| FOXO6 transcription inhibition of CTRP3 promotes OGD/R-triggered cardiac microvascular endothelial barrier disruption via SIRT1/Nrf2 signalling. | FOXO6 transcription inhibition of CTRP3 promotes OGD/R-triggered cardiac microvascular endothelial barrier disruption via SIRT1/Nrf2 signalling.
Zheng S, Wang Y, Guo W, Tan H. | 04/4/2024 |
| Upregulation of FoxO6 in nucleus pulposus cells promotes DNA damage repair via activation of RAD51. | Upregulation of FoxO6 in nucleus pulposus cells promotes DNA damage repair via activation of RAD51.
Cong L, Zhang XL, Wang XK, Wang Y, Jia YY, Yin H, Li ZH. | 03/12/2022 |
| LncRNA HOXC-AS1 promotes nasopharyngeal carcinoma (NPC) progression by sponging miR-4651 and subsequently upregulating FOXO6. | LncRNA HOXC-AS1 promotes nasopharyngeal carcinoma (NPC) progression by sponging miR-4651 and subsequently upregulating FOXO6.
Tang Z, Zeng X, Li J, Qiu S, Zhao H, Wang Z, Zheng Y. | 01/15/2022 |
| Knockdown of long non-coding MIR210HG inhibits cell proliferation, migration, and invasion in hepatoblastoma via the microRNA-608-FOXO6 axis. | Knockdown of long non-coding MIR210HG inhibits cell proliferation, migration, and invasion in hepatoblastoma via the microRNA-608-FOXO6 axis.
Duan Y, Wu H, Hao X, Li F, Liu J, Zhu C, Dong Q., Free PMC Article | 12/25/2021 |
| Association of genetic variants of FBXO32 and FOXO6 in the FOXO pathway with breast cancer risk. | Association of genetic variants of FBXO32 and FOXO6 in the FOXO pathway with breast cancer risk.
Wang H, Liu H, Zhao L, Luo S, Akinyemiju T, Hwang S, Yue Y, Wei Q., Free PMC Article | 11/13/2021 |
| Downregulation of FOXO6 alleviates hypoxia-induced apoptosis and oxidative stress in cardiomyocytes by enhancing Nrf2 activation via upregulation of SIRT6. | Downregulation of FOXO6 alleviates hypoxia-induced apoptosis and oxidative stress in cardiomyocytes by enhancing Nrf2 activation via upregulation of SIRT6.
Jin A, Zhang Q, Li S, Li B. | 08/28/2021 |
| Interaction between CHOP and FoxO6 promotes hepatic lipid accumulation. | Interaction between CHOP and FoxO6 promotes hepatic lipid accumulation.
Kim DH, Kim BM, Chung KW, Choi YJ, Yu BP, Chung HY., Free PMC Article | 08/7/2021 |
| suppression of FOXO6 protects ARPE-19 cells from HG-induced oxidative stress and apoptosis, which is in part mediated by the activation of Akt/Nrf2 pathway. | Knockdown of FOXO6 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells.
Zhou Z, Liu J, Bi C, Chen L, Jiao Y, Cui L. | 07/18/2020 |
| downstream effector in 5-HT1D-induced hepatocellular carcinoma progression | 5-Hydroxytryptamine Receptor 1D Aggravates Hepatocellular Carcinoma Progression Through FoxO6 in AKT-Dependent and Independent Manners.
Zuo X, Chen Z, Cai J, Gao W, Zhang Y, Han G, Pu L, Wu Z, You W, Qin J, Dai X, Shen H, Wu J, Wang X. | 06/20/2020 |
| The results indicated that FOXO6 knockdown inhibited colorectal cancer cell proliferation, migration, invasion, and glycolysis via the PI3K/Akt/mTOR pathway. | Silencing of FOXO6 inhibits the proliferation, invasion, and glycolysis in colorectal cancer cells.
Li Q, Tang H, Hu F, Qin C. | 06/20/2020 |
| FoxO6 regulated nuclear factor erythroid 2-related factor (Nrf2) expression via c-Myc after 3% isoflurane preconditioning and OGD exposure. Thus, isoflurane preconditioning prevented OGD-induced injury in LO2 cells by modulating FoxO6, c-Myc, and Nrf2 signaling. | Isoflurane preconditioning protects hepatocytes from oxygen glucose deprivation injury by regulating FoxO6.
Zhong Y, Hu X, Miao L. | 05/30/2020 |
| High FOXO6 expression is associated with gastric cancer. | The long noncoding RNA NORAD promotes the growth of gastric cancer cells by sponging miR-608.
Miao Z, Guo X, Tian L. | 01/19/2019 |
| this study established a correlation between FOXO6 expression and gastric cancer prognosis. FOXO6 could be a promising predictor for prognosis in gastric cancer. | Elevated FOXO6 expression correlates with progression and prognosis in gastric cancer.
Wang JH, Tang HS, Li XS, Zhang XL, Yang XZ, Zeng LS, Ruan Q, Huang YH, Liu GJ, Wang J, Cui SZ., Free PMC Article | 03/31/2018 |
| Lacking the FOXO6 risk allele was associated with an increase in negative schizophrenia symptoms and surface area reduction in the right orbitofrontal gyrus - an area previously associated with negative symptoms - suggesting that presence of the FOXO6 risk allele confers resistance against negative symptoms and associated neuroanatomical changes in individuals with first-episode schizophrenia. | Bipolar disorder risk gene FOXO6 modulates negative symptoms in schizophrenia: a neuroimaging genetics study.
Shenker JJ, Sengupta SM, Joober R, Malla A, Chakravarty MM, Lepage M., Free PMC Article | 02/24/2018 |
| In conclusion, the results of the present study indicated that the FOXO6/USP7 molecular network has an important role in the regulation of lung cancer development. | FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7.
Hu HJ, Zhang LG, Wang ZH, Guo XX. | 01/16/2016 |
| Studies indicate that FoxO6 is produced in the liver of both rodents and humans. | FoxO6 in glucose metabolism (FoxO6).
Kim DH, Zhang T, Lee S, Dong HH., Free PMC Article | 03/15/2014 |
| FOXO6 induces C-myc expression by associating to HNF4 and mediating histone acetylation, and the dissociation of HDAC3 from the promoter of the C-myc gene | FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C-myc.
Qinyu L, Long C, Zhen-dong D, Min-min S, Wei-ze W, Wei-ping Y, Cheng-hong P. | 09/7/2013 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 07/31/2012 |
| Studies indictet that the mammalian FoxO family consists of FoxO1, 3, 4 and 6 and are regulated by by AKT and 14-3-3 proteins. | FoxO transcription factors; Regulation by AKT and 14-3-3 proteins.
Tzivion G, Dobson M, Ramakrishnan G. | 12/24/2011 |
| investigation of role of FoxO6 in liver: Data suggest that a FoxO6-dependent pathway in hepatocytes orchestrates insulin regulation of gluconeogenesis. | FoxO6 integrates insulin signaling with gluconeogenesis in the liver.
Kim DH, Perdomo G, Zhang T, Slusher S, Lee S, Phillips BE, Fan Y, Giannoukakis N, Gramignoli R, Strom S, Ringquist S, Dong HH., Free PMC Article | 12/17/2011 |
| gene study of FOXO6, reveals no association with human longevity in Germans | Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no association with human longevity in Germans.
Kleindorp R, Flachsbart F, Puca AA, Malovini A, Schreiber S, Nebel A. | 12/17/2011 |
| cloning and characterization; structural and functional properties related to gene regulation | FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics.
Jacobs FM, van der Heide LP, Wijchers PJ, Burbach JP, Hoekman MF, Smidt MP. | 01/21/2010 |