| Study shows that TOM1 regulates neuronal accumulation of amyloid-beta oligomers by FcgammaRIIb2 variant in Alzheimer's Disease (AD). Study provides a molecular mechanism responsible for neuronal uptake of pathogenic Abeta found in AD. | TOM1 Regulates Neuronal Accumulation of Amyloid-β Oligomers by FcγRIIb2 Variant in Alzheimer's Disease.
Gwon Y, Kam TI, Kim SH, Song S, Park H, Lim B, Lee H, Lee W, Jo DG, Jung YK., Free PMC Article | 10/12/2019 |
| This study demonstrated that Tom1 is localized in dystrophic neurites of brain in patient with Alzheimer's disease. | Immunolocalization of Tom1 in relation to protein degradation systems in Alzheimer's disease.
Makioka K, Yamazaki T, Takatama M, Ikeda M, Murayama S, Okamoto K, Ikeda Y. | 04/22/2017 |
| Tom1 modulates binding of Tollip to phosphatidylinositol 3-phosphate via a coupled folding and binding mechanism. | Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism.
Xiao S, Brannon MK, Zhao X, Fread KI, Ellena JF, Bushweller JH, Finkielstein CV, Armstrong GS, Capelluto DGS. | 07/30/2016 |
| candidate multiple myeloma risk locus | Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma.
Swaminathan B, Thorleifsson G, Jöud M, Ali M, Johnsson E, Ajore R, Sulem P, Halvarsson BM, Eyjolfsson G, Haraldsdottir V, Hultman C, Ingelsson E, Kristinsson SY, Kähler AK, Lenhoff S, Masson G, Mellqvist UH, Månsson R, Nelander S, Olafsson I, Sigurðardottir O, Steingrimsdóttir H, Vangsted A, Vogel U, Waage A, Nahi H, Gudbjartsson DF, Rafnar T, Turesson I, Gullberg U, Stefánsson K, Hansson M, Thorsteinsdóttir U, Nilsson B., Free PMC Article | 04/16/2016 |
| phosphatidylinositol 5-monophosphate (PI5P) enrichment in signaling endosomes prevents endosomal maturation through the recruitment of TOM1, and point to a new function of PI5P in regulating discrete maturation steps in the endosomal system. | TOM1 is a PI5P effector involved in the regulation of endosomal maturation.
Boal F, Mansour R, Gayral M, Saland E, Chicanne G, Xuereb JM, Marcellin M, Burlet-Schiltz O, Sansonetti PJ, Payrastre B, Tronchère H. | 04/2/2016 |
| It was shown that that myosin VI, in concert with Tom1, plays a crucial role in autophagy. Tom1 was identified as a myosin VI binding partner on endosomes. | Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome.
Tumbarello DA, Waxse BJ, Arden SD, Bright NA, Kendrick-Jones J, Buss F., Free PMC Article | 01/12/2013 |
| TOM1 is a microRNA-126 target that may have an important role in regulating innate immune responses in the cystic fibrosis lung. | miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression.
Oglesby IK, Bray IM, Chotirmall SH, Stallings RL, O'Neill SJ, McElvaney NG, Greene CM. | 03/29/2010 |
| A 3-marker haplotype of SNPs within TOM1 was associated with psychotic bipolar affective disorder linkage | Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1.
Potash JB, Buervenich S, Cox NJ, Zandi PP, Akula N, Steele J, Rathe JA, Avramopoulos D, Detera-Wadleigh SD, Gershon ES, DePaulo JR Jr, Feinberg AP, McMahon FJ, NIMH Genetics Initiative Bipolar Disorder Consortium, Potash JB, Buervenich S, Cox NJ, Zandi PP, Akula N, Steele J, Rathe JA, Avramopoulos D, Detera-Wadleigh SD, Gershon ES, DePaulo JR Jr, Feinberg AP, McMahon FJ, NIMH Genetics Initiative Bipolar Disorder Consortium. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1.
Potash JB, Buervenich S, Cox NJ, Zandi PP, Akula N, Steele J, Rathe JA, Avramopoulos D, Detera-Wadleigh SD, Gershon ES, DePaulo JR Jr, Feinberg AP, McMahon FJ, NIMH Genetics Initiative Bipolar Disorder Consortium, Potash JB, Buervenich S, Cox NJ, Zandi PP, Akula N, Steele J, Rathe JA, Avramopoulos D, Detera-Wadleigh SD, Gershon ES, DePaulo JR Jr, Feinberg AP, McMahon FJ, NIMH Genetics Initiative Bipolar Disorder Consortium. | 03/13/2008 |
| Tollip and Tom1 form a complex and regulate endosomal trafficking of ubiquitinated proteins | Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes.
Katoh Y, Shiba Y, Mitsuhashi H, Yanagida Y, Takatsu H, Nakayama K. | 01/21/2010 |
| a Tom1-Tollip complex functions as a factor that links polyubiquitinated proteins to clathrin | Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin.
Yamakami M, Yoshimori T, Yokosawa H. | 01/21/2010 |
| marked recruitment of TOM1 to endosomes was observed in cells overexpressing endofin or its carboxyl-terminal fragment | Endofin recruits TOM1 to endosomes.
Seet LF, Liu N, Hanson BJ, Hong W. | 01/21/2010 |
| The results suggest that TOM1 is an important molecule for membrane recruitment of clathrin, and that endofin is able to exploit this recruitment at the endosome. | Endofin recruits clathrin to early endosomes via TOM1.
Seet LF, Hong W. | 01/21/2010 |