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    LINC00673 long intergenic non-protein coding RNA 673 [ Homo sapiens (human) ]

    Gene ID: 100499467, updated on 17-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Linc00673-V3 positively regulates autophagy by promoting Smad3-mediated LC3B transcription in NSCLC.

    Linc00673-V3 positively regulates autophagy by promoting Smad3-mediated LC3B transcription in NSCLC.
    Ni H, Tang S, Lu G, Niu Y, Xu J, Zhang H, Hu J, Shen HM, Wu Y, Xia D., Free PMC Article

    03/31/2024
    A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers.

    A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers.
    Cheng R, Li F, Zhang M, Xia X, Wu J, Gao X, Zhou H, Zhang Z, Huang N, Yang X, Zhang Y, Shen S, Kang T, Liu Z, Xiao F, Yao H, Xu J, Yan C, Zhang N., Free PMC Article

    01/14/2023
    Genetic Polymorphisms of lncRNA LINC00673 as Predictors of Hepatocellular Carcinoma Progression in an Elderly Population.

    Genetic Polymorphisms of lncRNA LINC00673 as Predictors of Hepatocellular Carcinoma Progression in an Elderly Population.
    Yuan LT, Yang YC, Lee HL, Shih PC, Chen LH, Tang CH, Chang LC, Wang HL, Yang SF, Chien MH., Free PMC Article

    11/19/2022
    Association between the LINC00673 rs11655237 C> T polymorphisms with cancer risk in the Chinese population: A meta-analysis.

    Association between the LINC00673 rs11655237 C> T polymorphisms with cancer risk in the Chinese population: A meta-analysis.
    Zhang H, Wu B, Liang K, Ke L, Ma X, Luo C, He Y., Free PMC Article

    10/22/2022
    [Effects of long-chain noncoding RNA Linc00673 overexpression on proliferation and apoptosis of gastric cancer cell line MGC-803].

    [Effects of long-chain noncoding RNA Linc00673 overexpression on proliferation and apoptosis of gastric cancer cell line MGC-803].
    Guo HY, Xu YR, Li GH, Sun XJ, Zhao ZL, Wu Q, Liu B.

    06/11/2022
    A review of linc00673 as a novel lncRNA for tumor regulation.

    A review of linc00673 as a novel lncRNA for tumor regulation.
    Zhu K, Gong Z, Li P, Jiang X, Zeng Z, Xiong W, Yu J., Free PMC Article

    09/18/2021
    Association of LINC00673 rs11655237 polymorphism with cancer susceptibility: A meta-analysis based on 23,478 subjects.

    Association of LINC00673 rs11655237 polymorphism with cancer susceptibility: A meta-analysis based on 23,478 subjects.
    Li N, Cui Z, Huang D, Gao M, Li S, Song M, Wang Y, Tong L, Yin Z.

    09/18/2021
    Long non-coding RNA LINC00673 silencing inhibits proliferation and drug resistance of prostate cancer cells via decreasing KLF4 promoter methylation.

    Long non-coding RNA LINC00673 silencing inhibits proliferation and drug resistance of prostate cancer cells via decreasing KLF4 promoter methylation.
    Jiang Z, Zhang Y, Chen X, Wu P, Chen D., Free PMC Article

    04/24/2021
    Targeting the Oncogenic Long Non-coding RNA SLNCR1 by Blocking Its Sequence-Specific Binding to the Androgen Receptor.

    Targeting the Oncogenic Long Non-coding RNA SLNCR1 by Blocking Its Sequence-Specific Binding to the Androgen Receptor.
    Schmidt K, Weidmann CA, Hilimire TA, Yee E, Hatfield BM, Schneekloth JS Jr, Weeks KM, Novina CD., Free PMC Article

    02/13/2021
    we failed to provide any evidence in favor of the significant susceptibility of rs11655237 C>T polymorphism in LINC00673 to Wilms tumor. These data could be useful for reinforcing our understanding of the potential contribution of LINC00673 rs11655237 C>T to Wilms tumor susceptibility.

    LINC00673 rs11655237 C>T and susceptibility to Wilms tumor: A five-center case-control study.
    Li S, Lin A, Han D, Zhou H, Cheng J, Zhang J, Fu W, Zhuo Z, He J.

    07/18/2020
    SLNCR recruits AR to EGR1-bound genomic loci and switches EGR1-mediated transcriptional activation to repression of the tumor suppressor p21(Waf1/Cip1).

    The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21.
    Schmidt K, Carroll JS, Yee E, Thomas DD, Wert-Lamas L, Neier SC, Sheynkman G, Ritz J, Novina CD., Free PMC Article

    07/11/2020
    These findings add new evidence of the importance of LINC00673 rs11655237 C>T to the risk of developing neuroblastoma.

    Additional data support the role of LINC00673 rs11655237 C>T in the development of neuroblastoma.
    Li Y, Zhuo ZJ, Zhou H, Liu J, Liu Z, Zhang J, Cheng J, Li S, Zhou H, Zhou R, He J, Zhao Y., Free PMC Article

    05/23/2020
    Increased LINC00673 expression in breast cancer associated with poor prognosis.

    LINC00673 is activated by YY1 and promotes the proliferation of breast cancer cells via the miR-515-5p/MARK4/Hippo signaling pathway.
    Qiao K, Ning S, Wan L, Wu H, Wang Q, Zhang X, Xu S, Pang D., Free PMC Article

    02/22/2020
    lncRNA SLNCR1 and secretory sPLA2 were both upregulated in NSCLC. lncRNA SLNCR1 may regulate cancer cell migration, invasion and stemness in NSCLC through interactions with secretory sPLA2.

    Long non‑coding RNA SLNCR1 regulates non‑small cell lung cancer migration, invasion and stemness through interactions with secretory phospholipase A2.
    Xu W, Xu Q, Kuang D, Wang Z, Lu Q, Lin Q, Wu H, Chen L., Free PMC Article

    02/8/2020
    any association between the LINC00673 rs11655237 C>T polymorphism and Wilm's tumor risk, was not found.

    Investigation of association between LINC00673 rs11655237 C>T and Wilms tumor susceptibility.
    Gao X, Jia W, Zhu J, Fu W, Zhu S, Xia H, He J, Liu G., Free PMC Article

    02/8/2020
    The expression level of lncRNA00673 is up-regulated in colorectal cancer tissues and cells, which is related to the degree of malignancy and poor prognosis

    Association of the upregulation of LncRNA00673 with poor prognosis for colorectal cancer.
    Feng LM, Zhao DW, Li SJ, Huang J.

    11/2/2019
    Case-control study results indicate that LINC00673 rs11655237 significantly increased susceptibility of cervical cancer in a Chinese population, possibly by down-regulating LINC00673 expression in cervical tissues.

    LINC00673 rs11655237 Polymorphism Is Associated With Increased Risk of Cervical Cancer in a Chinese Population.
    Wang Y, Luo T., Free PMC Article

    04/6/2019
    LINC00673 promotes the proliferation and metastasis of thyroid carcinoma.Upregulation of LINC00673 in thyroid carcinoma.LINC00673 regulates the metastasis of thyroid carcinoma cell lines by modulating epithelial-mesenchymal transition.KLF-2 is a downstream target of LINC00673 in the thyroid carcinoma.

    lncRNA LINC00673 induces proliferation, metastasis and epithelial-mesenchymal transition in thyroid carcinoma via Kruppel-like factor 2.
    Xia E, Bhandari A, Shen Y, Zhou X, Wang O., Free PMC Article

    03/30/2019
    data suggest ERRLR01 operates as an oncogene in triple-negative breast cancer, as well as a biomarker in breast cancer patients

    linc00673 (ERRLR01) is a prognostic indicator of overall survival in breast cancer.
    Abdul-Rahman U, Győrffy B, Adams BD., Free PMC Article

    10/20/2018
    we verified that the LINC00673 rs11655237 C>T polymorphism might be associated with neuroblastoma susceptibility. Prospective studies with a large sample size and different ethnicities are needed to validate our findings.

    LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population.
    Zhang Z, Chang Y, Jia W, Zhang J, Zhang R, Zhu J, Yang T, Xia H, Zou Y, He J., Free PMC Article

    08/18/2018
    lncRNA 00312 may serve an important role in the tumorigenesis and deterioration of human NSCLC. Moreover, linc00673 is upregulated in LAD but not in LSCC tissues, implying that it can be a potential candidate tissue specific lncRNA for NSCLC.

    Identification of long non-coding RNA 00312 and 00673 in human NSCLC tissues.
    Tan Q, Yu Y, Li N, Jing W, Zhou H, Qiu S, Liang C, Yu M, Tu J., Free PMC Article

    05/26/2018
    miR-150-5p inhibition abrogated linc00673 silence mediated proliferation, migration, invasion and epithelial mesenchymal transition suppressing effect.

    Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p.
    Lu W, Zhang H, Niu Y, Wu Y, Sun W, Li H, Kong J, Ding K, Shen HM, Wu H, Xia D, Wu Y., Free PMC Article

    04/14/2018
    Results indicate that linc00673 could silence HOXA5 expression by recruiting epigenetic repressor, EZH2, at its promoter regions, and identified the role of lin00673 in promoting invasion and migration of non-small-cell lung cancer cells.

    Long intergenic noncoding RNA 00673 promotes non-small-cell lung cancer metastasis by binding with EZH2 and causing epigenetic silencing of HOXA5.
    Ma C, Wu G, Zhu Q, Liu H, Yao Y, Yuan D, Liu Y, Lv T, Song Y., Free PMC Article

    03/24/2018
    findings suggested that linc00673 could play crucial role in non-small cell lung cancer progression

    Upregulation of long intergenic noncoding RNA 00673 promotes tumor proliferation via LSD1 interaction and repression of NCALD in non-small-cell lung cancer.
    Shi X, Ma C, Zhu Q, Yuan D, Sun M, Gu X, Wu G, Lv T, Song Y., Free PMC Article

    01/6/2018
    Increased expression of this lncRNA, SLNCR1, mediates melanoma invasion through a highly conserved sequence similar to that of the lncRNA SRA1.

    The lncRNA SLNCR1 Mediates Melanoma Invasion through a Conserved SRA1-like Region.
    Schmidt K, Joyce CE, Buquicchio F, Brown A, Ritz J, Distel RJ, Yoon CH, Novina CD., Free PMC Article

    11/26/2017
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