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    MIR216B microRNA 216b [ Homo sapiens (human) ]

    Gene ID: 100126319, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    [LncRNA RPL22P1-201 affects prostate cancer cell proliferation, cell cycle, and sensitivity to docetaxel by regulating miR-216b-5p expression].

    [LncRNA RPL22P1-201 affects prostate cancer cell proliferation, cell cycle, and sensitivity to docetaxel by regulating miR-216b-5p expression].
    Yang C, Xue JG.

    04/24/2024
    LncRNA-SNHG1 promotes paclitaxel resistance of gastric cancer cells through modulating the miR-216b-5p-hexokianse 2 axis.

    LncRNA-SNHG1 promotes paclitaxel resistance of gastric cancer cells through modulating the miR-216b-5p-hexokianse 2 axis.
    Xu J, Xu Y, Ye G, Qiu J.

    09/28/2023
    Long Noncoding RNA LINC01518 Modulates Proliferation and Migration in TGF-beta1-Treated Human Tenon Capsule Fibroblast Cells Through the Regulation of hsa-miR-216b-5p.

    Long Noncoding RNA LINC01518 Modulates Proliferation and Migration in TGF-β1-Treated Human Tenon Capsule Fibroblast Cells Through the Regulation of hsa-miR-216b-5p.
    Kong N, Bao Y, Zhao H, Kang X, Tai X, Chen X, Guo W, Shen Y.

    05/28/2022
    Ultrasound microbubbles-mediated miR-216b affects MALAT1-miRNA axis in non-small cell lung cancer cells.

    Ultrasound microbubbles-mediated miR-216b affects MALAT1-miRNA axis in non-small cell lung cancer cells.
    Wang J, Mo J, Xie Y, Wang C.

    03/26/2022
    MicroRNA-216b targets HK2 to potentiate autophagy and apoptosis of breast cancer cells via the mTOR signaling pathway.

    MicroRNA-216b targets HK2 to potentiate autophagy and apoptosis of breast cancer cells via the mTOR signaling pathway.
    Liu T, Ye P, Ye Y, Han B., Free PMC Article

    03/19/2022
    LncRNA MYCNOS promotes glioblastoma cell proliferation by regulating miR-216b/FOXM1 axis.

    LncRNA MYCNOS promotes glioblastoma cell proliferation by regulating miR-216b/FOXM1 axis.
    Zhao P, Li T, Wang Y, Wang Y, Gu Q, Li Z.

    01/22/2022
    LncRNA KCNQ1OT1 acts as miR-216b-5p sponge to promote colorectal cancer progression via up-regulating ZNF146.

    LncRNA KCNQ1OT1 acts as miR-216b-5p sponge to promote colorectal cancer progression via up-regulating ZNF146.
    Zhu S, Chen CY, Hao Y.

    11/27/2021
    MiR-216b regulates the tumorigenesis of gastric cancer by targeting PXN.

    MiR-216b regulates the tumorigenesis of gastric cancer by targeting PXN.
    Liu X, Xu D, Xu X, Xue Q, Gao X, Tang C.

    11/6/2021
    The expression of miRNA-216b is negatively correlated with 18F-FDG uptake in non-small cell lung cancer.

    The expression of miRNA-216b is negatively correlated with 18F-FDG uptake in non-small cell lung cancer.
    Zuo M, Yao L, Wen L, Shen J, Zhang N, Bai T, Huang Q., Free PMC Article

    09/11/2021
    Dysregulation of lnc-SNHG1 and miR-216b-5p correlate with chemoresistance and indicate poor prognosis of serous epithelial ovarian cancer.

    Dysregulation of lnc-SNHG1 and miR-216b-5p correlate with chemoresistance and indicate poor prognosis of serous epithelial ovarian cancer.
    Pei ML, Zhao ZX, Shuang T., Free PMC Article

    08/7/2021
    MiR-216b inhibits gastric cancer proliferation and migration by targeting PARK7.

    MiR-216b inhibits gastric cancer proliferation and migration by targeting PARK7.
    Zhu GM, Chen SQ, Jiang QG, Cao Y, Guo Y, Ye LQ.

    07/24/2021
    MicroRNA-216b suppresses the cell growth of hepatocellular carcinoma by inhibiting Ubiquitin-specific peptidase 28 expression.

    MicroRNA-216b suppresses the cell growth of hepatocellular carcinoma by inhibiting Ubiquitin-specific peptidase 28 expression.
    Zhang JF.

    07/17/2021
    Correlation between carotid atherosclerotic plaque properties and serum levels of lncRNA CCAT2 and miRNA-216b.

    Correlation between carotid atherosclerotic plaque properties and serum levels of lncRNA CCAT2 and miRNA-216b.
    Huang CQ, Jin WX, Yu GF.

    04/24/2021
    LncRNA GAS5 affects epithelial-mesenchymal transition and invasion of breast cancer cells by regulating miR-216b.

    LncRNA GAS5 affects epithelial-mesenchymal transition and invasion of breast cancer cells by regulating miR-216b.
    Li Y, Guo XB, Wei YH.

    04/3/2021
    MicroRNA-216b regulates cell proliferation, invasion and cycle progression via interaction with cyclin T2 in gastric cancer.

    MicroRNA-216b regulates cell proliferation, invasion and cycle progression via interaction with cyclin T2 in gastric cancer.
    Chen X, Zhang L, Song Q, Chen Z.

    03/13/2021
    Therapeutic targeting of miRNA-216b in cancer.

    Therapeutic targeting of miRNA-216b in cancer.
    Jana S, Krishna M, Singhal J, Horne D, Awasthi S, Salgia R, Singhal SS.

    02/2/2021
    Long non-coding RNA 00152 promotes cell proliferation in cervical cancer via regulating miR-216b-5p/HOXA1 axis.

    Long non-coding RNA 00152 promotes cell proliferation in cervical cancer via regulating miR-216b-5p/HOXA1 axis.
    Zheng JJ, Du XJ, Wang HP, Zhou LY, Wang YJ, Zhang L, Xu H, Zhang J, Hu ZF.

    09/19/2020
    These findings may provide novel insights into the molecular mechanism of miR-216b and FoxM1 in the progression of Osteosarcoma (OS) , and suggested that miR-216b may serve as a potential tumor inhibitor of OS by targeting FoxM1.

    MiR-216b inhibits osteosarcoma cell proliferation, migration, and invasion by targeting Forkhead Box M1.
    Wang W, Guo Z, Yu H, Fan L.

    07/18/2020
    Collectively, serum exosomal miR-216b might be used as a potential diagnostic and prognostic biomarker for non-small cell lung cancer (NSCLC).

    Downregulation of serum exosomal miR-216b predicts unfavorable prognosis in patients with non-small cell lung cancer.
    Liu W, Liu J, Zhang Q, Wei L.

    06/13/2020
    SNHG7 positively regulated GALNT1 level through sponging miR-216b, and played an oncogenic role in colorectal cancer progression.

    LncRNA SNHG7 sponges miR-216b to promote proliferation and liver metastasis of colorectal cancer through upregulating GALNT1.
    Shan Y, Ma J, Pan Y, Hu J, Liu B, Jia L., Free PMC Article

    12/7/2019
    Low miR216b expression is associated with breast cancer.

    MiR-216b-5p inhibits cell proliferation in human breast cancer by down-regulating HDAC8 expression.
    Menbari MN, Rahimi K, Ahmadi A, Elyasi A, Darvishi N, Hosseini V, Mohammadi-Yeganeh S, Abdi M.

    11/30/2019
    We observed that the designed ss-miR-216b mimics engaged AGO2 to promote the silencing of KRAS. We also tested a new delivery strategy based on the use of palmityl-oleyl-phosphatidylcholine (POPC) liposomes functionalized with ss-miR-216b conjugated with two palmityl chains and a lipid-modified cell penetrating peptide . These versatile nanoparticles suppressed oncogenic KRAS in pancreatic ductal adenocarcinoma cells

    MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells.
    Ferino A, Miglietta G, Picco R, Vogel S, Wengel J, Xodo LE., Free PMC Article

    01/12/2019
    miR-216b expression was a valuable biomarker correlated with disease recurrence in acute myeloid leukemia.

    Overexpression of miR-216b: Prognostic and predictive value in acute myeloid leukemia.
    Zhang TJ, Wu DH, Zhou JD, Li XX, Zhang W, Guo H, Ma JC, Deng ZQ, Lin J, Qian J.

    12/22/2018
    MiR-216b exerted its tumor suppressor function through inhibiting the KRAS-related MAPK/ERK and PI3K/AKT pathways.

    miR-216b Post-Transcriptionally Downregulates Oncogene KRAS and Inhibits Cell Proliferation and Invasion in Clear Cell Renal Cell Carcinoma.
    Wang Y, Dong D, Jiang S, Zhang E, Zheng W, Mao L, Li W, Zhou J, Fan L, Cheng R, Li Z, Fang Z, Gui Y, Li X.

    10/20/2018
    MiR-216b directly targets c-Jun, thereby reducing AP-1-dependent transcription and sensitizing cells to ER stress-dependent apoptosis.

    miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis.
    Xu Z, Bu Y, Chitnis N, Koumenis C, Fuchs SY, Diehl JA., Free PMC Article

    07/28/2018
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