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    BCL2L11 BCL2 like 11 [ Homo sapiens (human) ]

    Gene ID: 10018, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Pokemon inhibits Bim transcription to promote the proliferation, anti-anoikis, invasion, histological grade, and dukes stage of colorectal neoplasms.

    Pokemon inhibits Bim transcription to promote the proliferation, anti-anoikis, invasion, histological grade, and dukes stage of colorectal neoplasms.
    Wang Y, Zeng H, Li L, Liu J, Lin J, Bie Y, Wang S, Cheng X, Nashun B, Yao Y, Hu X, Zhao Y., Free PMC Article

    08/6/2024
    Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy.

    Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy.
    Zhang Q, Wu Q, Huan XJ, Song SS, Bao XB, Miao ZH, Wang YQ.

    04/25/2024
    Coexpression of TP53, BIM, and PTEN Enhances the Therapeutic Efficacy of Non-Small-Cell Lung Cancer.

    Coexpression of TP53, BIM, and PTEN Enhances the Therapeutic Efficacy of Non-Small-Cell Lung Cancer.
    Lu L, Ma D, Xi Z.

    02/15/2024
    Protein interaction networks characterizing the A549 cells Klotho transfected are associated with activated pro-apoptotic Bim and suppressed Wnt/beta-catenin signaling pathway.

    Protein interaction networks characterizing the A549 cells Klotho transfected are associated with activated pro-apoptotic Bim and suppressed Wnt/β-catenin signaling pathway.
    Matsumoto M, Ogawa N, Fukuda T, Bando Y, Nishimura T, Usuda J., Free PMC Article

    02/5/2024
    Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis.

    Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis.
    Lambrecht R, Rudolf F, Ückert AK, Sladky VC, Phan TS, Jansen J, Naim S, Kaufmann T, Keogh A, Kirschnek S, Mangerich A, Stengel F, Leist M, Villunger A, Brunner T., Free PMC Article

    01/12/2024
    Expression Levels of MicroRNA-300/BCL2L11 in Papillary Thyroid Cancer and Their Clinical Diagnostic Values.

    Expression Levels of MicroRNA-300/BCL2L11 in Papillary Thyroid Cancer and Their Clinical Diagnostic Values.
    Shen Y, Li X, Xie R, Chen Y, Hu X, Liu Y, Ma H.

    09/7/2023
    Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity.

    Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity.
    Lu Y, Tang K, Wang S, Tian Z, Fan Y, Li B, Wang M, Zhao J, Xie J.

    05/17/2023
    miR-24-3p down-regulates the expression of the apoptotic factors FasL and BIM in human natural killer cells.

    miR-24-3p down-regulates the expression of the apoptotic factors FasL and BIM in human natural killer cells.
    Regis S, Dondero A, Spaggiari GM, Serra M, Caliendo F, Bottino C, Castriconi R.

    09/10/2022
    MicroRNA-17-5p Protects against Propofol Anesthesia-Induced Neurotoxicity and Autophagy Impairment via Targeting BCL2L11.

    MicroRNA-17-5p Protects against Propofol Anesthesia-Induced Neurotoxicity and Autophagy Impairment via Targeting BCL2L11.
    Xiu M, Luan H, Gu X, Liu C, Xu D., Free PMC Article

    07/16/2022
    Significant role of long non-coding RNA MALAT1 in deep vein thrombosis via the regulation of vascular endothelial cell physiology through the microRNA-383-5p/BCL2L11 axis.

    Significant role of long non-coding RNA MALAT1 in deep vein thrombosis via the regulation of vascular endothelial cell physiology through the microRNA-383-5p/BCL2L11 axis.
    Wang H, Lin S, Yang Y, Zhao M, Li X, Zhang L., Free PMC Article

    06/25/2022
    EGFR Inhibitors Plus Bevacizumab are Superior Than EGFR Inhibitors Alone as First-Line Setting in Advanced NSCLC With EGFR Mutations and BIM Deletion Polymorphisms (BIM-CLICaP).

    EGFR Inhibitors Plus Bevacizumab are Superior Than EGFR Inhibitors Alone as First-Line Setting in Advanced NSCLC With EGFR Mutations and BIM Deletion Polymorphisms (BIM-CLICaP).
    Cardona AF, Ordóñez-Reyes C, Ruiz-Patiño A, Garcia-Robledo JE, Barron LZ, Recondo G, Rojas L, Corrales L, Martín C, Barrón F, Sotelo C, Rodríguez J, Ricaurte L, Rolfo C, Ávila J, Mayorga D, Archila P, Otero J, Mas L, Bermudez M, Gamez T, Carranza H, Vargas C, Rosell R, Arrieta O.

    03/26/2022
    FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3/ITD acute leukemia cells through BIM activation.

    FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3/ITD acute leukemia cells through BIM activation.
    Zhu R, Li L, Nguyen B, Seo J, Wu M, Seale T, Levis M, Duffield A, Hu Y, Small D., Free PMC Article

    03/26/2022
    Prognostic Value of BIM Deletion in EGFR-Mutant NSCLC Patients Treated with EGFR-TKIs: A Meta-Analysis.

    Prognostic Value of BIM Deletion in EGFR-Mutant NSCLC Patients Treated with EGFR-TKIs: A Meta-Analysis.
    Lv F, Sun L, Yang Q, Pan Z, Zhang Y., Free PMC Article

    01/29/2022
    Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation.

    Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation.
    Woo SM, Seo SU, Min KJ, Kwon TK.

    01/22/2022
    [Effect of U2AF1 Mutation to Inflammatory Cytokine Expression in SKM-1 Cells through FOXO3a-Bim Signaling Pathway].

    [Effect of U2AF1 Mutation to Inflammatory Cytokine Expression in SKM-1 Cells through FOXO3a-Bim Signaling Pathway].
    Zhu YQ, Wu LY.

    12/18/2021
    Bim's Effect on the Expression of miR-423-3p in Promoting Primary Hepatic Cancer (PHC) and Role of miR-423-3p in PHC Proliferation and Invasion.

    Bim's Effect on the Expression of miR-423-3p in Promoting Primary Hepatic Cancer (PHC) and Role of miR-423-3p in PHC Proliferation and Invasion.
    Liu Z, Cui Y.

    10/2/2021
    Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer.

    Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer.
    Fevereiro J, Fraga AG, Capela C, Sopoh GE, Dossou A, Ayelo GA, Peixoto MJ, Cunha C, Carvalho A, Rodrigues F, Pedrosa J., Free PMC Article

    08/21/2021
    Efficacy of EGFR tyrosine kinase inhibitors in patients having EGFR-activating mutations with or without BIM polymorphisms.

    Efficacy of EGFR tyrosine kinase inhibitors in patients having EGFR-activating mutations with or without BIM polymorphisms.
    Ariyasu R, Yanagitani N, Tadokoro K, Yamaguchi T, Uchibori K, Kitazono S, Fujita N, Katayama R, Nishio M.

    05/22/2021
    Renal tubular Bim mediates the tubule-podocyte crosstalk via NFAT2 to induce podocyte cytoskeletal dysfunction.

    Renal tubular Bim mediates the tubule-podocyte crosstalk via NFAT2 to induce podocyte cytoskeletal dysfunction.
    Xu C, Zhou X, Xie T, Zhou Y, Zhang Q, Jiang S, Zhang R, Liao L, Dong J., Free PMC Article

    05/22/2021
    MicroRNA253p regulates human nucleus pulposus cell proliferation and apoptosis in intervertebral disc degeneration by targeting Bim.

    MicroRNA‑25‑3p regulates human nucleus pulposus cell proliferation and apoptosis in intervertebral disc degeneration by targeting Bim.
    Zhao Z, Zheng J, Ye Y, Zhao K, Wang R, Wang R., Free PMC Article

    05/1/2021
    Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells.

    Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells.
    Cai Z, Aguilera F, Ramdas B, Daulatabad SV, Srivastava R, Kotzin JJ, Carroll M, Wertheim G, Williams A, Janga SC, Zhang C, Henao-Mejia J, Kapur R., Free PMC Article

    05/1/2021
    Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1.

    Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1.
    Dong L, Vaux DL., Free PMC Article

    04/17/2021
    The pro-apoptotic domain of BIM protein forms toxic amyloid fibrils.

    The pro-apoptotic domain of BIM protein forms toxic amyloid fibrils.
    Malishev R, Ben-Zichri S, Oren O, Shauloff N, Peretz T, Taube R, Papo N, Jelinek R., Free PMC Article

    04/3/2021
    miR-885 mediated cardioprotection against hypoxia/reoxygenation-induced apoptosis in human cardiomyocytes via inhibition of PTEN and BCL2L11 and modulation of AKT/mTOR signaling.

    miR-885 mediated cardioprotection against hypoxia/reoxygenation-induced apoptosis in human cardiomyocytes via inhibition of PTEN and BCL2L11 and modulation of AKT/mTOR signaling.
    Meng X, Mei L, Zhao C, Chen W, Zhang N.

    03/13/2021
    Clinical significance of BIM deletion polymorphism in chemoradiotherapy for non-small cell lung cancer.

    Clinical significance of BIM deletion polymorphism in chemoradiotherapy for non-small cell lung cancer.
    Wakabayashi Y, Masuda T, Fujitaka K, Nakashima T, Okumoto J, Shimoji K, Nishimura Y, Yamaguchi K, Sakamoto S, Horimasu Y, Miyamoto S, Iwamoto H, Ohshimo S, Hamada H, Hattori N., Free PMC Article

    03/6/2021
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