcinoma compared to mesothelioma and is a marker of tumor progression and chemoresistance.
    Dos Santos MV, Holth A, Bischof K, Davidson B., Free PMC Article

    02/9/2024
    Roles of epidermal growth factor receptor, claudin-1 and occludin in multi-step entry of hepatitis C virus into polarized hepatoma spheroids.

    Roles of epidermal growth factor receptor, claudin-1 and occludin in multi-step entry of hepatitis C virus into polarized hepatoma spheroids.
    So CW, Sourisseau M, Sarwar S, Evans MJ, Randall G., Free PMC Article

    01/16/2024
    Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder.

    Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder.
    Bilgiç A, Ferahkaya H, Karagöz H, Kılınç İ, Energin VM.

    10/26/2023
    Hepatitis C Virus Disrupts Annexin 5-Mediated Occludin Integrity through Downregulation of Protein Kinase Calpha (PKCalpha) and PKCeta Expression, Thereby Promoting Viral Propagation.

    Hepatitis C Virus Disrupts Annexin 5-Mediated Occludin Integrity through Downregulation of Protein Kinase Cα (PKCα) and PKCη Expression, Thereby Promoting Viral Propagation.
    Abe T, Marutani Y, Deng L, Matsui C, Fukasawa M, Suzuki R, Wakita T, Matsuura Y, Shoji I., Free PMC Article

    07/12/2023
    Tight junction protein occludin is an internalization factor for SARS-CoV-2 infection and mediates virus cell-to-cell transmission.

    Tight junction protein occludin is an internalization factor for SARS-CoV-2 infection and mediates virus cell-to-cell transmission.
    Zhang J, Yang W, Roy S, Liu H, Roberts RM, Wang L, Shi L, Ma W., Free PMC Article

    05/9/2023
    [Porphyromonas gingivalis infection causes umbilical vein endothelial barrier dysfunction in vitro by down-regulating ZO-1, occludin and VE-cadherin expression].

    [Porphyromonas gingivalis infection causes umbilical vein endothelial barrier dysfunction in vitro by down-regulating ZO-1, occludin and VE-cadherin expression].
    Zeng J, Li X, Yin L, Chen T, Hou J., Free PMC Article

    03/27/2023
    The role of mir-197-3p in regulating the tight junction permeability of celiac disease patients under gluten free diet.

    The role of mir-197-3p in regulating the tight junction permeability of celiac disease patients under gluten free diet.
    Asri N, Fallah S, Rostami-Nejad M, Fallah Z, Khanlari-Kochaksaraei M, Jafari-Marandi S, Forouzesh F, Shahrokh S, Jahani-Sherafat S, Zali MR.

    03/16/2023
    Does the Blood-Brain Barrier Integrity Change in Regard to the Onset of Fetal Growth Restriction?

    Does the Blood-Brain Barrier Integrity Change in Regard to the Onset of Fetal Growth Restriction?
    Misan N, Michalak S, Kapska K, Osztynowicz K, Ropacka-Lesiak M, Kawka-Paciorkowska K., Free PMC Article

    02/28/2023
    MiR-224-5p Targeting OCLN Promotes the Proliferation, Migration, and Invasion of Clear Cell Renal Cell Carcinoma Cells.

    MiR-224-5p Targeting OCLN Promotes the Proliferation, Migration, and Invasion of Clear Cell Renal Cell Carcinoma Cells.
    Liu Y, Nie H, Zhang Y, Zhang N, Han M, Liu H, Sun D, Wu X, Xiao X, Cao X.

    11/19/2022
    Occludin stalls HCV particle dynamics apart from hepatocyte tight junctions, promoting virion internalization.

    Occludin stalls HCV particle dynamics apart from hepatocyte tight junctions, promoting virion internalization.
    Deffieu MS, Clément CMH, Dorobantu CM, Partiot E, Bare Y, Faklaris O, Rivière B, Ayala-Nunez NV, Baumert TF, Rondé P, Mély Y, Lucansky V, Gaudin R.

    10/15/2022
    Application of quantitative immunofluorescence assays to analyze the expression of cell contact proteins during Zika virus infections.

    Application of quantitative immunofluorescence assays to analyze the expression of cell contact proteins during Zika virus infections.
    Leiva S, Dizanzo MP, Fabbri C, Bugnon Valdano M, Luppo V, Levis S, Cavatorta AL, Morales MA, Gardiol D.

    04/30/2022
    Occludin facilitates tumour angiogenesis in bladder cancer by regulating IL8/STAT3 through STAT4.

    Occludin facilitates tumour angiogenesis in bladder cancer by regulating IL8/STAT3 through STAT4.
    Yang F, Liu XQ, He JZ, Xian SP, Yang PF, Mai ZY, Li M, Liu Y, Zhang XD., Free PMC Article

    04/16/2022
    Occludin Promotes Adhesion of CD8(+) T Cells and Melanocytes in Vitiligo via the HIF-1alpha Signaling Pathway.

    Occludin Promotes Adhesion of CD8(+) T Cells and Melanocytes in Vitiligo via the HIF-1α Signaling Pathway.
    Zou P, Xiao Y, Deng Q, Shi Y, You R, Pi Z, Liu J, Zhan Y, Zeng Q, Zeng Z, Xiao R., Free PMC Article

    03/19/2022
    OCLN gene variants identified in three patients with severe neurodevelopmental disorder associated with epilepsy, intellectual disability and malformation of cortical development.

    OCLN gene variants identified in three patients with severe neurodevelopmental disorder associated with epilepsy, intellectual disability and malformation of cortical development.
    Oner TO, Unalp A, Hiz S, Bayram E, Kaytan I, Cingoz S.

    03/12/2022
    Compromised barrier integrity of human feto-placental vessels from gestational diabetic pregnancies is related to downregulation of occludin expression.

    Compromised barrier integrity of human feto-placental vessels from gestational diabetic pregnancies is related to downregulation of occludin expression.
    Villota SD, Toledo-Rodriguez M, Leach L., Free PMC Article

    01/8/2022
    Reduced occludin and claudin-7 expression is associated with urban locations and exposure to second-hand smoke in allergic rhinitis patients.

    Reduced occludin and claudin-7 expression is associated with urban locations and exposure to second-hand smoke in allergic rhinitis patients.
    Nur Husna SM, Siti Sarah CO, Tan HT, Md Shukri N, Mohd Ashari NS, Wong KK., Free PMC Article

    08/14/2021
    Peripheral Blood Occludin Level as a Biomarker for Perioperative Cerebral Edema in Patients with Brain Tumors.

    Peripheral Blood Occludin Level as a Biomarker for Perioperative Cerebral Edema in Patients with Brain Tumors.
    Shi S, Cheng J, Zhang C, Liang T, Zhang Y, Sun Y, Zhao Y, Li W, Wang B., Free PMC Article

    07/3/2021
    Occludin, caveolin-1, and Alix form a multi-protein complex and regulate HIV-1 infection of brain pericytes.

    Occludin, caveolin-1, and Alix form a multi-protein complex and regulate HIV-1 infection of brain pericytes.
    Torices S, Roberts SA, Park M, Malhotra A, Toborek M., Free PMC Article

    04/24/2021
    A homozygote frameshift mutation in OCLN gene result in Pseudo-TORCH syndrome type I: A case report extending the phenotype with central diabetes insipidus and renal dysfunction.

    A homozygote frameshift mutation in OCLN gene result in Pseudo-TORCH syndrome type I: A case report extending the phenotype with central diabetes insipidus and renal dysfunction.
    Ekinci F, Yildizdas RD, Horoz OO, Herguner O, Bisgin A.

    01/2/2021
    Progesterone decreases gut permeability through upregulating occludin expression in primary human gut tissues and Caco-2 cells.

    Progesterone decreases gut permeability through upregulating occludin expression in primary human gut tissues and Caco-2 cells.
    Zhou Z, Bian C, Luo Z, Guille C, Ogunrinde E, Wu J, Zhao M, Fitting S, Kamen DL, Oates JC, Gilkeson G, Jiang W., Free PMC Article

    10/24/2020
    miR-424-5p could affect the expression of tight junction proteins, ZO-1 and occludin, via Endophilin-1, and thereby regulate blood brain barrier (BBB) permeability in an BBB model in vitro with Amyloid-beta incubated endothelial cells.

    miR-424-5p maybe regulate blood-brain barrier permeability in a model in vitro with Abeta incubated endothelial cells.
    Lin M, Zhu L, Wang J, Xue Y, Shang X.

    05/30/2020
    Eighteen residues in the c-terminus are essential for occludin trafficking and hepatitis C virus infection.

    Role of the cytosolic domain of occludin in trafficking and hepatitis C virus infection.
    Lavie M, Linna L, Moustafa RI, Belouzard S, Fukasawa M, Dubuisson J.

    05/16/2020
    OCLN interacted with mitotic spindle regulators, NuMA and RAN, while full-length OCLN loss impaired spindle pole morphology, astral and mitotic microtubule integrity.

    Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex.
    Bendriem RM, Singh S, Aleem AA, Antonetti DA, Ross ME., Free PMC Article

    05/16/2020
    These results suggest that HO-1 protects the function of placental cells in oxidative stress via regulating ZO-1/occludin.

    Activation of HO-1 protects placental cells function in oxidative stress via regulating ZO-1/occludin.
    Li J, Zhou J, Tian B, Chu Y, Zhang N, Hu X, Wan X, Ye Y.

    01/18/2020
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